Strain Name:
C57BL/6J-MtgxR4073Btlr/Mmmh
Stock Number:
041621-MU
Citation ID:
RRID:MMRRC_041621-MU
Other Names:
R4073 (G1), C57BL/6J-MtgxR4073Btlr
Major Collection:

Gene Information

Gpd2
Name: glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms: Gdm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14571
HGNC: HGNC:4456
Homologene: 352
Calb1
Name: calbindin 1
Synonyms: Calb, Calb-1, calbindin-D (28k), CB, Brain-2, CalbindinD28K, calbindin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12307
HGNC: HGNC:1434
Homologene: 21026
Egf
Name: epidermal growth factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13645
HGNC: HGNC:3229
Homologene: 1483
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Clasp1
Name: CLIP associating protein 1
Synonyms: 5730583A19Rik, 1700030C23Rik, mCLASP1, CLASP1alpha, CLASP1, B130045P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76707
Homologene: 41024
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9430095K15Rik, 9130004I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, flat, mechanistic target of rapamycin (serine/threonine kinase), Frap1, 2610315D21Rik, RAPT1, RAFT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Erbin
Name: Erbb2 interacting protein
Synonyms: Erbb2ip, Erbin, 1700028E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 59079
Homologene: 41282
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: CIF150, TAF2B, 150kDa, TAFII150, 4732460C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Nf2
Name: neurofibromin 2
Synonyms: moesin-ezrin-radixin-like protein, schwannomin, merlin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18016
HGNC: HGNC:7773
Homologene: 2180
Dock7
Name: dedicator of cytokinesis 7
Synonyms: LOC242555, m, 3110056M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Jph4
Name: junctophilin 4
Synonyms: JP-4, 9330157P13Rik, JPHL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 319984
Homologene: 13034
Cytl1
Name: cytokine-like 1
Synonyms: 4930443F05Rik, C17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231162
Homologene: 10254
Tab3
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 3
Synonyms: Map3k7ip3, 4921526G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 66724
Homologene: 17673
Rrbp1
Name: ribosome binding protein 1
Synonyms: mRRp5.4, 5730465C04Rik, mRRp47, mRRp41, mRRp15a, mRRp15b, mRRp16.8, mRRp10, mRRp0, mRRp2, mRRp1.8, p180, ES/130, 1700087N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 81910
Homologene: 68138
Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Synonyms: Vr1, OTRPC1, VR-1, capsaicin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 193034
Homologene: 12920
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh4, Zfh-4, C130041O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, avc4, b2b1279Clo, b2b1727Clo, b2b1203Clo, Dnahc11, b2b1289Clo, b2b598Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Spink12
Name: serine peptidase inhibitor, Kazal type 12
Synonyms: 9230117E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 78242
Homologene: 87071
Sbk3
Name: SH3 domain binding kinase family, member 3
Synonyms: Gm1078, LOC381835
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381835
Homologene: 82595
Srp72
Name: signal recognition particle 72
Synonyms: 5730576P14Rik, 72kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66661
Homologene: 38254
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209590
Homologene: 16930
Phactr1
Name: phosphatase and actin regulator 1
Synonyms: 9630030F18Rik, Rpel1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218194
Homologene: 33597
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: D330001F17Rik, Heatr7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223658
Homologene: 44882
Olfr729
Name: olfactory receptor 729
Synonyms: GA_x6K02T2PMLR-5839874-5838903, MOR246-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258275
Homologene: 17167
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: equatorin, 4930579C15Rik, Afaf, 1700028B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Obox3
