Strain Name:
C57BL/6J-MtgxR4439Btlr/Mmmh
Stock Number:
041704-MU
Citation ID:
RRID:MMRRC_041704-MU
Other Names:
R4439 (G1), C57BL/6J-MtgxR4439Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: PC1, PC-1, polycystin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Eno2
Name: enolase 2, gamma neuronal
Synonyms: D6Ertd375e, Eno-2, NSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13807
HGNC: HGNC:3353
Homologene: 74414
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330286
Homologene: 19782
Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: TM7LN3, EGF-TM7, F4/80, DD7A5-7, Emr1, Ly71
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Pcf11
Name: PCF11 cleavage and polyadenylation factor subunit
Synonyms: 2500001H09Rik, 5730417B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74737
Homologene: 32282
Pias2
Name: protein inhibitor of activated STAT 2
Synonyms: PIASxalpha, PIASxb, Dib, ARIP3, PIASxbeta, Miz1, 6330408K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17344
VEGA: 18
Homologene: 20979
Plxnd1
Name: plexin D1
Synonyms: 6230425C21Rik, b2b553Clo, b2b1863Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67784
HGNC: HGNC:9107
Homologene: 22866
Kcnj1
Name: potassium inwardly-rectifying channel, subfamily J, member 1
Synonyms: ROMK, ROMK-2, Kir1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 56379
VEGA: 9
HGNC: HGNC:6255
Homologene: 56764
Mysm1
Name: myb-like, SWIRM and MPN domains 1
Synonyms: C530050H10Rik, C130067A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 320713
Homologene: 66204
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: 3110054G10Rik, D130023A07Rik, CAGH26, Tnrc6, 2010321I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233833
Homologene: 41399
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: Bwq1, LOC330474, Kiaa1064-hp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330474
Homologene: 87150
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108989
Homologene: 37753
Prss16
Name: protease, serine 16 (thymus)
Synonyms: TSSP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 54373
HGNC: HGNC:9480
Homologene: 38106
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Doc4, ELM2, l7Rn3, Odz4, Ten-m4, l(7)-3Rn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 23966
Homologene: 8034
Gad1
Name: glutamate decarboxylase 1
Synonyms: GAD67, GAD25, Z49976, EP10, Gad-1, GAD44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14415
HGNC: HGNC:4092
Homologene: 635
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 71175
VEGA: 15
Homologene: 15850
Vrk3
Name: vaccinia related kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101568
Homologene: 9509
Scfd2
Name: Sec1 family domain containing 2
Synonyms: E430013M20Rik, STXBP1L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 212986
Homologene: 77411
Elmsan1
Name: ELM2 and Myb/SANT-like domain containing 1
Synonyms: C130039O16Rik, 9430029N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238317
Homologene: 19330
Tespa1
Name: thymocyte expressed, positive selection associated 1
Synonyms: Itprid3, 5830405N20Rik, A430001F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67596
VEGA: 10
Homologene: 106645
Tns2
Name: tensin 2
Synonyms: nep, Tenc1, nph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 209039
VEGA: 15
Homologene: 37077
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Plpp4
Name: phospholipid phosphatase 4
Synonyms: Ppapdc1a, LOC381925, C030048B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381925
Homologene: 38751
Kif5c
Name: kinesin family member 5C
Synonyms: Khc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16574
HGNC: HGNC:6325
Homologene: 56234
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329278
Homologene: 18634
Olfr1285
Name: olfactory receptor 1285
Synonyms: MOR248-17P, GA_x6K02T2Q125-72459956-72460837, MOR248-25_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 545447
HGNC: null
Homologene: null
Grk3
Name: G protein-coupled receptor kinase 3
Synonyms: Adrbk2, Bark-2, beta ARK2, Adrbk-2, 4833444A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 320129
HGNC: HGNC:290
Homologene: 21072
Pla2g4b
Name: phospholipase A2, group IVB (cytosolic)
Synonyms: A030011C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 211429
HGNC: HGNC:9036
Homologene: 3730
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235441
Homologene: 4766
Kcnk4
Name: potassium channel, subfamily K, member 4
Synonyms: TRAAKt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 16528
VEGA: 19
HGNC: HGNC:6279
Homologene: 7391
Hist1h3b
Name: histone cluster 1, H3b
Synonyms: H3-53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 319150
HGNC: HGNC:4775
Homologene: 134491
Garem2
Name: GRB2 associated regulator of MAPK1 subtype 2
Synonyms: Fam59b, LOC242915, Gareml
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242915
Homologene: 19063
Vmn1r60
