Strain Name:
C57BL/6J-MtgxR4480Btlr/Mmmh
Stock Number:
041737-MU
Citation ID:
RRID:MMRRC_041737-MU
Other Names:
R4480 (G1), C57BL/6J-MtgxR4480Btlr
Major Collection:

Strain Information

Ptprcap
Name: protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
Synonyms: LSM-1, CD-45-AP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19265
HGNC: HGNC:9667
Homologene: 48358
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Eif2s2
Name: eukaryotic translation initiation factor 2, subunit 2 (beta)
Synonyms: EIF2B, EIF2, 2810026E11Rik, 38kDa, D2Ertd303e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67204
HGNC: HGNC:3266
Homologene: 2904
Wdr73
Name: WD repeat domain 73
Synonyms: 1200011I23Rik, 2410008B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71968
Homologene: 41899
Katna1
Name: katanin p60 (ATPase-containing) subunit A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 23924
HGNC: HGNC:6216
Homologene: 56014
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239667
Homologene: 72227
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433804
Homologene: 133076
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209018
Homologene: 44592
Eif4g1
Name: eukaryotic translation initiation factor 4, gamma 1
Synonyms: E030015G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208643
HGNC: HGNC:3296
Homologene: 110725
Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Synonyms: Gapd, Gapd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14433
HGNC: HGNC:4141
Homologene: 107053
Ifne
Name: interferon epsilon
Synonyms: Ifnt1, Ifne1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230405
Homologene: 18534
Ptprs
Name: protein tyrosine phosphatase, receptor type, S
Synonyms: PTP-NU3, PTPsigma, RPTPsigma, Ptpt9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Rab35
Name: RAB35, member RAS oncogene family
Synonyms: RAB1C, H-ray, 9530019H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77407
HGNC: HGNC:9774
Homologene: 21361
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, D430038H04Rik, 9430076A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: A830096D10Rik, Bai3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244484
Homologene: 12460
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Pcdhb5
Name: protocadherin beta 5
Synonyms: Pcdhb4A, PcdhbE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93876
HGNC: HGNC:8689
Homologene: 75103
Abcc6
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Synonyms: DCC, Mrp6, Dyscalc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333315
Homologene: 35388
D130040H23Rik
Name: RIKEN cDNA D130040H23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 211135
Homologene: 138403
Or10g1
Name: olfactory receptor family 10 subfamily G member 1
Synonyms: GA_x6K02T2RJGY-583652-584608, MOR223-6, Olfr1510
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258423
HGNC: HGNC:8170
Homologene: 87788
Cdh15
Name: cadherin 15
Synonyms: Cdh14, Mcad, M cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70866
Homologene: 86643
Psg18
Name: pregnancy specific beta-1-glycoprotein 18
Synonyms: mmCGM6, Cea-3, Cea3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26438
HGNC: HGNC:1816
Homologene: 110989
Hkdc1
Name: hexokinase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216019
Homologene: 128937
Sostdc1
Name: sclerostin domain containing 1
Synonyms: Sostl, ectodin, USAG-1, Wise
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66042
VEGA: 12
Homologene: 9154
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269529
Homologene: 19544
Gm3159
Name: predicted gene 3159
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100041139
Homologene: 115686
Tmem179
Name: transmembrane protein 179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104885
VEGA: 12
Homologene: 16809
Fpr2
Name: formyl peptide receptor 2
Synonyms: E330010I07Rik, Fpr-rs2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14289
HGNC: HGNC:3827
Homologene: 74395
Or2t48
Name: olfactory receptor family 2 subfamily T member 48
Synonyms: GA_x6K02T2NKPP-895420-896349, MOR275-1, Olfr330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258879
Homologene: 133015
Gm14471
Name: predicted gene 14471
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
D10Bwg1379e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Gm28498
Name: predicted gene 28498
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 25,111,748 bp
  • T to A, chromosome 1 at 98,507,574 bp
  • T to A, chromosome 2 at 30,322,129 bp
  • T to C, chromosome 2 at 154,888,270 bp
  • T to C, chromosome 4 at 45,048,470 bp
  • T to C, chromosome 4 at 88,879,601 bp
  • A to G, chromosome 4 at 147,584,079 bp
  • C to A, chromosome 5 at 115,637,764 bp
  • A to G, chromosome 6 at 125,163,182 bp
  • T to C, chromosome 6 at 140,526,479 bp
  • C to T, chromosome 7 at 18,350,862 bp
  • T to C, chromosome 7 at 46,005,239 bp
  • T to C, chromosome 7 at 80,893,221 bp
  • T to A, chromosome 7 at 104,860,690 bp
  • A to G, chromosome 8 at 54,664,964 bp
  • C to A, chromosome 8 at 69,302,503 bp
  • A to T, chromosome 8 at 80,611,357 bp
  • A to G, chromosome 8 at 122,864,676 bp
  • G to A, chromosome 9 at 15,998,271 bp
  • A to G, chromosome 9 at 42,373,233 bp
  • T to C, chromosome 10 at 7,738,830 bp
  • A to T, chromosome 10 at 18,600,600 bp
  • T to C, chromosome 10 at 62,391,372 bp
  • T to C, chromosome 10 at 117,761,332 bp
  • G to T, chromosome 11 at 58,529,801 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • A to G, chromosome 12 at 36,317,166 bp
  • A to G, chromosome 12 at 109,034,123 bp
  • T to C, chromosome 12 at 112,503,303 bp
  • T to C, chromosome 14 at 4,398,584 bp
  • G to A, chromosome 14 at 52,410,308 bp
  • C to T, chromosome 15 at 100,186,301 bp
  • G to T, chromosome 16 at 20,678,843 bp
  • A to T, chromosome 16 at 21,545,236 bp
  • C to T, chromosome 17 at 17,893,753 bp
  • A to G, chromosome 17 at 56,426,404 bp
  • T to A, chromosome 18 at 37,320,752 bp
  • A to G, chromosome 19 at 4,156,224 bp
  • A to G, chromosome 19 at 21,815,489 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4480 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041737-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.