Name: oocyte specific homeobox 3
Synonyms: Ohx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246791
Homologene: 44937
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Tyro7, Ark, Ufo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213234
Homologene: 11661
Ehhadh
Name: enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
Synonyms: L-PBE, MFP1, 1300002P22Rik, MFP, L-bifunctional enzyme, HD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74147
HGNC: HGNC:3247
Homologene: 1486
Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Synonyms: Xpf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 50505
HGNC: HGNC:3436
Homologene: 3836
Slc24a3
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms: NCKX3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94249
Homologene: 41390
Alox12
Name: arachidonate 12-lipoxygenase
Synonyms: Alox12p, P-12LO, 9930022G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11684
HGNC: HGNC:429
Homologene: 560
Slc28a3
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Synonyms: Cnt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 114304
Homologene: 32533
Lamp3
Name: lysosomal-associated membrane protein 3
Synonyms: 1200002D17Rik, Cd208, DC-LAMP, TSC403
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239739
VEGA: 16
Homologene: 8670
Vmn1r25
Name: vomeronasal 1 receptor 25
Synonyms: V1rc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113865
Homologene: 137652
Pbx3
Name: pre B cell leukemia homeobox 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18516
HGNC: HGNC:8634
Homologene: 21243
Pde11a
Name: phosphodiesterase 11A
Synonyms: 6330414F14Rik, A630086N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Pidd1
Name: p53 induced death domain protein 1
Synonyms: Lrdd, Pidd, 1200011D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57913
Homologene: 11220
Cbs
Name: cystathionine beta-synthase
Synonyms: HIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12411
Homologene: 37258
Tas2r131
Name: taste receptor, type 2, member 131
Synonyms: mt2r61, T2R31, Tas2r31, mGR31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387356
Homologene: 52298
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp4c, Rnh2, Nalp-alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83564
Homologene: 75315
Lrrc71
Name: leucine rich repeat containing 71
Synonyms: 4933430H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74485
Homologene: 83646
Ttc4
Name: tetratricopeptide repeat domain 4
Synonyms: L62, 2810002P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72354
Homologene: 31249
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: Pghs1, cyclooxygenase 1, COX1, Cox-1, Cox-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
Olfr328
Name: olfactory receptor 328
Synonyms: MOR275-2, GA_x6K02T2NKPP-873285-874217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258495
Homologene: 133015
Usp21
Name: ubiquitin specific peptidase 21
Synonyms: Usp16, W53272, ESTM28, Usp23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 30941
Homologene: 56572
Tmprss11e
Name: transmembrane protease, serine 11e
Synonyms: DESC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243084
Homologene: 8543
Olfr1469
Name: olfactory receptor 1469
Synonyms: MOR202-11, GA_x6K02T2RE5P-3743369-3744289
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258690
HGNC: HGNC:8324
Homologene: 133675
Zfp128
Name: zinc finger protein 128
Synonyms: mZnf8, 9630016P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243833
Homologene: 10889
Las1l
Name: LAS1-like (S. cerevisiae)
Synonyms: 5830482G23Rik, 1810030A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 76130
Homologene: 32746
Olfr303
Name: olfactory receptor 303
Synonyms: GA_x6K02T2NHDJ-9712819-9713778, MOR104-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258612
Homologene: 105157
Slc35a3
Name: solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
Synonyms: 2310050P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229782
Homologene: 40826
Olfr885
Name: olfactory receptor 885
Synonyms: MOR162-12, GA_x6K02T2PVTD-31740639-31741568
