Strain Name:
C57BL/6J-MtgxR4595Btlr/Mmmh
Stock Number:
041811-MU
Citation ID:
RRID:MMRRC_041811-MU
Other Names:
R4595 (G1), C57BL/6J-MtgxR4595Btlr
Major Collection:

Gene Information

Drd2
Name: dopamine receptor D2
Synonyms: D2R, Drd-2, D2 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13489
VEGA: 9
HGNC: HGNC:3023
Homologene: 22561
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: Cerp, PRCE, ESP1, separase, PRCE, SSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105988
VEGA: 15
Homologene: 32151
Ptch1
Name: patched 1
Synonyms: Ptc1, Patched 1, A230106A15Rik, wig, Ptc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Ccne2
Name: cyclin E2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12448
HGNC: HGNC:1590
Homologene: 7660
Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: p110beta, 1110001J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP2, C330012H03Rik, IMP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 319765
Homologene: 4774
Slc6a4
Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms: Sert, 5-HTT, Htt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15567
Homologene: 817
Brd4
Name: bromodomain containing 4
Synonyms: HUNK1, WI-11513, MCAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 57261
Homologene: 136213
Cenpp
Name: centromere protein P
Synonyms: 4921518G09Rik, 1700022C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 66336
VEGA: 13
Homologene: 23543
Chmp7
Name: charged multivesicular body protein 7
Synonyms: 6330407G04Rik, CHMP family, member 7, 4930596K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105513
VEGA: 14
Homologene: 14613
Dcaf13
Name: DDB1 and CUL4 associated factor 13
Synonyms: Wdsof1, LOC223499
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223499
Homologene: 6430
Dpp8
Name: dipeptidylpeptidase 8
Synonyms: 4932434F09Rik, 2310004I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74388
VEGA: 9
Homologene: 57098
Taf1b
Name: TATA-box binding protein associated factor, RNA polymerase I, B
Synonyms: mTAFI68, 4930408G01Rik, A230108M10Rik, p63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 21340
VEGA: 12
Homologene: 31331
Pebp1
Name: phosphatidylethanolamine binding protein 1
Synonyms: RKIP, Raf-1 inhibitor protein, Pbp1, Pebp1, Pbpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 23980
HGNC: HGNC:8630
Homologene: 37637
Aco1
Name: aconitase 1
Synonyms: Irp1, Irebp, Aco-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11428
HGNC: HGNC:117
Homologene: 1657
Micu3
Name: mitochondrial calcium uptake family, member 3
Synonyms: 2900075B16Rik, Efha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 78506
Homologene: 15058
Zbtb16
Name: zinc finger and BTB domain containing 16
Synonyms: Green's luxoid, Zfp145, PLZF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235320
VEGA: 9
Homologene: 21214
Tnc
Name: tenascin C
Synonyms: hexabrachion, Hxb, cytotactin, tenascin-C, C130033P17Rik, TN-C, TN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Glul
Name: glutamate-ammonia ligase (glutamine synthetase)
Synonyms: Glns, GS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14645
HGNC: HGNC:4341
Homologene: 37567
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Wcrf180, Acf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Copg2
Name: coatomer protein complex, subunit gamma 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 54160
HGNC: HGNC:2237
Homologene: 56292
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 76967
Homologene: 8839
Trp73
Name: transformation related protein 73
Synonyms: deltaNp73, TAp73, p73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22062
Homologene: 3960
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 212124
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, Nesp2g, nesprin-2, syne-2, dice, Cpfl8, 6820443O06Rik, diminished cone electroretinogram
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319565
Homologene: 56700
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20663
Homologene: 38253
Rab11fip1
Name: RAB11 family interacting protein 1 (class I)
Synonyms: 2010200K21Rik, 4833414G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 75767
Homologene: 11853
Nhsl1
Name: NHS-like 1
Synonyms: A630035H13Rik, 5730409E15Rik, D10Bwg0940e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215819
Homologene: 27834
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: LOC381522, E230008N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381522
Homologene: 117988
AU018091
Name: expressed sequence AU018091
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 245128
Homologene: 106376
Lipn
Name: lipase, family member N
Synonyms: Lipl4, 2210418G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 70166
Homologene: 66969
Gm14412
Name: predicted gene 14412
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 102640477
Homologene: 134324
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225638
Homologene: 50475
Pld2
Name: phospholipase D2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18806
HGNC: HGNC:9068
Homologene: 55672
Hipk3
Name: homeodomain interacting protein kinase 3
Synonyms: FIST3, DYRK6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 15259
HGNC: HGNC:4915
Homologene: 55923
Mfsd2b
Name: major facilitator superfamily domain containing 2B
Synonyms: Gm1964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 432628
Homologene: 47753
Tnfsf15
Name: tumor necrosis factor (ligand) superfamily, member 15
