Strain Name:
C57BL/6J-MtgxR4377Btlr/Mmmh
Stock Number:
041676-MU
Citation ID:
RRID:MMRRC_041676-MU
Other Names:
R4377 (G1), C57BL/6J-MtgxR4377Btlr
Major Collection:

Gene Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: Tr-kit, Gsfsco1, c-KIT, Steel Factor Receptor, Gsfsco5, Dominant white spotting, CD117, belly-spot, SOW3, SCO5, SCO1, Gsfsow3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, Mll3, E330008K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: SSE, PRCE, separase, ESP1, Cerp, PRCE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: pCIP, bHLHe42, TRAM1, KAT13B, 2010305B15Rik, RAC3, AIB1, TRAM-1, Src3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Gon4l
Name: gon-4-like (C.elegans)
Synonyms: 2610100B20Rik, 1500041I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76022
Homologene: 13002
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Srisnf2l, G630026H09Rik, Arip4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 81000
Homologene: 56698
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269400
Homologene: 13168
Gart
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Gaps, Prgs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14450
HGNC: HGNC:4163
Homologene: 637
Mark2
Name: MAP/microtubule affinity regulating kinase 2
Synonyms: Emk, Par-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13728
HGNC: HGNC:3332
Homologene: 69013
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: mNAT1, Narg1, 5730450D16Rik, ASTBDN, tubedown, Tbdn-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74838
Homologene: 14211
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: D330025H14Rik, ORP-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237542
VEGA: 10
Homologene: 68813
Prcc
Name: papillary renal cell carcinoma (translocation-associated)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 94315
HGNC: HGNC:9343
Homologene: 38120
C330007P06Rik
Name: RIKEN cDNA C330007P06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 77644
Homologene: 11133
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: Ayu21-9, PEPP2, AMH-Cre, 2810431N21Rik, Gt(Ayu21)9Imeg, Tg(AMH-cre)1Flor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Ing3
Name: inhibitor of growth family, member 3
Synonyms: P47ING3, 1300013A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71777
Homologene: 6804
Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Synonyms: Lyt-4, Ly-5, CD45, T200, B220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Krt33a
Name: keratin 33A
Synonyms: 2310015J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71888
Homologene: 74433
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Mvk
Name: mevalonate kinase
Synonyms: 2310010A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17855
HGNC: HGNC:7530
Homologene: 372
Napb
Name: N-ethylmaleimide sensitive fusion protein attachment protein beta
Synonyms: I47, Brp14, E161, SNARE, b-SNAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17957
Homologene: 5332
Hk1
Name: hexokinase 1
Synonyms: mHk1-s, Hk1-s, Hk-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Pdia4
Name: protein disulfide isomerase associated 4
Synonyms: Erp72, ERp72, U48620, Cai
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12304
Homologene: 21020
Dapk1
Name: death associated protein kinase 1
Synonyms: 2310039H24Rik, D13Ucla1, 2810425C21Rik, DAP-Kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72333
Homologene: 75052
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Gm4560, Fbl7, lalina, 5530401A10Rik, Fbxl11, Jhdm1a, Cxxc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225876
Homologene: 56564
Armh4
Name: armadillo-like helical domain containing 4
Synonyms: 3632451O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67419
Homologene: 12127
Zmiz1
Name: zinc finger, MIZ-type containing 1
Synonyms: Zimp10, Rai17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328365
Homologene: 10667
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alphaMHC, Myhca, cardiomyopathy, hypertrophic 1, alpha-MHC, Myhc-a, A830009F23Rik, alpha myosin, alpha cardiac MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Kcp
Name: kielin/chordin-like protein
Synonyms: KCP, LOC333088, Crim2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 333088
Homologene: 87817
Olfr965
Name: olfactory receptor 965
Synonyms: GA_x6K02T2PVTD-33416730-33417668, MOR171-28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258165
VEGA: 9
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: Ptpn15, GLEPP1, PTP-U2, PTP-BK, PTP-phi, PTPROt, D28, PTP-oc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Csf1
Name: colony stimulating factor 1 (macrophage)
Synonyms: CSF-1, Csfm, M-CSF, colony-stimulating factor-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12977
HGNC: HGNC:2432
Homologene: 7282
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75777
