Strain Name:
C57BL/6J-MtgxR4685Btlr/Mmmh
Stock Number:
041936-MU
Citation ID:
RRID:MMRRC_041936-MU
Other Names:
R4685 (G1), C57BL/6J-MtgxR4685Btlr
Major Collection:

Gene Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Tln2
Name: talin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
Synonyms: DARPP-32, Darpp32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19049
HGNC: HGNC:9287
Homologene: 12972
Arhgef10
Name: Rho guanine nucleotide exchange factor (GEF) 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234094
Homologene: 22827
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: 2610318I15Rik, p70/85s6k, p70s6k, S6K1, p70S6K1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72508
Homologene: 81703
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: Jmjd2b, 4732474L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 193796
Homologene: 27773
Terf1
Name: telomeric repeat binding factor 1
Synonyms: Trf1, Trbf1, Pin2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21749
Homologene: 7570
Znfx1
Name: zinc finger, NFX1-type containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98999
Homologene: 10877
Gpat4
Name: glycerol-3-phosphate acyltransferase 4
Synonyms: Agpat6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102247
Homologene: 32425
Itgb2
Name: integrin beta 2
Synonyms: Mac-1 beta, Cd18, 2E6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16414
HGNC: HGNC:6155
Homologene: 20092
Syt9
Name: synaptotagmin IX
Synonyms: Sytv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60510
Homologene: 11062
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Sphk1
Name: sphingosine kinase 1
Synonyms: 1110006G24Rik, SK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20698
Homologene: 39748
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Ecel1
Name: endothelin converting enzyme-like 1
Synonyms: XCE, DINE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13599
HGNC: HGNC:3147
Homologene: 3549
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Katnbl1
Name: katanin p80 subunit B like 1
Synonyms: 2410042D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72425
Homologene: 11495
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: Ankrd15, A930031B09Rik, D330024H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107351
Homologene: 17706
2810021J22Rik
Name: RIKEN cDNA 2810021J22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69944
Homologene: 138400
Egfr
Name: epidermal growth factor receptor
Synonyms: Wa5, 9030024J15Rik, Errb1, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Erbb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Sc5d
Name: sterol-C5-desaturase
Synonyms: A830073K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235293
VEGA: 9
Homologene: 5044
Rbm33
Name: RNA binding motif protein 33
Synonyms: 3200001K10Rik, 6430512A10Rik, Prr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381626
Homologene: 137386
Lman1l
Name: lectin, mannose-binding 1 like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235416
HGNC: HGNC:6632
Homologene: 11047
Ostf1
Name: osteoclast stimulating factor 1
Synonyms: SH3P2, Sh3d3, C78236
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20409
HGNC: HGNC:8510
Homologene: 8227
Tomm40
Name: translocase of outer mitochondrial membrane 40
Synonyms: Tom40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53333
Homologene: 101105
Paxip1
Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: D5Ertd149e, PTIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 55982
HGNC: HGNC:8624
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: IASPP, wa3, NFkB interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 333654
Homologene: 84635
Ccdc85c
Name: coiled-coil domain containing 85C
Synonyms: hhy, Gm9010
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 668158
VEGA: 12
Homologene: 82238
Skiv2l
Name: superkiller viralicidic activity 2-like (S. cerevisiae)
Synonyms: 4930534J06Rik, Ski2w
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 108077
Homologene: 123971
Bmf
Name: BCL2 modifying factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 171543
Homologene: 14130
