Strain Name:
C57BL/6J-MtgxR4289Btlr/Mmmh
Stock Number:
041654-MU
Citation ID:
RRID:MMRRC_041654-MU
Other Names:
R4289 (G1), C57BL/6J-MtgxR4289Btlr
Major Collection:

Gene Information

Mms19
Name: MMS19 cytosolic iron-sulfur assembly component
Synonyms: 2610042O15Rik, Mms19, C86341, Mms19l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72199
Homologene: 41480
Plekhg5
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269608
Homologene: 10768
Ift122
Name: intraflagellar transport 122
Synonyms: C86139, Wdr10, sopb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 81896
Homologene: 12819
Cntn2
Name: contactin 2
Synonyms: Tax, TAG-1, axonin, D130012K04Rik, TAG1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21367
HGNC: HGNC:2172
Homologene: 3720
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, eyes2, crf11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329872
Homologene: 27049
Mmp14
Name: matrix metallopeptidase 14 (membrane-inserted)
Synonyms: Membrane type 1-MMP, MT1-MMP, sabe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17387
HGNC: HGNC:7160
Homologene: 21040
Rph3a
Name: rabphilin 3A
Synonyms: 2900002P20Rik, Doc2 family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19894
Homologene: 7921
Tbc1d1
Name: TBC1 domain family, member 1
Synonyms: 1110062G02Rik, Nob1, Nobq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57915
Homologene: 56856
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: CD56, NCAM-1, NCAM-120, NCAM-140, NCAM-180, E-NCAM, NCAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Arhgdib
Name: Rho, GDP dissociation inhibitor (GDI) beta
Synonyms: D4, Ly-GDI, Gdid4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11857
HGNC: HGNC:679
Homologene: 20318
Fcrl5
Name: Fc receptor-like 5
Synonyms: BXMAS1-like protein 2, Fcrh3, mBXMH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329693
Homologene: 137404
Kirrel3
Name: kirre like nephrin family adhesion molecule 3
Synonyms: Neph2, 1500010O20Rik, 2900036G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67703
Homologene: 57050
Cdhr5
Name: cadherin-related family member 5
Synonyms: 1810074H01Rik, Mucdhl, Mupcdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72040
HGNC: HGNC:7521
Homologene: 69345
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Wcrf180, Acf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: lysyl hydroxylase 2, LH2, Plod-2, D530025C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Actl6a
Name: actin-like 6A
Synonyms: Actl6, Baf53a, 2810432C06Rik, ARP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56456
Homologene: 55811
Cfap97
Name: cilia and flagella associated protein 97
Synonyms: 1110068E21Rik, 4933411K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66756
Homologene: 12026
Rbis
Name: ribosomal biogenesis factor
Synonyms: 1810022K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69126
Homologene: 47794
Zfp748
Name: zinc finger protein 748
Synonyms: 2610014M12Rik, mszf54, KRAB-O, Zfp208
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212276
Homologene: 134552
Tyw3
Name: tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
Synonyms: 5230400J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 209584
Homologene: 44531
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTP-BL, Ptpri, PTPL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Pycrl
Name: pyrroline-5-carboxylate reductase-like
Synonyms: 1110058B13Rik, 2700073G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66194
VEGA: 15
Homologene: 56130
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Prss45
Name: protease, serine 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 260408
Homologene: 51905
Tcp11l2
Name: t-complex 11 (mouse) like 2
Synonyms: E430026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216198
Homologene: 17129
Gm10267
Name: predicted gene 10267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100042855
Homologene: 104911
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: PAG1, IGFBP-4ase, PAPP-A, 8430414N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Zfp217
Name: zinc finger protein 217
Synonyms: 4933431C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228913
Homologene: 4757
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546980
Homologene: 115466
Mypn
Name: myopalladin
Synonyms: 1110056A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68802
VEGA: 10
Homologene: 23778
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Cyp3a57
Name: cytochrome P450, family 3, subfamily a, polypeptide 57
Synonyms: EG622127
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 622127
Homologene: 135775
Gm5581
Name: predicted gene 5581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Zfp267
Name: zinc finger protein 267
Synonyms: D3Ertd254e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241944
Homologene: 117700
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219140
