Strain Name:
C57BL/6J-MtgxR4179Btlr/Mmmh
Stock Number:
041015-MU
Citation ID:
RRID:MMRRC_041015-MU
Other Names:
R4179 (G1), C57BL/6J-MtgxR4179Btlr
Major Collection:

Gene Information

Rgs9
Name: regulator of G-protein signaling 9
Synonyms: Rgs9-2, RGS9-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19739
Homologene: 2845
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Ptch1
Name: patched 1
Synonyms: Ptc, Patched 1, Ptc1, A230106A15Rik, wig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74996
Homologene: 9929
Gck
Name: glucokinase
Synonyms: hexokinase 4, MODY2, HK4, Gls006, Hlb62
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103988
HGNC: HGNC:4195
Homologene: 55440
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226409
Homologene: 32770
Cnot2
Name: CCR4-NOT transcription complex, subunit 2
Synonyms: 2600016M12Rik, 2810470K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72068
HGNC: HGNC:7878
Homologene: 40953
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: ANCO-2, GAC-1, 2900001A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106585
Homologene: 9059
Rrm1
Name: ribonucleotide reductase M1
Synonyms: RnrM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20133
Homologene: 806
Myo1b
Name: myosin IB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Tonsl
Name: tonsoku-like, DNA repair protein
Synonyms: 2810439M11Rik, Nfkbil2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72749
HGNC: HGNC:7801
Homologene: 22754
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74015
Homologene: 22869
Atad3a
Name: ATPase family, AAA domain containing 3A
Synonyms: Tob3, 2400004H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 108888
Homologene: 10059
Foxo1
Name: forkhead box O1
Synonyms: FKHR, Fkhr1, Afxh, Foxo1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56458
HGNC: HGNC:3819
Homologene: 1527
Riok1
Name: RIO kinase 1
Synonyms: 5430416A05Rik, 3110046C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71340
VEGA: 13
Homologene: 6950
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99003
Homologene: 11710
Wdr18
Name: WD repeat domain 18
Synonyms: 2310012I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216156
VEGA: 10
Homologene: 32573
Smox
Name: spermine oxidase
Synonyms: B130066H01Rik, SMO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228608
Homologene: 69268
Pak2
Name: p21 (RAC1) activated kinase 2
Synonyms: PAK-2, A130002K10Rik, D16Ertd269e, 5330420P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224105
HGNC: HGNC:8591
Homologene: 99711
Jag1
Name: jagged 1
Synonyms: Serrate-1, Headturner, Htu, ABE2, Ozz, Gsfabe2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Arrdc2
Name: arrestin domain containing 2
Synonyms: 4632416I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70807
Homologene: 79540
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ctsb
Name: cathepsin B
Synonyms: CB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13030
VEGA: 14
HGNC: HGNC:2527
Homologene: 37550
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Plekhg4
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Synonyms: 4931414L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102075
Homologene: 18516
Gvin3
Name: GTPase, very large interferon inducible, family member 3
Synonyms: Gm1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434223
Homologene: 32708
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp9c, Nalp-zeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330490
Homologene: 116072
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr5, Jr4, ZIZ3, 9330153B10Rik, A630054M16Rik, Zizimin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210293
Homologene: 45952
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: D13Lsd1, Naip, Birc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Psd3
Name: pleckstrin and Sec7 domain containing 3
Synonyms: 4931420C21Rik, EFA6D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234353
Homologene: 87257
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 252866
Homologene: 78104
Gm7168
Name: predicted gene 7168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 635895
Homologene: 133217
Serpina1f
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1F
Synonyms: epserin, 0610012A11Rik, Serpina2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68348
Homologene: 87037
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Lipo3
Name: lipase, member O3
Synonyms: Lipo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381236
Homologene: 103863
Ranbp3l
Name: RAN binding protein 3-like
Synonyms: C130037N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223332
VEGA: 15
Homologene: 35407
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93880
Homologene: 87124
Tsen54
Name: tRNA splicing endonuclease subunit 54
Synonyms: 0610034P02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76265
Homologene: 35476
Loxl3
Name: lysyl oxidase-like 3
Synonyms: Lor2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16950
Homologene: 56591
Olfr149
