Strain Name:
C57BL/6J-MtgxR4194Btlr/Mmmh
Stock Number:
041025-MU
Citation ID:
RRID:MMRRC_041025-MU
Other Names:
R4194 (G1), C57BL/6J-MtgxR4194Btlr
Major Collection:

Strain Information

Mef2d
Name: myocyte enhancer factor 2D
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17261
HGNC: HGNC:6997
Homologene: 4327
Cdyl2
Name: chromodomain protein, Y chromosome-like 2
Synonyms: 4930453I21Rik, 1700029M19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75796
Homologene: 41779
Kifap3
Name: kinesin-associated protein 3
Synonyms: KAP3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16579
Homologene: 7799
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, D16Ium21, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Ctnnd1
Name: catenin delta 1
Synonyms: Catns, Ctnnd, catenin (cadherin associated protein), delta 1, p120-catenin, P120
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Dnttip2
Name: deoxynucleotidyltransferase, terminal, interacting protein 2
Synonyms: 4930588M11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99480
Homologene: 124162
Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Synonyms: 4430401P03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20662
VEGA: 17
Homologene: 4117
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Sptb
Name: spectrin beta, erythrocytic
Synonyms: LOC383567, D330027P03Rik, Spnb1, spectrin R, Spnb-1, brain erythroid spectrin (235E)
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20741
Homologene: 295
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 5930437A14Rik, punctin-1, 6720426B09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Raf1
Name: v-raf-leukemia viral oncogene 1
Synonyms: sarcoma 3611 oncogene, Raf-1, v-Raf, 6430402F14Rik, c-Raf, Craf1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110157
HGNC: HGNC:9829
Homologene: 48145
Ankrd26
Name: ankyrin repeat domain 26
Synonyms: 5730521P14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232339
Homologene: 45968
Fam185a
Name: family with sequence similarity 185, member A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330050
Homologene: 51828
Zfp473
Name: zinc finger protein 473
Synonyms: D030014N22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243963
Homologene: 18698
Vtcn1
Name: V-set domain containing T cell activation inhibitor 1
Synonyms: B7x, B7-H4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242122
Homologene: 11627
Tas1r3
Name: taste receptor, type 1, member 3
Synonyms: T1r3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83771
Homologene: 12890
Grb7
Name: growth factor receptor bound protein 7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14786
HGNC: HGNC:4567
Homologene: 3881
Bud13
Name: BUD13 homolog
Synonyms: D030060M11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215051
Homologene: 13102
Zfp990
Name: zinc finger protein 990
Synonyms: Gm13225
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101056073
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Prss59
Name: serine protease 59
Synonyms: 1700074P13Rik, Tryx5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73481
Homologene: 49905
Cyp2d41-ps
Name: cytochrome P450, family 2, subfamily d, member 41, pseudogene
Synonyms: Gm5062
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 271300
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Mppe1
Name: metallophosphoesterase 1
Synonyms: Pgap5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225651
VEGA: 18
Homologene: 41512
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: GluK5, D16Ium24, Glurbeta1, Glur-5, D16Ium24e, A830007B11Rik, Glur5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74521
Homologene: 12571
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381122
VEGA: 17
Homologene: 27026
Ctbs
Name: chitobiase
Synonyms: 2210401K11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74245
HGNC: HGNC:2496
Homologene: 3231
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
Fbxo11
Name: F-box protein 11
Synonyms: Jf, GENA 104
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225055
Homologene: 11843
Klhl35
Name: kelch-like 35
