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Strain Name:
C57BL/6J-MtgxR4685Btlr/Mmmh
Stock Number:
041936-MU
Citation ID:
RRID:MMRRC_041936-MU
Other Names:
R4685 (G1), C57BL/6J-MtgxR4685Btlr
Major Collection:

Strain Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
Synonyms: DARPP-32, Darpp32
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19049
HGNC: HGNC:9287
Homologene: 12972
Arhgef10
Name: Rho guanine nucleotide exchange factor 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234094
Homologene: 22827
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: p70/85s6k, p70s6k, S6K1, 2610318I15Rik, p70S6K1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72508
Homologene: 81703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 15,818,961 bp
  • T to C, chromosome 1 at 46,211,328 bp
  • G to T, chromosome 1 at 87,152,946 bp
  • T to C, chromosome 1 at 116,446,680 bp
  • A to T, chromosome 1 at 164,066,260 bp
  • C to A, chromosome 1 at 192,595,054 bp
  • T to A, chromosome 2 at 22,407,422 bp
  • A to G, chromosome 2 at 30,188,265 bp
  • T to C, chromosome 2 at 112,406,338 bp
  • G to A, chromosome 2 at 118,546,802 bp
  • A to G, chromosome 2 at 120,305,015 bp
  • T to A, chromosome 2 at 163,864,994 bp
  • C to T, chromosome 2 at 166,638,332 bp
  • T to A, chromosome 2 at 167,039,030 bp
  • A to G, chromosome 4 at 96,761,980 bp
  • T to C, chromosome 4 at 107,567,645 bp
  • A to T, chromosome 5 at 27,761,677 bp
  • A to T, chromosome 5 at 28,408,282 bp
  • C to T, chromosome 5 at 77,275,243 bp
  • C to A, chromosome 6 at 32,165,844 bp
  • T to A, chromosome 6 at 41,311,299 bp
  • A to G, chromosome 6 at 48,492,894 bp
  • G to T, chromosome 6 at 125,980,124 bp
  • T to C, chromosome 7 at 17,090,534 bp
  • A to T, chromosome 7 at 18,255,928 bp
  • T to C, chromosome 7 at 19,375,383 bp
  • A to G, chromosome 7 at 19,701,836 bp
  • C to G, chromosome 7 at 87,297,508 bp
  • T to A, chromosome 7 at 107,436,471 bp
  • T to A, chromosome 8 at 14,956,963 bp
  • TAGAAGA to TAGA, chromosome 8 at 23,182,849 bp
  • C to A, chromosome 8 at 110,462,522 bp
  • T to C, chromosome 8 at 111,942,518 bp
  • C to T, chromosome 9 at 42,258,650 bp
  • T to A, chromosome 9 at 57,609,200 bp
  • C to T, chromosome 9 at 67,302,572 bp
  • T to C, chromosome 10 at 41,681,686 bp
  • T to C, chromosome 10 at 53,698,500 bp
  • T to A, chromosome 10 at 77,550,103 bp
  • T to C, chromosome 10 at 79,194,328 bp
  • T to C, chromosome 10 at 79,867,525 bp
  • G to A, chromosome 11 at 16,858,980 bp
  • T to C, chromosome 11 at 58,880,924 bp
  • A to G, chromosome 11 at 68,922,839 bp
  • A to T, chromosome 11 at 72,537,270 bp
  • C to T, chromosome 11 at 86,519,887 bp
  • G to A, chromosome 11 at 98,355,481 bp
  • A to G, chromosome 11 at 98,551,291 bp
  • A to G, chromosome 11 at 104,328,049 bp
  • A to G, chromosome 11 at 116,535,280 bp
  • A to G, chromosome 12 at 8,006,456 bp
  • T to C, chromosome 12 at 17,007,184 bp
  • A to T, chromosome 12 at 108,207,175 bp
  • A to G, chromosome 13 at 6,556,542 bp
  • T to C, chromosome 13 at 11,692,646 bp
  • A to T, chromosome 13 at 23,011,630 bp
  • A to G, chromosome 13 at 27,316,324 bp
  • A to G, chromosome 13 at 33,671,228 bp
  • A to T, chromosome 13 at 42,305,253 bp
  • T to C, chromosome 13 at 68,727,905 bp
  • G to A, chromosome 13 at 75,878,932 bp
  • T to A, chromosome 14 at 9,870,091 bp
  • T to C, chromosome 14 at 12,467,139 bp
  • A to G, chromosome 15 at 64,737,438 bp
  • T to C, chromosome 16 at 45,679,348 bp
  • G to A, chromosome 17 at 25,840,694 bp
  • C to A, chromosome 17 at 34,845,197 bp
  • G to A, chromosome 17 at 36,461,796 bp
  • T to A, chromosome 17 at 56,401,675 bp
  • C to A, chromosome 18 at 20,539,736 bp
  • A to T, chromosome 19 at 18,581,288 bp
  • C to T, chromosome 19 at 25,410,034 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4685 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@missouri.edu
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

When this strain becomes available, Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.