Strain Name:
C57BL/6J-MtgxR4183Btlr/Mmmh
Stock Number:
041019-MU
Citation ID:
RRID:MMRRC_041019-MU
Other Names:
R4183 (G1), C57BL/6J-MtgxR4183Btlr
Major Collection:

Gene Information

Mapk8
Name: mitogen-activated protein kinase 8
Synonyms: c-Jun N-terminal kinase, JNK1, Prkm8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 26419
HGNC: HGNC:6881
Homologene: 56760
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: BC032203, Gltscr1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Arhgap12
Name: Rho GTPase activating protein 12
Synonyms: 2810011M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75415
Homologene: 23089
Ddx1
Name: DEAD box helicase 1
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 3010027A04Rik, 9530048I21Rik, 2410104C19Rik, Yod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77087
Homologene: 69134
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Arpc2
Name: actin related protein 2/3 complex, subunit 2
Synonyms: 2210023N03Rik, p34-Arc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76709
HGNC: HGNC:705
Homologene: 4187
Zfp972
Name: zinc finger protein 972
Synonyms: C330013J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78703
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98956
Homologene: 6785
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74015
Homologene: 22869
Il15ra
Name: interleukin 15 receptor, alpha chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16169
HGNC: HGNC:5978
Homologene: 1650
Zfp982
Name: zinc finger protein 982
Synonyms: Gm13152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 195531
Wdr25
Name: WD repeat domain 25
Synonyms: B930090D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 212198
VEGA: 12
Homologene: 56993
Inpp5j
Name: inositol polyphosphate 5-phosphatase J
Synonyms: Pipp, Pib5pa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170835
HGNC: HGNC:8956
Homologene: 8682
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Rb1
Name: RB transcriptional corepressor 1
Synonyms: pRb, Rb-1, retinoblastoma 1, Rb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19645
HGNC: HGNC:9884
Homologene: 272
Naxd
Name: NAD(P)HX dehydratase
Synonyms: 2810407E01Rik, 0710008K08Rik, Carkd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69225
Homologene: 6333
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Gprc5b
Name: G protein-coupled receptor, family C, group 5, member B
Synonyms: hypothetical protein, clone 2-63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 64297
Homologene: 9435
Ttn
Name: titin
Synonyms: D830007G01Rik, connectin, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ttc16
Name: tetratricopeptide repeat domain 16
Synonyms: 1200002K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 338348
Homologene: 17011
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Pcdhgb8
Name: protocadherin gamma subfamily B, 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93705
Homologene: 81868
Il11ra1
Name: interleukin 11 receptor, alpha chain 1
Synonyms: Il-11ra, NR1, Il11ra, Il-11ra-alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16157
HGNC: HGNC:5967
Homologene: 88705
Tnn
Name: tenascin N
Synonyms: tenascin-W, Tnw
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329278
Homologene: 18634
Me3
Name: malic enzyme 3, NADP(+)-dependent, mitochondrial
Synonyms: 1700020C08Rik, B230207H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 109264
HGNC: HGNC:6985
Homologene: 100773
Degs2
Name: delta(4)-desaturase, sphingolipid 2
Synonyms: 2210008A03Rik, Des2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70059
VEGA: 12
Homologene: 23617
Mndal
Name: myeloid nuclear differentiation antigen like
Synonyms: Ifi212
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040462
HGNC: HGNC:5395
Homologene: 115929
Ccdc27
Name: coiled-coil domain containing 27
Synonyms: LOC381580
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381580
Homologene: 17596
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 621430
Homologene: 115466
Mapkbp1
Name: mitogen-activated protein kinase binding protein 1
Synonyms: 2810483F24Rik, Jnkbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26390
Homologene: 69109
Atp11a
Name: ATPase, class VI, type 11A
Synonyms: Ih, 4930558F19Rik, 9130422H11Rik, LOC100045280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50770
Homologene: 75050
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: 1200011I03Rik, Mamdc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74762
Homologene: 17780
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Vmn1r201
Name: vomeronasal 1 receptor 201
