Strain Name:
C57BL/6J-MtgxR4638Btlr/Mmmh
Stock Number:
041900-MU
Citation ID:
RRID:MMRRC_041900-MU
Other Names:
R4638 (G1), C57BL/6J-MtgxR4638Btlr
Major Collection:

Gene Information

Park7
Name: Parkinson disease (autosomal recessive, early onset) 7
Synonyms: DJ-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 57320
Homologene: 38295
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Slc12a8
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 171286
Homologene: 11628
Nek7
Name: NIMA (never in mitosis gene a)-related expressed kinase 7
Synonyms: 2810460C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 59125
Homologene: 69340
Camk1g
Name: calcium/calmodulin-dependent protein kinase I gamma
Synonyms: CaMKIgamma, CLICK-III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 215303
Homologene: 48706
Coro7
Name: coronin 7
Synonyms: 0610011B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 78885
Homologene: 11573
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: 5430435M13Rik, C130002K18Rik, 2610207I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233789
Homologene: 56697
Abcg8
Name: ATP binding cassette subfamily G member 8
Synonyms: 1300003C16Rik, Sterolin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 67470
Homologene: 23361
Cebpa
Name: CCAAT/enhancer binding protein (C/EBP), alpha
Synonyms: Cebp, C/EBP alpha, C/ebpalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12606
HGNC: HGNC:1833
Homologene: 3211
Naa16
Name: N(alpha)-acetyltransferase 16, NatA auxiliary subunit
Synonyms: Narg1l, 1300019C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 66897
Homologene: 134838
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232491
Homologene: 11758
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Sp2
Name: Sp2 transcription factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78912
Homologene: 2340
Sympk
Name: symplekin
Synonyms: 1500016F02Rik, 4632415H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68188
Homologene: 37969
Lnpep
Name: leucyl/cystinyl aminopeptidase
Synonyms: 2010309L07Rik, 4732490P18Rik, IRAP, vp165, gp160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240028
VEGA: 17
HGNC: HGNC:6656
Homologene: 21148
Pgap1
Name: post-GPI attachment to proteins 1
Synonyms: PGAP1, oto, 9030223K07Rik, 5033403E17Rik, D230012E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241062
Homologene: 41605
Tmem81
Name: transmembrane protein 81
Synonyms: 4930429O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74626
Homologene: 12579
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: Cngb1, Cngb1b, BC016201
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Ano4
Name: anoctamin 4
Synonyms: A330096O15Rik, Tmem16d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 320091
Homologene: 66599
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 26875
Homologene: 69111
Srp72
Name: signal recognition particle 72
Synonyms: 5730576P14Rik, 72kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 66661
Homologene: 38254
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227644
Homologene: 2321
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: DPD, E330028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Fbn2
Name: fibrillin 2
Synonyms: Sne, Fib-2, sy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Ermp1
Name: endoplasmic reticulum metallopeptidase 1
Synonyms: D19Wsu12e, D19Ertd410e, b2b2633Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226090
Homologene: 121891
Caskin1
Name: CASK interacting protein 1
Synonyms: 3300002N10Rik, C630036E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268932
VEGA: 17
Homologene: 25873
Tie1
Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Synonyms: TIE, tie-1, D430008P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21846
Homologene: 3957
Pth1r
Name: parathyroid hormone 1 receptor
Synonyms: PPR, Pthr1, PTH1R, PTH-related peptide receptor, PTH/PTHrP receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19228
HGNC: HGNC:9608
Homologene: 267
Krba1
Name: KRAB-A domain containing 1
Synonyms: A930040G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 77827
Homologene: 15880
Kin
Name: Kin17 DNA and RNA binding protein
Synonyms: antigenic determinant of rec-A protein, Kin17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16588
HGNC: HGNC:6327
Homologene: 8196
Olfr699
Name: olfactory receptor 699
Synonyms: GA_x6K02T2PBJ9-9168355-9167405, MOR283-10P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258180
Homologene: 79391
Olfr1126
Name: olfactory receptor 1126
Synonyms: MOR264-5, GA_x6K02T2Q125-48959068-48960012
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258834
Homologene: 133659
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 319876
Homologene: 8933
Zfp773
Name: zinc finger protein 773
Synonyms: 2810409K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76373
Homologene: 137393
Slc7a10
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
Synonyms: D7Bwg0847e, Asc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 53896
Homologene: 56767
Tmem198
Name: transmembrane protein 198
Synonyms: A230078I05Rik, Tmem198-1, Tmem198a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 319998
Homologene: 44245
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: Nramp, Lsh, Ity1, Ity, Bcg, ity, Nramp1, host resistance locus Bcg/Ity/Lsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18173
Homologene: 73884
Pcdhgc4
Name: protocadherin gamma subfamily C, 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93707
HGNC: HGNC:8717
Homologene: 110932
B4galt7
Name: xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218271
HGNC: HGNC:930
Homologene: 5248
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,525,412 bp
  • G to A, chromosome 1 at 74,375,278 bp
  • G to T, chromosome 1 at 75,479,707 bp
  • A to G, chromosome 1 at 132,508,205 bp
  • A to T, chromosome 1 at 138,544,300 bp
  • T to A, chromosome 1 at 193,356,359 bp
  • A to G, chromosome 2 at 10,090,359 bp
  • A to G, chromosome 2 at 26,365,302 bp
  • T to C, chromosome 2 at 65,099,237 bp
  • A to T, chromosome 2 at 76,822,477 bp
  • T to C, chromosome 2 at 87,457,983 bp
  • G to C, chromosome 2 at 98,664,007 bp
  • T to C, chromosome 2 at 180,190,413 bp
  • A to T, chromosome 3 at 119,266,077 bp
  • C to T, chromosome 4 at 118,483,842 bp
  • G to A, chromosome 4 at 150,907,099 bp
  • C to A, chromosome 5 at 14,680,433 bp
  • A to G, chromosome 5 at 76,990,295 bp
  • T to A, chromosome 6 at 48,409,751 bp
  • C to G, chromosome 6 at 142,354,741 bp
  • T to A, chromosome 7 at 7,135,336 bp
  • G to T, chromosome 7 at 19,043,460 bp
  • A to G, chromosome 7 at 35,120,262 bp
  • A to G, chromosome 7 at 35,197,930 bp
  • A to T, chromosome 7 at 106,790,998 bp
  • T to C, chromosome 7 at 118,195,926 bp
  • G to A, chromosome 8 at 95,266,019 bp
  • A to G, chromosome 9 at 110,727,073 bp
  • C to T, chromosome 10 at 88,954,697 bp
  • A to G, chromosome 11 at 96,957,474 bp
  • T to C, chromosome 13 at 13,696,794 bp
  • T to C, chromosome 13 at 55,600,146 bp
  • C to A, chromosome 14 at 79,340,033 bp
  • A to T, chromosome 16 at 4,632,287 bp
  • T to G, chromosome 16 at 33,590,323 bp
  • G to A, chromosome 17 at 17,575,307 bp
  • G to A, chromosome 17 at 24,506,628 bp
  • A to G, chromosome 17 at 84,691,941 bp
  • G to A, chromosome 18 at 37,817,278 bp
  • A to G, chromosome 18 at 58,010,304 bp
  • A to G, chromosome 19 at 29,639,959 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4638 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041900-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.