Strain Name:
C57BL/6J-MtgxR4280Btlr/Mmmh
Stock Number:
041648-MU
Citation ID:
RRID:MMRRC_041648-MU
Other Names:
R4280 (G1), C57BL/6J-MtgxR4280Btlr
Major Collection:

Gene Information

Dgat2
Name: diacylglycerol O-acyltransferase 2
Synonyms: 0610010B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67800
Homologene: 23580
Mov10
Name: Mov10 RISC complex RNA helicase
Synonyms: Mov-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 17454
HGNC: HGNC:7200
Homologene: 10365
Rbm47
Name: RNA binding motif protein 47
Synonyms: 9530077J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 245945
Homologene: 36932
Plxnd1
Name: plexin D1
Synonyms: 6230425C21Rik, b2b553Clo, b2b1863Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67784
HGNC: HGNC:9107
Homologene: 22866
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Mhdadsk9, Dsk9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: SCAN1, E430034L06Rik, 4921509N21Rik, 2810481F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 104884
Homologene: 5424
Atp2c1
Name: ATPase, Ca++-sequestering
Synonyms: ATP2C1A, 1700121J11Rik, SPCA, PMR1, D930003G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235574
Homologene: 56672
Arl6ip1
Name: ADP-ribosylation factor-like 6 interacting protein 1
Synonyms: ARMER, AIP-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 54208
HGNC: HGNC:697
Homologene: 41008
Supt5
Name: suppressor of Ty 5, DSIF elongation factor subunit
Synonyms: Supt5h, Spt5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20924
Homologene: 2384
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: Grit, 3426406O18Rik, PX-RICS, GC-GAP, p200RhoGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 330914
Homologene: 8812
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: D15Ertd586e, trichorhinophalangeal syndrome I (human)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 83925
Homologene: 8556
Slc38a10
Name: solute carrier family 38, member 10
Synonyms: 1810073N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 72055
Homologene: 41556
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C030046E11Rik, C130057E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226089
Homologene: 13806
Rrp36
Name: ribosomal RNA processing 36 homolog (S. cerevisiae)
Synonyms: BC011248
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224823
VEGA: 17
Homologene: 40346
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Tsbp, Tsp, Sh2bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22083
Homologene: 40668
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: Fabph1, Fabph-4, Fabph-1, Fabph4, Mdgi, H-FABP, Fabp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Cd274
Name: CD274 antigen
Synonyms: B7-H1, PD-L1, Pdcd1lg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 60533
Homologene: 8560
Tob1
Name: transducer of ErbB-2.1
Synonyms: Tob, Trob
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22057
Homologene: 31334
Cep76
Name: centrosomal protein 76
Synonyms: 6230425F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225659
VEGA: 18
Homologene: 11774
Rec8
Name: REC8 meiotic recombination protein
Synonyms: mrec, Rec8L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 56739
Homologene: 3768
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 212124
Homologene: null
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Ush2a
Name: usherin
Synonyms: Ush2a, Ushrn, MUSH2A, A930037M10Rik, A930011D15Rik, LOC269160, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22283
Homologene: 66151
Hephl1
Name: hephaestin-like 1
Synonyms: LOC244698, cw, thd, Zp, zyklopen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244698
Homologene: 9112
Zfp429
Name: zinc finger protein 429
Synonyms: 2810487A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 72807
HGNC: null
Homologene: 110878
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Psma8
Name: proteasome (prosome, macropain) subunit, alpha type, 8
Synonyms: 2410072D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 73677
VEGA: 18
Homologene: 2086
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242627
HGNC: null
Homologene: 135888
Arvcf
Name: armadillo repeat gene deleted in velocardiofacial syndrome
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11877
HGNC: HGNC:728
Homologene: 31046
Gmip
Name: Gem-interacting protein
Synonyms: 5031419I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 78816
Homologene: 9570
Rrs1
Name: ribosome biogenesis regulator 1
Synonyms: 5730466A07Rik, D1Ertd701e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 59014
Homologene: 41014
Gm13078
Name: predicted gene 13078
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 277666
HGNC: null
Homologene: 133722
Olfr1130
Name: olfactory receptor 1130
Synonyms: MOR264-4, GA_x6K02T2Q125-49112575-49113519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258835