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257885
Homologene: 79400
Ccdc103
Name: coiled-coil domain containing 103
Synonyms: 1700039D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73293
Homologene: 45831
Olfr1274
Name: olfactory receptor 1274
Synonyms: MOR228-5, GA_x6K02T2Q125-51676372-51677301, MOR228-4, Olfr1274-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258330
Homologene: 133650
Ighv1-29
Name: immunoglobulin heavy variable V1-29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 780887
Gm28379
Name: predicted gene 28379
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Gm15063
Name: predicted gene 15063
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Mark1-ps3
Name: MAP/microtubule affinity-regulating kinase 1, pseudogene 3
Synonyms: Gm19518
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Gm26702
Name: predicted gene, 26702
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Rpp25
Name: ribonuclease P/MRP 25 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102614
VEGA: 9
Homologene: 23048
Ppp1r18os
Name: protein phosphatase 1, regulatory subunit 18, opposite strand
Synonyms: 5530401N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 118,503,848 bp
  • T to C, chromosome 1 at 171,282,172 bp
  • G to A, chromosome 2 at 25,579,028 bp
  • T to C, chromosome 2 at 34,224,412 bp
  • C to T, chromosome 2 at 36,237,776 bp
  • A to G, chromosome 2 at 57,290,013 bp
  • C to T, chromosome 2 at 76,337,898 bp
  • T to C, chromosome 2 at 90,400,993 bp
  • T to G, chromosome 2 at 143,963,110 bp
  • T to A, chromosome 2 at 145,613,716 bp
  • G to T, chromosome 3 at 5,399,324 bp
  • C to T, chromosome 3 at 75,105,671 bp
  • G to A, chromosome 3 at 87,745,262 bp
  • T to C, chromosome 3 at 116,675,238 bp
  • C to T, chromosome 3 at 129,735,969 bp
  • A to G, chromosome 4 at 15,895,497 bp
  • A to G, chromosome 4 at 94,919,962 bp
  • A to T, chromosome 4 at 99,008,059 bp
  • T to C, chromosome 4 at 106,670,485 bp
  • T to A, chromosome 4 at 148,549,375 bp
  • A to G, chromosome 5 at 37,735,596 bp
  • C to A, chromosome 5 at 76,998,251 bp
  • T to C, chromosome 5 at 86,715,643 bp
  • A to G, chromosome 6 at 57,978,587 bp
  • A to G, chromosome 6 at 67,486,122 bp
  • A to T, chromosome 6 at 132,957,839 bp
  • G to T, chromosome 7 at 4,970,502 bp
  • A to G, chromosome 7 at 6,072,710 bp
  • A to G, chromosome 7 at 12,891,221 bp
  • G to T, chromosome 7 at 15,625,799 bp
  • A to G, chromosome 7 at 25,763,911 bp
  • T to A, chromosome 7 at 86,394,947 bp
  • A to G, chromosome 7 at 141,440,826 bp
  • T to C, chromosome 9 at 38,061,869 bp
  • T to C, chromosome 9 at 57,504,309 bp
  • A to G, chromosome 9 at 66,418,492 bp
  • A to G, chromosome 9 at 114,622,947 bp
  • C to T, chromosome 10 at 126,013,408 bp
  • T to C, chromosome 11 at 4,848,958 bp
  • T to C, chromosome 11 at 58,552,062 bp
  • T to C, chromosome 11 at 70,247,310 bp
  • T to C, chromosome 11 at 73,250,780 bp
  • C to T, chromosome 11 at 102,884,099 bp
  • C to T, chromosome 12 at 114,817,401 bp
  • A to G, chromosome 12 at 118,045,678 bp
  • ACTT to A, chromosome 13 at 43,059,769 bp
  • T to A, chromosome 13 at 55,247,728 bp
  • T to C, chromosome 13 at 58,559,290 bp
  • T to C, chromosome 13 at 103,860,111 bp
  • A to G, chromosome 14 at 50,148,043 bp
  • T to C, chromosome 14 at 55,115,040 bp
  • A to G, chromosome 15 at 55,052,237 bp
  • A to G, chromosome 15 at 76,407,985 bp
  • G to A, chromosome 16 at 13,130,685 bp
  • A to G, chromosome 16 at 19,700,716 bp
  • T to C, chromosome 16 at 21,766,507 bp
  • C to T, chromosome 17 at 31,633,005 bp
  • T to A, chromosome 17 at 35,861,532 bp
  • C to T, chromosome 17 at 53,724,466 bp
  • A to G, chromosome 18 at 44,104,664 bp
  • G to A, chromosome 19 at 13,410,935 bp
  • T to C, chromosome X at 75,575,052 bp
  • G to T, chromosome X at 85,614,457 bp
  • T to C, chromosome X at 95,950,381 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4073 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041621-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.