Strain Name:
C57BL/6J-MtgxR4511Btlr/Mmmh
Stock Number:
041586-MU
Citation ID:
RRID:MMRRC_041586-MU
Other Names:
R4511 (G1), C57BL/6J-MtgxR4511Btlr
Major Collection:

Gene Information

Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Rngtt
Name: RNA guanylyltransferase and 5'-phosphatase
Synonyms: mouse capping enzyme
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 24018
Homologene: 37851
Arid1a
Name: AT rich interactive domain 1A (SWI-like)
Synonyms: Osa1, Smarcf1, 1110030E03Rik, BAF250a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 93760
Homologene: 21216
Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: Adprt1, 5830444G22Rik, parp-1, Adprp, sPARP-1, PARP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 11545
HGNC: HGNC:270
Homologene: 1222
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Sec23ip
Name: Sec23 interacting protein
Synonyms: p125, D7Ertd373e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 207352
Homologene: 38288
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 103573
Homologene: 2554
Ints9
Name: integrator complex subunit 9
Synonyms: D14Ertd231e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 210925
VEGA: 14
Homologene: 10096
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: ABIN1, A20-binding inhibitor of NF-kappa B activation, Nef, VAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 57783
Homologene: 31355
Smc4
Name: structural maintenance of chromosomes 4
Synonyms: 2500002A22Rik, Smc4l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 70099
Homologene: 4015
Nol6
Name: nucleolar protein family 6 (RNA-associated)
Synonyms: Nrap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230082
Homologene: 41505
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 195018
Homologene: 9027
Tnfrsf21
Name: tumor necrosis factor receptor superfamily, member 21
Synonyms: DR6, Death receptor 6, TR7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 94185
VEGA: 17
Homologene: 8696
Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms: Rip1, Rinp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19766
Homologene: 2820
Polg
Name: polymerase (DNA directed), gamma
Synonyms: polymerase gamma, Pol gamma, Polga, mitochondrial DNA polymerase gamma, mitochondrial DNA polymerase-gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18975
HGNC: HGNC:9179
Homologene: 2016
Gabbr1
Name: gamma-aminobutyric acid (GABA) B receptor, 1
Synonyms: GABAbR1, GABAB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 54393
HGNC: HGNC:4070
Homologene: 1132
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Doc4, ELM2, l7Rn3, Odz4, Ten-m4, l(7)-3Rn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 23966
Homologene: 8034
Lnx1
Name: ligand of numb-protein X 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16924
HGNC: HGNC:6657
Homologene: 7819
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, 2900010L19Rik, Sorla, mSorLA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20660
Homologene: 2336
Phlda3
Name: pleckstrin homology like domain, family A, member 3
Synonyms: TDAG/lpl homolog 1, Tih1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 27280
HGNC: HGNC:8934
Homologene: 8233
Arhgap1
Name: Rho GTPase activating protein 1
Synonyms: p50rhoGAP, B230365D05Rik, Cdc42GAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228359
HGNC: HGNC:673
Homologene: 20909
Ackr4
Name: atypical chemokine receptor 4
Synonyms: PPR1, Ccrl1, A630091E18Rik, VSHK1, CCX-CKR, CCR11, CCBP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 252837
HGNC: HGNC:1611
Homologene: 49474
Samd4
Name: sterile alpha motif domain containing 4
Synonyms: 1700024G08Rik, Smaug, 4933436G17Rik, sunk, 1700111L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 74480
Homologene: 19167
Fgfr4
Name: fibroblast growth factor receptor 4
Synonyms: Fgfr-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14186
HGNC: HGNC:3691
Homologene: 20461
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: A2mr, b2b1554Clo, CD91
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: LTRPC3, 6330504P12Rik, MLSN2, melastatin 2, B930001P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226025
VEGA: 19
Homologene: 62287
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Slc7a1
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Synonyms: Rev-1, Rec-1, Cat1, 4831426K01Rik, Atrc1, mCAT-1, Atrc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11987
Homologene: 20658
Irak3
Name: interleukin-1 receptor-associated kinase 3
Synonyms: 4833428C18Rik, IRAK-M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 73914
Homologene: 36215
Gm12794
