Strain Name:
C57BL/6J-MtgxR4683Btlr/Mmmh
Stock Number:
041935-MU
Citation ID:
RRID:MMRRC_041935-MU
Other Names:
R4683 (G1), C57BL/6J-MtgxR4683Btlr
Major Collection:

Gene Information

Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: Edd1, Edd, 4432411E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Lrrc2
Name: leucine rich repeat containing 2
Synonyms: 2400002D05Rik, 4933431K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74249
Homologene: 23454
Efr3a
Name: EFR3 homolog A
Synonyms: C920006C10Rik, D030063F01Rik, A130089M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76740
Homologene: 44222
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Nup133
Name: nucleoporin 133
Synonyms: 4832420O05Rik, mermaid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234865
Homologene: 32402
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Gab1
Name: growth factor receptor bound protein 2-associated protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14388
HGNC: HGNC:4066
Homologene: 1542
4930430F08Rik
Name: RIKEN cDNA 4930430F08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68281
VEGA: 10
Homologene: 18409
Pcsk9
Name: proprotein convertase subtilisin/kexin type 9
Synonyms: Narc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100102
Homologene: 17790
Gm14124
Name: predicted gene 14124
Synonyms: Gm10749, EG640962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100216455
Homologene: 134546
Bloc1s6
Name: biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Synonyms: BLOC-1 subunit, Pldn, BLOC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18457
HGNC: HGNC:8549
Homologene: 40841
Ackr3
Name: atypical chemokine receptor 3
Synonyms: Cmkor1, Cxcr7, Rdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12778
Homologene: 22419
Dsg4
Name: desmoglein 4
Synonyms: lah, CDHF13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16769
Homologene: 65341
Slf2
Name: SMC5-SMC6 complex localization factor 2
Synonyms: Fam178a, 6030443O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226151
VEGA: 19
Homologene: 23077
Mxd3
Name: Max dimerization protein 3
Synonyms: Mad3, bHLHc13, 4631412E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17121
Homologene: 32333
AW554918
Name: expressed sequence AW554918
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225289
Homologene: 52652
Pcyt1b
Name: phosphate cytidylyltransferase 1, choline, beta isoform
Synonyms: CTTbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 236899
HGNC: HGNC:8755
Homologene: 3564
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnahc2, Dnhd3, 2900022L05Rik, D330014H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: b2b585Clo, PC6, PC5A, SPC6, b2b1549Clo, PC5/6A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Def6
Name: differentially expressed in FDCP 6
Synonyms: IBP, SLAT, 6430538D02Rik, 2410003F05Rik, IRF-4-binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 23853
HGNC: HGNC:2760
Homologene: 11103
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Gucy2d
Name: guanylate cyclase 2d
Synonyms: guanylyl cyclase D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14918
Homologene: 71540
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 2810455B10Rik, Als2cr19, 1810008K04Rik, 2010002N16Rik, PAR3B, PAR3L, PAR3beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72823
Homologene: 35389
Cdh17
Name: cadherin 17
Synonyms: HPT-1, BILL-cadherin, LI-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12557
HGNC: HGNC:1756
Homologene: 56859
Trnau1ap
Name: tRNA selenocysteine 1 associated protein 1
Synonyms: SECp43, 1110007F05Rik, Trspap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71787
Homologene: 49509
Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms: 4930568D07Rik, PFK-2/FBPase-2 gene B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18640
HGNC: HGNC:8873
Homologene: 88554
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268527
Homologene: 8780
Pcnx
Name: pecanex homolog
Synonyms: 2900024E21Rik, 3526401J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, Vwa6, EG235580, 1110001D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381157
Homologene: 73393
Gm1110
Name: predicted gene 1110
Synonyms: LOC382064
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382064
VEGA: 9
Homologene: 78608
Ccno
Name: cyclin O
Synonyms: Ung2, Ccnu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218630
VEGA: 13
Homologene: 50171
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: Bai1, B830018M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Sox5
Name: SRY (sex determining region Y)-box 5
Synonyms: A730017D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20678
Homologene: 21378
Gm10288
Name: predicted gene 10288
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100040540
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216188
Homologene: 51942
Olfr525
Name: olfactory receptor 525
