Strain Name:
C57BL/6J-MtgxR4107Btlr/Mmmh
Stock Number:
040986-MU
Citation ID:
RRID:MMRRC_040986-MU
Other Names:
R4107 (G1), C57BL/6J-MtgxR4107Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, Mll3, E330008K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Enc1
Name: ectodermal-neural cortex 1
Synonyms: PIG10, Nrpb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13803
VEGA: 13
HGNC: HGNC:3345
Homologene: 2694
Rbms1
Name: RNA binding motif, single stranded interacting protein 1
Synonyms: YC1, MSSP-1, 2600014B10Rik, MSSP-2, MSSP-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56878
HGNC: HGNC:9907
Homologene: 9640
Mta3
Name: metastasis associated 3
Synonyms: 1110002J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 116871
Homologene: 14282
Sult6b1
Name: sulfotransferase family, cytosolic, 6B, member 1
Synonyms: 2410078J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73671
Homologene: 42242
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208628
Homologene: 32227
Zfp407
Name: zinc finger protein 407
Synonyms: 6430585N13Rik, LOC240469, LOC381139
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240476
Homologene: 86402
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: CS1, SPAG13, KRAP, CS-1, Ssfa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70599
Homologene: 4912
Clpb
Name: ClpB caseinolytic peptidase B
Synonyms: Skd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20480
Homologene: 32067
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola-2, Col1a-2, Cola2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: C130041O22Rik, Zfh-4, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Ttn
Name: titin
Synonyms: L56, 2310074I15Rik, 2310036G12Rik, 1100001C23Rik, connectin, shru, D830007G01Rik, mdm, D330041I19Rik, 2310057K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Acad10
Name: acyl-Coenzyme A dehydrogenase family, member 10
Synonyms: 2410021P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71985
Homologene: 49825
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70882
Homologene: 31589
Cyp2j7
Name: cytochrome P450, family 2, subfamily j, polypeptide 7
Synonyms: Cyp2j7-ps, OTTMUSG00000007941
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 546837
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234686
Homologene: 136406
Rnasel
Name: ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
Synonyms: E230029I04Rik, 2-5A-dependent RNAase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 24014
Homologene: 8040
Tpo
Name: thyroid peroxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22018
Homologene: 461
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: b2b1304Clo, b2b2025.1Clo, prh, 4921507O14Rik, D3Ertd789e, b2b1735Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51938
Homologene: 12149
Xcr1
Name: chemokine (C motif) receptor 1
Synonyms: Ccxcr1, C motif-1/lymphotactin receptor, XCR1, GPR5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23832
HGNC: HGNC:1625
Homologene: 21095
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: 8430408C16Rik, Pept2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57738
Homologene: 56912
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, Endo180, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17534
Homologene: 4408
Arhgap31
Name: Rho GTPase activating protein 31
Synonyms: CdGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12549
Homologene: 10644
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: TR2, Gpr71, T1r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 83770
Homologene: 75323
Nlrp4f
Name: NLR family, pyrin domain containing 4F
Synonyms: Nalp-kappa, C330026N02Rik, Nalp4f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 97895
VEGA: 13
Homologene: 87252
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: A230084E24Rik, ThTr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 80721
Homologene: 23530
Tmem44
Name: transmembrane protein 44
Synonyms: 1700007N03Rik, 9330161C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224090
Homologene: 26702
Rpusd4
Name: RNA pseudouridylate synthase domain containing 4
Synonyms: 2410001E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71989
Homologene: 32794
Stbd1
Name: starch binding domain 1
Synonyms: D530019K15Rik, D5Ertd593e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52331
Homologene: 2929
Acox3
Name: acyl-Coenzyme A oxidase 3, pristanoyl
Synonyms: EST-s59, PCOX, pristanoyl-CoA oxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80911
HGNC: HGNC:121
Homologene: 37792
Trim68
Name: tripartite motif-containing 68
Synonyms: Rnf137, F730114J12Rik, SS-56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101700
Homologene: 9991
Cox5b-ps
Name: cytochrome c oxidase subunit 5B, pseudogene
Synonyms: Gm11273
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100040340
Olfr259
Name: olfactory receptor 259
Synonyms: GA_x6K02T2N869-1820-882, MOR172-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258766
Homologene: 106833
Pou4f3
Name: POU domain, class 4, transcription factor 3
Synonyms: Brn3c, Brn-3.1, Brn3.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18998
HGNC: HGNC:9220
Homologene: 2023
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 83,022,957 bp
  • A to G, chromosome 1 at 153,754,796 bp
  • G to A, chromosome 2 at 19,288,909 bp
  • A to G, chromosome 2 at 60,758,816 bp
  • T to C, chromosome 2 at 76,739,141 bp
  • T to G, chromosome 2 at 79,644,831 bp
  • T to A, chromosome 2 at 87,107,655 bp
  • C to T, chromosome 3 at 5,329,617 bp
  • A to G, chromosome 3 at 33,825,479 bp
  • T to C, chromosome 4 at 96,199,450 bp
  • G to A, chromosome 4 at 139,660,052 bp
  • C to A, chromosome 5 at 22,034,584 bp
  • A to G, chromosome 5 at 25,298,920 bp
  • T to C, chromosome 5 at 35,601,552 bp
  • A to G, chromosome 5 at 92,605,280 bp
  • G to T, chromosome 5 at 121,631,464 bp
  • T to A, chromosome 5 at 123,762,598 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • T to C, chromosome 7 at 101,778,613 bp
  • G to T, chromosome 7 at 102,678,451 bp
  • T to C, chromosome 8 at 105,338,038 bp
  • T to C, chromosome 9 at 35,275,128 bp
  • A to G, chromosome 9 at 123,856,088 bp
  • G to A, chromosome 11 at 105,348,431 bp
  • G to A, chromosome 12 at 30,092,586 bp
  • T to C, chromosome 12 at 98,841,548 bp
  • T to C, chromosome 13 at 21,501,337 bp
  • C to A, chromosome 13 at 65,183,065 bp
  • C to A, chromosome 13 at 97,245,138 bp
  • G to A, chromosome 16 at 30,543,408 bp
  • G to T, chromosome 16 at 36,782,393 bp
  • A to G, chromosome 16 at 38,602,426 bp
  • G to T, chromosome 17 at 78,906,862 bp
  • A to G, chromosome 17 at 83,762,914 bp
  • A to G, chromosome 18 at 42,395,922 bp
  • T to A, chromosome 18 at 84,343,007 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4107 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040986-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.