Strain Name:
C57BL/6J-MtgxR4233Btlr/Mmmh
Stock Number:
041642-MU
Citation ID:
RRID:MMRRC_041642-MU
Other Names:
R4233 (G1), C57BL/6J-MtgxR4233Btlr
Major Collection:

Strain Information

Casp8
Name: caspase 8
Synonyms: Mch5, MACH, FLICE, Caspase-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Ifi203
Name: interferon activated gene 203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15950
Homologene: 115929
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Plxnd1
Name: plexin D1
Synonyms: 6230425C21Rik, b2b553Clo, b2b1863Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67784
HGNC: HGNC:9107
Homologene: 22866
Arhgef18
Name: rho/rac guanine nucleotide exchange factor (GEF) 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102098
Homologene: 32254
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: 5530401C11Rik, ARHGAP10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71435
Homologene: 10822
Atg14
Name: autophagy related 14
Synonyms: D14Ertd114e, D14Ertd436e, Barkor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100504663
VEGA: 14
Homologene: 45423
Gpa33
Name: glycoprotein A33 (transmembrane)
Synonyms: A33 antigen, 2210401D16Rik, 2010310L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59290
HGNC: HGNC:4445
Homologene: 4245
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11736
Homologene: 9491
Ccar2
Name: cell cycle activator and apoptosis regulator 2
Synonyms: 2610301G19Rik, Dbc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219158
VEGA: 14
Homologene: 10910
Spc24
Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms: 2410030K01Rik, Spbc24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67629
VEGA: 9
Homologene: 12166
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Tulip1, 2310003F20Rik, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Scube1
Name: signal peptide, CUB domain, EGF-like 1
Synonyms: A630023E24Rik, 7330410C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64706
Homologene: 11224
Fbxo32
Name: F-box protein 32
Synonyms: 4833442G10Rik, ATROGIN1, MAFbx, atrogin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67731
VEGA: 15
Homologene: 12182
Aph1c
Name: aph1 homolog C, gamma secretase subunit
Synonyms: 0610008A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68318
Homologene: 134745
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, Dnchc2, b2b414Clo, m407Asp, m152Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Gzf1
Name: GDNF-inducible zinc finger protein 1
Synonyms: 8430437G08Rik, Zfp336
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74533
Homologene: 11200
Zfp599
Name: zinc finger protein 599
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235048
Homologene: 138456
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
1700123K08Rik
Name: RIKEN cDNA 1700123K08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76658
Homologene: 86127
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1289Clo, b2b1727Clo, b2b1279Clo, b2b1203Clo, Dnahc11, avc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Gpn2
Name: GPN-loop GTPase 2
Synonyms: Atpbd1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100210
Homologene: 7006
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: LOC381229, Ccdc147
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381229
VEGA: 19
Homologene: 77312
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: IMP150, SPACR, A930015H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Abca15
Name: ATP-binding cassette, sub-family A (ABC1), member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320631
Homologene: 87255
Sclt1
Name: sodium channel and clathrin linker 1
Synonyms: 4931421F20Rik, 2610207F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67161
Homologene: 27031
Fhip2b
Name: FHF complex subunit HOOK interacting protein 2B
Synonyms: G430067P06Rik, Rai16, Fam160b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239170
VEGA: 14
Homologene: 23379
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: NY-CO-33, D18Bwg1409e, 5730407I04Rik, Mtsh1, Sdccag33, teashirt1, Tsh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 110796
Homologene: 4227
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Ldlrap1
Name: low density lipoprotein receptor adaptor protein 1
Synonyms: Arh1, Arh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100017
Homologene: 9219
Ercc6l2
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2
Synonyms: 1700019D06Rik, 9330134C04Rik, 0610007P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76251
Homologene: 32564
Slc7a13
Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
Synonyms: XAT2, AGT1, AGT-1, 0610009O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74087
Homologene: 23656
Arhgef40