Name: predicted gene 12794
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 332923
HGNC: null
Homologene: null
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: 1700056P18Rik, testase 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Stk19
Name: serine/threonine kinase 19
Synonyms: G11, RP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 54402
Homologene: 10449
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: 1600012D06Rik, Abp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: BCSC-1, Loh11cr2a, 5830475I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 78771
Homologene: 75211
Gcnt1
Name: glucosaminyl (N-acetyl) transferase 1, core 2
Synonyms: beta-1, 6-N-acetylglucosaminyltransferase, IGnT, C2 GlcNAcT, 5630400D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 14537
HGNC: HGNC:4203
Homologene: 37486
Slc6a21
Name: solute carrier family 6 member 21
Synonyms: 1700039E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76713
Homologene: 66347
Prkd1
Name: protein kinase D1
Synonyms: Prkcm, PKD1, Pkcm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18760
VEGA: 12
HGNC: HGNC:9407
Homologene: 55680
Abcc10
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Synonyms: Mrp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Ldlrad1
Name: low density lipoprotein receptor class A domain containing 1
Synonyms: OTTMUSG00000008594
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 546840
Homologene: 54473
Tekt5
Name: tektin 5
Synonyms: 3300001K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 70426
Homologene: 71928
Slc4a1ap
Name: solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms: kanadaptin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20534
Homologene: 7543
Igkv2-109
Name: immunoglobulin kappa variable 2-109
Synonyms: ENSMUSG00000060986
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 628268
HGNC: null
Homologene: null
Gm21976
Name: predicted gene 21976
Synonyms: ENSMUSG00000071224, Gm8780
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 102637808
HGNC: null
Homologene: null
Lalba
Name: lactalbumin, alpha
Synonyms: lactalbumin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16770
VEGA: 15
HGNC: HGNC:6480
Homologene: 1720
Kcng2
Name: potassium voltage-gated channel, subfamily G, member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240444
HGNC: HGNC:6249
Homologene: 8178
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 135,766,662 bp
  • A to G, chromosome 1 at 180,591,276 bp
  • G to A, chromosome 2 at 91,669,506 bp
  • G to A, chromosome 2 at 130,935,577 bp
  • T to A, chromosome 3 at 69,016,647 bp
  • T to C, chromosome 3 at 98,146,321 bp
  • A to T, chromosome 4 at 33,339,032 bp
  • G to C, chromosome 4 at 41,123,526 bp
  • A to T, chromosome 4 at 101,941,560 bp
  • T to G, chromosome 4 at 107,209,518 bp
  • A to C, chromosome 4 at 133,695,699 bp
  • A to T, chromosome 5 at 31,527,403 bp
  • C to T, chromosome 5 at 74,620,192 bp
  • G to T, chromosome 5 at 148,340,562 bp
  • C to A, chromosome 6 at 48,907,806 bp
  • A to G, chromosome 6 at 68,302,978 bp
  • A to G, chromosome 7 at 45,287,289 bp
  • T to C, chromosome 7 at 79,455,522 bp
  • T to C, chromosome 7 at 96,894,863 bp
  • G to A, chromosome 7 at 128,779,176 bp
  • G to T, chromosome 8 at 40,826,291 bp
  • A to G, chromosome 9 at 21,399,215 bp
  • A to G, chromosome 9 at 38,722,557 bp
  • C to T, chromosome 9 at 41,977,572 bp
  • A to G, chromosome 9 at 62,761,588 bp
  • T to C, chromosome 9 at 104,098,731 bp
  • T to A, chromosome 10 at 120,145,908 bp
  • T to C, chromosome 10 at 127,593,848 bp
  • A to G, chromosome 11 at 23,287,401 bp
  • T to A, chromosome 11 at 54,926,790 bp
  • A to G, chromosome 11 at 72,888,170 bp
  • T to C, chromosome 12 at 50,392,979 bp
  • T to C, chromosome 13 at 34,026,748 bp
  • C to A, chromosome 13 at 55,161,515 bp
  • G to A, chromosome 13 at 76,825,272 bp
  • A to G, chromosome 13 at 98,305,331 bp
  • T to A, chromosome 14 at 47,077,585 bp
  • A to G, chromosome 14 at 65,028,932 bp
  • A to G, chromosome 15 at 98,482,541 bp
  • A to C, chromosome 16 at 10,358,013 bp
  • G to A, chromosome 16 at 37,048,563 bp
  • T to C, chromosome 17 at 34,832,528 bp
  • A to G, chromosome 17 at 37,069,211 bp
  • A to G, chromosome 17 at 43,065,019 bp
  • A to G, chromosome 17 at 46,307,210 bp
  • G to T, chromosome 18 at 80,295,715 bp
  • G to A, chromosome 19 at 17,330,277 bp
  • A to G, chromosome 19 at 22,988,017 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4511 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041586-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.