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Strain Name:
C57BL/6J-MtgxR4193Btlr/Mmmh
Stock Number:
041024-MU
Citation ID:
RRID:MMRRC_041024-MU
Other Names:
R4193 (G1), C57BL/6J-MtgxR4193Btlr
Major Collection:

Strain Information

Septin4
Name: septin 4
Synonyms: cell division control-related protein 2b, Pnutl2, Bh5, septin H5, Gm11492, ARTS, Sept4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18952
HGNC: HGNC:9165
Homologene: 6107
Slc17a5
Name: solute carrier family 17 (anion/sugar transporter), member 5
Synonyms: 4631416G20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235504
Homologene: 56571
Eif3h
Name: eukaryotic translation initiation factor 3, subunit H
Synonyms: EIF3-gamma, EIF3-P40, 9430017H16Rik, 1110008A16Rik, Eif3s3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68135
VEGA: 15
HGNC: HGNC:3273
Homologene: 2785
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Tmprss12
Name: transmembrane (C-terminal) protease, serine 12
Synonyms: 4930478A21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75002
VEGA: 15
Homologene: 16598
Senp2
Name: SUMO/sentrin specific peptidase 2
Synonyms: 4930538C18Rik, 2310007L05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75826
VEGA: 16
Homologene: 11005
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 25,111,758 bp
  • A to G, chromosome 1 at 40,365,048 bp
  • G to C, chromosome 1 at 42,953,558 bp
  • T to C, chromosome 1 at 53,447,334 bp
  • T to C, chromosome 1 at 131,869,962 bp
  • A to T, chromosome 1 at 161,863,959 bp
  • T to A, chromosome 1 at 175,614,841 bp
  • C to T, chromosome 2 at 69,467,143 bp
  • C to T, chromosome 2 at 85,800,018 bp
  • T to A, chromosome 2 at 86,085,700 bp
  • T to A, chromosome 2 at 92,365,359 bp
  • A to G, chromosome 2 at 146,342,573 bp
  • T to A, chromosome 2 at 178,283,152 bp
  • T to C, chromosome 3 at 22,200,358 bp
  • T to G, chromosome 3 at 67,431,720 bp
  • A to G, chromosome 4 at 120,548,138 bp
  • A to T, chromosome 4 at 143,698,333 bp
  • A to G, chromosome 4 at 155,901,777 bp
  • G to A, chromosome 5 at 8,715,068 bp
  • A to C, chromosome 5 at 24,878,760 bp
  • T to C, chromosome 5 at 38,398,706 bp
  • T to C, chromosome 5 at 63,807,465 bp
  • G to A, chromosome 5 at 71,007,998 bp
  • T to G, chromosome 6 at 39,169,096 bp
  • C to T, chromosome 6 at 56,730,689 bp
  • A to C, chromosome 6 at 59,003,453 bp
  • T to C, chromosome 6 at 67,896,383 bp
  • A to G, chromosome 6 at 83,743,103 bp
  • T to C, chromosome 6 at 125,373,118 bp
  • A to T, chromosome 7 at 10,748,248 bp
  • T to C, chromosome 7 at 66,025,308 bp
  • A to G, chromosome 7 at 100,998,450 bp
  • A to T, chromosome 8 at 40,795,315 bp
  • G to A, chromosome 8 at 45,992,167 bp
  • A to T, chromosome 8 at 111,011,348 bp
  • C to T, chromosome 8 at 117,113,469 bp
  • A to G, chromosome 8 at 124,600,486 bp
  • A to T, chromosome 9 at 30,959,308 bp
  • T to A, chromosome 9 at 36,843,727 bp
  • T to C, chromosome 9 at 62,952,004 bp
  • C to A, chromosome 9 at 78,559,106 bp
  • G to A, chromosome 9 at 108,956,672 bp
  • T to C, chromosome 9 at 116,109,941 bp
  • A to G, chromosome 10 at 41,335,945 bp
  • T to A, chromosome 10 at 62,253,179 bp
  • C to T, chromosome 10 at 67,096,681 bp
  • T to A, chromosome 10 at 83,301,221 bp
  • A to T, chromosome 10 at 86,540,619 bp
  • C to A, chromosome 10 at 112,928,705 bp
  • T to C, chromosome 10 at 116,252,864 bp
  • A to C, chromosome 11 at 49,495,307 bp
  • T to A, chromosome 11 at 58,949,241 bp
  • C to G, chromosome 11 at 73,603,417 bp
  • A to T, chromosome 11 at 87,583,316 bp
  • A to G, chromosome 11 at 102,469,685 bp
  • G to A, chromosome 11 at 105,914,062 bp
  • T to C, chromosome 12 at 84,043,174 bp
  • A to G, chromosome 12 at 116,901,008 bp
  • T to C, chromosome 13 at 21,467,342 bp
  • T to A, chromosome 13 at 27,776,278 bp
  • G to A, chromosome 13 at 114,886,649 bp
  • C to T, chromosome 14 at 13,914,416 bp
  • G to T, chromosome 14 at 36,096,579 bp
  • A to T, chromosome 15 at 51,799,299 bp
  • T to A, chromosome 15 at 59,978,085 bp
  • T to C, chromosome 15 at 79,311,935 bp
  • T to C, chromosome 15 at 100,289,304 bp
  • C to T, chromosome 15 at 100,971,603 bp
  • A to T, chromosome 16 at 16,673,647 bp
  • C to T, chromosome 16 at 18,073,640 bp
  • G to T, chromosome 16 at 22,046,667 bp
  • A to G, chromosome 16 at 45,250,482 bp
  • A to G, chromosome 16 at 56,268,411 bp
  • A to T, chromosome 16 at 91,404,344 bp
  • C to T, chromosome 17 at 22,851,170 bp
  • A to T, chromosome 17 at 26,213,860 bp
  • A to T, chromosome 17 at 46,479,247 bp
  • A to G, chromosome 17 at 78,586,826 bp
  • A to G, chromosome 18 at 37,267,146 bp
  • G to C, chromosome 18 at 37,763,541 bp
  • T to A, chromosome 18 at 65,447,675 bp
  • T to G, chromosome 19 at 4,142,907 bp
  • G to A, chromosome 19 at 5,907,016 bp
  • T to A, chromosome 19 at 56,851,341 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4193 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041024-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.