Strain Name:
C57BL/6J-MtgxR4241Btlr/Mmmh
Stock Number:
041058-MU
Citation ID:
RRID:MMRRC_041058-MU
Other Names:
R4241 (G1), C57BL/6J-MtgxR4241Btlr
Major Collection:

Strain Information

Rcan2
Name: regulator of calcineurin 2
Synonyms: Dscr1l1, ZAKI-4, MCIP2, Csp2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53901
VEGA: 17
HGNC: HGNC:3041
Homologene: 130985
Csnk1e
Name: casein kinase 1, epsilon
Synonyms: tau, KC1epsilon, CK1epsilon, CKI epsilon, CKIepsilon
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 27373
Homologene: 121695
Zmat5
Name: zinc finger, matrin type 5
Synonyms: D11Bwg1548e, 2610510L01Rik, D11Bwg0572e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67178
Homologene: 32439
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Klhl13
Name: kelch-like 13
Synonyms: 1200009K10Rik, D130072F20Rik, Bklhd2
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 67455
Homologene: 23571
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22222
Homologene: 7582
Kif1b
Name: kinesin family member 1B
Synonyms: N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, A530096N05Rik, Kif1b alpha, Kif1b beta
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Eif3e
Name: eukaryotic translation initiation factor 3, subunit E
Synonyms: eIF3-p48, Int6, eIF3-p46, Eif3s6, 48kDa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16341
VEGA: 15
HGNC: HGNC:3277
Homologene: 1205
Bcas3
Name: BCAS3 microtubule associated cell migration factor
Synonyms: breast carcinoma amplified sequence 3, K20D4, 2610028P08Rik, 1500019F07Rik, rudhira, Phaf2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192197
Homologene: 9778
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, tbl, D130015N03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Ubfd1
Name: ubiquitin family domain containing 1
Synonyms: D7Wsu128e, D7Wsu105e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 28018
Homologene: 10430
Atoh1
Name: atonal bHLH transcription factor 1
Synonyms: Hath1, bHLHa14, Math1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11921
HGNC: HGNC:797
Homologene: 31297
Cdh9
Name: cadherin 9
Synonyms: T1-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12565
HGNC: HGNC:1768
Homologene: 9450
Lingo1
Name: leucine rich repeat and Ig domain containing 1
Synonyms: LINGO-1, UNQ201, 4930471K13Rik, Lrrn6a, LERN1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235402
Homologene: 41891
Lmbrd1
Name: LMBR1 domain containing 1
Synonyms: 0910001K20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68421
Homologene: 10156
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 1110061O17Rik, 9630046L06Rik, 9430004C13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Dbt
Name: dihydrolipoamide branched chain transacylase E2
Synonyms: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, BCKAD E2, D3Wsu60e, dihydrolipoyl transacylase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13171
HGNC: HGNC:2698
Homologene: 1444
Cyp2d41-ps
Name: cytochrome P450, family 2, subfamily d, member 41, pseudogene
Synonyms: Gm5062
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 271300
Sprr3
Name: small proline-rich protein 3
Synonyms: SPR3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20766
Homologene: 135951
Kynu
Name: kynureninase
Synonyms: 4432411A05Rik, L-kynurenine hydrolase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70789
HGNC: HGNC:6469
Homologene: 2925
Abca14
Name: ATP-binding cassette, sub-family A member 14
Synonyms: 4930539G24Rik, 1700110B15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67928
Homologene: 86128
Pde6c
Name: phosphodiesterase 6C, cGMP specific, cone, alpha prime
Synonyms: cpfl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 110855
VEGA: 19
HGNC: HGNC:8787
Homologene: 4521
Col16a1
Name: collagen, type XVI, alpha 1
Synonyms: [a]1 (XVI) collagen, A530052M23Rik, 2700007F12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107581
HGNC: HGNC:2193
Homologene: 1397
Ccdc83
Name: coiled-coil domain containing 83
Synonyms: 4932423M01Rik, 4930549K11Rik, 4930554C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75338
Homologene: 32709
Gpr176
Name: G protein-coupled receptor 176
