Strain Name:
C57BL/6J-MtgxR4642Btlr/Mmmh
Stock Number:
041904-MU
Citation ID:
RRID:MMRRC_041904-MU
Other Names:
R4642 (G1), C57BL/6J-MtgxR4642Btlr
Major Collection:

Gene Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: Fltn, D0Jmb2, myosin IIA, NMHC II-A, E030044M24Rik, Myhn1, Myhn-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: Cav3.1d, a1G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Abce1
Name: ATP-binding cassette, sub-family E (OABP), member 1
Synonyms: RNS4l (Eye), Rnaseli, Oabp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 24015
HGNC: HGNC:69
Homologene: 2205
Ufc1
Name: ubiquitin-fold modifier conjugating enzyme 1
Synonyms: 1110021H02Rik, ESTM29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66155
Homologene: 9500
Camk1g
Name: calcium/calmodulin-dependent protein kinase I gamma
Synonyms: CaMKIgamma, CLICK-III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215303
Homologene: 48706
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: 2610207I05Rik, C130002K18Rik, 5430435M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Zfp64
Name: zinc finger protein 64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22722
Homologene: 7604
Tbl1xr1
Name: transducin (beta)-like 1X-linked receptor 1
Synonyms: Ira1, DC42, 8030499H02Rik, TBLR1, C21, A630076E03Rik, C230089I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 81004
Homologene: 69382
Gas2l3
Name: growth arrest-specific 2 like 3
Synonyms: LOC237436, 8430435B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237436
VEGA: 10
Homologene: 18386
Lrrc28
Name: leucine rich repeat containing 28
Synonyms: 2210012C09Rik, 2310058O11Rik, 1300004K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67867
Homologene: 16944
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232491
Homologene: 11758
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: A530025K05Rik, LOC327983, acetyl-CoA carboxylase, Acc1, Acac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Crebrf
Name: CREB3 regulatory factor
Synonyms: A930001N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77128
Homologene: 12672
Prune2
Name: prune homolog 2
Synonyms: A230083H22Rik, A330102H22Rik, 6330414G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Cpxm2
Name: carboxypeptidase X 2 (M14 family)
Synonyms: 4632435C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 55987
Homologene: 69259
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Fam38a, Piezo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234839
Homologene: 124356
Ccdc184
Name: coiled-coil domain containing 184
Synonyms: AI836003
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239650
VEGA: 15
Homologene: 18612
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, calcium release channel isoform 1, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Nadk2
Name: NAD kinase 2, mitochondrial
Synonyms: Nadkd1, MNADK, 1110020G09Rik, 4933430B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68646
Homologene: 14638
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110027P15Rik, 3110001A05Rik, 1810064L21Rik, Ugcgl2, A230065J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66435
Homologene: 56875
Rasgrp3
Name: RAS, guanyl releasing protein 3
Synonyms: LOC240168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240168
VEGA: 17
Homologene: 15019
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, Dnahc2, 2900022L05Rik, Dnhd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Pcdhb11
Name: protocadherin beta 11
Synonyms: PcdhbK, Pcdhb5E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93882
Homologene: 62178
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Pdzd8
Name: PDZ domain containing 8
Synonyms: Pdzk8, A630041P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107368
VEGA: 19
Homologene: 14879
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Adamts16
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 271127
Homologene: 15146
Caskin1
Name: CASK interacting protein 1
