Strain Name:
C57BL/6J-MtgxR4406Btlr/Mmmh
Stock Number:
041688-MU
Citation ID:
RRID:MMRRC_041688-MU
Other Names:
R4406 (G1), C57BL/6J-MtgxR4406Btlr
Major Collection:

Gene Information

Traip
Name: TRAF-interacting protein
Synonyms: Trip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22036
Homologene: 31343
Mif4gd
Name: MIF4G domain containing
Synonyms: 1110014L05Rik, 2310075G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69674
Homologene: 41389
Mib1
Name: mindbomb E3 ubiquitin protein ligase 1
Synonyms: Mib, E430019M12Rik, mind bomb-1, skeletrophin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225164
Homologene: 10810
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: Zfat1, LOC380993, Zfp406
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 380993
Homologene: 16829
Nomo1
Name: nodal modulator 1
Synonyms: PM5, D7Ertd156e, Nomo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 211548
Homologene: 13810
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, Itpr-1, Pcp1, opt, wblo, InsP3R type I, Ip3r, IP3R1, Pcp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Zfp472
Name: zinc finger protein 472
Synonyms: Krim-1, Krim-1A, Krim-1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224691
Homologene: 77422
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lec2, 2900070I05Rik, Lphn1, lectomedin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330814
Homologene: 8951
Trak1
Name: trafficking protein, kinesin binding 1
Synonyms: hyrt, 2310001H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67095
Homologene: 25103
Map3k12
Name: mitogen-activated protein kinase kinase kinase 12
Synonyms: MUK, DLK, Zpk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26404
HGNC: HGNC:6851
Homologene: 4592
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: Fabph4, Fabph1, Mdgi, Fabph-4, Fabph-1, Fabp3, H-FABP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: Acac, LOC327983, A530025K05Rik, Acc1, acetyl-CoA carboxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: Mtmr15, 6030441H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330554
Homologene: 45598
Lrfn4
Name: leucine rich repeat and fibronectin type III domain containing 4
Synonyms: SALM3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225875
Homologene: 36415
Fbln1
Name: fibulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14114
HGNC: HGNC:3600
Homologene: 21295
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109242
Homologene: 52346
Osbpl10
Name: oxysterol binding protein-like 10
Synonyms: OPR-10, 4933433D06Rik, C820004B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74486
Homologene: 69240
Ppan
Name: peter pan homolog
Synonyms: A230087P06Rik, SSF1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235036
HGNC: HGNC:9227
Homologene: 5690
Umod
Name: uromodulin
Synonyms: Tamm-Horsfall glycoprotein, uromucoid, urehr4, Urehd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22242
Homologene: 2522
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Fat2
Name: FAT atypical cadherin 2
Synonyms: Fath2, LOC245827, EMI2, mKIAA0811
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Ces1f
Name: carboxylesterase 1F
Synonyms: CesML1, TGH-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234564
HGNC: HGNC:1863
Homologene: 134311
Acss3
Name: acyl-CoA synthetase short-chain family member 3
Synonyms: LOC380660, 8430416H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380660
Homologene: 11587
Ly75
Name: lymphocyte antigen 75
Synonyms: DEC-205, CD205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17076
HGNC: HGNC:6729
Homologene: 31085
Olfr1458
Name: olfactory receptor 1458
Synonyms: GA_x6K02T2RE5P-3430689-3429787, EG667271, MOR202-24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 667271
Mrpl4
Name: mitochondrial ribosomal protein L4
Synonyms: 1110017G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66163
VEGA: 9
Homologene: 32286
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230622
Homologene: 135888
Ubqlnl
Name: ubiquilin-like
Synonyms: 4922504M18Rik, LOC244179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244179
Homologene: 17034
Slco2b1
Name: solute carrier organic anion transporter family, member 2b1
