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Strain Name:
C57BL/6J-MtgxR4685Btlr/Mmmh
Stock Number:
041936-MU
Citation ID:
RRID:MMRRC_041936-MU
Other Names:
R4685 (G1), C57BL/6J-MtgxR4685Btlr
Major Collection:

Strain Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
Synonyms: DARPP-32, Darpp32
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19049
HGNC: HGNC:9287
Homologene: 12972
Arhgef10
Name: Rho guanine nucleotide exchange factor 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234094
Homologene: 22827
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: p70/85s6k, p70s6k, S6K1, 2610318I15Rik, p70S6K1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72508
Homologene: 81703
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: 4732474L06Rik, Jmjd2b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193796
Homologene: 27773
Terf1
Name: telomeric repeat binding factor 1
Synonyms: Trf1, Trbf1, Pin2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21749
Homologene: 7570
Znfx1
Name: zinc finger, NFX1-type containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98999
Homologene: 10877
Gpat4
Name: glycerol-3-phosphate acyltransferase 4
Synonyms: Agpat6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102247
Homologene: 32425
Itgb2
Name: integrin beta 2
Synonyms: Mac-1 beta, 2E6, Cd18
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16414
HGNC: HGNC:6155
Homologene: 20092
Syt9
Name: synaptotagmin IX
Synonyms: Sytv
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60510
Homologene: 11062
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Sphk1
Name: sphingosine kinase 1
Synonyms: 1110006G24Rik, SK1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20698
Homologene: 39748
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Ecel1
Name: endothelin converting enzyme-like 1
Synonyms: DINE, XCE
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13599
HGNC: HGNC:3147
Homologene: 3549
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Katnbl1
Name: katanin p80 subunit B like 1
Synonyms: 2410042D21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72425
Homologene: 11495
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: D330024H06Rik, A930031B09Rik, Ankrd15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
2810021J22Rik
Name: RIKEN cDNA 2810021J22 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69944
Homologene: 138400
Egfr
Name: epidermal growth factor receptor
Synonyms: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb, Wa5, 9030024J15Rik, Errb1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Sc5d
Name: sterol-C5-desaturase
Synonyms: A830073K23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235293
VEGA: 9
Homologene: 5044
Rbm33
Name: RNA binding motif protein 33
Synonyms: 6430512A10Rik, 3200001K10Rik, Prr8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381626
Homologene: 137386
Lman1l
Name: lectin, mannose-binding 1 like
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235416
HGNC: HGNC:6632
Homologene: 11047
Ostf1
Name: osteoclast stimulating factor 1
Synonyms: SH3P2, C78236, Sh3d3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20409
HGNC: HGNC:8510
Homologene: 8227
Tomm40
Name: translocase of outer mitochondrial membrane 40
Synonyms: Tom40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53333
Homologene: 101105
Paxip1
Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: PTIP, D5Ertd149e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 55982
HGNC: HGNC:8624
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: NFkB interacting protein 1, wa3, IASPP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 333654
Homologene: 84635
Ccdc85c
Name: coiled-coil domain containing 85C
Synonyms: Gm9010, hhy
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668158
VEGA: 12
Homologene: 82238
Skic2
Name: SKI2 subunit of superkiller complex
Synonyms: Ski2w, 4930534J06Rik, Skiv2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108077
Homologene: 123971
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Gabarapl2
Name: GABA type A receptor associated protein like 2
Synonyms: 0610012F20Rik, Gef2, GATE-16, 2900019O08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93739
Homologene: 68550
Sell
Name: selectin, lymphocyte
Synonyms: L-selectin, CD62L, LECAM-1, Ly-22, Ly-m22, Lnhr, Lyam1, Lyam-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20343
Homologene: 539
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Tmprss7
Name: transmembrane serine protease 7
Synonyms: LOC385645, B230219I23Rik, matriptase-3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208171
Homologene: 18178
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Vmn1r213
Name: vomeronasal 1 receptor 213
Synonyms: V1rh6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171249
Homologene: 110880
Gm12695
Name: predicted gene 12695
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 620779
Homologene: 51847
Prl6a1
Name: prolactin family 6, subfamily a, member 1
Synonyms: PLP-B, Prlpb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19111
Homologene: 49261
Odf4
Name: outer dense fiber of sperm tails 4
Synonyms: Oppo1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 252868
Homologene: 17099
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: SPI3D, Gm11390
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238568
HGNC: HGNC:8950
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Rhobtb3
Name: Rho-related BTB domain containing 3
Synonyms: 1700040C17Rik, 4930503C18Rik, 2610033K01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73296
Homologene: 8932
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Pitrm1
Name: pitrilysin metallepetidase 1
Synonyms: 2310012C15Rik, MP-1, Ntup1, PreP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69617
VEGA: 13
Homologene: 5742
Cimip5
Name: ciliary microtubule inner protein 5
Synonyms: 2410004P03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73667
Homologene: 77698
