Strain Name:
C57BL/6J-MtgxR4007Btlr/Mmmh
Stock Number:
041610-MU
Citation ID:
RRID:MMRRC_041610-MU
Other Names:
R4007 (G1), C57BL/6J-MtgxR4007Btlr
Major Collection:

Strain Information

Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: Her4, ErbB4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
Synonyms: 5-HT2A receptor, Htr-2, Htr2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15558
VEGA: 14
HGNC: HGNC:5293
Homologene: 68073
Nup188
Name: nucleoporin 188
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227699
Homologene: 45683
Ubtd1
Name: ubiquitin domain containing 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226122
VEGA: 19
Homologene: 11799
Aff1
Name: AF4/FMR2 family, member 1
Synonyms: Rob, Mllt2h, 9630032B01Rik, Af4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17355
HGNC: HGNC:7135
Homologene: 4340
Wdr7
Name: WD repeat domain 7
Synonyms: TRAG, TGF-beta resistance associated gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Elp1
Name: elongator complex protein 1
Synonyms: C78473, Ikbkap, IKAP, 3110040G09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Mrps5
Name: mitochondrial ribosomal protein S5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77721
Homologene: 32726
Fntb
Name: farnesyltransferase, CAAX box, beta
Synonyms: 2010013E13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110606
Homologene: 1535
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
F11r
Name: F11 receptor
Synonyms: Ly106, JAM-A, JAM-1, ESTM33, BV11 antigen, Jcam1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16456
Homologene: 14255
Cul4a
Name: cullin 4A
Synonyms: 2810470J21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 99375
HGNC: HGNC:2554
Homologene: 81724
Nup54
Name: nucleoporin 54
Synonyms: 3110079L04Rik, 54kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269113
Homologene: 41169
Dhx37
Name: DEAH-box helicase 37
Synonyms: LOC208144, LOC381671
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208144
Homologene: 6641
Opn4
Name: opsin 4 (melanopsin)
Synonyms: 1110007J02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30044
VEGA: 14
Homologene: 69152
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Gprc5b
Name: G protein-coupled receptor, family C, group 5, member B
Synonyms: hypothetical protein, clone 2-63
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64297
Homologene: 9435
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: E030034C22Rik, Dnahc1, G1-415-19, MDHC7, ferf1, B230373P09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, C530008O15Rik, 1500031A17Rik, C630040K21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 665113
Homologene: 77943
Zfp385b
Name: zinc finger protein 385B
Synonyms: Zfp533, B830010L13Rik, C130013B13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241494
Homologene: 17606
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Prp9-1, Chd7, 2600010P09Rik, Mi-2 alpha, Prp7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: 5031414D18Rik, LOC380917
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Aknad1
Name: AKNA domain containing 1
Synonyms: 4921525H12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329738
Homologene: 51892
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Plcb2
Name: phospholipase C, beta 2
Synonyms: B230205M18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18796
HGNC: HGNC:9055
Homologene: 20957
Farp1
Name: FERM, ARH/RhoGEF and pleckstrin domain protein 1
Synonyms: Cdep
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223254
HGNC: HGNC:3591
Homologene: 38098
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 9030605H24Rik, 5930426O13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319767
Homologene: 70969
Ifitm6
Name: interferon induced transmembrane protein 6
Synonyms: fragilis5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 213002
Homologene: 72556
Rpap2
Name: RNA polymerase II associated protein 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231571
Homologene: 11733
Vmn2r18
Name: vomeronasal 2, receptor 18
Synonyms: EG632671
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 632671
Filip1
Name: filamin A interacting protein 1
Synonyms: FILIP, 5730485H21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70598
Homologene: 6700
Slc26a4
Name: solute carrier family 26, member 4
Synonyms: Pds, pendrin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23985
VEGA: 12
HGNC: HGNC:8818
Homologene: 20132
Ampd1
Name: adenosine monophosphate deaminase 1
Synonyms: Ampd-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229665
HGNC: HGNC:468
Homologene: 20
Ttc7
Name: tetratricopeptide repeat domain 7
Synonyms: fsn, 1110035E02Rik, 1700007L07Rik, hea
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225049
Homologene: 12515
Rbsn
Name: rabenosyn, RAB effector
