Strain Name:
C57BL/6J-MtgxR4562Btlr/Mmmh
Stock Number:
041787-MU
Citation ID:
RRID:MMRRC_041787-MU
Other Names:
R4562 (G1), C57BL/6J-MtgxR4562Btlr
Major Collection:

Gene Information

Pax2
Name: paired box 2
Synonyms: Pax-2, Opdc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18504
HGNC: HGNC:8616
Homologene: 2968
Orc1
Name: origin recognition complex, subunit 1
Synonyms: MmORC1, Orc1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
P4htm
Name: prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Synonyms: 4933406E20Rik, P4h-tm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74443
Homologene: 41765
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Tasor
Name: transcription activation suppressor
Synonyms: 4933409E02Rik, D14Abb1e, MommeD6, Fam208a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Huwe1
Name: HECT, UBA and WWE domain containing 1
Synonyms: Ib772, 5430439H10Rik, LOC382250, Ureb1, C430014N20Rik, Arf-bp1, Mule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 59026
Homologene: 45994
Erap1
Name: endoplasmic reticulum aminopeptidase 1
Synonyms: PILSAP, ERAAP, Arts1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 80898
VEGA: 13
Homologene: 56754
Lypd8
Name: LY6/PLAUR domain containing 8
Synonyms: 2210415F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70163
Homologene: 52815
Tln1
Name: talin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21894
Homologene: 21267
Esco1
Name: establishment of sister chromatid cohesion N-acetyltransferase 1
Synonyms: A930014I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 77805
Homologene: 62166
Ttc13
Name: tetratricopeptide repeat domain 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234875
Homologene: 11569
Trerf1
Name: transcriptional regulating factor 1
Synonyms: Trep132, Trep-132, 9430096I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224829
Homologene: 14129
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74144
Homologene: 10397
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: FIC1, Ic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Mef2b
Name: myocyte enhancer factor 2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17259
HGNC: HGNC:6995
Homologene: 48381
Plekhh2
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213556
VEGA: 17
Homologene: 35317
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: Mlsn1, 4732499L03Rik, melastatin, LTRPC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Olfr980
Name: olfactory receptor 980
Synonyms: GA_x6K02T2PVTD-33705428-33704496, MOR223-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259110
VEGA: 9
Homologene: 81557
Kdm7a
Name: lysine (K)-specific demethylase 7A
Synonyms: A630082K20Rik, ENSMUSG00000073143, Kdm7a, Jhdm1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 338523
Homologene: 25281
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Wdr31
Name: WD repeat domain 31
Synonyms: 5430402I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71354
Homologene: 11360
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-2, Aox-1, Aox2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: MJAM, OATP-D, 5830414C08Rik, Anr1, Slc21a11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108116
Homologene: 40862
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Zfp947
Name: zinc finger protein 947
Synonyms: Gm4769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210853
Homologene: 133253
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Tm6sf1
Name: transmembrane 6 superfamily member 1
Synonyms: C630016D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 107769
Homologene: 11305
Acad9
Name: acyl-Coenzyme A dehydrogenase family, member 9
Synonyms: NPD002, 2600017P15Rik, C630012L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229211
Homologene: 8539
Acap1
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms: Centb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216859
Homologene: 22835
Kcna5
Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms: Kv1.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16493
HGNC: HGNC:6224
Homologene: 1683
Mfsd2b
Name: major facilitator superfamily domain containing 2B
Synonyms: Gm1964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 432628
Homologene: 47753
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235441
Homologene: 4766
Asap2
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Synonyms: LOC385250, Ddef2, 6530401G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211914
HGNC: HGNC:2721
Homologene: 2888
Ift22
Name: intraflagellar transport 22
Synonyms: 3110017O03Rik, Rabl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67286
Homologene: 11253
Dffb
Name: DNA fragmentation factor, beta subunit
Synonyms: Didff, 40kDa, 5730477D02Rik, DFF40, CPAN, caspase-activated DNase, CAD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13368
HGNC: HGNC:2773
Homologene: 3241
Bace2
Name: beta-site APP-cleaving enzyme 2
Synonyms: 1110059C24Rik, CEAP1, CDA13, ASP21, ALP56, BAE2, ARP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 56175
VEGA: 16
HGNC: HGNC:934
