Strain Name:
C57BL/6J-MtgxR4466Btlr/Mmmh
Stock Number:
041723-MU
Citation ID:
RRID:MMRRC_041723-MU
Other Names:
R4466 (G1), C57BL/6J-MtgxR4466Btlr
Major Collection:

Gene Information

Sh3gl2
Name: SH3-domain GRB2-like 2
Synonyms: endophilin I, Sh3d2a, B930049H17Rik, 9530001L19Rik, endophilin A1, EEN-B1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 20404
Homologene: 20652
Arid4b
Name: AT rich interactive domain 4B (RBP1-like)
Synonyms: 6720480E17Rik, RBBP1L1, Rbp1l1, SAP180, 6330417L24Rik, BRCAA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 94246
Homologene: 12847
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Gpr21
Name: G protein-coupled receptor 21
Synonyms: C230004C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 338346
HGNC: HGNC:4476
Homologene: 74546
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Akap13
Name: A kinase (PRKA) anchor protein 13
Synonyms: 1700026G02Rik, 5830460E08Rik, 5730522G15Rik, AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Mrpl47
Name: mitochondrial ribosomal protein L47
Synonyms: CGI-204, 4833424P18Rik, NCM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74600
Homologene: 32475
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, D4Abb1e, 4833432B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100019
Homologene: 39689
Stag2
Name: stromal antigen 2
Synonyms: SAP2, SA-2, 9230105L23Rik, nuclear protein SA2, B230112I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 20843
Homologene: 38206
M6pr
Name: mannose-6-phosphate receptor, cation dependent
Synonyms: CD-MPR, Mpr46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 17113
HGNC: HGNC:6752
Homologene: 31086
Zik1
Name: zinc finger protein interacting with K protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22775
Homologene: 32076
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 195018
Homologene: 9027
Taf6
Name: TATA-box binding protein associated factor 6
Synonyms: Taf2e, 80kDa, p80
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21343
Homologene: 7561
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: 128kDa, D630020H17Rik, RPA116, RPA2, Rpo1-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20017
Homologene: 7133
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: Fabph1, Fabph-4, Fabph-1, Fabph4, Mdgi, H-FABP, Fabp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Sez6l2
Name: seizure related 6 homolog like 2
Synonyms: Psk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233878
Homologene: 8237
Crygb
Name: crystallin, gamma B
Synonyms: DGcry-3, Cryg-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12965
HGNC: HGNC:2409
Homologene: 3816
Sox8
Name: SRY (sex determining region Y)-box 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20681
Homologene: 7950
Eps15
Name: epidermal growth factor receptor pathway substrate 15
Synonyms: 2410112D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 13858
HGNC: HGNC:3419
Homologene: 128359
Mtfr2
Name: mitochondrial fission regulator 2
Synonyms: Fam54a, 2610016C23Rik, 4933412C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71804
VEGA: 10
Homologene: 69441
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: 5530401A10Rik, Jhdm1a, Fbl7, lalina, Gm4560, Fbxl11, Cxxc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 225876
Homologene: 56564
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, tf, Itpr-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Frmd4b
Name: FERM domain containing 4B
Synonyms: 6030440G05Rik, GRSP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232288
Homologene: 14916
Klhl6
Name: kelch-like 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239743
Homologene: 15603
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Fhad1
Name: forkhead-associated (FHA) phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329977
Homologene: 77947
Psma8
Name: proteasome (prosome, macropain) subunit, alpha type, 8
Synonyms: 2410072D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 73677
VEGA: 18
Homologene: 2086
Gm5134
Name: predicted gene 5134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 333669
HGNC: null
Homologene: 129891
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20192
Homologene: 68151
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18795
Homologene: 22876
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 76376
Homologene: 10669
Stk35
Name: serine/threonine kinase 35
Synonyms: 1700054C12Rik, CLIK1, CLP-36 interacting kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67333
Homologene: 15441
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: 2310014D11Rik, Sh3md1, Tks5, Fish
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 14218
VEGA: 19
Homologene: 7317
Serpina3g
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms: alpha-1 antiproteinase, alpha-1 antiproteinase,, Spi2A, 2A2, Spi2/eb.1, Spi2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20715
HGNC: HGNC:16
Homologene: 115927
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 214642
Homologene: 57014
Itgal
Name: integrin alpha L
Synonyms: Cd11a, LFA-1, Ly-21, Ly-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Mup6
Name: major urinary protein 6