Name: olfactory receptor 149
Synonyms: M31, MOR224-8, GA_x6K02T2PVTD-33400306-33399371
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235256
VEGA: 9
Homologene: 28452
Cdadc1
Name: cytidine and dCMP deaminase domain containing 1
Synonyms: NYD-SP15, 2310010M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71891
VEGA: 14
Homologene: 12794
Zfp709
Name: zinc finger protein 709
Synonyms: GIOT-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 236193
Homologene: 136795
Prkd1
Name: protein kinase D1
Synonyms: Pkcm, PKD1, Prkcm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18760
VEGA: 12
HGNC: HGNC:9407
Homologene: 55680
Eci1
Name: enoyl-Coenzyme A delta isomerase 1
Synonyms: eci, Dci
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13177
VEGA: 17
HGNC: HGNC:2703
Homologene: 37554
Sult2b1
Name: sulfotransferase family, cytosolic, 2B, member 1
Synonyms: SULT2B, Gm5897
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54200
Homologene: 49487
Dqx1
Name: DEAQ RNA-dependent ATPase
Synonyms: 2310066E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93838
Homologene: 14143
Lrif1
Name: ligand dependent nuclear receptor interacting factor 1
Synonyms: 2010012G17Rik, 4933421E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 321000
Homologene: 10160
Bco2
Name: beta-carotene oxygenase 2
Synonyms: beta-diox-II, B-diox-II, CMO2, Bcdo2, Bcmo2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 170752
Homologene: 12912
Pkd2l1
Name: polycystic kidney disease 2-like 1
Synonyms: polycystin-L, Pkdl, PCL, TRPP3, PKD2L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 329064
HGNC: HGNC:9011
Homologene: 22946
Crnn
Name: cornulin
Synonyms: LOC381457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381457
HGNC: HGNC:1230
Homologene: 9416
Pde2a
Name: phosphodiesterase 2A, cGMP-stimulated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207728
HGNC: HGNC:8777
Homologene: 1952
Ly6g
Name: lymphocyte antigen 6 complex, locus G
Synonyms: Gr1, Ly-6G, Gr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 546644
Homologene: 113718
Cmtr2
Name: cap methyltransferase 2
Synonyms: C730036L12Rik, Ftsjd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234728
Homologene: 10144
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
Idh3g
Name: isocitrate dehydrogenase 3 (NAD+), gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 15929
HGNC: HGNC:5386
Homologene: 55803
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 51,778,526 bp
  • A to C, chromosome 1 at 80,510,417 bp
  • A to T, chromosome 1 at 127,960,864 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • A to G, chromosome 2 at 104,776,384 bp
  • G to A, chromosome 2 at 131,524,850 bp
  • A to G, chromosome 2 at 137,101,658 bp
  • C to A, chromosome 3 at 52,345,419 bp
  • T to C, chromosome 3 at 93,146,813 bp
  • T to C, chromosome 3 at 106,733,091 bp
  • A to G, chromosome 4 at 155,754,093 bp
  • T to C, chromosome 5 at 115,588,050 bp
  • G to A, chromosome 6 at 83,037,584 bp
  • A to G, chromosome 6 at 83,059,479 bp
  • G to A, chromosome 6 at 84,186,509 bp
  • G to A, chromosome 7 at 26,384,661 bp
  • T to A, chromosome 7 at 45,735,311 bp
  • A to G, chromosome 7 at 101,481,383 bp
  • T to A, chromosome 7 at 102,457,198 bp
  • T to C, chromosome 7 at 106,600,408 bp
  • T to C, chromosome 7 at 112,087,884 bp
  • T to C, chromosome 8 at 43,651,091 bp
  • T to C, chromosome 8 at 67,904,132 bp
  • A to T, chromosome 8 at 70,837,177 bp
  • A to G, chromosome 8 at 71,714,720 bp
  • A to G, chromosome 8 at 71,889,906 bp
  • T to A, chromosome 8 at 105,381,398 bp
  • C to G, chromosome 8 at 110,221,037 bp
  • A to G, chromosome 9 at 39,702,091 bp
  • T to C, chromosome 9 at 50,559,287 bp
  • T to C, chromosome 10 at 79,965,041 bp
  • A to T, chromosome 10 at 116,498,143 bp
  • T to C, chromosome 11 at 5,910,295 bp
  • C to A, chromosome 11 at 109,281,448 bp
  • T to C, chromosome 11 at 115,820,852 bp
  • C to A, chromosome 12 at 50,366,448 bp
  • A to T, chromosome 12 at 103,691,920 bp
  • T to C, chromosome 13 at 38,048,955 bp
  • C to T, chromosome 13 at 63,534,329 bp
  • T to A, chromosome 13 at 100,426,176 bp
  • T to G, chromosome 14 at 16,409,189 bp
  • G to T, chromosome 14 at 59,592,486 bp
  • A to G, chromosome 14 at 63,133,452 bp
  • T to C, chromosome 15 at 9,057,198 bp
  • A to C, chromosome 15 at 44,523,649 bp
  • A to G, chromosome 15 at 75,155,718 bp
  • T to C, chromosome 15 at 76,180,215 bp
  • A to G, chromosome 15 at 76,624,475 bp
  • C to G, chromosome 16 at 32,052,187 bp
  • A to G, chromosome 17 at 13,949,003 bp
  • T to C, chromosome 17 at 24,436,277 bp
  • A to G, chromosome 17 at 65,972,315 bp
  • T to A, chromosome 18 at 36,941,476 bp
  • T to A, chromosome 18 at 37,401,115 bp
  • A to G, chromosome 19 at 33,556,471 bp
  • T to C, chromosome 19 at 44,192,181 bp
  • A to T, chromosome X at 73,782,004 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4179 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041015-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.