Homologene: 44907
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: E230008N13Rik, LOC381522
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381522
Homologene: 117988
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 207792
Homologene: 19490
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230622
Homologene: 135888
Itgal
Name: integrin alpha L
Synonyms: Ly-21, Cd11a, Ly-15, LFA-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: D230016L12Rik, Top-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17837
Homologene: 136663
Csn1s2a
Name: casein alpha s2-like A
Synonyms: Csn1s2a, Csng
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12993
Homologene: 7284
Arhgap22
Name: Rho GTPase activating protein 22
Synonyms: RHOGAP2, B230341L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239027
Homologene: 23292
Olfr608
Name: olfactory receptor 608
Synonyms: MOR26-3, GA_x6K02T2PBJ9-6191595-6192545
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258751
Frmd3
Name: FERM domain containing 3
Synonyms: EPB41L4O, 4.1O, P410, 9430066I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242506
Homologene: 16012
Adck5
Name: aarF domain containing kinase 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 268822
Homologene: 34378
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240427
Homologene: 9192
Cd209c
Name: CD209c antigen
Synonyms: mSIGNR2, SIGNR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170776
HGNC: HGNC:1641
Homologene: 87186
Atp10d
Name: ATPase, class V, type 10D
Synonyms: IMAGE:1069176, 9830145H18Rik, D5Buc24e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231287
Zfp583
Name: zinc finger protein 583
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 213011
Homologene: 65048
Pfn4
Name: profilin family, member 4
Synonyms: 2900024P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 382562
VEGA: 12
Homologene: 20046
Gm7251
Name: predicted pseudogene 7251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 638833
Tes3-ps
Name: testis derived transcript 3, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 54339
VEGA: 13
Rpl11
Name: ribosomal protein L11
Synonyms: 2010203J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67025
Homologene: 37376
Pusl1
Name: pseudouridylate synthase-like 1
Synonyms: 2810021I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433813
Homologene: 13655
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 138,067,925 bp
  • A to G, chromosome 1 at 155,232,450 bp
  • A to C, chromosome 2 at 148,732,264 bp
  • T to G, chromosome 2 at 166,054,497 bp
  • T to A, chromosome 2 at 181,355,796 bp
  • T to C, chromosome 3 at 51,448,365 bp
  • A to G, chromosome 3 at 87,867,407 bp
  • C to A, chromosome 3 at 88,907,387 bp
  • T to A, chromosome 3 at 107,756,739 bp
  • T to A, chromosome 4 at 45,941,877 bp
  • T to A, chromosome 4 at 74,128,298 bp
  • T to C, chromosome 4 at 113,236,518 bp
  • G to A, chromosome 4 at 136,051,143 bp
  • A to G, chromosome 4 at 155,890,580 bp
  • C to T, chromosome 5 at 25,315,326 bp
  • T to C, chromosome 5 at 72,296,975 bp
  • T to C, chromosome 5 at 75,640,499 bp
  • T to C, chromosome 5 at 87,775,821 bp
  • T to A, chromosome 5 at 110,337,205 bp
  • A to G, chromosome 5 at 114,452,961 bp
  • C to A, chromosome 6 at 21,950,064 bp
  • C to T, chromosome 6 at 29,493,203 bp
  • G to A, chromosome 6 at 47,798,392 bp
  • G to T, chromosome 6 at 122,071,007 bp
  • T to A, chromosome 6 at 137,380,266 bp
  • T to C, chromosome 6 at 140,579,465 bp
  • A to G, chromosome 7 at 6,317,681 bp
  • T to C, chromosome 7 at 103,470,071 bp
  • A to G, chromosome 7 at 127,328,281 bp
  • T to C, chromosome 8 at 3,954,635 bp
  • A to C, chromosome 8 at 61,533,372 bp
  • T to A, chromosome 9 at 39,719,807 bp
  • A to G, chromosome 9 at 106,693,222 bp
  • C to A, chromosome 10 at 62,315,540 bp
  • T to A, chromosome 10 at 111,269,419 bp
  • T to C, chromosome 11 at 100,012,427 bp
  • T to A, chromosome 12 at 4,770,182 bp
  • A to G, chromosome 13 at 49,494,431 bp
  • T to A, chromosome 13 at 49,805,200 bp
  • A to G, chromosome 13 at 60,719,684 bp
  • T to G, chromosome 14 at 16,409,189 bp
  • T to C, chromosome 14 at 25,636,010 bp
  • A to G, chromosome 14 at 33,369,510 bp
  • T to A, chromosome 14 at 49,770,436 bp
  • T to A, chromosome 14 at 54,962,108 bp
  • CT to CTTGGATT, chromosome 15 at 10,537,562 bp
  • G to A, chromosome 15 at 10,537,566 bp
  • A to G, chromosome 15 at 76,594,335 bp
  • A to G, chromosome 15 at 102,312,989 bp
  • G to A, chromosome 16 at 91,634,094 bp
  • T to C, chromosome 18 at 78,859,922 bp
  • C to T, chromosome 19 at 4,329,054 bp
  • T to C, chromosome 19 at 7,290,689 bp
  • C to A, chromosome X at 36,824,159 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4377 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041676-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.