Synonyms: Gm12544
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 620807
HGNC: null
Homologene: 74304
Olfr339
Name: olfactory receptor 339
Synonyms: MOR136-3, GA_x6K02T2NLDC-33116096-33117025
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258951
HGNC: null
Homologene: 133615
Apol7c
Name: apolipoprotein L 7c
Synonyms: 2210421G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 108956
VEGA: 15
HGNC: null
Homologene: 40940
Serpina3m
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3M
Synonyms: Spi2.4, contrapsin-like, MMSPi2.4, Spi2-rs1, antitrypsin, alpha-1 antiproteinase, Spi-2l, 3e46, MMCM7, Spi-2rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20717
HGNC: HGNC:16
Homologene: 111129
Oas2
Name: 2'-5' oligoadenylate synthetase 2
Synonyms: 2'-5' oligoadenylate synthetase-like 11, Oasl11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 246728
HGNC: HGNC:8087
Homologene: 49478
Amn1
Name: antagonist of mitotic exit network 1
Synonyms: C730024G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232566
Homologene: 45811
Olfr1489
Name: olfactory receptor 1489
Synonyms: GA_x6K02T2RE5P-3965668-3966609, MOR202-19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258628
HGNC: null
Homologene: 45021
Ano5
Name: anoctamin 5
Synonyms: Gdd1, Tmem16e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233246
Homologene: 100071
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: 2810433K04Rik, Pycs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Fam102b
Name: family with sequence similarity 102, member B
Synonyms: B430201A12Rik, 1600010D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329739
Homologene: 46568
Irx1
Name: Iroquois homeobox 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 16371
Homologene: 19065
Adgra1
Name: adhesion G protein-coupled receptor A1
Synonyms: 2900059M17Rik, Gpr123, D7Ertd680e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 52389
Homologene: 18582
Smyd2
Name: SET and MYND domain containing 2
Synonyms: 1110020E07Rik, KMT3C, Zmynd14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226830
Homologene: 32466
Olfr883
Name: olfactory receptor 883
Synonyms: MOR162-6, GA_x6K02T2PVTD-31705144-31706073
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258414
HGNC: null
Homologene: 86689
Tmem181a
Name: transmembrane protein 181A
Synonyms: Gpr178, Tmem181, 5930418K15Rik, C76977
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 77106
Homologene: 44787
Ten1
Name: TEN1 telomerase capping complex subunit
Synonyms: 2310004N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69535
Homologene: 28494
4930449A18Rik
Name: RIKEN cDNA 4930449A18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: null
HGNC: null
Homologene: null
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 65,080,486 bp
  • A to G, chromosome 1 at 189,882,152 bp
  • A to T, chromosome 2 at 36,422,296 bp
  • A to G, chromosome 2 at 37,517,558 bp
  • A to G, chromosome 2 at 76,713,700 bp
  • T to C, chromosome 2 at 112,653,102 bp
  • A to T, chromosome 2 at 129,123,882 bp
  • C to A, chromosome 2 at 129,801,516 bp
  • A to T, chromosome 2 at 135,260,537 bp
  • G to A, chromosome 3 at 32,730,091 bp
  • A to T, chromosome 3 at 59,838,466 bp
  • T to A, chromosome 3 at 108,979,808 bp
  • C to A, chromosome 4 at 32,751,354 bp
  • T to C, chromosome 4 at 60,004,000 bp
  • A to G, chromosome 4 at 85,381,451 bp
  • A to T, chromosome 4 at 87,227,862 bp
  • G to A, chromosome 4 at 109,366,530 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • A to T, chromosome 4 at 141,957,658 bp
  • A to G, chromosome 5 at 120,749,602 bp
  • A to C, chromosome 5 at 138,181,201 bp
  • A to T, chromosome 6 at 22,123,652 bp
  • A to G, chromosome 6 at 97,323,653 bp
  • A to G, chromosome 6 at 122,313,269 bp
  • T to C, chromosome 6 at 149,166,845 bp
  • G to T, chromosome 7 at 10,490,966 bp
  • T to A, chromosome 7 at 51,570,275 bp
  • T to A, chromosome 7 at 75,602,773 bp
  • T to A, chromosome 7 at 126,959,851 bp
  • C to T, chromosome 7 at 127,328,512 bp
  • T to A, chromosome 7 at 139,840,836 bp
  • T to A, chromosome 9 at 38,026,183 bp
  • C to A, chromosome 9 at 53,448,169 bp
  • A to G, chromosome 10 at 20,348,413 bp
  • G to C, chromosome 10 at 76,008,575 bp
  • T to A, chromosome 11 at 72,924,659 bp
  • A to C, chromosome 11 at 116,204,997 bp
  • C to T, chromosome 12 at 104,237,923 bp
  • A to T, chromosome 12 at 104,391,615 bp
  • A to T, chromosome 13 at 14,132,510 bp
  • C to A, chromosome 13 at 71,959,982 bp
  • T to C, chromosome 15 at 77,526,464 bp
  • T to C, chromosome 16 at 19,957,268 bp
  • T to A, chromosome 17 at 6,295,786 bp
  • C to A, chromosome 17 at 25,568,905 bp
  • T to C, chromosome 17 at 27,106,342 bp
  • C to T, chromosome 17 at 83,421,674 bp
  • T to C, chromosome 18 at 14,721,174 bp
  • A to T, chromosome 19 at 4,320,300 bp
  • G to A, chromosome 19 at 13,633,437 bp
  • G to A, chromosome 19 at 40,557,667 bp
  • A to G, chromosome 19 at 47,364,707 bp
  • A to G, chromosome X at 42,233,872 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4466 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041723-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.