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Gabarapl2
Name: gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2
Synonyms: 2900019O08Rik, 0610012F20Rik, Gef2, GATE-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 93739
Homologene: 68550
Sell
Name: selectin, lymphocyte
Synonyms: Lyam-1, CD62L, Ly-m22, L-selectin, LECAM-1, Lnhr, Lyam1, Ly-22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20343
Homologene: 539
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, 1700034M11Rik, hy3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Tmprss7
Name: transmembrane serine protease 7
Synonyms: B230219I23Rik, LOC385645, matriptase-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208171
Homologene: 18178
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Vmn1r213
Name: vomeronasal 1 receptor 213
Synonyms: V1rh6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171249
Homologene: 110880
Gm12695
Name: predicted gene 12695
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 620779
Homologene: 51847
Prl6a1
Name: prolactin family 6, subfamily a, member 1
Synonyms: PLP-B, Prlpb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19111
Homologene: 49261
Odf4
Name: outer dense fiber of sperm tails 4
Synonyms: Oppo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 252868
Homologene: 17099
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: SPI3D, Gm11390
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238568
HGNC: HGNC:8950
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Rhobtb3
Name: Rho-related BTB domain containing 3
Synonyms: 1700040C17Rik, 2610033K01Rik, 4930503C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 73296
Homologene: 8932
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 624765
Homologene: 83483
Pitrm1
Name: pitrilysin metallepetidase 1
Synonyms: Ntup1, PreP, 2310012C15Rik, MP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69617
VEGA: 13
Homologene: 5742
2410004P03Rik
Name: RIKEN cDNA 2410004P03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73667
Homologene: 77698
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Rims4
Name: regulating synaptic membrane exocytosis 4
Synonyms: Rim4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241770
Homologene: 18123
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Edn1
Name: endothelin 1
Synonyms: ET-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13614
VEGA: 13
HGNC: HGNC:3176
Homologene: 1476
Kyat1
Name: kynurenine aminotransferase 1
Synonyms: Kat1, KATI, 2010009K05Rik, cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase), Ccbl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70266
HGNC: HGNC:1564
Homologene: 37872
H2-M10.4
Name: histocompatibility 2, M region locus 10.4
Synonyms: 15H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224753
Homologene: 117973
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277360
Homologene: 10821
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 636808
Homologene: 43974
Nox4
Name: NADPH oxidase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 50490
HGNC: HGNC:7891
Homologene: 41065
Psg16
Name: pregnancy specific glycoprotein 16
Synonyms: Cea11, bCEA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26436
Hhat
Name: hedgehog acyltransferase
Synonyms: Skn, 2810432O22Rik, AP-2CRE, Tg(TFAP2A-cre)1Will
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226861
Homologene: 41232
Fam184a
Name: family with sequence similarity 184, member A
Synonyms: 4930438C08Rik, 3110012E06Rik, 4930589M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 75906
Homologene: 11600
Mill1
Name: MHC I like leukocyte 1
Synonyms: 5530400I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 266815
Homologene: 105329
Fhit
Name: fragile histidine triad gene
Synonyms: Fra14A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14198
HGNC: HGNC:3701
Homologene: 21661
Glis1
Name: GLIS family zinc finger 1
Synonyms: GliH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230587
Homologene: 77390
Pla2g4f
Name: phospholipase A2, group IVF
Synonyms: Pla2zeta, 4732472I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271844
