Strain Name:
C57BL/6J-MtgxR4282Btlr/Mmmh
Stock Number:
041650-MU
Citation ID:
RRID:MMRRC_041650-MU
Other Names:
R4282 (G1), C57BL/6J-MtgxR4282Btlr
Major Collection:

Gene Information

Dnmt3a
Name: DNA methyltransferase 3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13435
HGNC: HGNC:2978
Homologene: 7294
Colgalt2
Name: collagen beta(1-O)galactosyltransferase 2
Synonyms: Glt25d2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269132
Homologene: 22865
Ndrg3
Name: N-myc downstream regulated gene 3
Synonyms: Ndr3, 4833415O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 29812
Homologene: 40903
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20562
Homologene: 2302
Orc1
Name: origin recognition complex, subunit 1
Synonyms: MmORC1, Orc1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
Por
Name: cytochrome p450 oxidoreductase
Synonyms: NADH cytochrome P450 oxydoreductase, CYPOR, CPR, 4933424M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18984
HGNC: HGNC:9208
Homologene: 725
Kcnq2
Name: potassium voltage-gated channel, subfamily Q, member 2
Synonyms: KQT2, Nmf134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16536
HGNC: HGNC:6296
Homologene: 26174
Kansl1
Name: KAT8 regulatory NSL complex subunit 1
Synonyms: 1700081L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76719
Homologene: 9140
Trappc9
Name: trafficking protein particle complex 9
Synonyms: 4632408O18Rik, 2900005P22Rik, Nibp, TRS130, 1810044A24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Smurf1
Name: SMAD specific E3 ubiquitin protein ligase 1
Synonyms: 4930431E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75788
Homologene: 10712
Slc38a10
Name: solute carrier family 38, member 10
Synonyms: 1810073N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72055
Homologene: 41556
Sh3gl1
Name: SH3-domain GRB2-like 1
Synonyms: SH3P8, EEN, endophilin II, Sh3d2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20405
VEGA: 17
Homologene: 55709
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105522
VEGA: 14
Homologene: 35374
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: H-FABP, Fabph-4, Fabph-1, Fabph4, Fabph1, Mdgi, Fabp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Abca17
Name: ATP-binding cassette, sub-family A (ABC1), member 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381072
Homologene: 86807
Zbtb18
Name: zinc finger and BTB domain containing 18
Synonyms: RP58, Zfp238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 30928
Homologene: 21276
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1, steerin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Tarsl2
Name: threonyl-tRNA synthetase-like 2
Synonyms: A530046H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 272396
Homologene: 65036
Rec8
Name: REC8 meiotic recombination protein
Synonyms: mrec, Rec8L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56739
Homologene: 3768
Maml2
Name: mastermind like transcriptional coactivator 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270118
Homologene: 134147
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Bbs7
Name: Bardet-Biedl syndrome 7 (human)
Synonyms: 8430406N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71492
Homologene: 12395
Vmn2r25
Name: vomeronasal 2, receptor 25
Synonyms: EG545874
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545874
Homologene: 135915
Tas2r123
Name: taste receptor, type 2, member 123
Synonyms: T2R23, Tas2r23, STC 9-2, mGR23, mt2r55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353167
Homologene: 45450
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210274
Homologene: 105965
Jsrp1
Name: junctional sarcoplasmic reticulum protein 1
Synonyms: JP-45, 2310032K21Rik, 2300003C06Rik, JP45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71912
Homologene: 12422
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94229
Homologene: 23340
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333315
Homologene: 35388
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234311
Homologene: 23031
Gmip
Name: Gem-interacting protein
Synonyms: 5031419I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78816
Homologene: 9570
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Slco6b1
Name: solute carrier organic anion transporter family, member 6b1
Synonyms: 1700022M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67854
Homologene: 12199
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Great, LGR8, Gpr106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140498
Homologene: 15402
Pcdhb14
Name: protocadherin beta 14
Synonyms: Pcdhb17, PcdhbN, 2210006M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93885
Homologene: 70876
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: Dtgn1, MDC-L, D430033C21Rik, C130072N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Aldh3b2
Name: aldehyde dehydrogenase 3 family, member B2
Synonyms: C130048D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 621603
HGNC: HGNC:411
Homologene: 84430
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, Snep, D430044C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208777
Homologene: 14708
Tmem67
Name: transmembrane protein 67