Name: Rho guanine nucleotide exchange factor (GEF) 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268739
Homologene: 19560
Or52n4
Name: olfactory receptor family 52 subfamily N member 4
Synonyms: GA_x6K02T2PBJ9-7273558-7272587, MOR34-5, Olfr658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259051
Homologene: 105161
Tas2r140
Name: taste receptor, type 2, member 140
Synonyms: TRB3, TRB5, mTRB3, Tas2r40, T2R40, mt2r64, Tas2r13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387616
Homologene: 87013
Tmem38b
Name: transmembrane protein 38B
Synonyms: 1600017F22Rik, D4Ertd89e, TRIC-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 52076
Homologene: 10010
Coro2b
Name: coronin, actin binding protein, 2B
Synonyms: E130012P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235431
HGNC: HGNC:2256
Homologene: 21228
Stard13
Name: StAR-related lipid transfer (START) domain containing 13
Synonyms: GT650, DLC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243362
Homologene: 64844
Skint11
Name: selection and upkeep of intraepithelial T cells 11
Synonyms: A630098G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230623
Homologene: 136292
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: D930028F11Rik, Fam55d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244853
VEGA: 9
Homologene: 83471
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 4921504D23Rik, 2900079B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70839
Homologene: 11260
Sult2a8
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
Synonyms: 2810007J24Rik, mL-STL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76971
Or7g30
Name: olfactory receptor family 7 subfamily G member 30
Synonyms: GA_x6K02T2PVTD-13176842-13177780, MOR151-1, Olfr849
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258520
HGNC: HGNC:8466
Homologene: 74179
Ajuba
Name: ajuba LIM protein
Synonyms: Jub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16475
VEGA: 14
Homologene: 7789
Gm26678
Name: predicted gene, 26678
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Gm5108
Name: predicted gene 5108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330097
Gm12034
Name: predicted gene 12034
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100502908
Slc13a2os
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2, opposite strand
Synonyms: Gm11194
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 790911
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,844,770 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • A to T, chromosome 1 at 97,864,394 bp
  • A to T, chromosome 1 at 166,146,771 bp
  • A to T, chromosome 1 at 173,936,533 bp
  • A to G, chromosome 2 at 20,887,137 bp
  • T to C, chromosome 2 at 91,178,236 bp
  • C to T, chromosome 2 at 148,686,533 bp
  • T to A, chromosome 3 at 41,671,430 bp
  • T to C, chromosome 3 at 54,633,083 bp
  • T to G, chromosome 3 at 59,257,223 bp
  • T to C, chromosome 4 at 19,819,070 bp
  • T to C, chromosome 4 at 53,840,710 bp
  • C to A, chromosome 4 at 114,244,659 bp
  • T to A, chromosome 4 at 133,584,705 bp
  • T to A, chromosome 4 at 134,757,338 bp
  • C to A, chromosome 5 at 67,975,153 bp
  • A to T, chromosome 5 at 96,714,376 bp
  • A to T, chromosome 5 at 138,564,192 bp
  • A to G, chromosome 5 at 151,062,699 bp
  • T to C, chromosome 6 at 115,965,953 bp
  • A to T, chromosome 6 at 133,054,952 bp
  • T to A, chromosome 7 at 14,413,683 bp
  • A to G, chromosome 7 at 104,644,988 bp
  • C to T, chromosome 7 at 120,402,979 bp
  • T to C, chromosome 8 at 3,450,317 bp
  • T to C, chromosome 9 at 7,134,360 bp
  • T to A, chromosome 9 at 19,441,590 bp
  • T to C, chromosome 9 at 21,756,202 bp
  • T to A, chromosome 9 at 22,249,745 bp
  • A to T, chromosome 9 at 48,398,837 bp
  • T to C, chromosome 9 at 62,426,185 bp
  • A to G, chromosome 9 at 66,833,321 bp
  • A to G, chromosome 9 at 80,345,329 bp
  • A to G, chromosome 11 at 20,446,785 bp
  • G to A, chromosome 11 at 72,714,484 bp
  • A to G, chromosome 11 at 78,403,535 bp
  • T to A, chromosome 12 at 53,139,671 bp
  • C to T, chromosome 12 at 55,640,644 bp
  • T to C, chromosome 12 at 117,916,791 bp
  • T to C, chromosome 13 at 11,750,725 bp
  • T to C, chromosome 13 at 63,872,168 bp
  • T to C, chromosome 14 at 47,551,345 bp
  • T to C, chromosome 14 at 51,990,171 bp
  • T to C, chromosome 14 at 54,569,526 bp
  • T to C, chromosome 14 at 70,151,091 bp
  • A to C, chromosome 14 at 70,586,878 bp
  • G to T, chromosome 15 at 58,192,333 bp
  • C to T, chromosome 15 at 83,620,069 bp
  • C to T, chromosome 16 at 15,835,919 bp
  • C to A, chromosome 18 at 84,016,195 bp
  • G to A, chromosome 19 at 47,975,555 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4233 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041642-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.