Strain Name:
C57BL/6J-MtgxR4261Btlr/Mmmh
Stock Number:
041074-MU
Citation ID:
RRID:MMRRC_041074-MU
Other Names:
R4261 (G1), C57BL/6J-MtgxR4261Btlr
Major Collection:

Gene Information

Pald1
Name: phosphatase domain containing, paladin 1
Synonyms: paladin, X99384
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27355
VEGA: 10
Homologene: 8453
Ide
Name: insulin degrading enzyme
Synonyms: 4833415K22Rik, 1300012G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Pkp4
Name: plakophilin 4
Synonyms: Armrp, 9430019K17Rik, 5031422I09Rik, p0071
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227937
HGNC: HGNC:9026
Homologene: 2689
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: 1190003A07Rik, U5-102K, 2610031L17Rik, ANT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68879
Homologene: 5368
Kif4
Name: kinesin family member 4
Synonyms: Kns4, N-5 kinesin, D330050K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 16571
Homologene: 69022
Grhl2
Name: grainyhead like transcription factor 2
Synonyms: Tcfcp2l3, 0610015A08Rik, BOM, clft3, grainyheadlike
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 252973
HGNC: HGNC:2799
Homologene: 32616
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: Myst4, qkf, querkopf, B130044K16Rik, Morf, monocytic leukemia
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54169
Homologene: 136480
Ppp2r5d
Name: protein phosphatase 2, regulatory subunit B', delta
Synonyms: Tex271, B'delta, TEG-271
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21770
VEGA: 17
HGNC: HGNC:9312
Homologene: 37661
Tcf7l2
Name: transcription factor 7 like 2, T cell specific, HMG box
Synonyms: mTcf-4B, Tcf4, TCF4E, TCF4B, mTcf-4E, Tcf-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21416
Homologene: 7564
Dlgap5
Name: DLG associated protein 5
Synonyms: C86398, Dlg7, Hurp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218977
Homologene: 8840
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: tbl, 2810449H11Rik, D130015N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Actr10
Name: ARP10 actin-related protein 10
Synonyms: Arp11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56444
VEGA: 12
Homologene: 10220
Dock7
Name: dedicator of cytokinesis 7
Synonyms: m, LOC242555, 3110056M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Ube3b
Name: ubiquitin protein ligase E3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 117146
Homologene: 13775
Mphosph8
Name: M-phase phosphoprotein 8
Synonyms: 4930548G07Rik, 1500035L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75339
Homologene: 11380
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: CD140b, Pdgfr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Hspa9
Name: heat shock protein 9
Synonyms: mthsp70, C3H-specific antigen, Hsc74, mortalin, mot-2, Hspa9a, Hsp74a, Hsp74, CSA, PBP74, GRP75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 15526
HGNC: HGNC:5244
Homologene: 39452
Raf1
Name: v-raf-leukemia viral oncogene 1
Synonyms: v-Raf, Craf1, c-Raf, 6430402F14Rik, sarcoma 3611 oncogene, Raf-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110157
HGNC: HGNC:9829
Homologene: 48145
Rfx7
Name: regulatory factor X, 7
Synonyms: 2510005N23Rik, Rfxdc2, 9930116O05Rik, D130086K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319758
Homologene: 11275
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74144
Homologene: 10397
Pgk2
Name: phosphoglycerate kinase 2
Synonyms: Tcp-2, Tcp-2, Pgk-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18663
VEGA: 17
HGNC: HGNC:8898
Homologene: 57138
Adamts4
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
Synonyms: aggrecanase-1, ADAM-TS4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240913
HGNC: HGNC:220
Homologene: 36169
Ttn
Name: titin
Synonyms: D330041I19Rik, mdm, L56, connectin, 2310074I15Rik, 2310057K23Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17876
Homologene: 69079
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: 9430031G15Rik, Ltbp1L, LTBP-1, b2b1000Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Slc38a4
Name: solute carrier family 38, member 4
Synonyms: 1110012E16Rik, 1700012A18Rik, Ata3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69354
VEGA: 15
Homologene: 75077
1700010I14Rik
Name: RIKEN cDNA 1700010I14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66931
Homologene: 49841
Exoc3l
Name: exocyst complex component 3-like
Synonyms: C730015A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 277978
Homologene: 18629
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: Slack, slo2, C030030G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227632
Homologene: 11055
Fam234b
Name: family with sequence similarity 234, member B
