Strain Name:
C57BL/6J-MtgxR4086Btlr/Mmmh
Stock Number:
041625-MU
Citation ID:
RRID:MMRRC_041625-MU
Other Names:
R4086 (G1), C57BL/6J-MtgxR4086Btlr
Major Collection:

Gene Information

Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
Synonyms: DARPP-32, Darpp32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19049
HGNC: HGNC:9287
Homologene: 12972
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68732
Homologene: 9757
Xpo4
Name: exportin 4
Synonyms: B430309A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57258
Homologene: 10733
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: 5330419I02Rik, D530019K20Rik, G1-403-16, Wdr9, repro5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 93871
Homologene: 23130
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: D730028O18Rik, ARFGEP1, P200, BIG1, D130059B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211673
Homologene: 4687
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, GC-GAP, PX-RICS, 3426406O18Rik, Grit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330914
Homologene: 8812
Ets2
Name: E26 avian leukemia oncogene 2, 3' domain
Synonyms: Ets-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 23872
HGNC: HGNC:3489
Homologene: 3838
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Adrm1
Name: adhesion regulating molecule 1
Synonyms: ARM-1, 2510006J17Rik, Gp110, 1110063P18Rik, Rpn13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56436
Homologene: 10513
Ipo9
Name: importin 9
Synonyms: 0710008K06Rik, Imp9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226432
Homologene: 5874
Zbtb21
Name: zinc finger and BTB domain containing 21
Synonyms: Znf295, 5430437K12Rik, B430213I24Rik, Zfp295
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 114565
VEGA: 16
Homologene: 10799
Mafa
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
Synonyms: RIPE3b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 378435
VEGA: 15
Homologene: 65867
Prkcq
Name: protein kinase C, theta
Synonyms: PKC-0, Pkcq, A130035A12Rik, PKC-theta, PKC theta, PKCtheta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18761
HGNC: HGNC:9410
Homologene: 21263
Zfp281
Name: zinc finger protein 281
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226442
Homologene: 8270
Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Synonyms: 4430401P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20662
VEGA: 17
Homologene: 4117
Nxph4
Name: neurexophilin 4
Synonyms: 1110036M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 104080
HGNC: HGNC:8078
Homologene: 11020
Calcoco1
Name: calcium binding and coiled coil domain 1
Synonyms: 1810009B06Rik, CoCoA, Gcap11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67488
Homologene: 10845
Septin10
Name: septin 10
Synonyms: 9430099J10Rik, 4921515A04Rik, Sept10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103080
VEGA: 10
Homologene: 27035
Ppp1r21
Name: protein phosphatase 1, regulatory subunit 21
Synonyms: 1110018J12Rik, Ccdc128, Klraq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73825
Homologene: 44811
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Plekhe1, Phlpp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98432
Homologene: 11015
Rnf44
Name: ring finger protein 44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105239
Homologene: 8934
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Arhgef28
Name: Rho guanine nucleotide exchange factor (GEF) 28
Synonyms: RIP2, RhoGEF, Rho specific exchange factor, D13Bwg1089e, 9230110L08Rik, p190RhoGEF, Rgnef
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71355
Homologene: 65061
Ftsj3
Name: FtsJ RNA methyltransferase homolog 3 (E. coli)
Synonyms: D11Ertd400e, C79843, Epcs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56095
Homologene: 5451
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213262
Homologene: 10584
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, D430038H04Rik, 9430076A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Acss3
Name: acyl-CoA synthetase short-chain family member 3
Synonyms: LOC380660, 8430416H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380660
Homologene: 11587
Trim14
Name: tripartite motif-containing 14
Synonyms: 5830400N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74735
Homologene: 13241
Ube2u
Name: ubiquitin-conjugating enzyme E2U (putative)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381534
Homologene: 17594
Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: D030049F17Rik, Nedl2, A730039N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329152
Homologene: 66192
Thap12
Name: THAP domain containing 12
Synonyms: 2900052B10Rik, Dap4, Prkrir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72981
HGNC: HGNC:9440
Homologene: 37952
Trim65
Name: tripartite motif-containing 65
Synonyms: 4732463G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 338364
Homologene: 27844
Traf3ip3
Name: TRAF3 interacting protein 3
Synonyms: 6030423D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215243
Homologene: 11885
Fbxo41
Name: F-box protein 41