Synonyms: 5330426D11Rik, Zfyve20, Rabenosyn-5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78287
Homologene: 41477
A1cf
Name: APOBEC1 complementation factor
Synonyms: apobec-1 complementation factor, 1810073H04Rik, ACF
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69865
VEGA: 19
Homologene: 16363
Fcna
Name: ficolin A
Synonyms: Fcn1, ficolin A
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14133
Homologene: 117949
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: D3F15S2h, D9H3F15S2, Hgfl, DNF15S2h
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15235
Homologene: 7360
Sv2c
Name: synaptic vesicle glycoprotein 2c
Synonyms: 4930527L09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75209
Homologene: 57152
Tfpi2
Name: tissue factor pathway inhibitor 2
Synonyms: PP5/TFPI-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21789
Homologene: 38194
Or8k35
Name: olfactory receptor family 8 subfamily K member 35
Synonyms: MOR192-4_p, GA_x6K02T2Q125-48079993-48079157, Olfr1082
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404473
Homologene: 104285
Krtap4-22
Name: keratin associated protein 4-22
Synonyms: Gm11595
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Zfp493
Name: zinc finger protein 493
Synonyms: 2900054J07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72958
Gml
Name: glycosylphosphatidylinositol anchored molecule like
Synonyms: EG625599
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 625599
HGNC: HGNC:4375
Homologene: 48071
Reg1
Name: regenerating islet-derived 1
Synonyms: pancreatic stone protein
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19692
Homologene: 68282
Syce1
Name: synaptonemal complex central element protein 1
Synonyms: 4933406J07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74075
Homologene: 77044
Rcor2
Name: REST corepressor 2
Synonyms: 1A13, CoREST
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104383
Homologene: 14280
Card9
Name: caspase recruitment domain family, member 9
Synonyms: LOC332579
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 332579
Homologene: 14150
Runx1t1
Name: RUNX1 translocation partner 1
Synonyms: Cbfa2t1h, ETO, MTG8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12395
HGNC: HGNC:1535
Homologene: 3801
Pramex1
Name: PRAME like, X-linked 1
Synonyms: Prame, 4930534P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 75829
Homologene: 87352
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 68,740,401 bp
  • A to G, chromosome 1 at 90,802,569 bp
  • A to G, chromosome 1 at 171,461,348 bp
  • A to G, chromosome 2 at 25,626,006 bp
  • T to A, chromosome 2 at 26,353,000 bp
  • G to A, chromosome 2 at 30,309,878 bp
  • C to T, chromosome 2 at 77,719,492 bp
  • T to C, chromosome 2 at 86,594,564 bp
  • T to C, chromosome 2 at 118,710,793 bp
  • C to A, chromosome 2 at 127,591,835 bp
  • A to G, chromosome 3 at 28,604,281 bp
  • A to G, chromosome 3 at 103,092,460 bp
  • T to C, chromosome 3 at 108,775,282 bp
  • A to G, chromosome 4 at 13,838,014 bp
  • G to A, chromosome 4 at 56,794,139 bp
  • T to A, chromosome 5 at 89,214,593 bp
  • A to G, chromosome 5 at 92,431,027 bp
  • A to T, chromosome 5 at 103,784,222 bp
  • A to G, chromosome 5 at 107,603,872 bp
  • G to A, chromosome 5 at 125,424,931 bp
  • T to C, chromosome 5 at 137,463,939 bp
  • A to T, chromosome 5 at 151,585,246 bp
  • A to G, chromosome 6 at 3,963,454 bp
  • A to G, chromosome 6 at 78,427,030 bp
  • T to A, chromosome 6 at 92,189,819 bp
  • A to G, chromosome 6 at 121,376,228 bp
  • A to G, chromosome 7 at 64,366,561 bp
  • G to A, chromosome 7 at 118,984,214 bp
  • C to A, chromosome 7 at 140,779,896 bp
  • T to A, chromosome 7 at 141,016,714 bp
  • A to G, chromosome 8 at 13,122,859 bp
  • A to G, chromosome 9 at 79,818,727 bp
  • A to G, chromosome 9 at 108,082,948 bp
  • A to T, chromosome 10 at 52,118,232 bp
  • A to T, chromosome 11 at 43,259,852 bp
  • A to T, chromosome 11 at 69,349,001 bp
  • C to T, chromosome 11 at 99,772,035 bp
  • T to A, chromosome 12 at 31,540,533 bp
  • C to A, chromosome 12 at 76,887,888 bp
  • A to G, chromosome 13 at 67,783,919 bp
  • A to G, chromosome 13 at 95,986,833 bp
  • T to C, chromosome 14 at 31,303,784 bp
  • A to T, chromosome 14 at 34,599,832 bp
  • A to T, chromosome 14 at 74,642,141 bp
  • G to T, chromosome 14 at 75,049,703 bp
  • T to C, chromosome 14 at 121,275,577 bp
  • T to A, chromosome 15 at 74,813,699 bp
  • G to A, chromosome 17 at 87,290,251 bp
  • T to A, chromosome 18 at 63,760,800 bp
  • T to A, chromosome 19 at 7,273,192 bp
  • T to C, chromosome 19 at 31,918,124 bp
  • G to T, chromosome 19 at 42,032,116 bp
  • A to T, chromosome X at 135,613,625 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4007 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041610-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.