Strain Name:
C57BL/6J-MtgxR4467Btlr/Mmmh
Stock Number:
041724-MU
Citation ID:
RRID:MMRRC_041724-MU
Other Names:
R4467 (G1), C57BL/6J-MtgxR4467Btlr
Major Collection:

Gene Information

Cds2
Name: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Synonyms: D2Wsu127e, 5730460C18Rik, 5730450N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110911
HGNC: HGNC:1801
Homologene: 37854
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd1, Edd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Bms1
Name: BMS1, ribosome biogenesis factor
Synonyms: Bms1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213895
Homologene: 7065
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cux, Cux-1, Cutl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Caprin1
Name: cell cycle associated protein 1
Synonyms: Gpiap1, MMGPIP137, caprin-1, RNG105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 53872
HGNC: HGNC:6743
Homologene: 4310
Dmtf1
Name: cyclin D binding myb-like transcription factor 1
Synonyms: Dmp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23857
Homologene: 8017
Stag2
Name: stromal antigen 2
Synonyms: SA-2, nuclear protein SA2, 9230105L23Rik, B230112I07Rik, SAP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 20843
Homologene: 38206
Ufl1
Name: UFM1 specific ligase 1
Synonyms: Maxer, Rcad, 1810074P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67490
Homologene: 9093
Stim2
Name: stromal interaction molecule 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 116873
Homologene: 32490
Brat1
Name: BRCA1-associated ATM activator 1
Synonyms: Baat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231841
Homologene: 16776
Fzd10
Name: frizzled class receptor 10
Synonyms: Fz-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 93897
HGNC: HGNC:4039
Homologene: 21411
Lamp5
Name: lysosomal-associated membrane protein family, member 5
Synonyms: 3110035N03Rik, 6330527O06Rik, BAD-LAMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76161
Homologene: 8173
Zfp980
Name: zinc finger protein 980
Synonyms: Gm13242
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041379
Homologene: 133076
Uty
Name: ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Synonyms: Hydb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22290
Klk12
Name: kallikrein related-peptidase 12
Synonyms: 2310008B01Rik, KLK-L5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69511
HGNC: HGNC:6360
Homologene: 44690
Pon2
Name: paraoxonase 2
Synonyms: 6330405I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330260
HGNC: HGNC:9205
Homologene: 385
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Piezo1, Fam38a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234839
Homologene: 124356
Atg4a-ps
Name: autophagy related 4A, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 102926
Elf3
Name: E74-like factor 3
Synonyms: ESX, ESE-1, jen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13710
HGNC: HGNC:3318
Homologene: 3265
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: Btbd12, D16Bwg1016e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 52864
Homologene: 23770
4930402H24Rik
Name: RIKEN cDNA 4930402H24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228602
Homologene: 12623
Prkce
Name: protein kinase C, epsilon
Synonyms: PKCepsilon, Pkce, PKC[e], 5830406C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18754
HGNC: HGNC:9401
Homologene: 48343
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: 4933431N12Rik, C76116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71310
Homologene: 57079
Chrnd
Name: cholinergic receptor, nicotinic, delta polypeptide
Synonyms: Achr-4, Acrd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11447
HGNC: HGNC:1965
Homologene: 37340
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241263
Homologene: 19381
Olfr786
Name: olfactory receptor 786
Synonyms: GA_x6K02T2PULF-11116958-11117896, MOR111-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258542
HGNC: HGNC:8355
Homologene: 133582
Cpa3
Name: carboxypeptidase A3, mast cell
Synonyms: MC-CPA, mast cell carboxypeptidase A, mMC-CPA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12873
HGNC: HGNC:2298
Homologene: 122138
Tctn2
Name: tectonic family member 2
Synonyms: 4432405B04Rik, Tect2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67978
Homologene: 11729
Slc2a7
Name: solute carrier family 2 (facilitated glucose transporter), member 7
Synonyms: OTTMUSG00000010396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 435818
Homologene: 72470
Has1
Name: hyaluronan synthase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15116
VEGA: 17
HGNC: HGNC:4818
Homologene: 1165
Stat6
Name: signal transducer and activator of transcription 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20852
Homologene: 2373
Hdac3
Name: histone deacetylase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 15183
HGNC: HGNC:4854
Homologene: 48250
F11
Name: coagulation factor XI
Synonyms: plasma thromboplastin antecedent, Cf11, 1600027G01Rik, FXI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
