Strain Name:
C57BL/6J-MtgxR4362Btlr/Mmmh
Stock Number:
041671-MU
Citation ID:
RRID:MMRRC_041671-MU
Other Names:
R4362 (G1), C57BL/6J-MtgxR4362Btlr
Major Collection:

Strain Information

Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd1, Edd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Fbxl3
Name: F-box and leucine-rich repeat protein 3
Synonyms: Fbl3a, Fbxl3a, Ovtm, Play68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50789
Homologene: 8127
Slc6a4
Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms: 5-HTT, Htt, Sert
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15567
Homologene: 817
Cap1
Name: CAP, adenylate cyclase-associated protein 1 (yeast)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12331
Homologene: 74572
Gins1
Name: GINS complex subunit 1 (Psf1 homolog)
Synonyms: Psf1, 2810418N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69270
Homologene: 44516
Garem1
Name: GRB2 associated regulator of MAPK1 subtype 1
Synonyms: LOC381126, Fam59a, Garem
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381126
VEGA: 18
Homologene: 11237
Bicc1
Name: BicC family RNA binding protein 1
Synonyms: Bic-C, jcpk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83675
Homologene: 12856
Chodl
Name: chondrolectin
Synonyms: MT75, 3110074E07Rik, PRED12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 246048
Homologene: 11795
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: FIC1, Ic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Muc19
Name: mucin 19
Synonyms: apomucin, sld
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Adamts13
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
Synonyms: LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Synonyms: osteoclastogenesis inhibitory factor, OCIF, OPG, Opg, TR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18383
VEGA: 15
Homologene: 1912
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73692
Homologene: 11315
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Abcc6
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Synonyms: DCC, Mrp6, Dyscalc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Or10a2
Name: olfactory receptor family 10 subfamily A member 2
Synonyms: GA_x6K02T2PBJ9-9453401-9454354, MOR263-2, P4, Olfr714
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259035
Homologene: 72055
Vmn2r18
Name: vomeronasal 2, receptor 18
Synonyms: EG632671
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 632671
Ttpa
Name: tocopherol (alpha) transfer protein
Synonyms: alpha TTP, alpha-TTP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50500
Homologene: 37295
Tmem168
Name: transmembrane protein 168
Synonyms: 5730526F17Rik, 8430437G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101118
Homologene: 11202
Ppp1r32
Name: protein phosphatase 1, regulatory subunit 32
Synonyms: IIIG9L, IIIG9, IIIG9S, 4930579J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67752
VEGA: 19
Homologene: 15863
Edc3
Name: enhancer of mRNA decapping 3
Synonyms: Yjdc, Lsm16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 353190
Homologene: 11827
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Otulinl
Name: OTU deubiquitinase with linear linkage specificity like
Synonyms: Fam105a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223433
VEGA: 15
Homologene: 41302
Or1e21
Name: olfactory receptor family 1 subfamily E member 21
Synonyms: GA_x6K02T2P1NL-3613021-3612086, MOR135-1, Olfr380
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259027
Homologene: 74109
Icam4
Name: intercellular adhesion molecule 4, Landsteiner-Wiener blood group
Synonyms: Cd242, 1810015M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78369
VEGA: 9
HGNC: HGNC:5347
Homologene: 74401
Setd4
Name: SET domain containing 4
Synonyms: ORF21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224440
HGNC: HGNC:1258
Homologene: 41173
Dus4l
Name: dihydrouridine synthase 4-like (S. cerevisiae)
Synonyms: 2700089B10Rik, 2310069P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71916
VEGA: 12
Homologene: 6535
Tas2r136
Name: taste receptor, type 2, member 136
Synonyms: mt2r52, Tas2r36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353165
Homologene: 136304
Rhot2
Name: ras homolog family member T2
Synonyms: Miro2, Arht2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 214952
Homologene: 56038
Vmn2r32
Name: vomeronasal 2, receptor 32
Synonyms: V2r5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22311
Homologene: 113703
Nedd9
Name: neural precursor cell expressed, developmentally down-regulated gene 9
Synonyms: E230025G09Rik, CasL, HEF1, Cas-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18003
VEGA: 13
HGNC: HGNC:7733
Homologene: 4669
Cplx2
Name: complexin 2
Synonyms: 921-L, Gm34843
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12890
HGNC: HGNC:2310
Homologene: 38212
2200002D01Rik
Name: RIKEN cDNA 2200002D01 gene
Synonyms: H2RSP, HAI-2 related small protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72275
Homologene: 137385
Glrx2
Name: glutaredoxin 2 (thioltransferase)
Synonyms: 1700010P22Rik, Grx2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69367
Homologene: 41098
Fam219aos
Name: family with sequence similarity 219, member A, opposite strand
Synonyms: 1700066J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76992
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 133,739,931 bp
  • A to G, chromosome 1 at 143,741,680 bp
  • G to A, chromosome 2 at 27,004,782 bp
  • G to A, chromosome 2 at 150,909,762 bp
  • G to T, chromosome 4 at 20,023,827 bp
  • C to T, chromosome 4 at 41,518,844 bp
  • G to A, chromosome 4 at 122,862,987 bp
  • C to T, chromosome 5 at 151,572,903 bp
  • A to C, chromosome 6 at 13,595,073 bp
  • C to A, chromosome 6 at 132,778,009 bp
  • A to T, chromosome 7 at 7,479,858 bp
  • C to T, chromosome 7 at 29,248,262 bp
  • A to G, chromosome 7 at 45,998,832 bp
  • T to C, chromosome 7 at 107,074,592 bp
  • G to A, chromosome 7 at 109,896,343 bp
  • A to G, chromosome 9 at 21,026,312 bp
  • C to T, chromosome 9 at 57,713,546 bp
  • ATGTG to ATG, chromosome 10 at 70,943,374 bp
  • T to C, chromosome 11 at 73,453,565 bp
  • A to G, chromosome 11 at 77,017,078 bp
  • A to C, chromosome 12 at 31,648,828 bp
  • A to T, chromosome 13 at 41,317,953 bp
  • A to T, chromosome 13 at 54,378,817 bp
  • A to T, chromosome 14 at 103,092,313 bp
  • T to C, chromosome 15 at 8,218,597 bp
  • T to A, chromosome 15 at 8,270,745 bp
  • C to T, chromosome 15 at 27,664,343 bp
  • A to G, chromosome 15 at 38,078,403 bp
  • G to A, chromosome 15 at 53,107,591 bp
  • T to A, chromosome 15 at 54,256,159 bp
  • T to C, chromosome 15 at 91,878,571 bp
  • G to T, chromosome 16 at 78,944,658 bp
  • T to C, chromosome 16 at 93,583,686 bp
  • A to G, chromosome 17 at 25,842,091 bp
  • T to A, chromosome 18 at 20,050,157 bp
  • T to C, chromosome 18 at 21,236,115 bp
  • C to T, chromosome 18 at 64,564,537 bp
  • T to C, chromosome 19 at 10,475,021 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4362 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041671-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.