Strain Name:
C57BL/6J-MtgxR4105Btlr/Mmmh
Stock Number:
040985-MU
Citation ID:
RRID:MMRRC_040985-MU
Other Names:
R4105 (G1), C57BL/6J-MtgxR4105Btlr
Major Collection:

Gene Information

Zmym6
Name: zinc finger, MYM-type 6
Synonyms: Zfp258, D4Wsu24e, 9330177P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100177
Homologene: 5186
Sult6b1
Name: sulfotransferase family, cytosolic, 6B, member 1
Synonyms: 2410078J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 73671
Homologene: 42242
Nfya
Name: nuclear transcription factor-Y alpha
Synonyms: Sez10, Cbf-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18044
HGNC: HGNC:7804
Homologene: 32114
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: HELIC2, A330064G03Rik, Ascc3l1, U5-200KD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320632
Homologene: 5859
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: 3110031G15Rik, GMAP-210, TRIP230, 6030460N08Rik, 2610511G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 109181
Homologene: 20897
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: RPA194, 194kDa, Rpo1-4, 2900087K15Rik, 3010014K16Rik, mRPA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20019
Homologene: 7033
Clpb
Name: ClpB caseinolytic peptidase B
Synonyms: Skd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20480
Homologene: 32067
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: Pip5k3, 5230400C17Rik, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18711
Homologene: 32115
Scyl2
Name: SCY1-like 2 (S. cerevisiae)
Synonyms: CVAK104, D10Ertd802e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 213326
Homologene: 13349
Ypel3
Name: yippee like 3
Synonyms: 1190001G19Rik, Suap, 0610043B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66090
Homologene: 116010
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Eif2b3
Name: eukaryotic translation initiation factor 2B, subunit 3
Synonyms: 1190002P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 108067
HGNC: HGNC:3259
Homologene: 7005
Dnajb2
Name: DnaJ heat shock protein family (Hsp40) member B2
Synonyms: 2700059H22Rik, mDj8, Dnajb10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 56812
HGNC: HGNC:5228
Homologene: 4902
Ahcyl1
Name: S-adenosylhomocysteine hydrolase-like 1
Synonyms: 1110034F20Rik, IRBIT, Ahcy-rs3, DCAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229709
HGNC: HGNC:344
Homologene: 77353
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319670
VEGA: 12
Homologene: 26807
Smim13
Name: small integral membrane protein 13
Synonyms: BC024659, 2900036K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 108934
Homologene: 122114
Adar
Name: adenosine deaminase, RNA-specific
Synonyms: Adar1p150, mZaADAR, Adar1p110, ADAR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56417
HGNC: HGNC:225
Homologene: 9281
Fgf7
Name: fibroblast growth factor 7
Synonyms: Keratinocyte growth factor, Kgf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14178
HGNC: HGNC:3685
Homologene: 7316
Bmper
Name: BMP-binding endothelial regulator
Synonyms: CV-2, Crim3, Cv2, 3110056H04Rik, crossveinless-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 73230
VEGA: 9
Homologene: 12494
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233651
Homologene: 2771
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Birc1e, Naip-rs3, Lgn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Cyp2j7
Name: cytochrome P450, family 2, subfamily j, polypeptide 7
Synonyms: OTTMUSG00000007941, Cyp2j7-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 546837
Tpo
Name: thyroid peroxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 22018
Homologene: 461
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, C030048J01Rik, Lba1, LOC235639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320429
Homologene: 45845
Fam214a
Name: family with sequence similarity 214, member A
Synonyms: C130047D21Rik, BC031353, 6330415I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235493
VEGA: 9
Homologene: 35065
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 245860
Homologene: 34495
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: 8430408C16Rik, Pept2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 57738
Homologene: 56912
Pnmal1
Name: PNMA-like 1
Synonyms: 4930488B01Rik, 0710005I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71691
Homologene: 10073
Postn
Name: periostin, osteoblast specific factor
Synonyms: Osf2, OSF-2, Periostin, A630052E07Rik, peri
