Strain Name:
C57BL/6J-MtgxR4670Btlr/Mmmh
Stock Number:
041926-MU
Citation ID:
RRID:MMRRC_041926-MU
Other Names:
R4670 (G1), C57BL/6J-MtgxR4670Btlr
Major Collection:

Gene Information

Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: WWP3, Gukmi1, AIP3, BAP1, Baiap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Arhgef18
Name: rho/rac guanine nucleotide exchange factor (GEF) 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319493
Homologene: 32254
Vasp
Name: vasodilator-stimulated phosphoprotein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22323
Homologene: 7592
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212281
Homologene: 133713
Srebf2
Name: sterol regulatory element binding factor 2
Synonyms: SREBP-2, nuc, SREBP2, SREBP2gc, bHLHd2, lop13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20788
VEGA: 15
Homologene: 20966
Snx8
Name: sorting nexin 8
Synonyms: B130023O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231834
Homologene: 8338
Atp5c1
Name: ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Synonyms: F1 gamma, 1700094F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11949
HGNC: HGNC:833
Homologene: 3792
Arf4
Name: ADP-ribosylation factor 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11843
HGNC: HGNC:655
Homologene: 55593
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, GC-GAP, PX-RICS, 3426406O18Rik, Grit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330914
Homologene: 8812
Wipi2
Name: WD repeat domain, phosphoinositide interacting 2
Synonyms: 1110018O08Rik, 2510001I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74781
Homologene: 90887
Galnt4
Name: polypeptide N-acetylgalactosaminyltransferase 4
Synonyms: ppGaNTase-T4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14426
HGNC: HGNC:4126
Homologene: 74511
Jcad
Name: junctional cadherin 5 associated
Synonyms: 9430020K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240185
VEGA: 18
Homologene: 19370
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Pcx
Name: pyruvate carboxylase
Synonyms: Pc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18563
VEGA: 19
HGNC: HGNC:8636
Homologene: 5422
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: D330024H06Rik, A930031B09Rik, Ankrd15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107351
Homologene: 17706
Cartpt
Name: CART prepropeptide
Synonyms: Cart
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 27220
VEGA: 13
Homologene: 3169
Alb
Name: albumin
Synonyms: Alb-1, Alb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11657
HGNC: HGNC:399
Homologene: 405
Cadm3
Name: cell adhesion molecule 3
Synonyms: Tsll1, BIgR, Necl1, Necl-1, SynCAM3, Igsf4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94332
Homologene: 10919
Gpr183
Name: G protein-coupled receptor 183
Synonyms: Ebi2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 321019
VEGA: 14
HGNC: HGNC:3128
Homologene: 28066
Itih5
Name: inter-alpha (globulin) inhibitor H5
Synonyms: 5430408M01Rik, 4631408O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209378
Homologene: 57115
Lypd4
Name: Ly6/Plaur domain containing 4
Synonyms: 4933400F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232973
Homologene: 45458
Rsrp1
Name: arginine/serine rich protein 1
Synonyms: D4Ucla2, 2700043I21Rik, D4Wsu53e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27981
Gin1
Name: gypsy retrotransposon integrase 1
Synonyms: 4930429M06, 4930429M06Rik, Zh2c2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 252876
Homologene: 69238
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230676
Homologene: 49413
Lrrc8c
Name: leucine rich repeat containing 8 family, member C
Synonyms: E430036I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100604
Homologene: 12997
Krt74
Name: keratin 74
Synonyms: Kb37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 406222
VEGA: 15
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237954
Homologene: 138824
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Usp29
Name: ubiquitin specific peptidase 29