Synonyms: V1ri4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171255
Homologene: 110880
Olfr624
Name: olfactory receptor 624
Synonyms: MOR4-2P, GA_x6K02T2PBJ9-6394126-6393197
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258189
Homologene: 66460
Grsf1
Name: G-rich RNA sequence binding factor 1
Synonyms: D5Wsu31e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231413
HGNC: HGNC:4610
Homologene: 20482
Olfr747
Name: olfactory receptor 747
Synonyms: MOR106-16, MOR106-7, GA_x6K02T2PMLR-6420220-6419279
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258264
Homologene: 10652
Chrnb1
Name: cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
Synonyms: AChR beta, Acrb, Achr-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11443
HGNC: HGNC:1961
Homologene: 594
Tfpi2
Name: tissue factor pathway inhibitor 2
Synonyms: PP5/TFPI-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21789
Homologene: 38194
Olfr1238
Name: olfactory receptor 1238
Synonyms: GA_x6K02T2Q125-50849945-50848998, MOR231-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258786
Homologene: 128093
Pcsk4
Name: proprotein convertase subtilisin/kexin type 4
Synonyms: PC4, SPC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18551
HGNC: HGNC:8746
Homologene: 22495
Olfr97
Name: olfactory receptor 97
Synonyms: MOR156-2, GA_x6K02T2PSCP-1672287-1671355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258505
Homologene: 133051
Olfr150
Name: olfactory receptor 150
Synonyms: GA_x6K02T2PVTD-33434302-33435240, M93, MOR171-18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258602
VEGA: 9
Mtfr1l
Name: mitochondrial fission regulator 1-like
Synonyms: Fam54b, 2410166I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76824
Homologene: 10472
Lurap1l
Name: leucine rich adaptor protein 1-like
Synonyms: WI-13707, D4Bwg0951e, 1110029A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 52829
Homologene: 12281
Mcidas
Name: multiciliate differentiation and DNA synthesis associated cell cycle protein
Synonyms: Mci, Idas, Mcin, Gm6320, multicilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 622408
VEGA: 13
Homologene: 83681
Fam167a
Name: family with sequence similarity 167, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219148
Homologene: 14243
Gm21917
Name: predicted gene, 21917
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 20,117,807 bp
  • T to A, chromosome 1 at 74,248,163 bp
  • T to C, chromosome 1 at 160,097,355 bp
  • T to A, chromosome 1 at 173,875,771 bp
  • C to A, chromosome 2 at 11,718,487 bp
  • A to G, chromosome 2 at 32,774,444 bp
  • A to G, chromosome 2 at 76,711,242 bp
  • T to C, chromosome 2 at 89,406,591 bp
  • A to G, chromosome 2 at 103,739,813 bp
  • A to G, chromosome 2 at 120,017,865 bp
  • G to A, chromosome 2 at 177,921,457 bp
  • T to A, chromosome 4 at 41,764,981 bp
  • G to A, chromosome 4 at 80,953,858 bp
  • T to C, chromosome 4 at 134,529,247 bp
  • A to G, chromosome 4 at 147,512,693 bp
  • TTCCTCCTCCTCCTCCTCCTC to TTCCTCCTCCTCCTCCTC, chromosome 4 at 154,036,306 bp
  • G to A, chromosome 5 at 88,664,156 bp
  • C to A, chromosome 6 at 3,963,926 bp
  • A to G, chromosome 7 at 87,001,891 bp
  • A to G, chromosome 7 at 89,851,830 bp
  • T to C, chromosome 7 at 103,670,971 bp
  • T to C, chromosome 7 at 118,984,526 bp
  • T to C, chromosome 8 at 11,502,757 bp
  • T to A, chromosome 8 at 12,816,990 bp
  • C to T, chromosome 8 at 15,910,464 bp
  • A to G, chromosome 8 at 71,710,410 bp
  • T to C, chromosome 8 at 122,899,676 bp
  • A to G, chromosome 9 at 39,737,048 bp
  • A to T, chromosome 9 at 110,636,675 bp
  • T to C, chromosome 10 at 58,465,666 bp
  • C to T, chromosome 10 at 80,325,011 bp
  • A to G, chromosome 11 at 3,501,134 bp
  • T to C, chromosome 11 at 67,349,610 bp
  • T to C, chromosome 11 at 69,787,096 bp
  • A to T, chromosome 12 at 13,231,503 bp
  • T to C, chromosome 12 at 108,692,099 bp
  • T to A, chromosome 12 at 109,027,331 bp
  • A to G, chromosome 13 at 22,474,852 bp
  • A to G, chromosome 13 at 112,994,372 bp
  • T to C, chromosome 14 at 33,382,220 bp
  • C to G, chromosome 14 at 50,681,050 bp
  • T to C, chromosome 14 at 63,452,320 bp
  • A to G, chromosome 14 at 73,198,526 bp
  • A to T, chromosome 15 at 74,588,127 bp
  • G to A, chromosome 15 at 99,933,685 bp
  • A to G, chromosome 17 at 29,969,990 bp
  • T to G, chromosome 17 at 37,231,848 bp
  • T to C, chromosome 17 at 46,814,029 bp
  • T to C, chromosome 18 at 6,111,734 bp
  • G to C, chromosome 18 at 37,763,541 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4183 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041019-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.