Synonyms: D6Ertd538e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330369
Homologene: 19837
Slc14a2
Name: solute carrier family 14 (urea transporter), member 2
Synonyms: UT-A3, UT-A5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 27411
VEGA: 18
Homologene: 5183
Sypl2
Name: synaptophysin-like 2
Synonyms: Mg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17306
Homologene: 7421
Wbp2nl
Name: WBP2 N-terminal like
Synonyms: 4930521I23Rik, PAWP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74716
VEGA: 15
Homologene: 17633
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
Olfr814
Name: olfactory receptor 814
Synonyms: GA_x6K02T2PULF-11553313-11552381, MOR113-5, MOR113-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 259165
Homologene: 133585
Gm15446
Name: predicted gene 15446
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100642166
Olah
Name: oleoyl-ACP hydrolase
Synonyms: E230009B14Rik, Thedc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99035
Homologene: 10136
Gm9934
Name: predicted gene 9934
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: mdr-3, Mdr1a, P-gp, P-glycoprotein, Pgy-3, Pgy3, multiple drug resistant 1a, MDR3, Pgp, Evi32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Zbtb22
Name: zinc finger and BTB domain containing 22
Synonyms: Bing1, 1110008J20Rik, Zfp297
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81630
Homologene: 3982
Trim30d
Name: tripartite motif-containing 30D
Synonyms: TRIM30-3, Trim79
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209387
Homologene: 114426
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22770
Homologene: 5225
Olfr987
Name: olfactory receptor 987
Synonyms: GA_x6K02T2Q125-46808500-46807571, MOR203-7P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257951
Homologene: 103791
Krtap31-1
Name: keratin associated protein 31-1
Synonyms: 4733401H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70831
Homologene: 134336
Gkn3
Name: gastrokine 3
Synonyms: 1190003M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68888
Homologene: 87422
Cldn34c4
Name: claudin 34C4
Synonyms: 4930412D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 73934
Homologene: 132184
Nlrp5-ps
Name: NLR family, pyrin domain containing 5, pseudogene
Synonyms: Gm18756
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100417675
BC046251
Name: cDNA sequence BC046251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 407810
Pgls
Name: 6-phosphogluconolactonase
Synonyms: 1110030K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66171
HGNC: HGNC:8903
Homologene: 6037
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,163,759 bp
  • T to C, chromosome 1 at 53,831,656 bp
  • A to G, chromosome 1 at 106,347,161 bp
  • A to G, chromosome 1 at 135,388,690 bp
  • T to A, chromosome 1 at 136,626,121 bp
  • A to G, chromosome 1 at 193,181,320 bp
  • G to A, chromosome 2 at 3,340,451 bp
  • A to G, chromosome 2 at 11,283,868 bp
  • C to A, chromosome 2 at 85,331,826 bp
  • A to G, chromosome 2 at 180,172,834 bp
  • G to T, chromosome 3 at 76,648,286 bp
  • A to G, chromosome 3 at 108,217,676 bp
  • G to A, chromosome 3 at 145,461,437 bp
  • T to A, chromosome 4 at 46,523,709 bp
  • T to A, chromosome 4 at 100,549,842 bp
  • C to T, chromosome 5 at 8,726,941 bp
  • A to G, chromosome 5 at 109,943,255 bp
  • C to T, chromosome 6 at 85,478,546 bp
  • C to T, chromosome 6 at 87,383,525 bp
  • G to A, chromosome 7 at 14,563,294 bp
  • A to G, chromosome 7 at 65,582,148 bp
  • T to C, chromosome 7 at 93,080,580 bp
  • A to G, chromosome 7 at 98,716,494 bp
  • T to C, chromosome 7 at 104,487,800 bp
  • T to A, chromosome 8 at 15,992,738 bp
  • G to A, chromosome 8 at 71,596,090 bp
  • A to G, chromosome 8 at 88,315,786 bp
  • G to A, chromosome 9 at 15,998,271 bp
  • A to C, chromosome 9 at 32,247,066 bp
  • A to T, chromosome 10 at 59,192,223 bp
  • T to G, chromosome 10 at 107,053,452 bp
  • T to C, chromosome 10 at 127,526,686 bp
  • A to G, chromosome 10 at 129,874,298 bp
  • C to T, chromosome 11 at 72,875,053 bp
  • T to C, chromosome 11 at 98,350,904 bp
  • C to T, chromosome 11 at 99,908,319 bp
  • T to C, chromosome 11 at 106,249,569 bp
  • G to A, chromosome 11 at 116,126,479 bp
  • G to T, chromosome 13 at 24,024,461 bp
  • T to C, chromosome 13 at 54,682,335 bp
  • T to C, chromosome 13 at 97,967,204 bp
  • C to T, chromosome 14 at 57,643,033 bp
  • T to C, chromosome 15 at 58,052,921 bp
  • T to G, chromosome 15 at 75,747,137 bp
  • A to G, chromosome 15 at 82,308,561 bp
  • C to G, chromosome 15 at 102,710,399 bp
  • C to A, chromosome 16 at 95,709,789 bp
  • T to C, chromosome 16 at 96,046,372 bp
  • A to T, chromosome 16 at 97,952,763 bp
  • T to A, chromosome 17 at 33,918,168 bp
  • A to G, chromosome 17 at 80,449,352 bp
  • A to G, chromosome 17 at 88,565,657 bp
  • A to T, chromosome 18 at 78,205,783 bp
  • A to T, chromosome X at 127,721,388 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4086 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041625-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.