Homologene: 22696
Ivl
Name: involucrin
Synonyms: 1110019C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16447
HGNC: HGNC:6187
Homologene: 137207
Mtmr10
Name: myotubularin related protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233315
Homologene: 9822
Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Synonyms: RANKL, OPGL, ODF, Ly109l, Trance, osteoclast differentiation factor, OPGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21943
VEGA: 14
Homologene: 2744
Olfr309
Name: olfactory receptor 309
Synonyms: GA_x6K02T2NHDJ-9801340-9802266, MOR251-4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258196
Homologene: 47595
Lrrc71
Name: leucine rich repeat containing 71
Synonyms: 4933430H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74485
Homologene: 83646
Pde6b
Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Synonyms: r, Pdeb, rd, rd10, rd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18587
HGNC: HGNC:8786
Homologene: 237
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320709
VEGA: 15
Homologene: 12992
Vmn2r-ps158
Name: vomeronasal 2, receptor, pseudogene 158
Synonyms: Gm9268, Vmn2r126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668612
Homologene: 104832
Arhgap8
Name: Rho GTPase activating protein 8
Synonyms: 3110043J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73167
Homologene: 23645
Olfr1289
Name: olfactory receptor 1289
Synonyms: GA_x6K02T2Q125-72534883-72535821, MOR245-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258399
HGNC: HGNC:8301
Tnfrsf22
Name: tumor necrosis factor receptor superfamily, member 22
Synonyms: Tnfrh2, 2810028K06Rik, SOBa, mDcTrailr2, C130035G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 79202
Homologene: 84848
Slc4a1ap
Name: solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms: kanadaptin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20534
Homologene: 7543
Gm10797
Name: predicted gene 10797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Defa24
Name: defensin, alpha, 24
Synonyms: Defcr24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 503491
Homologene: 113382
Gm10822
Name: predicted gene 10822
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
VEGA: 2
Klf14
Name: Kruppel-like factor 14
Synonyms: BTEB5, 5330411L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 619665
Homologene: 76469
Ighv3-5
Name: immunoglobulin heavy variable 3-5
Synonyms: Gm7112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 633457
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,059,056 bp
  • C to T, chromosome 2 at 73,899,489 bp
  • A to T, chromosome 2 at 111,483,564 bp
  • G to A, chromosome 3 at 36,066,182 bp
  • T to A, chromosome 3 at 87,745,408 bp
  • CCTGCTGCTGCT to CCTGCTGCTGCTGCT, chromosome 3 at 92,571,955 bp
  • C to A, chromosome 4 at 43,533,598 bp
  • A to C, chromosome 4 at 62,453,922 bp
  • T to C, chromosome 4 at 108,602,055 bp
  • A to G, chromosome 4 at 153,965,456 bp
  • G to A, chromosome 5 at 31,058,133 bp
  • G to A, chromosome 5 at 31,532,029 bp
  • A to G, chromosome 5 at 108,403,368 bp
  • A to G, chromosome 5 at 136,912,870 bp
  • G to A, chromosome 6 at 30,958,459 bp
  • C to T, chromosome 6 at 39,152,823 bp
  • T to C, chromosome 6 at 126,534,340 bp
  • C to A, chromosome 7 at 29,074,580 bp
  • C to T, chromosome 7 at 43,023,562 bp
  • C to G, chromosome 7 at 64,208,304 bp
  • C to T, chromosome 7 at 64,314,159 bp
  • G to A, chromosome 7 at 74,504,256 bp
  • T to A, chromosome 7 at 81,308,820 bp
  • G to A, chromosome 7 at 81,859,461 bp
  • A to G, chromosome 7 at 86,307,152 bp
  • C to T, chromosome 7 at 143,649,576 bp
  • A to G, chromosome 8 at 21,734,507 bp
  • G to A, chromosome 8 at 70,167,268 bp
  • A to G, chromosome 8 at 124,675,277 bp
  • CGG to CG, chromosome 9 at 37,411,490 bp
  • A to G, chromosome 9 at 40,006,281 bp
  • G to T, chromosome 9 at 66,520,765 bp
  • T to C, chromosome 9 at 108,581,996 bp
  • A to G, chromosome 10 at 67,572,685 bp
  • T to A, chromosome 11 at 58,382,389 bp
  • C to T, chromosome 11 at 69,885,351 bp
  • G to A, chromosome 11 at 116,233,399 bp
  • C to T, chromosome 12 at 4,867,619 bp
  • A to G, chromosome 12 at 21,112,093 bp
  • C to T, chromosome 12 at 102,991,461 bp
  • T to A, chromosome 12 at 114,262,878 bp
  • T to C, chromosome 13 at 74,673,659 bp
  • A to G, chromosome 14 at 27,466,308 bp
  • T to C, chromosome 14 at 78,278,580 bp
  • T to C, chromosome 15 at 47,899,844 bp
  • A to C, chromosome 15 at 84,741,913 bp
  • A to T, chromosome 15 at 95,094,796 bp
  • G to A, chromosome 16 at 97,421,980 bp
  • G to T, chromosome 17 at 22,146,143 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • G to A, chromosome 17 at 47,327,071 bp
  • A to G, chromosome 17 at 84,566,097 bp
  • A to G, chromosome 18 at 10,595,074 bp
  • A to T, chromosome 18 at 64,556,891 bp
  • A to G, chromosome 19 at 44,835,963 bp
  • A to T, chromosome X at 151,863,959 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4562 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041787-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.