Synonyms: GA_x6K02T2PBJ9-42472898-42473827, MOR251-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258958
Homologene: 138321
Zfp52
Name: zinc finger protein 52
Synonyms: Zfp76, KRAB11, Zfp-52, zfec29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22710
VEGA: 17
Homologene: 77326
Vmn1r230
Name: vomeronasal 1 receptor 230
Synonyms: V1re8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171231
Homologene: 136306
Asz1
Name: ankyrin repeat, SAM and basic leucine zipper domain containing 1
Synonyms: ORF3, Gasz, 4933400N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74068
HGNC: HGNC:1350
Homologene: 11374
Wnt10a
Name: wingless-type MMTV integration site family, member 10A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22409
Homologene: 22525
Sh2b2
Name: SH2B adaptor protein 2
Synonyms: Aps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23921
Homologene: 10309
Stk36
Name: serine/threonine kinase 36
Synonyms: Fused, 1700112N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269209
Homologene: 49432
Mrps22
Name: mitochondrial ribosomal protein S22
Synonyms: Rpms22, 3100002P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64655
Homologene: 57030
H1f7
Name: H1.7 linker histone
Synonyms: 1700026P10Rik, H1-7, H1fnt, H1T2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70069
VEGA: 15
Slc52a2
Name: solute carrier protein 52, member 2
Synonyms: D15Ertd747e, 2010003P03Rik, PAR2, Gpr172b, Rfvt2, GPCR42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 52710
VEGA: 15
Homologene: 56994
Cyp4f14
Name: cytochrome P450, family 4, subfamily f, polypeptide 14
Synonyms: leukotriene B4 omega hydroxylase, 1300014O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 64385
VEGA: 17
Homologene: 81872
Acyp1
Name: acylphosphatase 1, erythrocyte (common) type
Synonyms: 1110039O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66204
HGNC: HGNC:179
Homologene: 11932
Csf1r
Name: colony stimulating factor 1 receptor
Synonyms: M-CSFR, Fim-2, CD115, Csfmr, Fms, CSF-1R, Fim2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12978
HGNC: HGNC:2433
Homologene: 3817
Olfr127
Name: olfactory receptor 127
Synonyms: GA_x6K02T2PSCP-2354126-2355093, MOR218-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258374
Homologene: 134080
Clca6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Gm6180
Name: predicted pseudogene 6180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 620772
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 62,216,516 bp
  • T to A, chromosome 1 at 74,634,185 bp
  • C to T, chromosome 1 at 74,803,137 bp
  • T to C, chromosome 1 at 90,213,987 bp
  • T to A, chromosome 1 at 90,773,457 bp
  • T to A, chromosome 1 at 130,706,484 bp
  • T to C, chromosome 2 at 52,244,062 bp
  • T to C, chromosome 2 at 122,738,622 bp
  • T to A, chromosome 2 at 150,266,470 bp
  • C to T, chromosome 3 at 144,954,940 bp
  • T to A, chromosome 3 at 146,839,319 bp
  • A to T, chromosome 4 at 11,817,036 bp
  • A to T, chromosome 4 at 106,458,895 bp
  • A to T, chromosome 4 at 132,321,752 bp
  • C to T, chromosome 5 at 136,231,720 bp
  • T to C, chromosome 6 at 18,055,542 bp
  • T to C, chromosome 6 at 143,833,467 bp
  • T to C, chromosome 7 at 98,453,443 bp
  • T to C, chromosome 7 at 140,322,768 bp
  • A to T, chromosome 8 at 42,247,344 bp
  • A to C, chromosome 8 at 80,788,632 bp
  • G to A, chromosome 8 at 123,930,982 bp
  • A to G, chromosome 9 at 26,920,594 bp
  • A to T, chromosome 9 at 98,598,306 bp
  • A to G, chromosome 9 at 106,080,130 bp
  • A to T, chromosome 9 at 110,962,546 bp
  • A to G, chromosome 10 at 83,499,935 bp
  • T to C, chromosome 10 at 100,578,381 bp
  • A to T, chromosome 11 at 69,458,942 bp
  • C to T, chromosome 12 at 16,711,773 bp
  • A to G, chromosome 12 at 81,986,672 bp
  • A to G, chromosome 12 at 85,278,943 bp
  • T to C, chromosome 13 at 55,325,800 bp
  • C to A, chromosome 13 at 112,989,009 bp
  • C to T, chromosome 15 at 38,037,967 bp
  • C to A, chromosome 15 at 65,819,801 bp
  • A to T, chromosome 15 at 74,588,114 bp
  • C to A, chromosome 15 at 76,540,233 bp
  • A to T, chromosome 15 at 98,257,040 bp
  • T to C, chromosome 16 at 17,297,037 bp
  • C to T, chromosome 17 at 20,847,253 bp
  • A to G, chromosome 17 at 21,561,507 bp
  • A to G, chromosome 17 at 28,217,635 bp
  • T to C, chromosome 17 at 32,908,011 bp
  • A to G, chromosome 17 at 37,904,148 bp
  • T to A, chromosome 18 at 10,529,563 bp
  • T to C, chromosome 18 at 20,461,409 bp
  • T to C, chromosome 18 at 25,339,795 bp
  • T to G, chromosome 18 at 49,878,021 bp
  • T to A, chromosome 18 at 61,124,911 bp
  • A to T, chromosome 19 at 17,473,041 bp
  • C to G, chromosome 19 at 44,935,481 bp
  • C to A, chromosome X at 93,746,364 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4683 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041935-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.