Strain Name:
C57BL/6J-MtgxR4394Btlr/Mmmh
Stock Number:
041683-MU
Citation ID:
RRID:MMRRC_041683-MU
Other Names:
R4394 (G1), C57BL/6J-MtgxR4394Btlr
Major Collection:

Gene Information

Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Psen2
Name: presenilin 2
Synonyms: ALG-3, PS-2, PS2, Ad4h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19165
HGNC: HGNC:9509
Homologene: 386
Arid4b
Name: AT rich interactive domain 4B (RBP1-like)
Synonyms: RBBP1L1, SAP180, BRCAA1, Rbp1l1, 6720480E17Rik, 6330417L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 94246
Homologene: 12847
Tpst1
Name: protein-tyrosine sulfotransferase 1
Synonyms: Tango13a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22021
Homologene: 2667
Cltc
Name: clathrin, heavy polypeptide (Hc)
Synonyms: CHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Ttc5
Name: tetratricopeptide repeat domain 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219022
VEGA: 14
Homologene: 14397
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: Gtl6, 1110036I07Rik, 6720416K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14897
Homologene: 44226
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: D6Ertd380e, 9530019N15Rik, Mi-2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: 6330404E13Rik, MSK1, 3110005L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Mark3
Name: MAP/microtubule affinity regulating kinase 3
Synonyms: ETK-1, 1600015G02Rik, A430080F22Rik, C-TAK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17169
VEGA: 12
HGNC: HGNC:6897
Homologene: 55653
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: DBF3/PRP8, Prp8, D11Bwg0410e, Sfprp8l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192159
Homologene: 4706
Slc41a3
Name: solute carrier family 41, member 3
Synonyms: SLC41A1-L2, 1010001P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71699
Homologene: 23052
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, D230004I22Rik, 2600013A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268902
Homologene: 43188
Cpxm2
Name: carboxypeptidase X 2 (M14 family)
Synonyms: 4632435C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 55987
Homologene: 69259
Fam3b
Name: FAM3 metabolism regulating signaling molecule B
Synonyms: D16Jhu19e, 9030624C24Rik, ORF9, Pander
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 52793
HGNC: HGNC:1253
Homologene: 10766
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4921518A06Rik, 4933421G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Brip1
Name: BRCA1 interacting protein C-terminal helicase 1
Synonyms: 8030460J03Rik, BACH1, 3110009N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237911
Homologene: 32766
Slitrk1
Name: SLIT and NTRK-like family, member 1
Synonyms: 3200001I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76965
VEGA: 14
Homologene: 14174
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Tns2
Name: tensin 2
Synonyms: nep, nph, Tenc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 209039
VEGA: 15
Homologene: 37077
Ptprd
Name: protein tyrosine phosphatase, receptor type, D
Synonyms: 3000002J10Rik, B230219D21Rik, 1110002J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, D430038H04Rik, 9430076A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Prss38
Name: protease, serine 38
Synonyms: LOC216797, Gm249
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216797
Homologene: 18831
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: Si-s, sucrase-isomaltase, 2010204N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69983
Homologene: 37424
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320429
Homologene: 45845
Cntn1
Name: contactin 1
Synonyms: CNTN, F3cam, usl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12805
HGNC: HGNC:2171
Homologene: 7274
Snx25
Name: sorting nexin 25
Synonyms: LOC382008, SBBI31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102141
Homologene: 23744
Hal
Name: histidine ammonia lyase
Synonyms: histidase, Hsd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15109
HGNC: HGNC:4806
Homologene: 68229
Tshz3
Name: teashirt zinc finger family member 3
Synonyms: A630038G13Rik, Zfp537, teashirt3, Tsh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243931
Homologene: 10835
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81877
Homologene: 49589
Gm9581
Name: predicted gene 9581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930449A08Rik, 4930538D17Rik, Tmem180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75146
Homologene: 12592
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 621430
Homologene: 115466
Pcdhb8
Name: protocadherin beta 8
Synonyms: Pcdhb5C, PcdhbH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93879
Homologene: 89038
Postn
Name: periostin, osteoblast specific factor
Synonyms: OSF-2, Periostin, Osf2, peri, A630052E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 50706
Homologene: 4730
Wsb2
Name: WD repeat and SOCS box-containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 59043
Homologene: 32417
Hid1
Name: HID1 domain containing
Synonyms: C630004H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217310
Homologene: 12737
Lman2l
Name: lectin, mannose-binding 2-like
Synonyms: VIP36-like, A630028F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214895
Homologene: 57125
Olfr1057
Name: olfactory receptor 1057
Synonyms: GA_x6K02T2Q125-47844843-47843896, MOR185-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404325
Homologene: 83135
