Strain Name:
C57BL/6J-MtgxR4060Btlr/Mmmh
Stock Number:
041618-MU
Citation ID:
RRID:MMRRC_041618-MU
Other Names:
R4060 (G1), C57BL/6J-MtgxR4060Btlr
Major Collection:

Gene Information

Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Cdc5l
Name: cell division cycle 5-like (S. pombe)
Synonyms: PCDC5RP, 1200002I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71702
VEGA: 17
HGNC: HGNC:1743
Homologene: 13291
Tead1
Name: TEA domain family member 1
Synonyms: mTEF-1, 2610024B07Rik, TEF-1, TEAD-1, Tcf13, Gtrgeo5, B230114H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21676
Homologene: 2418
Zfp292
Name: zinc finger protein 292
Synonyms: 9430062L07Rik, Krox-10, Zfp-15, 5730450D02Rik, Zn-15, Zn-16, Zfp15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30046
Homologene: 8493
Cntn2
Name: contactin 2
Synonyms: Tax, axonin, TAG-1, TAG1, D130012K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21367
HGNC: HGNC:2172
Homologene: 3720
Usf2
Name: upstream transcription factor 2
Synonyms: Usf-2, bHLHb12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22282
Homologene: 2527
Fgfr2
Name: fibroblast growth factor receptor 2
Synonyms: KGFRTr, Bek, svs, Fgfr-7, Fgfr7, Fgfr-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14183
HGNC: HGNC:3689
Homologene: 22566
Ik
Name: IK cytokine
Synonyms: MuRED
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 24010
VEGA: 18
HGNC: HGNC:5958
Homologene: 36193
Cdan1
Name: congenital dyserythropoietic anemia, type I (human)
Synonyms: 1500015A01Rik, CDA1, codanin-1, CDA-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Fat1
Name: FAT atypical cadherin 1
Synonyms: Fath, mFat1, 2310038E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Foxo1
Name: forkhead box O1
Synonyms: Fkhr1, Afxh, FKHR, Foxo1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56458
HGNC: HGNC:3819
Homologene: 1527
Grm6
Name: glutamate receptor, metabotropic 6
Synonyms: mGluR6, nerg1, nob3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108072
HGNC: HGNC:4598
Homologene: 20232
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546071
Homologene: 66191
Abca8b
Name: ATP-binding cassette, sub-family A (ABC1), member 8b
Synonyms: Abca8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Olfr53
Name: olfactory receptor 53
Synonyms: GA_x6K02T2PBJ9-42798103-42799038, MOR253-5, IE12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258962
Homologene: 133678
Tspan9
Name: tetraspanin 9
Synonyms: 6720474K14Rik, 9430079M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109246
Homologene: 4860
Olfr342
Name: olfactory receptor 342
Synonyms: MOR136-4, GA_x6K02T2NLDC-33222024-33222962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258950
Homologene: 74223
Sh3pxd2b
Name: SH3 and PX domains 2B
Synonyms: G431001E03Rik, Tsk4, Fad49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268396
Homologene: 27952
Cfh
Name: complement component factor h
Synonyms: Sas1, Mud-1, Sas-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Ttbk2
Name: tau tubulin kinase 2
Synonyms: TTK, 2610507N02Rik, B930008N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140810
Homologene: 62795
Igfbp1
Name: insulin-like growth factor binding protein 1
Synonyms: IGFBP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16006
HGNC: HGNC:5469
Homologene: 498
Ssrp1
Name: structure specific recognition protein 1
Synonyms: Hmgi-rs3, T160, Hmg1-rs1, Hmgox
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20833
Homologene: 110735
Tas2r144
Name: taste receptor, type 2, member 144
Synonyms: Tas2r44, mt2r33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387515
Homologene: 47977
Otop2
Name: otopetrin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237987
Homologene: 27803
Slc23a3
Name: solute carrier family 23 (nucleobase transporters), member 3
Synonyms: Yspl1, SVCT3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22626
Homologene: 65865
Cd44
Name: CD44 antigen
Synonyms: Ly-24, Pgp-1, HERMES
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12505