Synonyms: 3300002N10Rik, C630036E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Ly86
Name: lymphocyte antigen 86
Synonyms: MD-1, MD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17084
VEGA: 13
Homologene: 48274
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243961
Homologene: 22949
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381260
Homologene: 124277
Rars2
Name: arginyl-tRNA synthetase 2, mitochondrial
Synonyms: 1500002I10Rik, Rarsl, PRO1992
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109093
Homologene: 5707
Hyal5
Name: hyaluronoglucosaminidase 5
Synonyms: 4933439A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74468
Homologene: 50610
Olfr830
Name: olfactory receptor 830
Synonyms: MOR152-1, GA_x6K02T2PVTD-12618399-12619337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258559
Homologene: 79360
Hdac7
Name: histone deacetylase 7
Synonyms: 5830434K02Rik, Hdac7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56233
Homologene: 9124
Sac3d1
Name: SAC3 domain containing 1
Synonyms: 2410004C24Rik, Shd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66406
VEGA: 19
Homologene: 40867
Medag
Name: mesenteric estrogen dependent adipogenesis
Synonyms: 6330406I15Rik, MEDA-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70717
Homologene: 12364
Dcstamp
Name: dendrocyte expressed seven transmembrane protein
Synonyms: DC-STAMP, 4833414I07Rik, Tm7sf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75766
VEGA: 15
Homologene: 12769
Mapk7
Name: mitogen-activated protein kinase 7
Synonyms: Erk5-T, ERK5, BMK1, b2b2346Clo, big MAP kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23939
HGNC: HGNC:6880
Homologene: 2060
Gm16391
Name: predicted pseudogene 16391
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100043886
Polr3h
Name: polymerase (RNA) III (DNA directed) polypeptide H
Synonyms: 5031409G22Rik, RPC8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78929
VEGA: 15
Homologene: 6337
Gm15958
Name: predicted gene 15958
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 59,558,114 bp
  • G to A, chromosome 1 at 66,671,714 bp
  • A to G, chromosome 1 at 68,250,632 bp
  • A to G, chromosome 1 at 171,289,894 bp
  • T to A, chromosome 1 at 193,356,359 bp
  • A to G, chromosome 2 at 168,934,931 bp
  • A to T, chromosome 3 at 22,188,420 bp
  • T to G, chromosome 4 at 34,656,229 bp
  • T to A, chromosome 5 at 137,464,188 bp
  • T to A, chromosome 5 at 149,411,979 bp
  • A to G, chromosome 6 at 24,876,622 bp
  • C to G, chromosome 6 at 142,354,741 bp
  • T to C, chromosome 7 at 29,086,038 bp
  • A to T, chromosome 7 at 44,313,141 bp
  • A to G, chromosome 7 at 67,619,081 bp
  • T to C, chromosome 7 at 118,154,264 bp
  • C to T, chromosome 7 at 132,070,881 bp
  • T to C, chromosome 8 at 79,689,353 bp
  • T to A, chromosome 8 at 122,495,454 bp
  • T to A, chromosome 9 at 18,876,167 bp
  • CACTCGTCATACT to CACT, chromosome 10 at 89,430,958 bp
  • A to G, chromosome 11 at 61,490,901 bp
  • T to C, chromosome 11 at 69,496,559 bp
  • A to T, chromosome 11 at 84,280,461 bp
  • A to G, chromosome 11 at 94,418,094 bp
  • A to T, chromosome 13 at 37,376,901 bp
  • G to A, chromosome 13 at 70,779,518 bp
  • A to T, chromosome 14 at 119,034,935 bp
  • T to C, chromosome 15 at 9,092,721 bp
  • T to C, chromosome 15 at 39,754,722 bp
  • T to C, chromosome 15 at 77,761,951 bp
  • T to C, chromosome 15 at 81,922,466 bp
  • T to C, chromosome 15 at 97,806,516 bp
  • T to G, chromosome 15 at 98,168,656 bp
  • G to A, chromosome 17 at 24,506,628 bp
  • G to T, chromosome 17 at 26,743,061 bp
  • T to C, chromosome 17 at 75,498,448 bp
  • T to G, chromosome 17 at 76,284,831 bp
  • T to A, chromosome 18 at 37,421,968 bp
  • A to T, chromosome 18 at 66,291,583 bp
  • G to A, chromosome 19 at 6,116,404 bp
  • T to C, chromosome 19 at 17,020,655 bp
  • C to T, chromosome 19 at 59,305,230 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4642 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041904-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.