Strain Name:
C57BL/6J-MtgxR4237Btlr/Mmmh
Stock Number:
041054-MU
Citation ID:
RRID:MMRRC_041054-MU
Other Names:
R4237 (G1), C57BL/6J-MtgxR4237Btlr
Major Collection:

Strain Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Gpr6
Name: G protein-coupled receptor 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 140741
VEGA: 10
HGNC: HGNC:4515
Homologene: 38026
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Rad54l
Name: RAD54 like (S. cerevisiae)
Synonyms: RAD54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19366
HGNC: HGNC:9826
Homologene: 48227
Prc1
Name: protein regulator of cytokinesis 1
Synonyms: D7Ertd348e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233406
HGNC: HGNC:9341
Homologene: 37868
Dpp8
Name: dipeptidylpeptidase 8
Synonyms: 4932434F09Rik, 2310004I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74388
VEGA: 9
Homologene: 57098
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237339
Homologene: 18226
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: MST027, EFG2, A930009M04Rik, 6530419G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 320806
Homologene: 6238
Rbpj-ps3
Name: recombination signal binding protein for immunoglobulin kappa J region, pseudogene 3
Synonyms: Igkrsbp-rs3, Rbpsuh-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19667
Cdc20
Name: cell division cycle 20
Synonyms: p55CDC, 2310042N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107995
HGNC: HGNC:1723
Homologene: 37459
Zfp157
Name: zinc finger protein 157
Synonyms: A630094N24Rik, 2610020C11Rik, Roma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72154
Homologene: 57009
Wnt5a
Name: wingless-type MMTV integration site family, member 5A
Synonyms: Wnt-5a, 8030457G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 22418
Homologene: 20720
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237954
Homologene: 138824
Wdr95
Name: WD40 repeat domain 95
Synonyms: 4930434E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381693
Homologene: 124480
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Antxr2
Name: anthrax toxin receptor 2
Synonyms: cI-35, CMG-2, CMG2, 2310046B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71914
Homologene: 43236
Galnt11
Name: polypeptide N-acetylgalactosaminyltransferase 11
Synonyms: E430002F06Rik, A430075I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231050
Homologene: 11126
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320429
Homologene: 45845
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Tom1l1
Name: target of myb1-like 1 (chicken)
Synonyms: 2310045L10Rik, Srcasm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71943
Homologene: 38055
Phactr1
Name: phosphatase and actin regulator 1
Synonyms: Rpel1, 9630030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218194
Homologene: 33597
Serpinb10
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241197
HGNC: HGNC:8942
Homologene: 68430
Trim28
Name: tripartite motif-containing 28
Synonyms: KRIP-1, KAP-1, Tif1b, MommeD9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21849
Homologene: 21175
Gm16069
Name: predicted gene 16069
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 102636781
Slc14a2
Name: solute carrier family 14 (urea transporter), member 2
Synonyms: UT-A3, UT-A5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 27411
VEGA: 18
Homologene: 5183
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244668
Homologene: 18956
Clip2
Name: CAP-GLY domain containing linker protein 2
Synonyms: CLIP-115, WSCR4, Cyln2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269713
HGNC: HGNC:2586
Homologene: 20718
Or7g31
Name: olfactory receptor family 7 subfamily G member 31
Synonyms: GA_x6K02T2PVTD-13214162-13213224, MOR147-2, Olfr850
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258516
Homologene: 121552
Zfp184
Name: zinc finger protein 184 (Kruppel-like)
Synonyms: 4930500C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 193452
Homologene: 113602
Proca1
Name: protein interacting with cyclin A1
Synonyms: 4933404M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216974