Name: vomeronasal 1 receptor 60
Synonyms: Gm7184
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 636697
HGNC: null
Homologene: 41799
Nkiras1
Name: NFKB inhibitor interacting Ras-like protein 1
Synonyms: 2400004O09Rik, KBRAS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 69721
Homologene: 10670
Fpgs
Name: folylpolyglutamyl synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14287
HGNC: HGNC:3824
Homologene: 6997
Zfp882
Name: zinc finger protein 882
Synonyms: ENSMUSG00000052439
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382019
HGNC: null
Homologene: 136303
Gm13084
Name: predicted gene 13084
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381569
HGNC: null
Homologene: 77858
Hint2
Name: histidine triad nucleotide binding protein 2
Synonyms: 1190005L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68917
Homologene: 13072
Tle2
Name: transducin-like enhancer of split 2
Synonyms: Grg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 21886
Homologene: 20693
Wdr86
Name: WD repeat domain 86
Synonyms: 2810046M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 269633
Homologene: 90112
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627367
HGNC: null
Homologene: 115024
Ipp
Name: IAP promoted placental gene
Synonyms: Mipp, D4Jhu8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16351
HGNC: HGNC:6108
Homologene: 4309
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: Grf2, 6330417G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Ugt2b34
Name: UDP glucuronosyltransferase 2 family, polypeptide B34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100727
Homologene: 117389
Cfap157
Name: cilia and flagella associated protein 157
Synonyms: 1700019L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227736
Homologene: 53056
Rd3l
Name: retinal degeneration 3-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217874
Homologene: 19151
Zfp607b
Name: zinc finger protein 607B
Synonyms: C030039L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 112415
Homologene: 134321
Fam78b
Name: family with sequence similarity 78, member B
Synonyms: C030014K22Rik, C030020L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226610
Homologene: 18451
Slco4a1
Name: solute carrier organic anion transporter family, member 4a1
Synonyms: Slc21a12, OATP-E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 108115
Homologene: 9482
Pjvk
Name: pejvakin
Synonyms: pejvakin, Dfnb59, LOC381375
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 381375
Homologene: 19773
RP24-257J5.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 150,403,961 bp
  • T to G, chromosome 1 at 160,116,080 bp
  • C to A, chromosome 1 at 167,078,922 bp
  • C to T, chromosome 2 at 32,687,501 bp
  • T to A, chromosome 2 at 32,777,865 bp
  • T to C, chromosome 2 at 49,688,725 bp
  • T to C, chromosome 2 at 70,572,860 bp
  • T to C, chromosome 2 at 76,651,406 bp
  • T to A, chromosome 2 at 111,409,308 bp
  • T to C, chromosome 2 at 120,039,258 bp
  • T to C, chromosome 2 at 180,472,662 bp
  • A to T, chromosome 3 at 5,214,815 bp
  • T to A, chromosome 4 at 43,654,919 bp
  • T to C, chromosome 4 at 94,965,212 bp
  • A to G, chromosome 4 at 116,515,077 bp
  • A to T, chromosome 4 at 143,811,573 bp
  • T to C, chromosome 5 at 24,730,237 bp
  • G to T, chromosome 5 at 30,113,346 bp
  • G to C, chromosome 5 at 74,397,707 bp
  • A to T, chromosome 5 at 86,892,867 bp
  • A to T, chromosome 5 at 112,946,677 bp
  • C to T, chromosome 5 at 114,246,496 bp
  • A to G, chromosome 6 at 38,194,761 bp
  • T to A, chromosome 6 at 115,993,976 bp
  • T to C, chromosome 6 at 124,762,959 bp
  • T to A, chromosome 7 at 5,544,489 bp
  • C to T, chromosome 7 at 16,429,111 bp
  • T to A, chromosome 7 at 27,702,724 bp
  • C to T, chromosome 7 at 44,775,442 bp
  • A to C, chromosome 7 at 92,658,017 bp
  • A to G, chromosome 7 at 96,895,815 bp
  • A to T, chromosome 7 at 123,152,182 bp
  • C to A, chromosome 7 at 129,257,089 bp
  • T to A, chromosome 8 at 71,913,609 bp
  • A to T, chromosome 9 at 32,394,118 bp
  • A to T, chromosome 9 at 66,518,494 bp
  • A to G, chromosome 10 at 81,581,682 bp
  • C to T, chromosome 10 at 130,361,957 bp
  • C to T, chromosome 12 at 84,156,471 bp
  • C to A, chromosome 12 at 111,979,658 bp
  • T to C, chromosome 13 at 22,009,405 bp
  • A to T, chromosome 13 at 23,752,725 bp
  • T to C, chromosome 13 at 91,983,678 bp
  • C to T, chromosome 14 at 18,276,784 bp
  • T to A, chromosome 15 at 8,338,724 bp
  • C to T, chromosome 15 at 102,108,934 bp
  • G to T, chromosome 17 at 18,930,354 bp
  • T to C, chromosome 17 at 24,585,692 bp
  • T to A, chromosome 17 at 57,447,954 bp
  • T to A, chromosome 18 at 77,097,703 bp
  • T to C, chromosome 19 at 6,932,761 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4439 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041704-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.