Strain Name:
C57BL/6J-MtgxR4381Btlr/Mmmh
Stock Number:
041122-MU
Citation ID:
RRID:MMRRC_041122-MU
Other Names:
R4381 (G1), C57BL/6J-MtgxR4381Btlr
Major Collection:

Strain Information

Pdgfc
Name: platelet-derived growth factor, C polypeptide
Synonyms: 1110064L01Rik, PDGF-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54635
HGNC: HGNC:8801
Homologene: 9423
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ranbp1
Name: RAN binding protein 1
Synonyms: Htf9a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19385
HGNC: HGNC:9847
Homologene: 21600
Rexo4
Name: REX4, 3'-5' exonuclease
Synonyms: XPMC2H, Rex4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227656
Homologene: 133948
Taf1d
Name: TATA-box binding protein associated factor, RNA polymerase I, D
Synonyms: 4930553M18Rik, TAFI41, Josd3, TAF(I)41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75316
VEGA: 9
Homologene: 11472
Zfp1
Name: zinc finger protein 1
Synonyms: mkr-1, Zfp-1, Fnp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22640
Homologene: 32132
Nif3l1
Name: Ngg1 interacting factor 3-like 1 (S. pombe)
Synonyms: 1110030G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 65102
Homologene: 5881
Mib2
Name: mindbomb E3 ubiquitin protein ligase 2
Synonyms: 2210008I11Rik, Zzank1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76580
Homologene: 16062
Eps15
Name: epidermal growth factor receptor pathway substrate 15
Synonyms: 2410112D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13858
HGNC: HGNC:3419
Homologene: 128359
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4921518A06Rik, 4933421G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Pbrm1
Name: polybromo 1
Synonyms: BAF180, 2610016F04Rik, 2310032M22Rik, Pb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66923
Homologene: 10044
Prkaa1
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Synonyms: C130083N04Rik, AMPKalpha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105787
VEGA: 15
HGNC: HGNC:9376
Homologene: 49590
Vrk3
Name: vaccinia related kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101568
Homologene: 9509
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, NKF3 kinase family member, C230081A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244895
Homologene: 18259
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Tstd2
Name: thiosulfate sulfurtransferase (rhodanese)-like domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 272027
Homologene: 16403
Dlgap2
Name: DLG associated protein 2
Synonyms: SAP90/PSD-95-associated protein 2, PSD-95/SAP90-binding protein 2, 6430596N04Rik, DAP2, Sapap2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244310
HGNC: HGNC:2906
Homologene: 3484
Mtpap
Name: mitochondrial poly(A) polymerase
Synonyms: 0610027A18Rik, Papd1, Tent6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67440
VEGA: 18
Homologene: 10008
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: 4930505G06Rik, A930002K18Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 77945
Homologene: 10679
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217718
Homologene: 13222
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241263
Homologene: 19381
Zyg11a
Name: zyg-11 family member A, cell cycle regulator
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230590
Homologene: 66294
Or10al3
Name: olfactory receptor family 10 subfamily AL member 3
Synonyms: MOR263-7, GA_x6K02T2PSCP-2159633-2160598, Olfr119
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258095
Homologene: 17195
Pla2g4c
Name: phospholipase A2, group IVC (cytosolic, calcium-independent)
Synonyms: CPLA2-gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232889
HGNC: HGNC:9037
Homologene: 115256
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Polrmt
Name: polymerase (RNA) mitochondrial (DNA directed)
Synonyms: 1110018N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216151
HGNC: HGNC:9200
Homologene: 37996
Nacad
Name: NAC alpha domain containing
Synonyms: mKIAA0363
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192950
Homologene: 135717
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71481
Homologene: 11849
Or7g34
Name: olfactory receptor family 7 subfamily G member 34
Synonyms: GA_x6K02T2PVTD-13313295-13312357, MOR147-3, Olfr854
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258515
Homologene: 128144
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il1rrp, Il18ralpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Qars
Name: glutaminyl-tRNA synthetase
Synonyms: 1110018N24Rik, 1200016L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 97541
HGNC: HGNC:9751
Homologene: 133975
Zdhhc16
Name: zinc finger, DHHC domain containing 16
Synonyms: APH2, 1500015N03Rik, Abl-philin 2, Ablphilin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74168
VEGA: 19
Homologene: 11377
Pcdha4
Name: protocadherin alpha 4
Synonyms: Cnr1, Crnr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12936
Homologene: 130626
RP24-350F17.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,163,235 bp
  • A to G, chromosome 1 at 40,471,790 bp
  • A to C, chromosome 1 at 58,455,579 bp
  • T to A, chromosome 2 at 21,827,592 bp
  • C to T, chromosome 2 at 26,956,358 bp
  • A to G, chromosome 3 at 81,209,251 bp
  • C to T, chromosome 3 at 127,729,373 bp
  • T to C, chromosome 4 at 46,119,933 bp
  • G to A, chromosome 4 at 108,201,320 bp
  • G to A, chromosome 4 at 109,366,530 bp
  • G to C, chromosome 4 at 155,657,612 bp
  • A to T, chromosome 7 at 8,471,913 bp
  • A to T, chromosome 7 at 13,346,065 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • C to T, chromosome 7 at 44,775,442 bp
  • A to G, chromosome 8 at 14,846,502 bp
  • T to A, chromosome 8 at 111,670,451 bp
  • T to A, chromosome 9 at 15,311,981 bp
  • A to G, chromosome 9 at 19,566,742 bp
  • G to T, chromosome 9 at 56,258,427 bp
  • G to A, chromosome 9 at 108,510,183 bp
  • A to C, chromosome 10 at 79,741,808 bp
  • T to A, chromosome 11 at 6,600,204 bp
  • T to A, chromosome 12 at 85,329,858 bp
  • A to G, chromosome 12 at 98,815,955 bp
  • T to A, chromosome 12 at 115,386,993 bp
  • T to C, chromosome 14 at 31,025,556 bp
  • C to T, chromosome 14 at 52,150,449 bp
  • A to T, chromosome 15 at 5,176,808 bp
  • A to G, chromosome 15 at 8,359,206 bp
  • G to A, chromosome 16 at 18,247,344 bp
  • G to T, chromosome 17 at 37,700,899 bp
  • T to C, chromosome 18 at 4,383,223 bp
  • A to G, chromosome 18 at 36,952,875 bp
  • A to G, chromosome 19 at 41,940,654 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4381 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041122-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.