Synonyms: Slc21a9, OATP-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101488
Homologene: 21419
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Olfr935
Name: olfactory receptor 935
Synonyms: MOR171-11, GA_x6K02T2PVTD-32691280-32690354
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258741
VEGA: 9
Homologene: 133683
Olfr1446
Name: olfactory receptor 1446
Synonyms: GA_x6K02T2RE5P-3220047-3219130, MOR202-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258699
Homologene: 74233
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: 1500001A10Rik, fp, nSR100, bv, flopsy, B230202K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68955
Homologene: 49869
Gm1527
Name: predicted gene 1527
Synonyms: LOC385263
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 385263
Homologene: 133976
Olfr1385
Name: olfactory receptor 1385
Synonyms: MOR256-41P, MOR256-42P, GA_x6K02T2QP88-5941817-5940888, MOR256-42P, Olfr1549-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258027
Homologene: 86692
Zfp936
Name: zinc finger protein 936
Synonyms: I1C0022H11Rik, EG435970, Gm9272
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668620
Lrp8
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms: Lr8b, 4932703M08Rik, apoER2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16975
HGNC: HGNC:6700
Homologene: 31250
Ankrd37
Name: ankyrin repeat domain 37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 654824
Homologene: 35347
Atp13a2
Name: ATPase type 13A2
Synonyms: 1110012E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74772
Homologene: 56940
Pdilt
Name: protein disulfide isomerase-like, testis expressed
Synonyms: 1700007B13Rik, PDILT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71830
Homologene: 18382
Sema3g
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218877
Homologene: 10602
Gm5084
Name: predicted gene 5084
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100503759
VEGA: 13
Olfr1411
Name: olfactory receptor 1411
Synonyms: MOR208-3, GA_x6K02T2R7CC-81157497-81156526
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258483
Homologene: 115530
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,147,663 bp
  • T to A, chromosome 1 at 92,597,314 bp
  • T to C, chromosome 2 at 60,354,550 bp
  • G to A, chromosome 3 at 28,895,725 bp
  • A to T, chromosome 4 at 41,393,954 bp
  • G to T, chromosome 4 at 107,846,561 bp
  • T to A, chromosome 4 at 113,156,486 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • C to T, chromosome 4 at 141,006,476 bp
  • C to T, chromosome 5 at 116,449,588 bp
  • T to A, chromosome 6 at 108,354,663 bp
  • A to G, chromosome 7 at 43,190,324 bp
  • A to G, chromosome 7 at 46,056,668 bp
  • A to G, chromosome 7 at 64,372,631 bp
  • A to T, chromosome 7 at 99,664,889 bp
  • C to T, chromosome 7 at 104,149,718 bp
  • G to A, chromosome 7 at 119,466,064 bp
  • A to C, chromosome 7 at 119,495,009 bp
  • A to G, chromosome 8 at 45,997,094 bp
  • T to C, chromosome 8 at 83,930,042 bp
  • T to C, chromosome 8 at 93,263,322 bp
  • C to A, chromosome 9 at 20,890,992 bp
  • T to C, chromosome 9 at 21,006,935 bp
  • T to C, chromosome 9 at 38,994,569 bp
  • T to C, chromosome 9 at 107,946,219 bp
  • C to T, chromosome 9 at 115,109,481 bp
  • T to C, chromosome 9 at 121,431,536 bp
  • A to T, chromosome 10 at 107,053,337 bp
  • G to A, chromosome 11 at 49,494,917 bp
  • G to A, chromosome 11 at 55,262,268 bp
  • C to T, chromosome 11 at 84,280,449 bp
  • T to A, chromosome 11 at 115,611,937 bp
  • A to G, chromosome 13 at 60,212,566 bp
  • G to A, chromosome 14 at 31,228,159 bp
  • A to G, chromosome 15 at 68,180,191 bp
  • T to A, chromosome 15 at 85,231,556 bp
  • T to C, chromosome 15 at 102,505,402 bp
  • C to A, chromosome 17 at 32,978,160 bp
  • A to C, chromosome 18 at 10,763,289 bp
  • T to A, chromosome 18 at 49,889,553 bp
  • T to C, chromosome 19 at 4,613,271 bp
  • A to T, chromosome 19 at 12,890,234 bp
  • A to G, chromosome 19 at 13,102,594 bp
  • A to G, chromosome 19 at 37,922,978 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4406 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041688-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.