Synonyms: 8430419L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74525
Homologene: 12572
Wdr91
Name: WD repeat domain 91
Synonyms: 9530020G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101240
Homologene: 8562
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17836
Homologene: 136663
Adam9
Name: a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Synonyms: MDC9, MDC9, Mltng, Mltng
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11502
HGNC: HGNC:216
Homologene: 20824
Car5a
Name: carbonic anhydrase 5a, mitochondrial
Synonyms: Car5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12352
HGNC: HGNC:1377
Homologene: 68200
Sgsm2
Name: small G protein signaling modulator 2
Synonyms: Rutbc1, D630003G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 97761
Homologene: 14780
Arhgap9
Name: Rho GTPase activating protein 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216445
VEGA: 10
Homologene: 13041
Zcwpw2
Name: zinc finger, CW type with PWWP domain 2
Synonyms: 4930430K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Homologene: 87409
Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: PRKN, Park2, Parkin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50873
HGNC: HGNC:8607
Homologene: 3355
Dvl3
Name: dishevelled segment polarity protein 3
Synonyms: b2b2866Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13544
HGNC: HGNC:3087
Homologene: 20928
Ugt3a2
Name: UDP glycosyltransferases 3 family, polypeptide A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223337
Homologene: 122787
Ppcs
Name: phosphopantothenoylcysteine synthetase
Synonyms: 6330579B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 106564
Homologene: 6173
Disp1
Name: dispatched RND transporter family member 1
Synonyms: 1190008H24Rik, DispA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68897
Homologene: 14133
Gm14396
Name: predicted gene 14396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Mthfr-ps1
Name: 5,10-methylenetetrahydrofolate reductase, pseudogene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 387594
Sat1
Name: spermidine/spermine N1-acetyl transferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 20229
Homologene: 37716
Lppr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
B430119L08Rik
Name: RIKEN cDNA B430119L08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 171,259,104 bp
  • A to T, chromosome 1 at 183,089,386 bp
  • C to T, chromosome 2 at 25,906,788 bp
  • A to G, chromosome 2 at 59,305,162 bp
  • C to A, chromosome 2 at 74,695,687 bp
  • T to A, chromosome 2 at 76,798,040 bp
  • T to C, chromosome 2 at 125,115,479 bp
  • T to C, chromosome 2 at 181,621,843 bp
  • A to G, chromosome 4 at 49,300,993 bp
  • A to T, chromosome 4 at 99,003,886 bp
  • A to G, chromosome 4 at 119,421,909 bp
  • A to C, chromosome 5 at 78,474,483 bp
  • T to C, chromosome 5 at 114,398,428 bp
  • T to A, chromosome 5 at 124,730,137 bp
  • T to A, chromosome 6 at 34,904,522 bp
  • C to T, chromosome 6 at 115,623,054 bp
  • A to G, chromosome 6 at 121,873,734 bp
  • G to A, chromosome 6 at 135,209,136 bp
  • G to A, chromosome 8 at 24,964,907 bp
  • T to C, chromosome 8 at 105,290,967 bp
  • A to T, chromosome 8 at 121,944,749 bp
  • C to A, chromosome 9 at 37,405,581 bp
  • CTGAGGACTCTTTG to CTG, chromosome 9 at 66,448,348 bp
  • C to T, chromosome 9 at 72,616,643 bp
  • T to A, chromosome 9 at 108,110,684 bp
  • T to C, chromosome 9 at 117,998,914 bp
  • A to G, chromosome 10 at 61,343,692 bp
  • G to A, chromosome 10 at 74,645,680 bp
  • G to C, chromosome 10 at 127,328,465 bp
  • T to A, chromosome 11 at 74,892,028 bp
  • T to C, chromosome 12 at 70,952,985 bp
  • T to C, chromosome 12 at 103,897,080 bp
  • T to A, chromosome 14 at 21,669,669 bp
  • T to G, chromosome 14 at 47,413,788 bp
  • A to G, chromosome 14 at 56,674,465 bp
  • G to A, chromosome 15 at 9,335,793 bp
  • G to A, chromosome 15 at 37,360,823 bp
  • A to G, chromosome 15 at 82,063,726 bp
  • A to G, chromosome 15 at 96,998,493 bp
  • A to G, chromosome 16 at 20,524,485 bp
  • T to C, chromosome 17 at 8,995,234 bp
  • T to C, chromosome 17 at 11,854,795 bp
  • T to G, chromosome 17 at 40,207,383 bp
  • G to A, chromosome 17 at 46,687,081 bp
  • T to A, chromosome 17 at 75,291,367 bp
  • A to G, chromosome 18 at 34,939,423 bp
  • A to G, chromosome 18 at 37,691,897 bp
  • A to C, chromosome 18 at 61,077,631 bp
  • A to C, chromosome 19 at 37,329,186 bp
  • A to G, chromosome 19 at 55,817,805 bp
  • T to C, chromosome X at 100,715,707 bp
  • T to C, chromosome X at 155,215,186 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4261 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041074-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.