Strain Name:
C57BL/6J-MtgxR4112Btlr/Mmmh
Stock Number:
040989-MU
Citation ID:
RRID:MMRRC_040989-MU
Other Names:
R4112 (G1), C57BL/6J-MtgxR4112Btlr
Major Collection:

Gene Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Del1, Col2a-1, Col2a, Col2, M100856, Rgsc856, Lpk, M100413, Rgsc413
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Angpt2
Name: angiopoietin 2
Synonyms: Ang2, Ang-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11601
HGNC: HGNC:485
Homologene: 22401
Sgca
Name: sarcoglycan, alpha (dystrophin-associated glycoprotein)
Synonyms: adhalin, 50DAG, Asg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20391
Homologene: 9
Rnd3
Name: Rho family GTPase 3
Synonyms: 2610017M01Rik, Arhe, Rhoe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74194
HGNC: HGNC:671
Homologene: 21074
Kcna6
Name: potassium voltage-gated channel, shaker-related, subfamily, member 6
Synonyms: Kv1.6, MK1.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16494
HGNC: HGNC:6225
Homologene: 1684
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, CRSP210, DRIP205, Pparbp, l11Jus15, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Srr
Name: serine racemase
Synonyms: M100034, Rgsc34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27364
Homologene: 22775
L3mbtl2
Name: L3MBTL2 polycomb repressive complex 1 subunit
Synonyms: 4732493N06Rik, m4mbt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 214669
Homologene: 12882
Armc9
Name: armadillo repeat containing 9
Synonyms: 5730415N24Rik, 3830422A13Rik, 4831423D23Rik, 4930438O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78795
Homologene: 11847
Rbm5
Name: RNA binding motif protein 5
Synonyms: D030069N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83486
HGNC: HGNC:9902
Homologene: 21177
Top2a
Name: topoisomerase (DNA) II alpha
Synonyms: DNA Topoisomerase II alpha, Top-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21973
Homologene: 830
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Nsmaf
Name: neutral sphingomyelinase (N-SMase) activation associated factor
Synonyms: Fan, factor associated with N-SMase activation
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18201
HGNC: HGNC:8017
Homologene: 2652
Glyr1
Name: glyoxylate reductase 1 homolog (Arabidopsis)
Synonyms: Npac, 2810419J22Rik, 3930401K13Rik, NDF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74022
VEGA: 16
Homologene: 12525
Stt3b
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Synonyms: Simp, 1300006C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68292
VEGA: 9
Homologene: 7387
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Sptb
Name: spectrin beta, erythrocytic
Synonyms: Spnb-1, spectrin R, D330027P03Rik, LOC383567, brain erythroid spectrin (235E), Spnb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20741
Homologene: 295
Src
Name: Rous sarcoma oncogene
Synonyms: pp60c-src
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20779
Homologene: 21120
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Plekhe1, Phlpp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98432
Homologene: 11015
Gemin4
Name: gem nuclear organelle associated protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276919
Homologene: 69193
Sucnr1
Name: succinate receptor 1
Synonyms: Gpr91
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 84112
HGNC: HGNC:4542
Homologene: 41865
Abcb4
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Synonyms: mdr-2, Mdr2, Pgy-2, Pgy2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Chia1
Name: chitinase, acidic 1
Synonyms: AMCase, YNL, 2200003E03Rik, Chia
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 81600
Homologene: 75168
Pus7
Name: pseudouridylate synthase 7
Synonyms: C330017I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 78697
Homologene: 6998
Scart2
Name: scavenger receptor family member expressed on T cells 2
Synonyms: 5830411N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244234
Homologene: 133218
Pcdh10
Name: protocadherin 10
Synonyms: 6430703F07Rik, 6430521D13Rik, OL-pc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18526
Homologene: 74967
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Klf17
Name: Kruppel-like factor 17
Synonyms: D4Ertd561e, 7420700M05Rik, Zfp393
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75753
Homologene: 12621
Gxylt2
Name: glucoside xylosyltransferase 2
Synonyms: LOC232313, Glt8d4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232313
Homologene: 16823
Cdh17
Name: cadherin 17
Synonyms: HPT-1, BILL-cadherin, LI-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12557
HGNC: HGNC:1756
Homologene: 56859
Ccdc7b
Name: coiled-coil domain containing 7B
Synonyms: 1700008F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75453
Homologene: 49919
Ttc24
Name: tetratricopeptide repeat domain 24
Synonyms: A430025D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 214191
Homologene: 82282
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: 1700074E13Rik, D130067I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210417
Homologene: 18180
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238405
Homologene: 128362
Bace2
Name: beta-site APP-cleaving enzyme 2