HGNC: HGNC:1681
Homologene: 508
Ifih1
Name: interferon induced with helicase C domain 1
Synonyms: 9130009C22Rik, Helicard, MDA-5, MDA5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71586
Homologene: 32535
Olfr832
Name: olfactory receptor 832
Synonyms: GA_x6K02T2PVTD-12687800-12688738, MOR153-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258075
HGNC: HGNC:8467
Homologene: 128143
Creb3l2
Name: cAMP responsive element binding protein 3-like 2
Synonyms: BBF2H7, C530025K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 208647
Homologene: 18690
Tas2r109
Name: taste receptor, type 2, member 109
Synonyms: mt2r62, T2R09, Tas2r9, mGR09
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387343
Homologene: 87292
Mrps24
Name: mitochondrial ribosomal protein S24
Synonyms: 3110030K20Rik, Rpms24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 64660
Homologene: 57043
Pcdhb20
Name: protocadherin beta 20
Synonyms: Pcdhb14, PcdhbT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93891
HGNC: HGNC:8685
Homologene: 134303
Gtpbp2
Name: GTP binding protein 2
Synonyms: nmf205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56055
HGNC: HGNC:4670
Homologene: 10420
Rnf146
Name: ring finger protein 146
Synonyms: 2610509H23Rik, Iduna
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68031
Homologene: 12227
1700019A02Rik
Name: RIKEN cDNA 1700019A02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69397
Serpinb9g
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9g
Synonyms: ovalbumin, 1600002F03Rik, NK21B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 93806
HGNC: HGNC:8955
Homologene: 69093
Hypk
Name: huntingtin interacting protein K
Synonyms: 2310003F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67693
Homologene: 9498
Trbv20
Name: T cell receptor beta, variable 20
Synonyms: Tcrb-V15, Gm16911
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100124685
Fam162a
Name: family with sequence similarity 162, member A
Synonyms: 2310056P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70186
VEGA: 16
Homologene: 8656
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 53,158,769 bp
  • T to G, chromosome 1 at 75,133,320 bp
  • T to A, chromosome 1 at 132,525,896 bp
  • T to C, chromosome 1 at 140,119,926 bp
  • A to G, chromosome 2 at 36,527,414 bp
  • T to C, chromosome 2 at 62,598,799 bp
  • T to G, chromosome 2 at 85,041,634 bp
  • T to C, chromosome 2 at 102,901,342 bp
  • T to C, chromosome 2 at 120,725,743 bp
  • T to A, chromosome 2 at 120,748,984 bp
  • A to G, chromosome 2 at 121,453,679 bp
  • A to G, chromosome 3 at 52,345,162 bp
  • A to G, chromosome 4 at 34,810,863 bp
  • T to C, chromosome 6 at 37,334,549 bp
  • T to G, chromosome 6 at 41,188,261 bp
  • T to C, chromosome 6 at 42,215,629 bp
  • T to C, chromosome 6 at 128,034,172 bp
  • A to T, chromosome 6 at 132,980,185 bp
  • T to A, chromosome 7 at 30,946,986 bp
  • T to A, chromosome 7 at 112,876,062 bp
  • A to G, chromosome 7 at 131,074,202 bp
  • T to C, chromosome 7 at 140,652,120 bp
  • A to T, chromosome 8 at 45,025,481 bp
  • A to G, chromosome 8 at 70,781,194 bp
  • T to C, chromosome 9 at 18,945,050 bp
  • T to C, chromosome 10 at 29,347,367 bp
  • G to A, chromosome 11 at 5,704,676 bp
  • C to A, chromosome 11 at 7,198,091 bp
  • G to T, chromosome 11 at 32,422,263 bp
  • A to G, chromosome 11 at 50,853,224 bp
  • A to T, chromosome 11 at 109,957,201 bp
  • G to A, chromosome 11 at 115,329,375 bp
  • G to A, chromosome 13 at 33,495,106 bp
  • C to T, chromosome 16 at 36,044,081 bp
  • A to G, chromosome 17 at 3,428,980 bp
  • C to T, chromosome 17 at 45,410,890 bp
  • G to A, chromosome 17 at 46,167,327 bp
  • A to G, chromosome 18 at 36,748,890 bp
  • A to G, chromosome 18 at 37,506,164 bp
  • T to C, chromosome 19 at 5,742,320 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4060 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041618-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.