Strain Name:
C57BL/6J-MtgxR4617Btlr/Mmmh
Stock Number:
041828-MU
Citation ID:
RRID:MMRRC_041828-MU
Other Names:
R4617 (G1), C57BL/6J-MtgxR4617Btlr
Major Collection:

Strain Information

Slc6a5
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms: Glyt2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 104245
Homologene: 37901
Egf
Name: epidermal growth factor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13645
HGNC: HGNC:3229
Homologene: 1483
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Rnf10
Name: ring finger protein 10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50849
Homologene: 40990
Mfap4
Name: microfibrillar-associated protein 4
Synonyms: 1110007F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76293
HGNC: HGNC:7035
Homologene: 134529
Traip
Name: TRAF-interacting protein
Synonyms: Trip
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22036
Homologene: 31343
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: Hbp, 1200004O12Rik, 5730456G07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56324
Homologene: 68490
Rgs12
Name: regulator of G-protein signaling 12
Synonyms: 4632412M04Rik, 1200016K18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71729
HGNC: HGNC:9994
Homologene: 2195
Mtmr12
Name: myotubularin related protein 12
Synonyms: C730015A02Rik, Pip3ap
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268783
Homologene: 10403
Tmem199
Name: transmembrane protein 199
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195040
Homologene: 45125
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: mDot1, KMT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Exoc4
Name: exocyst complex component 4
Synonyms: Sec8, Sec8l1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20336
Homologene: 40654
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, Xox1, Xor, xanthine oxidase, XO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Cyfip2
Name: cytoplasmic FMR1 interacting protein 2
Synonyms: Pir121, 6430511D02Rik, 1500004I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76884
Homologene: 7936
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4930515K21Rik, 4933435G09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98403
Homologene: 9188
Cthrc1
Name: collagen triple helix repeat containing 1
Synonyms: 1110014B07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68588
Homologene: 16320
Flrt2
Name: fibronectin leucine rich transmembrane protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399558
HGNC: HGNC:3761
Homologene: 8291
Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
Synonyms: JNK-interacting protein 3, Jip3, JSAP1, JUN/SAPK-associated protein 1, JSAP1d, JSAP1c, JSAP1b, JSAP1a, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, sunday driver 2, Syd2, D17Wsu15e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 30957
HGNC: HGNC:6884
Homologene: 22790
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: 4930429G18Rik, C030002J06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78787
Homologene: 90902
Sec24b
Name: SEC24 homolog B, COPII coat complex component
Synonyms: SEC24
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99683
Homologene: 55968
Tbc1d32
Name: TBC1 domain family, member 32
Synonyms: Bromi, C6orf170, D630037F22Rik, b2b2284Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 544696
VEGA: 10
Homologene: 51889
Fam168b
Name: family with sequence similarity 168, member B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214469
Homologene: 18390
Mplkipl1
Name: M-phase specific PLK1 intereacting protein like 1
Synonyms: Gm7102
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 633057
Elfn1
Name: leucine rich repeat and fibronectin type III, extracellular 1
Synonyms: A930017N06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243312
Homologene: 18465
Zfp990
Name: zinc finger protein 990
Synonyms: Gm13225
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101056073
Fbxw7
Name: F-box and WD-40 domain protein 7