Homologene: 77933
Rhot2
Name: ras homolog family member T2
Synonyms: Miro2, Arht2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 214952
Homologene: 56038
Zpbp2
Name: zona pellucida binding protein 2
Synonyms: 1700017D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69376
Homologene: 18892
Spns3
Name: spinster homolog 3
Synonyms: 9830002I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77577
Homologene: 45648
Plppr3
Name: phospholipid phosphatase related 3
Synonyms: BC005764, Lppr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216152
Homologene: 11769
Try5
Name: trypsin 5
Synonyms: 1810049H19Rik, Tc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 103964
HGNC: HGNC:9486
Homologene: 106639
Gm6976
Name: predicted gene 6976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 15,818,961 bp
  • T to C, chromosome 1 at 46,211,328 bp
  • G to T, chromosome 1 at 87,152,946 bp
  • T to C, chromosome 1 at 116,446,680 bp
  • A to T, chromosome 1 at 164,066,260 bp
  • C to A, chromosome 1 at 192,595,054 bp
  • T to A, chromosome 2 at 22,407,422 bp
  • A to G, chromosome 2 at 30,188,265 bp
  • T to C, chromosome 2 at 112,406,338 bp
  • G to A, chromosome 2 at 118,546,802 bp
  • A to G, chromosome 2 at 120,305,015 bp
  • T to A, chromosome 2 at 163,864,994 bp
  • C to T, chromosome 2 at 166,638,332 bp
  • T to A, chromosome 2 at 167,039,030 bp
  • A to G, chromosome 4 at 96,761,980 bp
  • T to C, chromosome 4 at 107,567,645 bp
  • A to T, chromosome 5 at 27,761,677 bp
  • A to T, chromosome 5 at 28,408,282 bp
  • C to T, chromosome 5 at 77,275,243 bp
  • C to A, chromosome 6 at 32,165,844 bp
  • T to A, chromosome 6 at 41,311,299 bp
  • A to G, chromosome 6 at 48,492,894 bp
  • G to T, chromosome 6 at 125,980,124 bp
  • T to C, chromosome 7 at 17,090,534 bp
  • A to T, chromosome 7 at 18,255,928 bp
  • T to C, chromosome 7 at 19,375,383 bp
  • A to G, chromosome 7 at 19,701,836 bp
  • C to G, chromosome 7 at 87,297,508 bp
  • T to A, chromosome 7 at 107,436,471 bp
  • T to A, chromosome 8 at 14,956,963 bp
  • TAGAAGA to TAGA, chromosome 8 at 23,182,849 bp
  • C to A, chromosome 8 at 110,462,522 bp
  • T to C, chromosome 8 at 111,942,518 bp
  • C to T, chromosome 9 at 42,258,650 bp
  • T to A, chromosome 9 at 57,609,200 bp
  • C to T, chromosome 9 at 67,302,572 bp
  • T to C, chromosome 10 at 41,681,686 bp
  • T to C, chromosome 10 at 53,698,500 bp
  • T to A, chromosome 10 at 77,550,103 bp
  • T to C, chromosome 10 at 79,194,328 bp
  • T to C, chromosome 10 at 79,867,525 bp
  • G to A, chromosome 11 at 16,858,980 bp
  • T to C, chromosome 11 at 58,880,924 bp
  • A to G, chromosome 11 at 68,922,839 bp
  • A to T, chromosome 11 at 72,537,270 bp
  • C to T, chromosome 11 at 86,519,887 bp
  • G to A, chromosome 11 at 98,355,481 bp
  • A to G, chromosome 11 at 98,551,291 bp
  • A to G, chromosome 11 at 104,328,049 bp
  • A to G, chromosome 11 at 116,535,280 bp
  • A to G, chromosome 12 at 8,006,456 bp
  • T to C, chromosome 12 at 17,007,184 bp
  • A to T, chromosome 12 at 108,207,175 bp
  • A to G, chromosome 13 at 6,556,542 bp
  • T to C, chromosome 13 at 11,692,646 bp
  • A to T, chromosome 13 at 23,011,630 bp
  • A to G, chromosome 13 at 27,316,324 bp
  • A to G, chromosome 13 at 33,671,228 bp
  • A to T, chromosome 13 at 42,305,253 bp
  • T to C, chromosome 13 at 68,727,905 bp
  • G to A, chromosome 13 at 75,878,932 bp
  • T to A, chromosome 14 at 9,870,091 bp
  • T to C, chromosome 14 at 12,467,139 bp
  • A to G, chromosome 15 at 64,737,438 bp
  • T to C, chromosome 16 at 45,679,348 bp
  • G to A, chromosome 17 at 25,840,694 bp
  • C to A, chromosome 17 at 34,845,197 bp
  • G to A, chromosome 17 at 36,461,796 bp
  • T to A, chromosome 17 at 56,401,675 bp
  • C to A, chromosome 18 at 20,539,736 bp
  • A to T, chromosome 19 at 18,581,288 bp
  • C to T, chromosome 19 at 25,410,034 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4685 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@missouri.edu
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

When this strain becomes available, Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.