Strain Name:
C57BL/6J-MtgxR4197Btlr/Mmmh
Stock Number:
041028-MU
Citation ID:
RRID:MMRRC_041028-MU
Other Names:
R4197 (G1), C57BL/6J-MtgxR4197Btlr
Major Collection:

Gene Information

Cd36
Name: CD36 molecule
Synonyms: FAT, fatty acid translocase, Scarb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12491
HGNC: HGNC:1663
Homologene: 73871
Rad23b
Name: RAD23 homolog B, nucleotide excision repair protein
Synonyms: mHR23B, 0610007D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19359
HGNC: HGNC:9813
Homologene: 37704
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Sf3b3
Name: splicing factor 3b, subunit 3
Synonyms: 5730409A01Rik, 1810061H24Rik, SAP130, RSE1, D8Ertd633e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 101943
Homologene: 6579
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 277854
Homologene: 34718
Xrcc6
Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Synonyms: Ku p70, Ku70, G22p1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14375
HGNC: HGNC:4055
Homologene: 37483
Sipa1l3
Name: signal-induced proliferation-associated 1 like 3
Synonyms: 2610511M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74206
Homologene: 77938
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPD1, PTPRL10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Fip1l1
Name: FIP1 like 1 (S. cerevisiae)
Synonyms: Rje, 1300019H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66899
Homologene: 136254
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17847
Homologene: 40978
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Pdcd10
Name: programmed cell death 10
Synonyms: TF-1 cell apoptosis related protein-15, Tfa15, 2410003B13Rik, CCM3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56426
HGNC: HGNC:8761
Homologene: 10505
Dlat
Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Synonyms: PDC-E2, 6332404G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235339
HGNC: HGNC:2896
Homologene: 6814
Slc44a4
Name: solute carrier family 44, member 4
Synonyms: NG22, 2210409B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70129
Homologene: 11359
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, D830007G01Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: NR2A, NMDAR2A, GluRepsilon1, GluN2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Pcdhb14
Name: protocadherin beta 14
Synonyms: Pcdhb17, PcdhbN, 2210006M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93885
Homologene: 70876
Sema5a
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Synonyms: M-Sema D, semF, Semaf, 9130201M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20356
VEGA: 15
Homologene: 2949
Ccno
Name: cyclin O
Synonyms: Ung2, Ccnu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218630
VEGA: 13
Homologene: 50171
Pde3b
Name: phosphodiesterase 3B, cGMP-inhibited
Synonyms: 9830102A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18576
HGNC: HGNC:8779
Homologene: 709
Dhx34
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 34
Synonyms: 1810012L18Rik, Ddx34, 1200013B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71723
Homologene: 69171
Vmn2r87
Name: vomeronasal 2, receptor 87
Synonyms: EG625131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625131
Homologene: 129606
Scel
Name: sciellin
Synonyms: 9230114I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 64929
VEGA: 14
Homologene: 2850
Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Synonyms: RANKL, OPGL, ODF, Ly109l, Trance, osteoclast differentiation factor, OPGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21943
VEGA: 14
Homologene: 2744
Klhl18
Name: kelch-like 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270201
Homologene: 14805
Sv2c
Name: synaptic vesicle glycoprotein 2c
Synonyms: 4930527L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75209
Homologene: 57152
Klhl31
Name: kelch-like 31
Synonyms: D930047P17Rik, Kbtbd1, 9830147P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244923
Homologene: 27819
Gstm2
Name: glutathione S-transferase, mu 2
Synonyms: Gstb-2, Gstb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14863
Homologene: 121492
Lypd10
Name: Ly6/PLAUR domain containing 10
Synonyms: BC049730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232972
Slco5a1
Name: solute carrier organic anion transporter family, member 5A1
Synonyms: A630033C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240726
Homologene: 57135
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nl1, NEPLP gamma, NEPLP beta, NEPLP alpha, SEP, Mell1, Nep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27390
Homologene: 22778
Or6a2
Name: olfactory receptor family 6 subfamily A member 2
Synonyms: I54, I7, Olfr41, MOR103-15, GA_x6K02T2PBJ9-9381439-9380456, Olfr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18317
Homologene: 2743
Gm5699
Name: predicted gene 5699
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435616
Tex11
Name: testis expressed gene 11
Synonyms: 4930565P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 83558
Homologene: 49962
Trav13n-4
Name: T cell receptor alpha variable 13N-4
Synonyms: ENSMUSG00000072517, Gm10907
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100126460
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 12,894,516 bp
  • T to A, chromosome 1 at 30,998,645 bp
  • T to C, chromosome 2 at 76,886,078 bp
  • A to T, chromosome 3 at 75,517,592 bp
  • G to A, chromosome 3 at 107,985,263 bp
  • C to T, chromosome 4 at 55,385,455 bp
  • T to C, chromosome 4 at 154,893,304 bp
  • T to A, chromosome 5 at 17,813,088 bp
  • T to A, chromosome 5 at 32,991,203 bp
  • T to A, chromosome 5 at 74,535,736 bp
  • G to T, chromosome 7 at 16,203,726 bp
  • A to G, chromosome 7 at 24,713,694 bp
  • A to T, chromosome 7 at 29,400,813 bp
  • T to C, chromosome 7 at 107,001,038 bp
  • T to G, chromosome 7 at 114,530,872 bp
  • A to T, chromosome 8 at 110,821,565 bp
  • T to C, chromosome 9 at 50,636,526 bp
  • T to A, chromosome 9 at 59,894,866 bp
  • T to C, chromosome 9 at 77,650,809 bp
  • A to T, chromosome 9 at 110,429,944 bp
  • G to A, chromosome 10 at 130,479,910 bp
  • T to C, chromosome 11 at 23,444,189 bp
  • T to C, chromosome 11 at 69,735,336 bp
  • G to T, chromosome 12 at 98,680,138 bp
  • A to T, chromosome 13 at 95,978,128 bp
  • G to A, chromosome 13 at 112,989,069 bp
  • C to T, chromosome 14 at 53,363,921 bp
  • A to T, chromosome 14 at 78,284,312 bp
  • A to T, chromosome 14 at 103,599,400 bp
  • A to G, chromosome 15 at 32,618,918 bp
  • A to G, chromosome 15 at 82,029,224 bp
  • T to C, chromosome 15 at 89,157,018 bp
  • A to C, chromosome 16 at 9,761,967 bp
  • G to A, chromosome 17 at 34,918,252 bp
  • A to G, chromosome 18 at 37,448,305 bp
  • C to A, chromosome X at 100,933,415 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4197 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041028-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.