Strain Name:
C57BL/6J-MtgxR4472Btlr/Mmmh
Stock Number:
041729-MU
Citation ID:
RRID:MMRRC_041729-MU
Other Names:
R4472 (G1), C57BL/6J-MtgxR4472Btlr
Major Collection:

Strain Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Cd28
Name: CD28 antigen
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12487
HGNC: HGNC:1653
Homologene: 4473
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Mtg2
Name: mitochondrial ribosome associated GTPase 2
Synonyms: 1810011P19Rik, D2Bwg0647e, 2900056P18Rik, Gtpbp5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 52856
Homologene: 9233
Morc3
Name: microrchidia 3
Synonyms: 1110051N18Rik, D16Jhu32e, 1110051N18Rik, Zcwcc3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 338467
Homologene: 32257
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF kappaB1, p50 subunit of NF kappaB, p50/p105, p50, nuclear factor kappaB p50, NF-kappaB, NF-kappaB p50
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Polk
Name: polymerase (DNA directed), kappa
Synonyms: Dinb1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27015
VEGA: 13
HGNC: HGNC:9183
Homologene: 32140
Fbrsl1
Name: fibrosin-like 1
Synonyms: LOC381668, 2410025L10Rik, Gm29766
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381668
Homologene: 45966
Rexo1
Name: REX1, RNA exonuclease 1
Synonyms: 1700021P10Rik, 2610511M11Rik, Tceb3bp1, Rex1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66932
Homologene: 41391
Wls
Name: wntless WNT ligand secretion mediator
Synonyms: 5031439A09Rik, Gpr177
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68151
Homologene: 11779
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: TAFII150, CIF150, TAF2B, 4732460C16Rik, 150kDa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Trim27
Name: tripartite motif-containing 27
Synonyms: Rfp
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19720
HGNC: HGNC:9975
Homologene: 111010
Atcay
Name: ataxia, cerebellar, Cayman type
Synonyms: 3322401A10Rik, BNIP-H, ji
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16467
HGNC: HGNC:779
Homologene: 13206
Adgrb2
Name: adhesion G protein-coupled receptor B2
Synonyms: Bai2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230775
HGNC: HGNC:944
Homologene: 1288
Lmbr1l
Name: limb region 1 like
Synonyms: 1110013E13Rik, D15Ertd735e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74775
Homologene: 10011
Adcy1
Name: adenylate cyclase 1
Synonyms: AC1, I-AC, D11Bwg1392e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432530
HGNC: HGNC:232
Homologene: 41419
Sv2a
Name: synaptic vesicle glycoprotein 2a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64051
Homologene: 32237
Syt17
Name: synaptotagmin XVII
Synonyms: Bk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110058
Homologene: 9553
Pcdh20
Name: protocadherin 20
Synonyms: PCDH13, C630015B17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219257
Homologene: 11277
Aph1c
Name: aph1 homolog C, gamma secretase subunit
Synonyms: 0610008A10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68318
Homologene: 134745
Nktr
Name: natural killer tumor recognition sequence
Synonyms: D9Wsu172e, 5330401F18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18087
HGNC: HGNC:7833
Homologene: 122148
Yme1l1
Name: YME1-like 1 (S. cerevisiae)
Synonyms: Ftsh, ATP-dependent metalloprotease FtsH1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27377
Homologene: 31996
Csnk1d
Name: casein kinase 1, delta
Synonyms: 1200006A05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104318
HGNC: HGNC:2452
Homologene: 74841
Oser1
Name: oxidative stress responsive serine rich 1
Synonyms: 3230401D17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66680
Homologene: 9521
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Plekhe1, Phlpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98432
Homologene: 11015
Dpy19l4
Name: dpy-19 like 4
Synonyms: LOC381510, Narg3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381510
Homologene: 18773
Prom2
Name: prominin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192212
Homologene: 44536
Fbxw9
Name: F-box and WD-40 domain protein 9
Synonyms: 1110017H11Rik, Fbw9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68628