0610040J01Rik
Name: RIKEN cDNA 0610040J01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76261
Homologene: 49537
Fdps
Name: farnesyl diphosphate synthetase
Synonyms: 6030492I17Rik, Fdpsl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 110196
HGNC: HGNC:3631
Homologene: 1519
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: Pycs, 2810433K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Rsad1
Name: radical S-adenosyl methionine domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237926
Homologene: 41252
Ovgp1
Name: oviductal glycoprotein 1
Synonyms: oviductin, muc9, mucin 9, MOGP, Chit5, OGP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12659
HGNC: HGNC:8524
Homologene: 74442
Cylc2
Name: cylicin, basic protein of sperm head cytoskeleton 2
Synonyms: 4930488P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74914
HGNC: HGNC:2583
Homologene: 136270
Crlf1
Name: cytokine receptor-like factor 1
Synonyms: CLF-1, cytokine receptor like molecule 3, CRLM3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12931
HGNC: HGNC:2364
Homologene: 3489
Bag4
Name: BCL2-associated athanogene 4
Synonyms: 2410112I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67384
HGNC: HGNC:940
Homologene: 31270
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: System xc, 9930009M05Rik, sut, xCT, xc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26570
Homologene: 22684
Dtx2
Name: deltex 2, E3 ubiquitin ligase
Synonyms: 2610524D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74198
Homologene: 56904
Vmn1r54
Name: vomeronasal 1 receptor 54
Synonyms: V1ra9, VN7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113851
Pih1d1
Name: PIH1 domain containing 1
Synonyms: Nop17, 1110061L23Rik, 4933413A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68845
Homologene: 9914
Slc22a7
Name: solute carrier family 22 (organic anion transporter), member 7
Synonyms: OAT2, NLT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 108114
VEGA: 17
Homologene: 21328
Tmem181a
Name: transmembrane protein 181A
Synonyms: C76977, 5930418K15Rik, Gpr178, Tmem181
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77106
Homologene: 44787
Rps6kl1
Name: ribosomal protein S6 kinase-like 1
Synonyms: A830084F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238323
VEGA: 12
Homologene: 12874
Rab36
Name: RAB36, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76877
HGNC: HGNC:9775
Homologene: 3610
Gm9978
Name: predicted gene 9978
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Gm15543
Name: predicted gene 15543
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 105242817
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 87,197,377 bp
  • A to G, chromosome 1 at 135,256,844 bp
  • T to A, chromosome 2 at 21,826,999 bp
  • A to G, chromosome 2 at 103,779,419 bp
  • A to G, chromosome 2 at 130,767,647 bp
  • T to A, chromosome 2 at 132,294,446 bp
  • A to G, chromosome 2 at 136,059,020 bp
  • A to T, chromosome 3 at 20,228,817 bp
  • C to T, chromosome 3 at 50,435,416 bp
  • A to T, chromosome 3 at 89,100,786 bp
  • A to G, chromosome 3 at 103,645,855 bp
  • A to G, chromosome 3 at 105,977,711 bp
  • A to T, chromosome 4 at 25,254,806 bp
  • C to G, chromosome 4 at 51,229,651 bp
  • G to A, chromosome 4 at 145,702,083 bp
  • T to C, chromosome 4 at 150,163,274 bp
  • T to C, chromosome 5 at 9,136,085 bp
  • T to C, chromosome 5 at 54,116,194 bp
  • G to T, chromosome 5 at 63,898,839 bp
  • T to C, chromosome 5 at 124,620,189 bp
  • C to A, chromosome 5 at 128,601,276 bp
  • T to A, chromosome 5 at 136,012,076 bp
  • C to G, chromosome 5 at 136,312,722 bp
  • T to C, chromosome 5 at 140,705,071 bp
  • C to T, chromosome 6 at 5,267,021 bp
  • T to C, chromosome 6 at 90,269,271 bp
  • G to A, chromosome 6 at 118,383,847 bp
  • A to T, chromosome 6 at 145,183,218 bp
  • A to T, chromosome 7 at 43,773,383 bp
  • A to G, chromosome 7 at 45,158,497 bp
  • C to T, chromosome 8 at 25,769,488 bp
  • T to A, chromosome 8 at 45,241,474 bp
  • G to A, chromosome 8 at 70,500,956 bp
  • A to G, chromosome 8 at 83,210,478 bp
  • T to C, chromosome 8 at 122,486,396 bp
  • C to T, chromosome 10 at 75,052,043 bp
  • T to A, chromosome 10 at 78,486,916 bp
  • T to G, chromosome 10 at 127,651,228 bp
  • T to C, chromosome 10 at 129,437,064 bp
  • T to C, chromosome 11 at 94,544,530 bp
  • C to T, chromosome 12 at 85,147,808 bp
  • T to A, chromosome 15 at 38,004,336 bp
  • A to G, chromosome 16 at 3,989,055 bp
  • T to A, chromosome 17 at 6,295,786 bp
  • C to T, chromosome 17 at 17,843,995 bp
  • T to C, chromosome 17 at 46,432,510 bp
  • A to G, chromosome 17 at 86,619,911 bp
  • C to T, chromosome 18 at 37,952,513 bp
  • G to A, chromosome 19 at 40,557,667 bp
  • A to G, chromosome X at 42,233,872 bp
  • A to G, chromosome Y at 1,158,372 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4467 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041724-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.