Homologene: 51856
Psmd8
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Synonyms: 6720456J22Rik, C76433
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57296
HGNC: HGNC:9566
Homologene: 37686
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74691
Homologene: 14311
Or2d2
Name: olfactory receptor family 2 subfamily D member 2
Synonyms: GA_x6K02T2PBJ9-9479517-9478573, MOR260-1, Olfr715
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258776
HGNC: HGNC:8244
Homologene: 81541
6820408C15Rik
Name: RIKEN cDNA 6820408C15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228778
Homologene: 51916
Ddi1
Name: DNA-damage inducible 1
Synonyms: 1700011N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71829
VEGA: 9
Homologene: 100549
Vmn2r76
Name: vomeronasal 2, receptor 76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 675969
Homologene: 104330
Qars
Name: glutaminyl-tRNA synthetase
Synonyms: 1110018N24Rik, 1200016L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 97541
HGNC: HGNC:9751
Homologene: 133975
Or12e8
Name: olfactory receptor family 12 subfamily E member 8
Synonyms: GA_x6K02T2Q125-48849180-48850100, MOR264-2, Olfr1120
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259031
Homologene: 72054
Fuca1
Name: fucosidase, alpha-L- 1, tissue
Synonyms: Afuc, 0610006A03Rik, 9530055J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71665
HGNC: HGNC:4006
Homologene: 20078
Or6a2
Name: olfactory receptor family 6 subfamily A member 2
Synonyms: I54, I7, Olfr41, MOR103-15, GA_x6K02T2PBJ9-9381439-9380456, Olfr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18317
Homologene: 2743
Tmem178b
Name: transmembrane protein 178B
Synonyms: Gm5567, A930009E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434008
Homologene: 86704
4930563M21Rik
Name: RIKEN cDNA 4930563M21 gene
Synonyms: Rfpl3s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75258
VEGA: 9
Homologene: 138467
Ighv3-4
Name: immunoglobulin heavy variable V3-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 629833
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 107,538,449 bp
  • T to C, chromosome 2 at 87,358,253 bp
  • C to T, chromosome 2 at 152,428,953 bp
  • G to A, chromosome 3 at 89,181,927 bp
  • A to G, chromosome 4 at 116,099,449 bp
  • C to T, chromosome 4 at 118,433,060 bp
  • G to A, chromosome 4 at 135,929,950 bp
  • G to A, chromosome 5 at 25,265,260 bp
  • A to T, chromosome 5 at 97,938,407 bp
  • A to G, chromosome 5 at 134,535,197 bp
  • A to G, chromosome 5 at 138,447,541 bp
  • A to T, chromosome 5 at 149,563,337 bp
  • G to A, chromosome 6 at 40,254,907 bp
  • A to T, chromosome 6 at 46,530,390 bp
  • T to A, chromosome 7 at 13,027,911 bp
  • G to A, chromosome 7 at 29,177,121 bp
  • G to A, chromosome 7 at 80,311,216 bp
  • T to A, chromosome 7 at 86,230,532 bp
  • T to C, chromosome 7 at 107,001,329 bp
  • A to G, chromosome 7 at 107,129,037 bp
  • T to C, chromosome 8 at 125,491,656 bp
  • A to G, chromosome 9 at 6,265,799 bp
  • C to T, chromosome 9 at 19,477,597 bp
  • T to C, chromosome 9 at 55,980,842 bp
  • A to G, chromosome 9 at 65,054,923 bp
  • T to C, chromosome 9 at 108,513,974 bp
  • A to G, chromosome 9 at 111,367,035 bp
  • G to A, chromosome 10 at 26,340,948 bp
  • T to C, chromosome 10 at 41,070,608 bp
  • A to G, chromosome 11 at 9,434,188 bp
  • A to G, chromosome 11 at 69,347,189 bp
  • A to G, chromosome 11 at 78,204,926 bp
  • G to T, chromosome 11 at 90,658,201 bp
  • G to A, chromosome 11 at 103,502,289 bp
  • A to G, chromosome 12 at 104,729,228 bp
  • T to C, chromosome 12 at 111,838,736 bp
  • C to T, chromosome 12 at 112,067,625 bp
  • A to T, chromosome 12 at 114,253,913 bp
  • G to A, chromosome 13 at 21,958,778 bp
  • T to A, chromosome 13 at 43,094,887 bp
  • T to C, chromosome 13 at 97,176,751 bp
  • T to C, chromosome 14 at 28,522,866 bp
  • G to A, chromosome 18 at 78,207,068 bp
  • C to T, chromosome 19 at 9,001,783 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4237 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041054-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.