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Rims4
Name: regulating synaptic membrane exocytosis 4
Synonyms: Rim4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241770
Homologene: 18123
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Edn1
Name: endothelin 1
Synonyms: ET-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13614
VEGA: 13
HGNC: HGNC:3176
Homologene: 1476
Kyat1
Name: kynurenine aminotransferase 1
Synonyms: cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase), 2010009K05Rik, KATI, Kat1, Ccbl1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70266
HGNC: HGNC:1564
Homologene: 37872
H2-M10.4
Name: histocompatibility 2, M region locus 10.4
Synonyms: 15H
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224753
Homologene: 117973
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277360
Homologene: 10821
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 636808
Homologene: 43974
Psg16
Name: pregnancy specific beta-1-glycoprotein 16
Synonyms: bCEA, Cea11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26436
Hhat
Name: hedgehog acyltransferase
Synonyms: Skn, 2810432O22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226861
Homologene: 41232
Fam184a
Name: family with sequence similarity 184, member A
Synonyms: 3110012E06Rik, 4930438C08Rik, 4930589M24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75906
Homologene: 11600
Mill1
Name: MHC I like leukocyte 1
Synonyms: 5530400I18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 266815
HGNC: HGNC:7090
Homologene: 105329
Fhit
Name: fragile histidine triad gene
Synonyms: Fra14A2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14198
HGNC: HGNC:3701
Homologene: 21661
Glis1
Name: GLIS family zinc finger 1
Synonyms: GliH1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230587
Homologene: 77390
Pla2g4f
Name: phospholipase A2, group IVF
Synonyms: 4732472I07Rik, Pla2zeta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271844
Homologene: 77933
Rhot2
Name: ras homolog family member T2
Synonyms: Miro2, Arht2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214952
Homologene: 56038
Zpbp2
Name: zona pellucida binding protein 2
Synonyms: 1700017D11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69376
Homologene: 18892
Spns3
Name: SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)
Synonyms: 9830002I17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77577
Homologene: 45648
Plppr3
Name: phospholipid phosphatase related 3
Synonyms: BC005764, Lppr3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216152
Homologene: 11769
Gm6976
Name: predicted gene 6976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 15,818,961 bp
  • T to C, chromosome 1 at 46,211,328 bp
  • G to T, chromosome 1 at 87,152,946 bp
  • T to C, chromosome 1 at 116,446,680 bp
  • A to T, chromosome 1 at 164,066,260 bp
  • C to A, chromosome 1 at 192,595,054 bp
  • T to A, chromosome 2 at 22,407,422 bp
  • A to G, chromosome 2 at 30,188,265 bp
  • T to C, chromosome 2 at 112,406,338 bp
  • G to A, chromosome 2 at 118,546,802 bp
  • A to G, chromosome 2 at 120,305,015 bp
  • T to A, chromosome 2 at 163,864,994 bp
  • C to T, chromosome 2 at 166,638,332 bp
  • T to A, chromosome 2 at 167,039,030 bp
  • A to G, chromosome 4 at 96,761,980 bp
  • T to C, chromosome 4 at 107,567,645 bp
  • A to T, chromosome 5 at 27,761,677 bp
  • A to T, chromosome 5 at 28,408,282 bp
  • C to T, chromosome 5 at 77,275,243 bp
  • C to A, chromosome 6 at 32,165,844 bp
  • T to A, chromosome 6 at 41,311,299 bp
  • A to G, chromosome 6 at 48,492,894 bp
  • G to T, chromosome 6 at 125,980,124 bp
  • T to C, chromosome 7 at 17,090,534 bp
  • A to T, chromosome 7 at 18,255,928 bp
  • T to C, chromosome 7 at 19,375,383 bp
  • A to G, chromosome 7 at 19,701,836 bp
  • C to G, chromosome 7 at 87,297,508 bp
  • T to A, chromosome 7 at 107,436,471 bp
  • T to A, chromosome 8 at 14,956,963 bp
  • TAGAAGA to TAGA, chromosome 8 at 23,182,849 bp
  • C to A, chromosome 8 at 110,462,522 bp
  • T to C, chromosome 8 at 111,942,518 bp
  • C to T, chromosome 9 at 42,258,650 bp
  • T to A, chromosome 9 at 57,609,200 bp
  • C to T, chromosome 9 at 67,302,572 bp
  • T to C, chromosome 10 at 41,681,686 bp
  • T to C, chromosome 10 at 53,698,500 bp
  • T to A, chromosome 10 at 77,550,103 bp
  • T to C, chromosome 10 at 79,194,328 bp
  • T to C, chromosome 10 at 79,867,525 bp
  • G to A, chromosome 11 at 16,858,980 bp
  • T to C, chromosome 11 at 58,880,924 bp
  • A to G, chromosome 11 at 68,922,839 bp
  • A to T, chromosome 11 at 72,537,270 bp
  • C to T, chromosome 11 at 86,519,887 bp
  • G to A, chromosome 11 at 98,355,481 bp
  • A to G, chromosome 11 at 98,551,291 bp
  • A to G, chromosome 11 at 104,328,049 bp
  • A to G, chromosome 11 at 116,535,280 bp
  • A to G, chromosome 12 at 8,006,456 bp
  • T to C, chromosome 12 at 17,007,184 bp
  • A to T, chromosome 12 at 108,207,175 bp
  • A to G, chromosome 13 at 6,556,542 bp
  • T to C, chromosome 13 at 11,692,646 bp
  • A to T, chromosome 13 at 23,011,630 bp
  • A to G, chromosome 13 at 27,316,324 bp
  • A to G, chromosome 13 at 33,671,228 bp
  • A to T, chromosome 13 at 42,305,253 bp
  • T to C, chromosome 13 at 68,727,905 bp
  • G to A, chromosome 13 at 75,878,932 bp
  • T to A, chromosome 14 at 9,870,091 bp
  • T to C, chromosome 14 at 12,467,139 bp
  • A to G, chromosome 15 at 64,737,438 bp
  • T to C, chromosome 16 at 45,679,348 bp
  • G to A, chromosome 17 at 25,840,694 bp
  • C to A, chromosome 17 at 34,845,197 bp
  • G to A, chromosome 17 at 36,461,796 bp
  • T to A, chromosome 17 at 56,401,675 bp
  • C to A, chromosome 18 at 20,539,736 bp
  • A to T, chromosome 19 at 18,581,288 bp
  • C to T, chromosome 19 at 25,410,034 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4685 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@missouri.edu
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

When this strain becomes available, Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.