Strain Name:
C57BL/6J-MtgxR4567Btlr/Mmmh
Stock Number:
041791-MU
Citation ID:
RRID:MMRRC_041791-MU
Other Names:
R4567 (G1), C57BL/6J-MtgxR4567Btlr
Major Collection:

Gene Information

Htr1d
Name: 5-hydroxytryptamine (serotonin) receptor 1D
Synonyms: Gpcr14, Htr1db
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15552
HGNC: HGNC:5289
Homologene: 20240
Uhmk1
Name: U2AF homology motif (UHM) kinase 1
Synonyms: KIS, Kist, OTTMUSG00000021542, C820018A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16589
Homologene: 7801
Xpo6
Name: exportin 6
Synonyms: Ranbp20, C230091E20Rik, 2610005L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74204
Homologene: 12544
Rtn1
Name: reticulon 1
Synonyms: Nsp, Rtn1-b, Rtn1-c, 0710005K15Rik, Rtn1-a, 4930441F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104001
Homologene: 49654
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: BRAG3, synarfGEF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243621
Homologene: 46091
Tjp1
Name: tight junction protein 1
Synonyms: ZO-1, ZO1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21872
Homologene: 2445
Syt17
Name: synaptotagmin XVII
Synonyms: Bk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 110058
Homologene: 9553
Erbb3
Name: erb-b2 receptor tyrosine kinase 3
Synonyms: Erbb-3, Erbb3r, HER3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13867
HGNC: HGNC:3431
Homologene: 20457
Smap2
Name: small ArfGAP 2
Synonyms: 1810031K02Rik, Smap2, Smap1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69780
Homologene: 41489
Alg12
Name: asparagine-linked glycosylation 12 (alpha-1,6-mannosyltransferase)
Synonyms: mannosyltransferase, ECM39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223774
Homologene: 36269
Slc9a4
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4
Synonyms: NHE4, D730009J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 110895
Homologene: 72232
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20679
Homologene: 22631
Ushbp1
Name: USH1 protein network component harmonin binding protein 1
Synonyms: MCC2, 2210404N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234395
Homologene: 12914
Ints11
Name: integrator complex subunit 11
Synonyms: 2410006F12Rik, Cpsf3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71957
Homologene: 9894
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
4931408C20Rik
Name: RIKEN cDNA 4931408C20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210940
Homologene: 86827
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Gm5155
Name: predicted gene 5155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381852
Homologene: 115938
Sik2
Name: salt inducible kinase 2
Synonyms: G630080D20Rik, Snf1lk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235344
Homologene: 22875
Olfr694
Name: olfactory receptor 694
Synonyms: GA_x6K02T2PBJ9-9067220-9066273, MOR283-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258444
Homologene: 79345
Acot11
Name: acyl-CoA thioesterase 11
Synonyms: BFIT1, 2010309H15Rik, Them1, 1110020M10Rik, Thea
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329910
Homologene: 11977
Gm1527
Name: predicted gene 1527
Synonyms: LOC385263
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 385263
Homologene: 133976
Rcn2
Name: reticulocalbin 2
Synonyms: taipoxin-associated calcium binding protein 49, TCBP-49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26611
HGNC: HGNC:9935
Homologene: 2176
Olfr141
Name: olfactory receptor 141
Synonyms: K17, GA_x6K02T2Q125-48299679-48298702, MOR179-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257913
Homologene: 28042
Olfr1371
Name: olfactory receptor 1371
Synonyms: GA_x6K02T2QP88-3214035-3214970, MOR256-58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276865
Pdzd3
Name: PDZ domain containing 3
Synonyms: sodium-phosphate cotransporter IIa C-terminal-associated protein 2, NaPi-Cap2, Pdzk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 170761
VEGA: 9
Homologene: 11719
Hsf2bp
Name: heat shock transcription factor 2 binding protein
Synonyms: 4932437G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74377
HGNC: HGNC:5226
Homologene: 38263
Abhd16a
Name: abhydrolase domain containing 16A
Synonyms: Bat5, NG26, D17H6S82E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 193742
Homologene: 10904
Slc25a42
Name: solute carrier family 25, member 42
Synonyms: 2900084M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73095
Homologene: 74852
Trim3
Name: tripartite motif-containing 3
Synonyms: BERP1, HAC1, Rnf22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 55992
Homologene: 21290
Phf11
Name: PHD finger protein 11
Synonyms: Phf11-ps, Gm6904
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 628693
VEGA: 14
Rasl2-9
Name: RAS-like, family 2, locus 9
Synonyms: Ran/M2, Rasl2-9-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19428
Homologene: 135303
Asmt
Name: acetylserotonin O-methyltransferase
Synonyms: Hiomt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 107626
VEGA: X
HGNC: HGNC:750
Prss23os
Name: protease, serine 23, opposite strand
Synonyms: 4930479H08Rik, 1700019G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108167445
Gm10718
Name: predicted gene 10718
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Gm12146
Name: predicted gene 12146
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 105244151
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 26,683,117 bp
  • T to C, chromosome 1 at 40,580,577 bp
  • G to A, chromosome 1 at 170,205,117 bp
  • A to G, chromosome 2 at 86,806,802 bp
  • A to T, chromosome 3 at 28,914,407 bp
  • C to T, chromosome 4 at 106,760,130 bp
  • A to C, chromosome 4 at 120,985,311 bp
  • T to A, chromosome 4 at 136,443,525 bp
  • T to C, chromosome 4 at 155,885,675 bp
  • A to G, chromosome 6 at 121,387,762 bp
  • AGG to A, chromosome 7 at 5,125,375 bp
  • T to C, chromosome 7 at 17,908,966 bp
  • A to G, chromosome 7 at 65,306,501 bp
  • T to A, chromosome 7 at 89,510,866 bp
  • C to T, chromosome 7 at 105,613,416 bp
  • G to A, chromosome 7 at 106,689,213 bp
  • T to C, chromosome 7 at 109,899,735 bp
  • T to C, chromosome 7 at 115,662,322 bp
  • A to G, chromosome 7 at 118,434,272 bp
  • G to T, chromosome 7 at 126,129,560 bp
  • A to T, chromosome 8 at 70,188,854 bp
  • G to A, chromosome 8 at 71,385,717 bp
  • A to T, chromosome 9 at 3,023,716 bp
  • C to A, chromosome 9 at 44,249,026 bp
  • A to G, chromosome 9 at 50,998,576 bp
  • A to T, chromosome 9 at 56,052,982 bp
  • G to A, chromosome 10 at 106,865,406 bp
  • A to G, chromosome 10 at 128,579,075 bp
  • T to C, chromosome 11 at 43,197,557 bp
  • T to C, chromosome 11 at 52,213,464 bp
  • C to T, chromosome 12 at 72,212,487 bp
  • A to T, chromosome 14 at 59,251,178 bp
  • T to C, chromosome 15 at 88,806,353 bp
  • C to T, chromosome 17 at 31,946,734 bp
  • T to A, chromosome 17 at 35,096,523 bp
  • A to G, chromosome X at 170,676,526 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4567 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041791-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.