Synonyms: Ocat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57775
Homologene: 49641
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Naip-rs4, Birc1f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Atp1a4
Name: ATPase, Na+/K+ transporting, alpha 4 polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27222
Homologene: 113769
Zbtb4
Name: zinc finger and BTB domain containing 4
Synonyms: 2310026P19Rik, 9230111I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75580
Homologene: 10846
Ift140
Name: intraflagellar transport 140
Synonyms: Wdtc2, Tce5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106633
Homologene: 40979
Vmn1r214
Name: vomeronasal 1 receptor 214
Synonyms: V1rh5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171248
Homologene: 110880
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234135
Homologene: 56960
Pkp3
Name: plakophilin 3
Synonyms: 2310056L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56460
HGNC: HGNC:9025
Homologene: 5200
Gm6471
Name: predicted gene 6471
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Mefv
Name: Mediterranean fever
Synonyms: marenostrin, pyrin, FMF, TRIM20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 54483
VEGA: 16
HGNC: HGNC:6998
Homologene: 32441
Olfr231
Name: olfactory receptor 231
Synonyms: GA_x6K02T2P20D-21053942-21054499, GA_x6K02T2LER7-6-623, GA_x6K02T02K39-452-3, MOR105-4, Olfr425, Olfr244
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 404222
Homologene: 17363
Cenpj
Name: centromere protein J
Synonyms: 4932437H03Rik, Sas4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219103
Homologene: 10204
Snapc2
Name: small nuclear RNA activating complex, polypeptide 2
Synonyms: 0610007H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102209
Homologene: 2318
Sgip1
Name: SH3-domain GRB2-like (endophilin) interacting protein 1
Synonyms: 3110007P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73094
Homologene: 13001
Traf3ip2
Name: TRAF3 interacting protein 2
Synonyms: Act1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103213
HGNC: HGNC:1343
Homologene: 15885
Arhgap22
Name: Rho GTPase activating protein 22
Synonyms: RHOGAP2, B230341L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239027
Homologene: 23292
Plscr4
Name: phospholipid scramblase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235527
Homologene: 23217
Bcas1
Name: brain enriched myelin associated protein 1
Synonyms: NABC1, 2210416M21Rik, 9030223A09Rik, breast carcinoma amplified sequence 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76960
HGNC: HGNC:974
Homologene: 2714
Olfr1084
Name: olfactory receptor 1084
Synonyms: GA_x6K02T2Q125-48121788-48120847, MOR192-3, MOR192-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258235
Homologene: 104285
Tubgcp4
Name: tubulin, gamma complex associated protein 4
Synonyms: 4932441P04Rik, D2Ertd435e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 51885
Homologene: 8690
Gpam
Name: glycerol-3-phosphate acyltransferase, mitochondrial
Synonyms: GPAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14732
Homologene: 7343
Acsm5
Name: acyl-CoA synthetase medium-chain family member 5
Synonyms: C730027J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 272428
Homologene: 69242
Cyp4f37
Name: cytochrome P450, family 4, subfamily f, polypeptide 37
Synonyms: Gm9705
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 677156
VEGA: 17
Homologene: 135840
Rhot2
Name: ras homolog family member T2
Synonyms: Miro2, Arht2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 214952
Homologene: 56038
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 4921504D23Rik, 2900079B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70839
Homologene: 11260
Ptgir
Name: prostaglandin I receptor (IP)
Synonyms: prostacyclin receptor, IP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19222
HGNC: HGNC:9602
Homologene: 7496
Zfp995
Name: zinc finger protein 995
Synonyms: 2210404O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70081
Homologene: 133253
Olfr612
Name: olfactory receptor 612
