Strain Name:
C57BL/6J-MtgxR4508Btlr/Mmmh
Stock Number:
041757-MU
Citation ID:
RRID:MMRRC_041757-MU
Other Names:
R4508 (G1), C57BL/6J-MtgxR4508Btlr
Major Collection:

Strain Information

Kifc3
Name: kinesin family member C3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16582
HGNC: HGNC:6326
Homologene: 124421
Cnnm2
Name: cyclin M2
Synonyms: Acdp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 94219
VEGA: 19
HGNC: HGNC:103
Homologene: 9761
Lhx5
Name: LIM homeobox protein 5
Synonyms: Lim2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16873
Homologene: 40621
Kcnc1
Name: potassium voltage gated channel, Shaw-related subfamily, member 1
Synonyms: Kv3.1, KV4, NGK2, KShIIIB, Kcr2-1, Shaw, C230009H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16502
HGNC: HGNC:6233
Homologene: 68134
Gldc
Name: glycine decarboxylase
Synonyms: D19Wsu57e, D030049L12Rik, b2b2679Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Ddc
Name: dopa decarboxylase
Synonyms: aromatic L-amino acid decarboxylase, Aadc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13195
HGNC: HGNC:2719
Homologene: 618
Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75560
Homologene: 38779
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Lig3
Name: ligase III, DNA, ATP-dependent
Synonyms: D11Wsu78e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16882
HGNC: HGNC:6600
Homologene: 32109
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68964
Homologene: 11830
Sp1
Name: trans-acting transcription factor 1
Synonyms: Sp1-1, 1110003E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20683
Homologene: 8276
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Tmprss6
Name: transmembrane serine protease 6
Synonyms: matriptase-2, 1300008A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71753
VEGA: 15
Homologene: 12408
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Ten-m2, D3Bwg1534e, 9330187F13Rik, 2610040L17Rik, Odz2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Gins1
Name: GINS complex subunit 1 (Psf1 homolog)
Synonyms: Psf1, 2810418N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69270
Homologene: 44516
Chrna2
Name: cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
Synonyms: Acra-2, Acra2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110902
HGNC: HGNC:1956
Homologene: 20193
Sp3
Name: trans-acting transcription factor 3
Synonyms: D130027J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20687
Homologene: 7952
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Lzts1
Name: leucine zipper, putative tumor suppressor 1
Synonyms: F37, FEZ1, PSD-Zip70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 211134
Homologene: 10873
Tmprss2
Name: transmembrane protease, serine 2
Synonyms: epitheliasin, D16Ertd61e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 50528
VEGA: 16
Homologene: 4136
Ank
Name: progressive ankylosis
Synonyms: D15Ertd221e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11732
Homologene: 10664
Doc2g
Name: double C2, gamma
Synonyms: D830013O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 60425
Homologene: 11036
Aldob
Name: aldolase B, fructose-bisphosphate
Synonyms: Aldo-2, Aldo2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230163
HGNC: HGNC:417
Homologene: 20060
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Ogfod2
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 2
Synonyms: 1300006G11Rik, 5730405M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66627
Homologene: 32588
Fbp2
Name: fructose bisphosphatase 2
Synonyms: FBPase muscle, Fbp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14120
VEGA: 13
HGNC: HGNC:3607
Homologene: 55784
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20663
Homologene: 38253
Or5h17
Name: olfactory receptor family 5 subfamily H member 17
Synonyms: GA_x54KRFPKG5P-55229158-55230087, MOR183-2, Olfr183
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258478
HGNC: HGNC:8346
Homologene: 27178
Rnh1
Name: ribonuclease/angiogenin inhibitor 1
Synonyms: RNH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 107702
Homologene: 2204
Ubqlnl
Name: ubiquilin-like
Synonyms: LOC244179, 4922504M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244179
Homologene: 17034
Irf6
Name: interferon regulatory factor 6
Synonyms: E230028I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54139
HGNC: HGNC:6121
Homologene: 4479
Klhl10
Name: kelch-like 10
Synonyms: 4921517C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66720
Homologene: 12018
Ccdc40
Name: coiled-coil domain containing 40
Synonyms: B930008I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207607
Homologene: 27890