Synonyms: LOC381413
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381413
Homologene: 5226
Vmn1r237
Name: vomeronasal 1 receptor 237
Synonyms: V1rf3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171234
Homologene: 64475
Coq6
Name: coenzyme Q6 monooxygenase
Synonyms: 5930427M12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217707
Homologene: 6039
Peli3
Name: pellino 3
Synonyms: 6030441F14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240518
Homologene: 27059
Btbd6
Name: BTB domain containing 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399566
VEGA: 12
Homologene: 41967
Slc10a5
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 5
Synonyms: LOC241877
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241877
Homologene: 78106
Or52e19
Name: olfactory receptor family 52 subfamily E member 19
Synonyms: Gm15117, ENSMUSG00000073953, Olfr596, GA_x6K02T2PBJ9-6019769-6019943, Olfr596-ps1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041187
Homologene: 121535
Hax1
Name: HCLS1 associated X-1
Synonyms: mHAX-1s, Hs1bp1, HS1-associated protein X-1, Silg111, HAX-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23897
Homologene: 4463
Vmn1r180
Name: vomeronasal 1 receptor 180
Synonyms: V1rd16, LOC232962
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232962
Homologene: 104166
Ap5b1
Name: adaptor-related protein complex 5, beta 1 subunit
Synonyms: Gm962
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381201
VEGA: 19
Homologene: 16299
Or7c70
Name: olfactory receptor family 7 subfamily C member 70
Synonyms: MOR142-1, GA_x6K02T2QGN0-2962025-2962987, MOR142-2_p, Olfr1356
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258305
Homologene: 71958
D10Bwg1379e
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Gm7135
Name: predicted gene 7135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 634346
Homologene: 86643
Stk16
Name: serine/threonine kinase 16
Synonyms: EDPK, PKL12, Krct, Embryo-Derived Protein Kinase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20872
Homologene: 2739
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 24,692,968 bp
  • T to C, chromosome 1 at 75,212,177 bp
  • A to G, chromosome 1 at 97,353,953 bp
  • A to T, chromosome 2 at 43,681,410 bp
  • A to T, chromosome 2 at 118,279,610 bp
  • T to C, chromosome 2 at 120,934,386 bp
  • T to A, chromosome 2 at 157,560,423 bp
  • A to G, chromosome 3 at 10,335,460 bp
  • A to G, chromosome 3 at 89,995,690 bp
  • A to G, chromosome 3 at 92,456,907 bp
  • T to C, chromosome 3 at 116,533,296 bp
  • A to T, chromosome 3 at 116,754,848 bp
  • C to T, chromosome 4 at 63,432,973 bp
  • G to T, chromosome 4 at 130,099,050 bp
  • A to G, chromosome 4 at 149,270,833 bp
  • A to C, chromosome 6 at 64,729,774 bp
  • A to T, chromosome 7 at 23,952,873 bp
  • A to G, chromosome 7 at 28,154,335 bp
  • A to C, chromosome 7 at 90,247,138 bp
  • G to T, chromosome 7 at 103,310,661 bp
  • C to A, chromosome 7 at 120,238,488 bp
  • T to C, chromosome 7 at 122,071,754 bp
  • A to G, chromosome 9 at 56,620,102 bp
  • CTGAGGACTCTTTG to CTG, chromosome 9 at 66,448,348 bp
  • A to G, chromosome 10 at 18,625,164 bp
  • T to A, chromosome 10 at 78,847,905 bp
  • A to G, chromosome 11 at 4,728,614 bp
  • T to A, chromosome 11 at 85,470,826 bp
  • A to T, chromosome 12 at 84,373,789 bp
  • C to T, chromosome 12 at 112,976,796 bp
  • C to T, chromosome 12 at 115,158,822 bp
  • T to G, chromosome 15 at 12,149,659 bp
  • A to G, chromosome 15 at 16,849,079 bp
  • G to A, chromosome 15 at 43,262,690 bp
  • A to G, chromosome 15 at 79,424,895 bp
  • T to A, chromosome 15 at 82,779,586 bp
  • C to T, chromosome 15 at 85,818,144 bp
  • C to T, chromosome 17 at 15,770,027 bp
  • A to G, chromosome 17 at 21,314,663 bp
  • T to A, chromosome 17 at 43,953,479 bp
  • T to C, chromosome 19 at 4,932,398 bp
  • C to T, chromosome 19 at 5,568,797 bp
  • G to A, chromosome 19 at 38,162,845 bp
  • T to A, chromosome X at 23,315,175 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4241 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041058-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.