Synonyms: GA_x6K02T2PBJ9-6251685-6250741, MOR15-3, EG545985
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545985
Homologene: 79675
Nsmce3
Name: NSE3 homolog, SMC5-SMC6 complex component
Synonyms: HCA4, 5730494G16Rik, Mageg1, Ndnl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66647
HGNC: HGNC:7677
Homologene: 41520
Spag8
Name: sperm associated antigen 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433700
Homologene: 8250
Nlrp1c-ps
Name: NLR family, pyrin domain containing 1C, pseudogene
Synonyms: Nalp1c, OTTMUSG00000006090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 627984
Gm6818
Name: predicted gene 6818
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 627975
Homologene: 80005
Gm7160
Name: predicted gene 7160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 635504
Gm9271
Name: predicted gene 9271
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668618
Homologene: 45597
Chst7
Name: carbohydrate (N-acetylglucosamino) sulfotransferase 7
Synonyms: GST5, 2600013M07Rik, C6ST-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 60322
Homologene: 10531
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 46,078,524 bp
  • C to T, chromosome 1 at 97,784,840 bp
  • A to T, chromosome 1 at 105,990,266 bp
  • T to A, chromosome 1 at 172,235,000 bp
  • T to A, chromosome 1 at 173,346,446 bp
  • T to A, chromosome 1 at 174,117,861 bp
  • A to T, chromosome 2 at 10,059,617 bp
  • A to C, chromosome 2 at 10,190,369 bp
  • T to C, chromosome 2 at 86,639,168 bp
  • T to A, chromosome 2 at 121,173,665 bp
  • T to C, chromosome 2 at 170,384,325 bp
  • T to C, chromosome 3 at 59,217,904 bp
  • A to G, chromosome 4 at 43,653,378 bp
  • A to T, chromosome 4 at 102,869,754 bp
  • C to G, chromosome 4 at 118,375,829 bp
  • A to G, chromosome 4 at 134,924,177 bp
  • T to A, chromosome 5 at 90,462,806 bp
  • G to A, chromosome 5 at 105,608,374 bp
  • A to G, chromosome 5 at 110,306,387 bp
  • A to G, chromosome 5 at 140,355,958 bp
  • G to C, chromosome 5 at 142,659,590 bp
  • A to T, chromosome 6 at 93,686,643 bp
  • T to A, chromosome 7 at 6,962,915 bp
  • A to G, chromosome 7 at 16,906,869 bp
  • T to C, chromosome 7 at 19,264,425 bp
  • T to C, chromosome 7 at 24,866,726 bp
  • T to A, chromosome 7 at 38,402,557 bp
  • T to A, chromosome 7 at 39,364,310 bp
  • A to T, chromosome 7 at 64,872,782 bp
  • A to G, chromosome 7 at 103,539,186 bp
  • T to C, chromosome 7 at 110,335,399 bp
  • T to A, chromosome 7 at 119,531,760 bp
  • C to T, chromosome 7 at 141,082,699 bp
  • G to A, chromosome 7 at 142,831,623 bp
  • T to A, chromosome 8 at 3,434,897 bp
  • A to G, chromosome 8 at 4,254,998 bp
  • C to T, chromosome 8 at 25,666,041 bp
  • A to G, chromosome 9 at 32,170,145 bp
  • T to C, chromosome 9 at 92,482,867 bp
  • C to T, chromosome 10 at 39,639,260 bp
  • A to G, chromosome 10 at 99,109,298 bp
  • A to T, chromosome 11 at 67,364,738 bp
  • T to A, chromosome 11 at 69,776,529 bp
  • T to C, chromosome 11 at 71,280,556 bp
  • A to G, chromosome 11 at 103,504,537 bp
  • A to G, chromosome 13 at 23,034,971 bp
  • T to A, chromosome 13 at 67,621,415 bp
  • C to T, chromosome 13 at 99,900,080 bp
  • A to G, chromosome 13 at 100,294,731 bp
  • A to G, chromosome 14 at 26,653,093 bp
  • T to C, chromosome 14 at 33,362,543 bp
  • A to T, chromosome 14 at 56,553,383 bp
  • T to C, chromosome 14 at 121,954,737 bp
  • T to C, chromosome 15 at 82,192,302 bp
  • A to T, chromosome 15 at 101,758,869 bp
  • T to A, chromosome 16 at 3,708,207 bp
  • A to T, chromosome 17 at 21,887,339 bp
  • C to A, chromosome 17 at 25,098,961 bp
  • A to C, chromosome 17 at 25,841,331 bp
  • A to T, chromosome 17 at 32,625,152 bp
  • A to G, chromosome 18 at 4,674,175 bp
  • T to A, chromosome 19 at 4,619,888 bp
  • T to C, chromosome 19 at 25,410,580 bp
  • A to G, chromosome 19 at 55,096,119 bp
  • C to A, chromosome X at 20,060,871 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4670 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041926-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.