Synonyms: SEL-10, AGO, Fbxo30, Fbxw6, 1110001A17Rik, Cdc4, Fbw7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 50754
Homologene: 117451
Ogdhl
Name: oxoglutarate dehydrogenase-like
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239017
VEGA: 14
Homologene: 56801
Cpd
Name: carboxypeptidase D
Synonyms: D830034L15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12874
HGNC: HGNC:2301
Homologene: 999
Ptprn
Name: protein tyrosine phosphatase receptor type N
Synonyms: IA-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19275
HGNC: HGNC:9676
Homologene: 48142
Zfp352
Name: zinc finger protein 352
Synonyms: 2czf48
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 236537
Homologene: 45160
Ccdc150
Name: coiled-coil domain containing 150
Synonyms: 4930511H11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78016
Homologene: 15814
Trmt1l
Name: tRNA methyltransferase 1 like
Synonyms: Trm1-like, 1190005F20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98685
Homologene: 12801
Or13f5
Name: olfactory receptor family 13 subfamily F member 5
Synonyms: GA_x6K02T2N78B-7168533-7167574, MOR262-2, Olfr275
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258857
Homologene: 17418
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 435626
Homologene: 52359
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
4933427D14Rik
Name: RIKEN cDNA 4933427D14 gene
Synonyms: Gm43951
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74477
Homologene: 8874
Tll2
Name: tolloid-like 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24087
VEGA: 19
Homologene: 56545
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327963
Homologene: 88945
Pdzrn4
Name: PDZ domain containing RING finger 4
Synonyms: SAMCAP3L, LNX4, 1110017D07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239618
VEGA: 15
Homologene: 85433
Cdh26
Name: cadherin-like 26
Synonyms: LOC381409
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381409
Homologene: 18643
Brinp1
Name: bone morphogenic protein/retinoic acid inducible neural specific 1
Synonyms: Dbccr1, Fam5a, Dbc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56710
HGNC: HGNC:2687
Homologene: 8754
Vsig1
Name: V-set and immunoglobulin domain containing 1
Synonyms: 1700062D20Rik, 4930405J24Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 78789
Homologene: 12703
Marchf1
Name: membrane associated ring-CH-type finger 1
Synonyms: 2900024D24Rik, March1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72925
Homologene: 113749
Stambp
Name: STAM binding protein
Synonyms: 5330424L14Rik, 5730422L11Rik, Amsh
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70527
Homologene: 4719
Poglut2
Name: protein O-glucosyltransferase 2
Synonyms: EP58, 1810049A15Rik, 5730416C13Rik, Kdel1, Kdelc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72050
Homologene: 11367
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
Gm4846
Name: predicted gene 4846
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226601
Homologene: 136281
Flacc1
Name: flagellum associated containing coiled-coil domains 1
Synonyms: 4933405P16Rik, 4933425F06Rik, Als2cr12
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108812
Homologene: 51399
Mrpl38
Name: mitochondrial ribosomal protein L38
Synonyms: MRP-L3, Rpml3, 4733401F03Rik, 1110036N21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 60441
Homologene: 11476
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Acaa1a
Name: acetyl-Coenzyme A acyltransferase 1A
Synonyms: peroxisomal 3-ketoacyl-CoA thiolase, PTL, D9Ertd25e, Acaa1, thiolase A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 113868
HGNC: HGNC:82
Homologene: 37497
Fbxw20
Name: F-box and WD-40 domain protein 20
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434440
Homologene: 110776
Pkd2l1
Name: polycystic kidney disease 2-like 1
Synonyms: polycystin-L, Pkdl, PCL, TRPP3, PKD2L
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329064
HGNC: HGNC:9011
Homologene: 22946
Lpcat2b
Name: lysophosphatidylcholine acyltransferase 2B
