Strain Name:
C57BL/6J-MtgxR4488Btlr/Mmmh
Stock Number:
041744-MU
Citation ID:
RRID:MMRRC_041744-MU
Other Names:
R4488 (G1), C57BL/6J-MtgxR4488Btlr
Major Collection:

Gene Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: D230017O13Rik, 2610103K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 268281
Homologene: 6489
Vcp
Name: valosin containing protein
Synonyms: CDC48, p97/VCP, p97, AAA ATPase p97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 269523
Homologene: 5168
Ngf
Name: nerve growth factor
Synonyms: Ngfb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18049
HGNC: HGNC:7808
Homologene: 1876
Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66743
Homologene: 10036
Hcrtr1
Name: hypocretin (orexin) receptor 1
Synonyms: OX1R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230777
HGNC: HGNC:4848
Homologene: 37492
Cep41
Name: centrosomal protein 41
Synonyms: 2810431D15Rik, Tsga14, 1700017E11Rik, Cep41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 83922
Homologene: 10284
Vmp1
Name: vacuole membrane protein 1
Synonyms: Tango5, 3110098I04Rik, Tmem49, 4930579A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 75909
Homologene: 23686
Sulf1
Name: sulfatase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240725
Homologene: 49408
Kif1bp
Name: KIF1 binding protein
Synonyms: 2510003E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 72320
Homologene: 9223
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74355
Homologene: 23665
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: FSA, Tweek
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229227
Homologene: 52105
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: D630048A14Rik, Ki67, Ki-67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Dlx6
Name: distal-less homeobox 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13396
HGNC: HGNC:2919
Homologene: 87855
Alkal1
Name: ALK and LTK ligand 1
Synonyms: EG620393, Fam150a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 620393
Homologene: 82437
Tra2a
Name: transformer 2 alpha
Synonyms: 1500010G04Rik, G430041M01Rik, mAWMS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 101214
Homologene: 40866
Glb1
Name: galactosidase, beta 1
Synonyms: Bge, Bgl-t, Bgl-s, Bgl-e, Bgl, Bgt, Bgs, C130097A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12091
VEGA: 9
HGNC: HGNC:4298
Homologene: 47922
Rsrp1
Name: arginine/serine rich protein 1
Synonyms: D4Ucla2, D4Wsu53e, 2700043I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 27981
Homer3
Name: homer scaffolding protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 26558
Homologene: 37972
Zfp949
Name: zinc finger protein 949
Synonyms: 4930422I07Rik, Nczf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 71640
Homologene: 129930
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225115
Homologene: 25090
Rbm45
Name: RNA binding motif protein 45
Synonyms: Drbp1, G430095G15Rik, Drb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241490
Homologene: 15560
Edc4
Name: enhancer of mRNA decapping 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234699
Homologene: 40937
Tek
Name: TEK receptor tyrosine kinase
Synonyms: tie-2, Tie2, Cd202b, Hyk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21687
Homologene: 397
Grm6
Name: glutamate receptor, metabotropic 6
Synonyms: nerg1, mGluR6, nob3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 108072
HGNC: HGNC:4598
Homologene: 20232
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: AIB3, RAP250, PRIP, NRC, ASC2, ASC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56406
Homologene: 137337
Cryz
Name: crystallin, zeta
Synonyms: Sez9, quinone reductase, SEZ9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12972
HGNC: HGNC:2419
Homologene: 133907
Vmn2r25
Name: vomeronasal 2, receptor 25
Synonyms: EG545874
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 545874
Homologene: 135915
Rnf122
Name: ring finger protein 122
Synonyms: 1110063C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 68867
Homologene: 11717
Cyp26c1
Name: cytochrome P450, family 26, subfamily c, polypeptide 1
Synonyms: EG546726
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 546726
VEGA: 19
Homologene: 28089
Glp1r
Name: glucagon-like peptide 1 receptor
Synonyms: GLP-1R, GLP1Rc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14652
VEGA: 17
HGNC: HGNC:4324
Homologene: 1558
Tmem143
Name: transmembrane protein 143
Synonyms: 2310076O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 70209
Homologene: 10105
Zup1
Name: zinc finger containing ubiquitin peptidase 1
Synonyms: 2700019D07Rik, Zufsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 72580
VEGA: 10
Homologene: 12472
Zkscan16
Name: zinc finger with KRAB and SCAN domains 16
Synonyms: Zfp483
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100041581
Homologene: 26419
Ccdc85a
Name: coiled-coil domain containing 85A
Synonyms: E030025D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216613
Homologene: 65605
Hao2
Name: hydroxyacid oxidase 2
Synonyms: Hao3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56185
HGNC: HGNC:4810
Homologene: 97412
Brox
Name: BRO1 domain and CAAX motif containing
Synonyms: 0610010K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71678
Homologene: 13499
Olfr676
Name: olfactory receptor 676
Synonyms: MOR32-1, GA_x6K02T2PBJ9-7664016-7664969
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259099
Homologene: 64955
Rnaset2b
Name: ribonuclease T2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 68195
VEGA: 17
Homologene: 31190
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 6,359,407 bp
  • G to T, chromosome 1 at 12,786,515 bp
  • A to G, chromosome 1 at 183,280,950 bp
  • T to C, chromosome 2 at 76,376,396 bp
  • A to G, chromosome 2 at 155,407,476 bp
  • A to T, chromosome 3 at 37,003,933 bp
  • T to A, chromosome 3 at 98,882,025 bp
  • G to A, chromosome 3 at 102,520,699 bp
  • C to A, chromosome 3 at 154,618,457 bp
  • A to T, chromosome 4 at 42,993,826 bp
  • A to G, chromosome 4 at 58,957,431 bp
  • A to G, chromosome 4 at 94,849,756 bp
  • A to G, chromosome 4 at 117,489,814 bp
  • A to G, chromosome 4 at 130,135,763 bp
  • A to G, chromosome 4 at 134,924,463 bp
  • T to C, chromosome 6 at 6,867,207 bp
  • A to T, chromosome 6 at 30,655,689 bp
  • A to G, chromosome 6 at 49,252,494 bp
  • A to T, chromosome 6 at 123,822,860 bp
  • T to C, chromosome 7 at 45,909,394 bp
  • T to C, chromosome 7 at 105,035,303 bp
  • G to A, chromosome 7 at 135,697,671 bp
  • A to G, chromosome 8 at 31,128,255 bp
  • G to A, chromosome 8 at 70,290,143 bp
  • T to A, chromosome 8 at 105,876,427 bp
  • T to C, chromosome 9 at 88,570,089 bp
  • T to C, chromosome 9 at 114,443,114 bp
  • A to T, chromosome 10 at 11,160,471 bp
  • G to A, chromosome 10 at 33,948,964 bp
  • A to G, chromosome 10 at 62,563,027 bp
  • C to T, chromosome 11 at 28,576,686 bp
  • T to C, chromosome 11 at 50,859,989 bp
  • A to C, chromosome 11 at 86,585,314 bp
  • A to G, chromosome 17 at 6,998,070 bp
  • A to C, chromosome 17 at 30,918,931 bp
  • T to C, chromosome 17 at 71,407,235 bp
  • T to C, chromosome 18 at 5,049,067 bp
  • T to C, chromosome 19 at 37,693,210 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4488 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041744-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.