Strain Name:
C57BL/6J-MtgxR4110Btlr/Mmmh
Stock Number:
040988-MU
Citation ID:
RRID:MMRRC_040988-MU
Other Names:
R4110 (G1), C57BL/6J-MtgxR4110Btlr
Major Collection:

Gene Information

Sgca
Name: sarcoglycan, alpha (dystrophin-associated glycoprotein)
Synonyms: adhalin, Asg, 50DAG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20391
Homologene: 9
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: Daple, 0610010D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 68339
VEGA: 12
Homologene: 18903
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 208440
Homologene: 40996
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 114873
VEGA: 9
Homologene: 79549
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, Bwf1, Alfy, 2610509D04Rik, Bchs, Ggtb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72145
Homologene: 22855
Cse1l
Name: chromosome segregation 1-like (S. cerevisiae)
Synonyms: Capts, Cas, Xpo2, 2610100P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 110750
HGNC: HGNC:2431
Homologene: 1006
Top2a
Name: topoisomerase (DNA) II alpha
Synonyms: Top-2, DNA Topoisomerase II alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 21973
Homologene: 830
Ssbp3
Name: single-stranded DNA binding protein 3
Synonyms: 2610200M23Rik, 2610021L12Rik, 5730488C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72475
Homologene: 23411
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: D330037A14Rik, LL5A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 102693
Homologene: 15903
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: 2400004E04Rik, NMHC II-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71960
Homologene: 23480
Tbr1
Name: T-box brain gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 21375
Homologene: 4807
Fzd3
Name: frizzled class receptor 3
Synonyms: D930050A07Rik, Fz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 14365
HGNC: HGNC:4041
Homologene: 23004
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Tnc
Name: tenascin C
Synonyms: hexabrachion, Hxb, cytotactin, tenascin-C, C130033P17Rik, TN-C, TN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Hhipl2
Name: hedgehog interacting protein-like 2
Synonyms: 4930507C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 78772
Homologene: 11690
H13
Name: histocompatibility 13
Synonyms: 4930443L17Rik, H-13, 1200006O09Rik, 5031424B04Rik, Spp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14950
Homologene: 7749
Casp2
Name: caspase 2
Synonyms: Caspase-2, Ich-1, Nedd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12366
HGNC: HGNC:1503
Homologene: 7254
Rpl24
Name: ribosomal protein L24
Synonyms: Bst, 0610008L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 68193
Homologene: 763
AW209491
Name: expressed sequence AW209491
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105351
VEGA: 13
Homologene: 11439
Sucnr1
Name: succinate receptor 1
Synonyms: Gpr91
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 84112
HGNC: HGNC:4542
Homologene: 41865
Muc19
Name: mucin 19
Synonyms: apomucin, sld
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239611
Sec31b
Name: Sec31 homolog B (S. cerevisiae)
Synonyms: Sec31l2, LOC240667
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 240667
Homologene: 56708
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Man2c1
Name: mannosidase, alpha, class 2C, member 1
Synonyms: 1110025H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 73744
HGNC: HGNC:6827
Homologene: 4887
Nqo2
Name: N-ribosyldihydronicotinamide quinone reductase 2
Synonyms: Ox2, NRH: quinone oxidoreductase, Ox-2, Nmor2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18105
VEGA: 13
HGNC: HGNC:7856
Homologene: 696
Acot10
Name: acyl-CoA thioesterase 10
Synonyms: MT-ACT48, Acate3, p48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 64833
VEGA: 15
Homologene: 8206
S100a16
Name: S100 calcium binding protein A16
Synonyms: 2300002L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67860
Homologene: 12201
Unc79
Name: unc-79 homolog
Synonyms: Mlca3, 9030205A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217843
Homologene: 41397
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Pkn1
Name: protein kinase N1
Synonyms: Pkn, F730027O18Rik, PAK1, Stk3, Prkcl1, PRK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Gsdmc
Name: gasdermin C
Synonyms: Gsdmc1, Mlze
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 83492
HGNC: HGNC:7151
Homologene: 69487
Als2cl
Name: ALS2 C-terminal like
Synonyms: D930044G19Rik, mRn.49018
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235633
Homologene: 17152
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: D130067I03Rik, 1700074E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210417
Homologene: 18180
1300017J02Rik
Name: RIKEN cDNA 1300017J02 gene
Synonyms: mICA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 71775
Homologene: 826
Raly
Name: hnRNP-associated with lethal yellow
Synonyms: Merc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19383
Homologene: 7216
Pdzrn4
Name: PDZ domain containing RING finger 4
Synonyms: SAMCAP3L, LNX4, 1110017D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239618
VEGA: 15
Homologene: 85433
Bace2
Name: beta-site APP-cleaving enzyme 2
Synonyms: CDA13, ASP21, ALP56, BAE2, 1110059C24Rik, ARP1, CEAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 56175
VEGA: 16
HGNC: HGNC:934
Homologene: 22696
Olfr1239
Name: olfactory receptor 1239
Synonyms: GA_x6K02T2Q125-50861284-50860367, MOR231-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258972
Homologene: 74244
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Gm6370