Synonyms: 4921521K07Rik, Aytl1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70902
Homologene: 86793
Zdhhc19
Name: zinc finger, DHHC domain containing 19
Synonyms: LOC245308
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 245308
Homologene: 34922
Gpr20
Name: G protein-coupled receptor 20
Synonyms: A430106B11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239530
HGNC: HGNC:4475
Homologene: 3870
Akr1cl
Name: aldo-keto reductase family 1, member C-like
Synonyms: 4921521F21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70861
Homologene: 133861
Mup18
Name: major urinary protein 18
Synonyms: Gm12561
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100048884
Homologene: 74304
Pcdhga9
Name: protocadherin gamma subfamily A, 9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93717
HGNC: HGNC:8707
Homologene: 56827
Gm20422
Name: predicted gene 20422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Speer1j
Name: spermatogenesis associated glutamate (E)-rich protein 1J
Synonyms: Gm8906
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 101055944
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 33,802,671 bp
  • A to G, chromosome 1 at 34,819,982 bp
  • A to C, chromosome 1 at 44,110,020 bp
  • A to G, chromosome 1 at 54,355,754 bp
  • A to T, chromosome 1 at 58,661,442 bp
  • A to G, chromosome 1 at 65,021,391 bp
  • T to C, chromosome 1 at 71,330,334 bp
  • C to A, chromosome 1 at 71,346,660 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • T to A, chromosome 1 at 75,252,287 bp
  • C to T, chromosome 1 at 151,454,048 bp
  • A to G, chromosome 1 at 166,495,981 bp
  • A to T, chromosome 2 at 52,715,704 bp
  • G to A, chromosome 2 at 113,834,078 bp
  • G to A, chromosome 2 at 118,790,162 bp
  • A to G, chromosome 2 at 177,476,168 bp
  • G to A, chromosome 2 at 178,460,642 bp
  • G to A, chromosome 3 at 84,969,241 bp
  • A to T, chromosome 3 at 129,690,793 bp
  • A to T, chromosome 3 at 130,040,764 bp
  • A to T, chromosome 4 at 52,825,399 bp
  • T to A, chromosome 4 at 61,671,917 bp
  • A to G, chromosome 4 at 68,762,961 bp
  • A to G, chromosome 4 at 90,225,081 bp
  • A to G, chromosome 4 at 145,537,046 bp
  • T to C, chromosome 5 at 11,503,831 bp
  • T to A, chromosome 5 at 35,020,356 bp
  • T to C, chromosome 5 at 107,433,999 bp
  • T to A, chromosome 5 at 115,248,703 bp
  • A to G, chromosome 5 at 139,972,009 bp
  • C to T, chromosome 6 at 33,862,204 bp
  • G to A, chromosome 6 at 83,561,978 bp
  • A to G, chromosome 7 at 49,912,020 bp
  • A to G, chromosome 8 at 66,418,834 bp
  • A to T, chromosome 8 at 69,743,294 bp
  • T to A, chromosome 9 at 107,970,019 bp
  • C to T, chromosome 9 at 109,217,563 bp
  • T to A, chromosome 9 at 119,348,940 bp
  • A to G, chromosome 10 at 56,170,904 bp
  • T to C, chromosome 10 at 80,785,084 bp
  • A to G, chromosome 11 at 46,254,018 bp
  • C to A, chromosome 11 at 61,485,509 bp
  • C to T, chromosome 11 at 72,198,370 bp
  • A to G, chromosome 11 at 74,071,737 bp
  • A to G, chromosome 11 at 76,840,615 bp
  • A to T, chromosome 11 at 78,509,682 bp
  • T to C, chromosome 11 at 116,132,452 bp
  • T to C, chromosome 12 at 95,780,229 bp
  • C to A, chromosome 14 at 20,550,338 bp
  • A to G, chromosome 14 at 32,325,885 bp
  • A to G, chromosome 15 at 12,270,046 bp
  • A to G, chromosome 15 at 39,086,764 bp
  • T to C, chromosome 15 at 73,695,736 bp
  • A to G, chromosome 15 at 92,769,842 bp
  • A to G, chromosome 16 at 32,497,676 bp
  • G to A, chromosome 17 at 24,904,787 bp
  • G to A, chromosome 17 at 73,918,394 bp
  • T to C, chromosome 18 at 37,738,500 bp
  • C to A, chromosome 18 at 38,197,860 bp
  • T to C, chromosome 19 at 41,098,636 bp
  • C to A, chromosome 19 at 44,154,134 bp
  • C to T, chromosome 19 at 61,175,926 bp
  • G to T, chromosome X at 140,926,386 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4617 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041828-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.