Homologene: 19482
Olfr297
Name: olfactory receptor 297
Synonyms: GA_x6K02T2NHDJ-9587747-9586815, MOR220-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258611
Homologene: 115526
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: VKIND, very-kind, 2410012C07Rik, B830014K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76484
Homologene: 45138
Arhgef39
Name: Rho guanine nucleotide exchange factor (GEF) 39
Synonyms: E130306D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230098
Homologene: 19225
Mks1
Name: MKS transition zone complex subunit 1
Synonyms: B8d3, avc6, Meckel syndrome, type 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380718
HGNC: HGNC:7121
Homologene: 9833
Trdn
Name: triadin
Synonyms: 2310045H21Rik, triadin-3, triadin-2, triadin-1, triadin 3, triadin 2, triadin 1, EG432451
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76757
VEGA: 10
Homologene: 38137
Gm2128
Name: predicted gene 2128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100039269
Homologene: 45597
Ear10
Name: eosinophil-associated, ribonuclease A family, member 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 93725
Homologene: 40596
Cyp4v3
Name: cytochrome P450, family 4, subfamily v, polypeptide 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102294
Homologene: 133054
Fdxacb1
Name: ferredoxin-fold anticodon binding domain containing 1
Synonyms: D630004A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382137
Homologene: 19813
Gtf2a1l
Name: general transcription factor IIA, 1-like
Synonyms: 1700011N16Rik, Alf, Gtf2a1lf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71828
Homologene: 86732
Sall2
Name: spalt like transcription factor 2
Synonyms: Msal-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50524
Homologene: 9269
Olfr1317
Name: olfactory receptor 1317
Synonyms: GA_x6K02T2Q125-73188162-73189112, MOR245-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258440
Homologene: 71983
Rdh14
Name: retinol dehydrogenase 14 (all-trans and 9-cis)
Synonyms: PAN2, 3110030G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 105014
VEGA: 12
Homologene: 75139
Mrpl36
Name: mitochondrial ribosomal protein L36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 94066
VEGA: 13
Homologene: 41872
Nfkbie
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18037
VEGA: 17
HGNC: HGNC:7799
Homologene: 36160
Vmn1r227
Name: vomeronasal 1 receptor 227
Synonyms: V1re6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171229
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 132,527,743 bp
  • T to C, chromosome 2 at 76,810,398 bp
  • T to A, chromosome 2 at 112,141,974 bp
  • C to T, chromosome 2 at 170,114,787 bp
  • T to C, chromosome 3 at 14,609,654 bp
  • C to T, chromosome 3 at 32,712,114 bp
  • A to G, chromosome 3 at 36,159,598 bp
  • A to G, chromosome 3 at 87,442,224 bp
  • A to T, chromosome 3 at 154,597,008 bp
  • A to G, chromosome 4 at 43,497,353 bp
  • C to T, chromosome 4 at 65,155,863 bp
  • T to C, chromosome 4 at 83,005,587 bp
  • C to T, chromosome 4 at 137,518,940 bp
  • T to C, chromosome 4 at 152,112,427 bp
  • T to A, chromosome 5 at 64,260,428 bp
  • A to G, chromosome 5 at 103,533,285 bp
  • G to A, chromosome 5 at 120,973,305 bp
  • G to A, chromosome 5 at 145,349,397 bp
  • T to C, chromosome 6 at 115,923,891 bp
  • C to T, chromosome 6 at 131,167,556 bp
  • T to C, chromosome 6 at 136,924,158 bp
  • G to T, chromosome 7 at 41,158,912 bp
  • C to T, chromosome 7 at 85,957,354 bp
  • T to A, chromosome 7 at 86,527,054 bp
  • A to G, chromosome 7 at 139,910,882 bp
  • A to T, chromosome 7 at 141,272,839 bp
  • A to C, chromosome 8 at 45,328,223 bp
  • T to A, chromosome 8 at 46,192,661 bp
  • A to T, chromosome 9 at 35,023,473 bp
  • G to T, chromosome 9 at 49,557,172 bp
  • A to T, chromosome 9 at 50,772,579 bp
  • G to A, chromosome 9 at 92,602,988 bp
  • C to T, chromosome 9 at 109,114,352 bp
  • A to G, chromosome 9 at 110,840,929 bp
  • C to T, chromosome 10 at 33,464,582 bp
  • T to C, chromosome 10 at 63,131,182 bp
  • T to C, chromosome 10 at 84,605,073 bp
  • T to C, chromosome 11 at 87,856,704 bp
  • A to T, chromosome 12 at 10,394,949 bp
  • G to A, chromosome 12 at 54,900,448 bp
  • T to A, chromosome 13 at 67,541,083 bp
  • A to T, chromosome 13 at 73,331,658 bp
  • T to C, chromosome 14 at 43,922,947 bp
  • C to A, chromosome 14 at 52,313,803 bp
  • A to T, chromosome 14 at 54,436,208 bp
  • T to A, chromosome 14 at 60,691,074 bp
  • T to C, chromosome 15 at 75,918,806 bp
  • G to T, chromosome 17 at 20,735,830 bp
  • T to C, chromosome 17 at 45,558,590 bp
  • A to G, chromosome 17 at 88,694,456 bp
  • T to C, chromosome 18 at 44,157,264 bp
  • T to C, chromosome 18 at 58,035,339 bp
  • A to G, chromosome 19 at 41,945,553 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4289 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041654-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.