Name: predicted gene 6370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 622924
Homologene: 86127
Cep250
Name: centrosomal protein 250
Synonyms: B230210E21Rik, Cep2, Inmp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Fam166a
Name: family with sequence similarity 166, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68222
Homologene: 12247
Zfp715
Name: zinc finger protein 715
Synonyms: mszf15, 2610041B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69930
Homologene: 74591
Zbtb3
Name: zinc finger and BTB domain containing 3
Synonyms: 4930563M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 75291
VEGA: 19
Homologene: 23485
Dnajb12
Name: DnaJ heat shock protein family (Hsp40) member B12
Synonyms: mDj10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 56709
Homologene: 9749
Olfr46
Name: olfactory receptor 46
Synonyms: GA_x6K02T2PBJ9-42759973-42760905, IF5, IB7, ID12, MOR253-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18345
Homologene: 110491
Dtwd2
Name: DTW domain containing 2
Synonyms: 8030470C17Rik, 1190002H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 68857
Homologene: 79701
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69324
Homologene: 78000
Fndc3c1
Name: fibronectin type III domain containing 3C1
Synonyms: LOC333564
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 333564
Homologene: 46440
Ldc1
Name: leucine decarboxylase 1
Synonyms: Gm853, LOC332942
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 332942
Homologene: 128653
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: Phpp-1, PC3, prohormone convertase 1/3, SPC3, PC1, Nec1, Nec-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Blvra
Name: biliverdin reductase A
Synonyms: Blvr, 0610006A11Rik, 2500001N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 109778
HGNC: HGNC:1062
Homologene: 572
Dnajc28
Name: DnaJ heat shock protein family (Hsp40) member C28
Synonyms: ORF28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 246738
HGNC: HGNC:1297
Homologene: 9869
Slc22a12
Name: solute carrier family 22 (organic anion/cation transporter), member 12
Synonyms: URAT1, Rst
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20521
Homologene: 56442
Hrh3
Name: histamine receptor H3
Synonyms: Eae8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99296
HGNC: HGNC:5184
Homologene: 5232
Olfr641
Name: olfactory receptor 641
Synonyms: GA_x6K02T2PBJ9-6773690-6774628, MOR13-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259075
Homologene: 17489
Fadd
Name: Fas (TNFRSF6)-associated via death domain
Synonyms: Mort1/FADD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14082
HGNC: HGNC:3573
Homologene: 2836
BC023105
Name: cDNA sequence BC023105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 667597
VEGA: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 105,553,815 bp
  • A to T, chromosome 1 at 130,116,619 bp
  • A to G, chromosome 1 at 183,424,012 bp
  • T to C, chromosome 2 at 25,221,377 bp
  • A to G, chromosome 2 at 52,148,766 bp
  • T to A, chromosome 2 at 52,244,125 bp
  • C to T, chromosome 2 at 61,811,732 bp
  • C to A, chromosome 2 at 89,418,100 bp
  • T to C, chromosome 2 at 127,095,155 bp
  • T to C, chromosome 2 at 152,681,109 bp
  • C to T, chromosome 2 at 154,857,458 bp
  • G to A, chromosome 2 at 155,992,632 bp
  • T to C, chromosome 2 at 166,942,050 bp
  • C to A, chromosome 2 at 180,102,850 bp
  • C to G, chromosome 3 at 60,086,794 bp
  • A to G, chromosome 3 at 90,542,072 bp
  • A to G, chromosome 4 at 64,014,951 bp
  • C to A, chromosome 4 at 107,047,196 bp
  • A to T, chromosome 4 at 130,219,174 bp
  • A to G, chromosome 4 at 131,819,037 bp
  • C to T, chromosome 5 at 101,900,058 bp
  • T to C, chromosome 5 at 146,493,892 bp
  • G to A, chromosome 6 at 42,267,894 bp
  • G to A, chromosome 6 at 85,620,888 bp
  • T to A, chromosome 7 at 43,297,880 bp
  • T to G, chromosome 7 at 44,628,550 bp
  • T to C, chromosome 7 at 104,040,402 bp
  • C to A, chromosome 7 at 140,610,264 bp
  • T to A, chromosome 7 at 140,610,265 bp
  • C to A, chromosome 7 at 144,580,751 bp
  • A to T, chromosome 8 at 83,691,199 bp
  • G to A, chromosome 9 at 44,715,831 bp
  • G to A, chromosome 9 at 45,732,068 bp
  • A to G, chromosome 9 at 57,136,771 bp
  • G to T, chromosome 9 at 103,309,959 bp
  • T to C, chromosome 9 at 110,884,047 bp
  • T to A, chromosome 10 at 59,894,314 bp
  • T to A, chromosome 10 at 76,606,169 bp
  • T to C, chromosome 11 at 94,972,570 bp
  • C to A, chromosome 11 at 99,022,960 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • A to G, chromosome 12 at 100,945,073 bp
  • T to C, chromosome 12 at 103,059,370 bp
  • G to T, chromosome 13 at 9,637,101 bp
  • T to C, chromosome 13 at 14,637,573 bp
  • A to T, chromosome 13 at 33,979,637 bp
  • A to G, chromosome 13 at 75,096,369 bp
  • A to G, chromosome 14 at 65,235,167 bp
  • A to T, chromosome 15 at 20,666,526 bp
  • T to A, chromosome 15 at 63,780,027 bp
  • T to A, chromosome 15 at 91,897,622 bp
  • A to G, chromosome 15 at 92,770,864 bp
  • T to C, chromosome 16 at 55,971,360 bp
  • G to A, chromosome 16 at 91,616,867 bp
  • A to G, chromosome 16 at 97,436,656 bp
  • A to C, chromosome 18 at 49,698,306 bp
  • A to G, chromosome 18 at 60,442,284 bp
  • C to A, chromosome 19 at 6,540,628 bp
  • G to C, chromosome 19 at 8,803,020 bp
  • G to T, chromosome 19 at 44,524,529 bp
  • T to C, chromosome X at 106,444,291 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4110 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040988-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.