Synonyms: 2810406K13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72184
Homologene: 27849
Muc21
Name: mucin 21
Synonyms: Gm9573, epiglycanin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 672682
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 171580
Homologene: 11246
H2-Eb2
Name: histocompatibility 2, class II antigen E beta2
Synonyms: H-2Eb2, Ia-5, A130038H09Rik, Ia5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381091
Homologene: 128636
Mfap3
Name: microfibrillar-associated protein 3
Synonyms: 2700079M14Rik, 2610509F16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216760
HGNC: HGNC:7034
Homologene: 4333
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
Rnf8
Name: ring finger protein 8
Synonyms: AIP37, 3830404E21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58230
Homologene: 2944
Lpxn
Name: leupaxin
Synonyms: 4933402K05Rik, A530083L21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107321
VEGA: 19
Homologene: 3536
Kank3
Name: KN motif and ankyrin repeat domains 3
Synonyms: 0610013D04Rik, Ankrd47, D17Ertd288e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 80880
Homologene: 12749
Ugt1a7c
Name: UDP glucuronosyltransferase 1 family, polypeptide A7C
Synonyms: A10'
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394432
Homologene: 136043
Sycp3
Name: synaptonemal complex protein 3
Synonyms: Scp3, Cor1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20962
Homologene: 7964
Phactr3
Name: phosphatase and actin regulator 3
Synonyms: 1500003N10Rik, scapinin, 4930415A02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74189
Homologene: 14482
Rpl31-ps17
Name: ribosomal protein L31, pseudogene 17
Synonyms: Gm16382
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 673582
RP23-303A11.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Gm23156
Name: predicted gene, 23156
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 88,095,727 bp
  • T to C, chromosome 1 at 163,915,825 bp
  • T to C, chromosome 2 at 84,603,701 bp
  • G to T, chromosome 2 at 113,841,994 bp
  • T to C, chromosome 2 at 178,283,109 bp
  • A to G, chromosome 3 at 88,158,303 bp
  • A to T, chromosome 3 at 100,888,209 bp
  • G to A, chromosome 3 at 122,280,761 bp
  • C to A, chromosome 3 at 146,450,613 bp
  • A to T, chromosome 4 at 86,054,008 bp
  • A to T, chromosome 4 at 145,536,977 bp
  • T to C, chromosome 4 at 155,862,985 bp
  • A to G, chromosome 5 at 21,425,454 bp
  • T to C, chromosome 5 at 137,463,555 bp
  • A to T, chromosome 6 at 40,921,071 bp
  • C to T, chromosome 6 at 85,677,990 bp
  • A to G, chromosome 6 at 115,626,946 bp
  • A to G, chromosome 6 at 118,523,678 bp
  • T to C, chromosome 7 at 44,732,252 bp
  • A to T, chromosome 7 at 99,473,851 bp
  • C to T, chromosome 8 at 71,359,624 bp
  • T to C, chromosome 8 at 116,579,164 bp
  • T to A, chromosome 8 at 125,491,672 bp
  • C to A, chromosome 8 at 128,759,865 bp
  • T to A, chromosome 9 at 46,298,495 bp
  • C to G, chromosome 9 at 105,945,914 bp
  • T to C, chromosome 9 at 108,843,302 bp
  • C to G, chromosome 10 at 41,481,628 bp
  • T to C, chromosome 10 at 88,463,375 bp
  • T to A, chromosome 11 at 57,529,703 bp
  • T to A, chromosome 11 at 98,455,055 bp
  • T to C, chromosome 11 at 101,525,287 bp
  • C to T, chromosome 12 at 54,701,649 bp
  • C to A, chromosome 12 at 76,613,010 bp
  • T to C, chromosome 12 at 103,558,445 bp
  • C to A, chromosome 13 at 81,498,996 bp
  • T to C, chromosome 15 at 82,781,953 bp
  • A to G, chromosome 16 at 87,946,728 bp
  • G to A, chromosome 16 at 94,422,277 bp
  • T to C, chromosome 17 at 29,631,668 bp
  • A to G, chromosome 17 at 33,822,263 bp
  • T to A, chromosome 17 at 34,333,326 bp
  • T to C, chromosome 17 at 35,628,165 bp
  • C to T, chromosome 17 at 73,339,484 bp
  • T to C, chromosome 17 at 80,398,584 bp
  • T to C, chromosome 17 at 88,009,108 bp
  • G to A, chromosome 18 at 67,228,068 bp
  • T to C, chromosome 19 at 12,833,235 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4194 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041025-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.