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, gp115, EMILIN-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100952
Homologene: 5117
Rab39
Name: RAB39, member RAS oncogene family
Synonyms: C230094F14Rik, Rab39a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270160
Homologene: 56773
Tbxas1
Name: thromboxane A synthase 1, platelet
Synonyms: TXS, CYP5A1, CYP5, TXAS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21391
Homologene: 130979
Dzip1l
Name: DAZ interacting protein 1-like
Synonyms: 2610524A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72507
Homologene: 12466
Olfr830
Name: olfactory receptor 830
Synonyms: GA_x6K02T2PVTD-12618399-12619337, MOR152-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258559
Homologene: 79360
Mgst2
Name: microsomal glutathione S-transferase 2
Synonyms: MGST-II, GST2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 211666
HGNC: HGNC:7063
Homologene: 1811
Abtb1
Name: ankyrin repeat and BTB (POZ) domain containing 1
Synonyms: BPOZ, EF1ABP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 80283
Homologene: 32731
Lrfn5
Name: leucine rich repeat and fibronectin type III domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238205
Homologene: 17582
Hyou1
Name: hypoxia up-regulated 1
Synonyms: CBP-140, Orp150, 140 kDa, Grp170, Cab140
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12282
Homologene: 4658
Ptpn9
Name: protein tyrosine phosphatase, non-receptor type 9
Synonyms: Meg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56294
VEGA: 9
HGNC: HGNC:9661
Homologene: 2121
Ces2f
Name: carboxylesterase 2F
Synonyms: 2310038E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71903
HGNC: HGNC:1864
Homologene: 135673
Tex44
Name: testis expressed 44
Synonyms: 1700019O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71863
Homologene: 51874
Fbxw20
Name: F-box and WD-40 domain protein 20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434440
Homologene: 110776
Bahd1
Name: bromo adjacent homology domain containing 1
Synonyms: LOC228536
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228536
Homologene: 8976
Jrkl
Name: Jrk-like
Synonyms: C030035D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77532
VEGA: 9
HGNC: HGNC:6200
Homologene: 2797
Gm8122
Name: predicted gene 8122
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Fgf6
Name: fibroblast growth factor 6
Synonyms: Fgf-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14177
HGNC: HGNC:3684
Homologene: 10870
Gm20528
Name: predicted gene 20528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Gm20946
Name: predicted gene, 20946
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100415900
A830036E02Rik
Name: RIKEN cDNA A830036E02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 36,439,723 bp
  • A to T, chromosome 1 at 84,725,741 bp
  • T to C, chromosome 1 at 86,427,767 bp
  • CAGAGAGAGAGAGA to CAGAGAGAGAGA, chromosome 1 at 88,211,984 bp
  • A to G, chromosome 1 at 93,431,483 bp
  • A to T, chromosome 1 at 180,240,782 bp
  • A to G, chromosome 2 at 31,931,952 bp
  • A to T, chromosome 2 at 52,187,513 bp
  • C to T, chromosome 2 at 86,375,179 bp
  • G to A, chromosome 2 at 118,922,523 bp
  • G to A, chromosome 3 at 51,664,528 bp
  • A to G, chromosome 3 at 54,370,955 bp
  • G to A, chromosome 3 at 72,956,149 bp
  • A to G, chromosome 4 at 76,128,685 bp
  • T to A, chromosome 5 at 16,618,951 bp
  • T to C, chromosome 5 at 30,918,135 bp
  • T to G, chromosome 5 at 117,363,578 bp
  • T to A, chromosome 5 at 130,102,502 bp
  • C to T, chromosome 6 at 39,027,779 bp
  • A to G, chromosome 6 at 88,836,584 bp
  • A to T, chromosome 6 at 90,635,330 bp
  • A to G, chromosome 6 at 125,121,618 bp
  • G to A, chromosome 6 at 127,015,582 bp
  • G to T, chromosome 7 at 29,094,242 bp
  • A to T, chromosome 7 at 36,769,605 bp
  • A to G, chromosome 7 at 87,001,891 bp
  • G to T, chromosome 7 at 132,057,667 bp
  • C to A, chromosome 8 at 20,833,165 bp
  • T to A, chromosome 8 at 44,952,346 bp
  • A to T, chromosome 8 at 46,035,678 bp
  • A to G, chromosome 8 at 104,950,954 bp
  • G to A, chromosome 9 at 13,245,141 bp
  • A to G, chromosome 9 at 15,922,792 bp
  • A to T, chromosome 9 at 18,875,611 bp
  • T to A, chromosome 9 at 44,381,872 bp
  • T to C, chromosome 9 at 53,686,650 bp
  • A to T, chromosome 9 at 57,036,563 bp
  • T to A, chromosome 9 at 99,639,854 bp
  • T to C, chromosome 9 at 109,232,330 bp
  • C to T, chromosome 9 at 111,365,197 bp
  • T to C, chromosome 10 at 93,496,559 bp
  • T to C, chromosome 11 at 59,373,028 bp
  • T to C, chromosome 11 at 75,492,523 bp
  • A to T, chromosome 11 at 86,074,298 bp
  • A to C, chromosome 11 at 86,733,630 bp
  • A to T, chromosome 11 at 99,422,082 bp
  • T to A, chromosome 11 at 115,367,642 bp
  • T to C, chromosome 12 at 61,843,490 bp
  • T to A, chromosome 12 at 100,581,319 bp
  • A to T, chromosome 12 at 111,604,523 bp
  • T to A, chromosome 13 at 14,154,972 bp
  • A to G, chromosome 14 at 43,234,068 bp
  • T to C, chromosome 14 at 50,781,505 bp
  • A to C, chromosome 14 at 108,911,303 bp
  • T to C, chromosome 15 at 8,361,861 bp
  • C to T, chromosome 15 at 92,291,764 bp
  • C to T, chromosome 15 at 102,108,934 bp
  • A to G, chromosome 16 at 59,560,095 bp
  • C to A, chromosome 16 at 73,948,379 bp
  • C to A, chromosome 16 at 97,481,786 bp
  • C to T, chromosome 17 at 34,678,662 bp
  • C to T, chromosome 18 at 37,356,882 bp
  • C to T, chromosome 19 at 46,371,992 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4394 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041683-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.