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 50706
Homologene: 4730
Mrc2
Name: mannose receptor, C type 2
Synonyms: Endo180, novel lectin, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17534
Homologene: 4408
Arhgap31
Name: Rho GTPase activating protein 31
Synonyms: CdGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 12549
Homologene: 10644
Lrrcc1
Name: leucine rich repeat and coiled-coil domain containing 1
Synonyms: 4932441F23Rik, 1200008A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71710
Homologene: 12559
Zscan4e
Name: zinc finger and SCAN domain containing 4E
Synonyms: EG665848
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 665848
Homologene: 85986
Cel
Name: carboxyl ester lipase
Synonyms: BAL, 1810036E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12613
HGNC: HGNC:1848
Homologene: 37529
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100009609
Polrmt
Name: polymerase (RNA) mitochondrial (DNA directed)
Synonyms: 1110018N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216151
HGNC: HGNC:9200
Homologene: 37996
Olfr1394
Name: olfactory receptor 1394
Synonyms: GA_x6K02T2QP88-6274566-6273628, MOR280-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258273
Homologene: 138305
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: TR2, Gpr71, T1r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 83770
Homologene: 75323
Slco2a1
Name: solute carrier organic anion transporter family, member 2a1
Synonyms: mPgt, Pgt, Slc21a2, 2310021C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 24059
Homologene: 38077
Ces2f
Name: carboxylesterase 2F
Synonyms: 2310038E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 71903
HGNC: HGNC:1864
Homologene: 135673
Asb18
Name: ankyrin repeat and SOCS box-containing 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 208372
Homologene: 16382
Zfp128
Name: zinc finger protein 128
Synonyms: mZnf8, 9630016P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243833
Homologene: 10889
Fbxo10
Name: F-box protein 10
Synonyms: LOC269529, FBX10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 269529
Homologene: 19544
Gm2832
Name: predicted gene 2832
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 100040545
RP23-216J17.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 65,190,520 bp
  • T to C, chromosome 1 at 65,196,746 bp
  • A to G, chromosome 1 at 75,185,959 bp
  • G to T, chromosome 1 at 75,236,899 bp
  • T to C, chromosome 1 at 89,968,521 bp
  • T to C, chromosome 2 at 28,558,027 bp
  • T to A, chromosome 2 at 126,035,679 bp
  • T to A, chromosome 2 at 127,228,016 bp
  • T to C, chromosome 3 at 14,550,328 bp
  • T to C, chromosome 3 at 54,376,041 bp
  • T to C, chromosome 3 at 89,740,094 bp
  • T to C, chromosome 3 at 107,667,212 bp
  • A to G, chromosome 4 at 45,059,054 bp
  • T to C, chromosome 4 at 96,199,450 bp
  • G to A, chromosome 4 at 117,081,634 bp
  • T to C, chromosome 4 at 127,088,408 bp
  • G to A, chromosome 4 at 139,660,052 bp
  • A to G, chromosome 6 at 71,976,191 bp
  • T to C, chromosome 7 at 11,307,510 bp
  • T to C, chromosome 7 at 12,884,740 bp
  • T to C, chromosome 7 at 16,961,179 bp
  • T to C, chromosome 7 at 38,568,478 bp
  • A to G, chromosome 7 at 84,946,483 bp
  • T to C, chromosome 7 at 101,778,613 bp
  • A to C, chromosome 7 at 105,765,140 bp
  • T to C, chromosome 7 at 126,778,093 bp
  • A to G, chromosome 8 at 45,036,851 bp
  • T to C, chromosome 8 at 104,951,192 bp
  • G to A, chromosome 9 at 23,224,763 bp
  • A to G, chromosome 9 at 75,008,776 bp
  • T to A, chromosome 9 at 103,067,876 bp
  • T to C, chromosome 9 at 103,073,250 bp
  • T to C, chromosome 9 at 111,352,197 bp
  • G to T, chromosome 10 at 79,741,733 bp
  • A to G, chromosome 10 at 89,678,425 bp
  • G to T, chromosome 10 at 107,572,967 bp
  • A to G, chromosome 11 at 49,160,548 bp
  • G to A, chromosome 11 at 105,348,431 bp
  • G to A, chromosome 12 at 30,092,586 bp
  • T to C, chromosome 12 at 98,841,548 bp
  • G to A, chromosome 12 at 101,894,322 bp
  • T to A, chromosome 13 at 41,272,651 bp
  • T to C, chromosome 13 at 100,219,739 bp
  • A to T, chromosome 14 at 41,280,899 bp
  • G to T, chromosome 16 at 36,782,393 bp
  • A to G, chromosome 16 at 38,602,426 bp
  • G to T, chromosome 17 at 48,392,884 bp
  • G to T, chromosome 17 at 78,906,862 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4105 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040985-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.