Homologene: 23598
H2-K1
Name: histocompatibility 2, K1, K region
Synonyms: H-2K
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14972
Homologene: 128352
Eif3f
Name: eukaryotic translation initiation factor 3, subunit F
Synonyms: 0610037M02Rik, Eif3s5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66085
HGNC: HGNC:3275
Homologene: 2783
Tubgcp6
Name: tubulin, gamma complex component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328580
Homologene: 32477
Gm4884
Name: predicted gene 4884
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233164
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Dcaf11
Name: DDB1 and CUL4 associated factor 11
Synonyms: 0710008A13Rik, GLO14, D14Ucla1, Wdr23
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 28199
Homologene: 11886
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms: Centg1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216439
VEGA: 10
Homologene: 86815
Nrxn3
Name: neurexin III
Synonyms: neurexin III beta, neurexin III alpha, neurexin III beta, neurexin III alpha, 9330112C09Rik, D12Bwg0831e, 4933401A11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Atg2a
Name: autophagy related 2A
Synonyms: 1810013C15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329015
Homologene: 86985
Trbv15
Name: T cell receptor beta, variable 15
Synonyms: Gm16775, Tcrb-V12
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124679
Myo1a
Name: myosin IA
Synonyms: BBM-I, brush border myosin 1, Myhl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432516
VEGA: 10
HGNC: HGNC:7595
Homologene: 21113
Hps1
Name: HPS1, biogenesis of lysosomal organelles complex 3 subunit 1
Synonyms: 6030422N11Rik, Hermansky-Pudlak syndrome 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 192236
HGNC: HGNC:5163
Homologene: 163
Tmem9
Name: transmembrane protein 9
Synonyms: 1500015G18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66241
Homologene: 9515
Oas2
Name: 2'-5' oligoadenylate synthetase 2
Synonyms: 2'-5' oligoadenylate synthetase-like 11, Oasl11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246728
HGNC: HGNC:8087
Homologene: 49478
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104015
Homologene: 48252
Card14
Name: caspase recruitment domain family, member 14
Synonyms: CARMA2, Bimp2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170720
Homologene: 11469
Cntn5
Name: contactin 5
Synonyms: LOC244683, NB-2, A830025P08Rik, 6720426O10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244682
HGNC: HGNC:2175
Homologene: 28447
Adgrg6
Name: adhesion G protein-coupled receptor G6
Synonyms: LOC215798, 1190004A11Rik, DREG, Gpr126
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215798
Homologene: 10724
Rnf31
Name: ring finger protein 31
Synonyms: Paul, HOIP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268749
Homologene: 33228
Bbs12
Name: Bardet-Biedl syndrome 12
Synonyms: LOC241950, LOC241950, LOC386537
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241950
Homologene: 17634
Accsl
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)-like
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381411
Homologene: 86007
Mrgpra4
Name: MAS-related GPR, member A4
Synonyms: MrgA4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 235854
Homologene: 131159
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: SIP1, Zfx1b, 9130203F04Rik, D130016B08Rik, Zfhx1b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24136
Homologene: 8868
Nkain4
Name: Na+/K+ transporting ATPase interacting 4
Synonyms: C030019F02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58237
Homologene: 10978
Or8g37
Name: olfactory receptor family 8 subfamily G member 37
Synonyms: GA_x6K02T2PVTD-33517322-33518257, MOR171-16, Olfr970
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258604
VEGA: 9
Homologene: 121532
Man1b1
Name: mannosidase, alpha, class 1B, member 1
Synonyms: LOC227619, MANA-ER, E430019H13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227619
HGNC: HGNC:6823
Homologene: 5230
Vmn1r89
Name: vomeronasal 1 receptor 89
Synonyms: V1rj2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171260
Homologene: 74345