Synonyms: TL1, TL1A, VEGI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 326623
Homologene: 3755
Trim5
Name: tripartite motif-containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 667823
Homologene: 75345
Marveld1
Name: MARVEL (membrane-associating) domain containing 1
Synonyms: Mrvldc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 277010
Homologene: 12881
Stt3a
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
Synonyms: Itm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 16430
HGNC: HGNC:6172
Homologene: 40617
4921536K21Rik
Name: RIKEN cDNA 4921536K21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67430
Homologene: 12129
Hmbox1
Name: homeobox containing 1
Synonyms: F830020C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219150
Homologene: 11589
Zmynd19
Name: zinc finger, MYND domain containing 19
Synonyms: 2700064H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67187
Homologene: 12093
Pcdhb21
Name: protocadherin beta 21
Synonyms: PcdhbU, Pcdhb18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93892
HGNC: HGNC:8682
Homologene: 134302
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, Kv4.3, potassium channel Kv4.3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Acads
Name: acyl-Coenzyme A dehydrogenase, short chain
Synonyms: Hdlq8, Bcd-1, SCAD, Bcd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11409
HGNC: HGNC:90
Homologene: 20057
Lrwd1
Name: leucine-rich repeats and WD repeat domain containing 1
Synonyms: Orca, 1200011O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71735
Homologene: 17678
Olfr1307
Name: olfactory receptor 1307
Synonyms: GA_x6K02T2Q125-72988111-72987173, MOR245-19P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257956
Homologene: 128383
Olfr1234
Name: olfactory receptor 1234
Synonyms: GA_x6K02T2Q125-50805620-50804676, MOR231-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258975
Homologene: 128156
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240427
Homologene: 9192
Mmp7
Name: matrix metallopeptidase 7
Synonyms: MAT, matrilysin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17393
HGNC: HGNC:7174
Homologene: 37619
Rhoq
Name: ras homolog family member Q
Synonyms: TC10, Arhq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 104215
Homologene: 22704
Olfr622
Name: olfactory receptor 622
Synonyms: MOR26-1, GA_x6K02T2PBJ9-6362863-6361910
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259087
Homologene: 100540
Gm26996
Name: predicted gene, 26996
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
Gm21976
Name: predicted gene 21976
Synonyms: ENSMUSG00000071224, Gm8780
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 102637808
Tex35
Name: testis expressed 35
Synonyms: 1700057K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 73435
Homologene: 49980
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 153,903,050 bp
  • T to A, chromosome 1 at 157,099,339 bp
  • A to G, chromosome 2 at 24,958,988 bp
  • C to T, chromosome 2 at 89,363,325 bp
  • T to C, chromosome 2 at 91,167,664 bp
  • T to A, chromosome 2 at 104,441,277 bp
  • T to C, chromosome 2 at 111,944,652 bp
  • T to C, chromosome 2 at 177,315,212 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • A to G, chromosome 4 at 11,202,986 bp
  • T to A, chromosome 4 at 40,167,139 bp
  • A to G, chromosome 4 at 45,945,023 bp
  • G to T, chromosome 4 at 63,729,943 bp
  • T to C, chromosome 4 at 63,995,745 bp
  • A to T, chromosome 4 at 121,045,155 bp
  • A to G, chromosome 4 at 154,064,417 bp
  • A to T, chromosome 5 at 115,113,064 bp
  • G to T, chromosome 5 at 117,283,410 bp
  • A to G, chromosome 5 at 136,123,956 bp
  • T to C, chromosome 6 at 30,749,450 bp
  • T to C, chromosome 6 at 130,580,483 bp
  • A to G, chromosome 7 at 3,158,428 bp
  • A to G, chromosome 7 at 103,640,101 bp
  • C to A, chromosome 7 at 104,265,432 bp
  • T to A, chromosome 7 at 139,652,404 bp
  • A to T, chromosome 8 at 27,154,575 bp
  • T to C, chromosome 8 at 40,359,397 bp
  • T to C, chromosome 9 at 7,697,666 bp
  • T to C, chromosome 9 at 36,735,512 bp
  • C to T, chromosome 9 at 48,832,080 bp
  • T to A, chromosome 9 at 49,404,789 bp
  • A to G, chromosome 9 at 65,075,803 bp
  • A to G, chromosome 9 at 99,055,406 bp
  • T to A, chromosome 10 at 18,527,609 bp
  • A to G, chromosome 11 at 3,890,052 bp
  • A to G, chromosome 11 at 66,168,152 bp
  • T to C, chromosome 11 at 70,542,020 bp
  • A to G, chromosome 11 at 77,019,863 bp
  • T to C, chromosome 12 at 4,865,807 bp
  • T to A, chromosome 12 at 24,500,442 bp
  • A to T, chromosome 12 at 54,895,093 bp
  • T to C, chromosome 12 at 69,616,889 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • A to T, chromosome 12 at 75,967,071 bp
  • A to T, chromosome 13 at 49,641,234 bp
  • T to C, chromosome 13 at 63,543,608 bp
  • A to T, chromosome 13 at 98,305,810 bp
  • A to T, chromosome 14 at 64,896,898 bp
  • A to G, chromosome 14 at 69,721,229 bp
  • G to A, chromosome 15 at 39,118,893 bp
  • A to G, chromosome 15 at 102,298,724 bp
  • T to C, chromosome 16 at 22,076,086 bp
  • A to T, chromosome 17 at 32,198,922 bp
  • T to C, chromosome 17 at 86,964,326 bp
  • T to A, chromosome 18 at 37,514,515 bp
  • T to C, chromosome 18 at 65,289,748 bp
  • T to C, chromosome 18 at 78,857,516 bp
  • T to G, chromosome 19 at 34,081,350 bp
  • T to A, chromosome 19 at 42,147,764 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4595 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041811-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.