Amer3
Name: APC membrane recruitment 3
Synonyms: Fam123c, 9430069J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211383
Homologene: 51888
Ptpre
Name: protein tyrosine phosphatase, receptor type, E
Synonyms: PTPe, PTPepsilon, RPTPepsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19267
HGNC: HGNC:9669
Homologene: 31387
Lilra6
Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms: 7M1, Pira3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18726
HGNC: HGNC:6609
Homologene: 134028
BB014433
Name: expressed sequence BB014433
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 434285
Garin1b
Name: golgi associated RAB2 interactor 1B
Synonyms: LOC330277, Fam71f1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330277
Homologene: 13077
Get1
Name: guided entry of tail-anchored proteins factor 1
Synonyms: C030018G21Rik, Chd5, 5530402J05Rik, Wrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71446
Homologene: 37945
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228482
Homologene: 8862
Epdr1
Name: ependymin related protein 1 (zebrafish)
Synonyms: MERP-1, MERP2, Ucc1, MERP-2, Epdr1, Epdr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105298
VEGA: 13
Homologene: 9714
Scly
Name: selenocysteine lyase
Synonyms: Selenocysteine reductase, Scly2, Scly1, SCL, A930015N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 50880
Homologene: 9548
Tmem38a
Name: transmembrane protein 38A
Synonyms: 1110001E17Rik, TRIC-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74166
Homologene: 11449
Or4f56
Name: olfactory receptor family 4 subfamily F member 56
Synonyms: GA_x6K02T2Q125-72930843-72929905, MOR245-8, Olfr1305
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258396
Homologene: 74056
Nlrp5-ps
Name: NLR family, pyrin domain containing 5, pseudogene
Synonyms: Gm18756
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100417675
Gm13449
Name: predicted gene 13449
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 118568511
Clec2f
Name: C-type lectin domain family 2, member f
Synonyms: Clrc, Clrz, Clec2f-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 435921
Homologene: 136171
Mrap
Name: melanocortin 2 receptor accessory protein
Synonyms: C21ORF61, 1110025G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77037
HGNC: HGNC:1304
Homologene: 12669
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,588,299 bp
  • G to A, chromosome 1 at 91,308,325 bp
  • G to A, chromosome 1 at 193,168,605 bp
  • A to C, chromosome 2 at 35,013,065 bp
  • A to T, chromosome 2 at 72,970,397 bp
  • A to T, chromosome 2 at 76,750,340 bp
  • A to C, chromosome 2 at 111,873,602 bp
  • T to A, chromosome 2 at 113,842,042 bp
  • A to G, chromosome 2 at 150,904,355 bp
  • A to G, chromosome 4 at 49,538,182 bp
  • T to C, chromosome 5 at 110,703,615 bp
  • T to C, chromosome 5 at 120,435,434 bp
  • C to T, chromosome 5 at 124,113,254 bp
  • T to C, chromosome 6 at 29,323,765 bp
  • C to A, chromosome 6 at 129,020,511 bp
  • G to T, chromosome 7 at 3,912,029 bp
  • T to C, chromosome 7 at 14,562,159 bp
  • C to T, chromosome 7 at 46,428,288 bp
  • C to T, chromosome 7 at 104,149,718 bp
  • T to C, chromosome 7 at 135,669,103 bp
  • T to C, chromosome 7 at 141,164,543 bp
  • G to A, chromosome 7 at 141,640,089 bp
  • T to C, chromosome 8 at 15,042,095 bp
  • C to T, chromosome 8 at 69,135,618 bp
  • C to T, chromosome 8 at 72,572,161 bp
  • T to C, chromosome 8 at 95,107,420 bp
  • T to A, chromosome 8 at 110,519,254 bp
  • A to C, chromosome 10 at 69,892,370 bp
  • C to T, chromosome 11 at 11,819,393 bp
  • T to C, chromosome 11 at 36,008,345 bp
  • A to G, chromosome 11 at 69,016,117 bp
  • T to C, chromosome 11 at 69,742,559 bp
  • C to A, chromosome 11 at 82,790,591 bp
  • A to G, chromosome 11 at 100,442,176 bp
  • C to A, chromosome 11 at 119,242,509 bp
  • A to T, chromosome 12 at 69,635,661 bp
  • T to C, chromosome 13 at 19,594,489 bp
  • A to T, chromosome 13 at 62,841,865 bp
  • C to A, chromosome 14 at 66,146,453 bp
  • C to T, chromosome 15 at 27,564,977 bp
  • A to G, chromosome 15 at 35,709,673 bp
  • A to T, chromosome 15 at 78,459,778 bp
  • A to C, chromosome 15 at 102,409,312 bp
  • T to A, chromosome 16 at 58,999,775 bp
  • T to C, chromosome 16 at 90,738,562 bp
  • T to A, chromosome 16 at 96,145,699 bp
  • C to A, chromosome 16 at 97,570,427 bp
  • G to A, chromosome 19 at 4,004,036 bp
  • G to T, chromosome 19 at 30,143,407 bp
  • G to A, chromosome 19 at 46,877,270 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4508 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041757-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.