Synonyms: 1110059C24Rik, CEAP1, CDA13, ASP21, ALP56, BAE2, ARP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 56175
VEGA: 16
HGNC: HGNC:934
Homologene: 22696
Etfrf1
Name: electron transfer flavoprotein regulatory factor 1
Synonyms: Ghiso, 4930469P12Rik, Lyrm5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67636
Homologene: 44219
Cyp3a25
Name: cytochrome P450, family 3, subfamily a, polypeptide 25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56388
Homologene: 135775
Pde4c
Name: phosphodiesterase 4C, cAMP specific
Synonyms: dunce, Dpde1, E130301F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 110385
HGNC: HGNC:8782
Homologene: 20256
Etfbkmt
Name: electron transfer flavoprotein beta subunit lysine methyltransferase
Synonyms: 4833442J19Rik, Mettl20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320204
Homologene: 14453
Tmem80
Name: transmembrane protein 80
Synonyms: 5530601I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71448
Homologene: 23629
Slc10a2
Name: solute carrier family 10, member 2
Synonyms: ASBT, 9130221J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20494
Homologene: 390
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69324
Homologene: 78000
Zfp3
Name: zinc finger protein 3
Synonyms: Fnp-1, Zfp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 193043
Homologene: 27406
Dnajc28
Name: DnaJ heat shock protein family (Hsp40) member C28
Synonyms: ORF28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 246738
HGNC: HGNC:1297
Homologene: 9869
Snap23
Name: synaptosomal-associated protein 23
Synonyms: Syndet, SNAP-23, Sndt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20619
Homologene: 37857
Prelid3a
Name: PRELI domain containing 3A
Synonyms: A230074A19Rik, Slmo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225655
VEGA: 18
Homologene: 90953
Rhox3f
Name: reproductive homeobox 3F
Synonyms: OTTMUSG00000017155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 621852
Homologene: 83502
Vmn2r129
Name: vomeronasal 2, receptor 129
Synonyms: V2r8, V2r9, Vmn2r-ps160, Vmn2r-ps159
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22314
Gm28364
Name: predicted gene 28364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108167628
Gm5578
Name: predicted pseudogene 5578
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434077
Gm6976
Name: predicted gene 6976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
D630029K05Rik
Name: RIKEN cDNA D630029K05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103175
Arf4os
Name: ADP-ribosylation factor 4, opposite strand
Synonyms: 4930570N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Gm20775
Name: predicted gene, 20775
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 665550
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,281,227 bp
  • T to A, chromosome 1 at 86,188,939 bp
  • A to G, chromosome 1 at 106,364,338 bp
  • A to T, chromosome 1 at 130,116,619 bp
  • T to A, chromosome 2 at 51,148,230 bp
  • C to T, chromosome 2 at 120,584,375 bp
  • T to A, chromosome 2 at 157,463,026 bp
  • G to A, chromosome 3 at 45,381,620 bp
  • C to G, chromosome 3 at 60,086,794 bp
  • T to A, chromosome 3 at 88,074,639 bp
  • T to C, chromosome 3 at 106,128,528 bp
  • A to C, chromosome 4 at 6,417,188 bp
  • T to C, chromosome 4 at 11,814,628 bp
  • A to G, chromosome 4 at 117,760,701 bp
  • G to T, chromosome 4 at 156,334,397 bp
  • A to G, chromosome 5 at 8,936,783 bp
  • A to G, chromosome 5 at 23,749,851 bp
  • A to T, chromosome 5 at 146,003,031 bp
  • G to A, chromosome 6 at 85,620,888 bp
  • A to G, chromosome 6 at 100,783,206 bp
  • A to G, chromosome 6 at 112,606,505 bp
  • G to C, chromosome 6 at 126,739,774 bp
  • T to C, chromosome 6 at 145,215,372 bp
  • T to C, chromosome 6 at 149,144,591 bp
  • G to T, chromosome 7 at 140,298,368 bp
  • A to G, chromosome 7 at 141,333,779 bp
  • C to T, chromosome 8 at 5,105,135 bp
  • T to A, chromosome 8 at 18,699,123 bp
  • T to C, chromosome 8 at 70,746,217 bp
  • A to C, chromosome 8 at 95,773,618 bp
  • G to T, chromosome 8 at 129,085,227 bp
  • A to T, chromosome 9 at 107,765,597 bp
  • A to T, chromosome 9 at 115,266,138 bp
  • T to A, chromosome 10 at 28,475,288 bp
  • T to A, chromosome 10 at 41,656,328 bp
  • A to T, chromosome 10 at 116,968,038 bp
  • T to A, chromosome 11 at 70,771,507 bp
  • G to T, chromosome 11 at 74,913,072 bp
  • T to A, chromosome 11 at 76,212,819 bp
  • T to C, chromosome 11 at 94,972,570 bp
  • A to T, chromosome 11 at 98,180,087 bp
  • C to A, chromosome 11 at 99,022,960 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • T to A, chromosome 12 at 76,597,779 bp
  • T to A, chromosome 12 at 113,489,636 bp
  • A to T, chromosome 14 at 26,628,518 bp
  • A to T, chromosome 15 at 55,363,559 bp
  • T to C, chromosome 15 at 81,681,969 bp
  • A to C, chromosome 15 at 97,983,701 bp
  • T to C, chromosome 16 at 5,018,486 bp
  • G to A, chromosome 16 at 91,616,867 bp
  • A to G, chromosome 16 at 97,436,656 bp
  • T to C, chromosome 18 at 67,472,897 bp
  • G to T, chromosome X at 37,582,019 bp
  • A to T, chromosome Y at 10,641,878 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4112 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040989-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.