Synonyms: 5330408M12Rik, b2b1291.1Clo, b2b1163.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329795
Homologene: 71886
Dus2
Name: dihydrouridine synthase 2
Synonyms: 2310016K04Rik, Dus2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66369
Homologene: 6838
Vmn1r23
Name: vomeronasal 1 receptor 23
Synonyms: V1rc24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171197
Homologene: 110825
Pcgf1
Name: polycomb group ring finger 1
Synonyms: 2010002K04Rik, Nspc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69837
Homologene: 13090
Troap
Name: trophinin associated protein
Synonyms: tastin, E130301L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78733
VEGA: 15
Homologene: 28697
Fancg
Name: Fanconi anemia, complementation group G
Synonyms: Xrcc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 60534
HGNC: HGNC:3588
Homologene: 3402
Adgra2
Name: adhesion G protein-coupled receptor A2
Synonyms: Tem5, 9530074E10Rik, 8430414O08Rik, Gpr124
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78560
Homologene: 13112
Cd55b
Name: CD55 molecule, decay accelerating factor for complement B
Synonyms: Daf-TM, complement-transmembrane, TM-DAF, Daf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13137
HGNC: HGNC:2665
Homologene: 479
Defb40
Name: defensin beta 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 360217
Homologene: 86851
Sftpd
Name: surfactant associated protein D
Synonyms: SP-D, Sftp4, Sfpd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20390
VEGA: 14
Homologene: 2272
Qsox1
Name: quiescin Q6 sulfhydryl oxidase 1
Synonyms: 1300003H02Rik, Qscn6, QSOX, b2b2673Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 104009
HGNC: HGNC:9756
Homologene: 37690
4930415L06Rik
Name: RIKEN cDNA 4930415L06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245511
Homologene: 133109
Tmem182
Name: transmembrane protein 182
Synonyms: 2310079P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381339
Homologene: 44899
Magea14
Name: MAGE family member A14
Synonyms: 1700080O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 74279
Defa27
Name: defensin, alpha, 27
Synonyms: ENSMUSG00000074438, Gm15299
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100041811
Homologene: 113382
Pnma5
Name: paraneoplastic antigen family 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 385377
Homologene: 14176
Hspb6
Name: heat shock protein, alpha-crystallin-related, B6
Synonyms: Hsp20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243912
Homologene: 36931
1700092K14Rik
Name: RIKEN cDNA 1700092K14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73536
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,838,370 bp
  • A to T, chromosome 1 at 93,285,855 bp
  • A to G, chromosome 1 at 96,997,390 bp
  • T to C, chromosome 1 at 130,416,859 bp
  • T to A, chromosome 1 at 135,457,913 bp
  • G to A, chromosome 1 at 152,468,531 bp
  • A to G, chromosome 1 at 154,426,550 bp
  • T to A, chromosome 1 at 155,786,925 bp
  • A to G, chromosome 1 at 177,447,479 bp
  • A to T, chromosome 2 at 22,340,278 bp
  • T to A, chromosome 2 at 62,244,343 bp
  • T to A, chromosome 2 at 76,754,824 bp
  • A to T, chromosome 2 at 156,948,294 bp
  • T to C, chromosome 2 at 181,081,153 bp
  • A to G, chromosome 3 at 36,573,571 bp
  • T to C, chromosome 4 at 12,073,922 bp
  • T to C, chromosome 4 at 43,003,830 bp
  • A to G, chromosome 4 at 108,606,274 bp
  • C to T, chromosome 4 at 130,312,452 bp
  • C to A, chromosome 5 at 135,715,961 bp
  • C to T, chromosome 5 at 144,882,593 bp
  • T to G, chromosome 5 at 150,070,270 bp
  • T to C, chromosome 6 at 57,926,467 bp
  • T to A, chromosome 6 at 83,079,733 bp
  • A to T, chromosome 6 at 123,823,647 bp
  • G to A, chromosome 6 at 132,848,045 bp
  • T to C, chromosome 7 at 30,553,464 bp
  • A to G, chromosome 7 at 65,682,802 bp
  • C to T, chromosome 7 at 144,395,480 bp
  • A to G, chromosome 8 at 18,978,077 bp
  • A to G, chromosome 8 at 21,315,616 bp
  • T to A, chromosome 8 at 27,119,244 bp
  • T to C, chromosome 8 at 61,994,393 bp
  • T to A, chromosome 8 at 69,813,601 bp
  • T to C, chromosome 8 at 80,614,141 bp
  • C to T, chromosome 8 at 106,048,654 bp
  • C to A, chromosome 9 at 13,620,110 bp
  • T to C, chromosome 10 at 80,810,356 bp
  • T to C, chromosome 11 at 104,378,689 bp
  • A to C, chromosome 11 at 114,199,144 bp
  • A to T, chromosome 11 at 120,129,264 bp
  • G to A, chromosome 12 at 3,901,665 bp
  • T to A, chromosome 12 at 11,456,464 bp
  • A to G, chromosome 14 at 31,745,225 bp
  • G to A, chromosome 14 at 41,172,580 bp
  • A to G, chromosome 14 at 55,618,634 bp
  • A to G, chromosome 14 at 68,647,706 bp
  • A to G, chromosome 15 at 72,590,792 bp
  • A to G, chromosome 15 at 99,078,832 bp
  • G to T, chromosome 17 at 24,299,060 bp
  • A to G, chromosome 17 at 56,036,456 bp
  • T to A, chromosome 18 at 37,450,142 bp
  • A to G, chromosome 19 at 3,977,636 bp
  • T to C, chromosome 19 at 41,614,417 bp
  • T to C, chromosome X at 51,968,990 bp
  • T to C, chromosome X at 73,035,430 bp
  • A to T, chromosome X at 89,932,499 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4282 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041650-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.