HGNC: null
Homologene: 133705
Epha1
Name: Eph receptor A1
Synonyms: 5730453L17Rik, Esk, Eph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Olfr1431
Name: olfactory receptor 1431
Synonyms: MOR214-5, GA_x6K02T2RE5P-2573738-2574676
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258409
HGNC: null
Homologene: 115495
Ccdc102a
Name: coiled-coil domain containing 102A
Synonyms: LOC234582
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234582
Homologene: 13240
Zfp28
Name: zinc finger protein 28
Synonyms: mkr-5, 2810438M17Rik, Zfp-28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22690
Homologene: 69047
Zbtb24
Name: zinc finger and BTB domain containing 24
Synonyms: ZNF450
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 268294
VEGA: 10
Homologene: 8870
Clec12a
Name: C-type lectin domain family 12, member a
Synonyms: Micl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232413
Homologene: 51378
1700001C19Rik
Name: RIKEN cDNA 1700001C19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 75462
HGNC: null
Homologene: 129540
1700057G04Rik
Name: RIKEN cDNA 1700057G04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 78459
HGNC: null
Homologene: 134508
Cplx2
Name: complexin 2
Synonyms: 921-L, Gm34843
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 12890
HGNC: HGNC:2310
Homologene: 38212
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: 8430438D04Rik, D330034A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 278279
Homologene: 25521
1700021F05Rik
Name: RIKEN cDNA 1700021F05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67851
Homologene: 41137
4930415L06Rik
Name: RIKEN cDNA 4930415L06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 245511
HGNC: null
Homologene: 133109
Scgb2b6
Name: secretoglobin, family 2B, member 6
Synonyms: Gm19607, Abpbg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100503242
HGNC: null
Homologene: 83171
Smim4
Name: small integral membrane protein 4
Synonyms: 2010107H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 66487
Homologene: null
Traj44
Name: T cell receptor alpha joining 44
Synonyms: Gm16926
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 100124344
HGNC: null
Homologene: null
Pnma5
Name: paraneoplastic antigen family 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 385377
Homologene: 14176
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 9,546,139 bp
  • A to G, chromosome 1 at 188,578,461 bp
  • T to A, chromosome 2 at 76,754,824 bp
  • A to G, chromosome 2 at 87,608,251 bp
  • A to C, chromosome 3 at 104,799,779 bp
  • T to A, chromosome 4 at 113,942,552 bp
  • C to T, chromosome 4 at 130,312,452 bp
  • A to G, chromosome 4 at 143,726,022 bp
  • T to C, chromosome 5 at 66,026,177 bp
  • G to T, chromosome 6 at 42,365,052 bp
  • C to A, chromosome 6 at 115,956,094 bp
  • A to T, chromosome 6 at 115,956,095 bp
  • A to G, chromosome 6 at 129,363,929 bp
  • A to T, chromosome 7 at 6,393,701 bp
  • G to A, chromosome 7 at 28,317,073 bp
  • A to G, chromosome 7 at 31,618,942 bp
  • A to G, chromosome 7 at 99,158,997 bp
  • A to G, chromosome 7 at 111,046,723 bp
  • AAAATAAATAAATAAATAAATAAATA to AAAATAAATAAATAAATAAATAAATAAATA, chromosome 7 at 118,121,899 bp
  • A to G, chromosome 7 at 139,615,151 bp
  • T to A, chromosome 8 at 69,813,601 bp
  • C to A, chromosome 8 at 94,907,816 bp
  • A to G, chromosome 9 at 15,112,034 bp
  • T to C, chromosome 9 at 32,259,889 bp
  • T to C, chromosome 9 at 92,343,648 bp
  • C to T, chromosome 9 at 105,413,077 bp
  • T to C, chromosome 10 at 41,464,920 bp
  • A to T, chromosome 10 at 43,532,909 bp
  • A to G, chromosome 10 at 105,348,433 bp
  • T to C, chromosome 11 at 79,546,409 bp
  • T to C, chromosome 11 at 94,214,322 bp
  • T to A, chromosome 11 at 115,990,935 bp
  • C to T, chromosome 11 at 120,137,878 bp
  • T to A, chromosome 12 at 99,891,567 bp
  • A to G, chromosome 13 at 54,379,564 bp
  • A to C, chromosome 13 at 67,390,795 bp
  • T to C, chromosome 14 at 31,107,312 bp
  • T to C, chromosome 14 at 54,173,691 bp
  • A to G, chromosome 14 at 55,618,634 bp
  • G to A, chromosome 15 at 50,846,082 bp
  • G to A, chromosome 16 at 18,397,991 bp
  • C to A, chromosome 16 at 37,082,057 bp
  • G to A, chromosome 17 at 46,672,376 bp
  • T to C, chromosome 17 at 47,413,855 bp
  • T to A, chromosome 18 at 14,721,235 bp
  • T to A, chromosome 18 at 67,640,159 bp
  • A to G, chromosome 19 at 12,209,938 bp
  • A to T, chromosome 19 at 29,380,471 bp
  • A to G, chromosome 19 at 29,586,550 bp
  • T to C, chromosome X at 73,035,430 bp
  • A to T, chromosome X at 89,932,499 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4280 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041648-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.