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269529
Homologene: 19544
Gpr150
Name: G protein-coupled receptor 150
Synonyms: PGR11, C030001A19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238725
Homologene: 18457
Pacsin3
Name: protein kinase C and casein kinase substrate in neurons 3
Synonyms: 4921507A02Rik, 6330413E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80708
HGNC: HGNC:8572
Homologene: 41117
Gm14295
Name: predicted gene 14295
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100039123
Homologene: 133105
Vmn2r30
Name: vomeronasal 2, receptor 30
Synonyms: V2r15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22306
Homologene: 113703
Spata3
Name: spermatogenesis associated 3
Synonyms: 4930424D10Rik, 1700011N12Rik, TSARG1, 1700029H01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70060
Homologene: 12517
Fam115a
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
1700001J11Rik
Name: RIKEN cDNA 1700001J11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72224
Trav4-4-dv10
Name: T cell receptor alpha variable 4-4-DV10
Synonyms: Gm13908
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100113414
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 60,763,234 bp
  • T to C, chromosome 1 at 86,026,430 bp
  • A to G, chromosome 1 at 90,822,014 bp
  • T to C, chromosome 1 at 105,648,220 bp
  • A to G, chromosome 1 at 106,386,446 bp
  • A to G, chromosome 1 at 136,027,496 bp
  • T to C, chromosome 2 at 23,186,332 bp
  • C to G, chromosome 2 at 25,332,855 bp
  • A to T, chromosome 2 at 45,023,011 bp
  • A to G, chromosome 2 at 91,262,943 bp
  • T to A, chromosome 2 at 93,863,991 bp
  • G to T, chromosome 2 at 93,863,992 bp
  • C to A, chromosome 2 at 127,540,191 bp
  • T to A, chromosome 2 at 163,415,580 bp
  • C to T, chromosome 2 at 163,415,581 bp
  • C to T, chromosome 2 at 176,809,593 bp
  • C to T, chromosome 2 at 180,082,154 bp
  • C to G, chromosome 2 at 180,954,622 bp
  • T to C, chromosome 3 at 37,319,220 bp
  • G to A, chromosome 3 at 96,192,494 bp
  • C to T, chromosome 3 at 135,615,420 bp
  • G to A, chromosome 3 at 159,897,383 bp
  • G to A, chromosome 4 at 11,304,053 bp
  • C to T, chromosome 4 at 45,043,693 bp
  • A to T, chromosome 4 at 123,395,989 bp
  • C to T, chromosome 4 at 130,008,353 bp
  • T to C, chromosome 5 at 77,281,180 bp
  • G to A, chromosome 5 at 110,379,066 bp
  • A to T, chromosome 5 at 120,741,155 bp
  • G to A, chromosome 6 at 41,141,559 bp
  • A to C, chromosome 6 at 42,679,314 bp
  • T to C, chromosome 7 at 7,317,092 bp
  • C to A, chromosome 7 at 13,219,872 bp
  • C to G, chromosome 7 at 41,043,263 bp
  • T to C, chromosome 7 at 47,981,791 bp
  • T to C, chromosome 7 at 108,940,946 bp
  • A to G, chromosome 7 at 118,436,817 bp
  • G to A, chromosome 8 at 85,060,200 bp
  • A to T, chromosome 9 at 10,048,771 bp
  • T to A, chromosome 9 at 39,820,574 bp
  • A to T, chromosome 9 at 40,050,698 bp
  • T to G, chromosome 9 at 66,827,769 bp
  • T to C, chromosome 9 at 121,748,896 bp
  • T to A, chromosome 10 at 14,436,781 bp
  • A to T, chromosome 10 at 80,542,658 bp
  • T to C, chromosome 10 at 81,212,527 bp
  • T to C, chromosome 10 at 127,091,213 bp
  • G to T, chromosome 10 at 127,710,458 bp
  • G to A, chromosome 11 at 7,130,369 bp
  • A to G, chromosome 11 at 119,333,958 bp
  • G to A, chromosome 11 at 120,964,974 bp
  • T to C, chromosome 12 at 90,204,741 bp
  • A to G, chromosome 13 at 21,189,886 bp
  • A to G, chromosome 13 at 76,056,154 bp
  • A to G, chromosome 13 at 96,493,905 bp
  • T to C, chromosome 14 at 53,683,730 bp
  • T to A, chromosome 14 at 55,565,606 bp
  • T to A, chromosome 14 at 55,603,320 bp
  • T to C, chromosome 14 at 88,468,998 bp
  • T to C, chromosome 15 at 55,058,880 bp
  • T to A, chromosome 15 at 89,103,654 bp
  • A to G, chromosome 15 at 98,906,297 bp
  • A to G, chromosome 16 at 90,969,181 bp
  • A to G, chromosome 16 at 93,874,757 bp
  • G to A, chromosome 17 at 33,999,524 bp
  • G to A, chromosome 19 at 6,258,955 bp
  • A to T, chromosome 19 at 42,762,496 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4472 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041729-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.