Strain Name:
C57BL/6J-MtgxR4692Btlr/Mmmh
Stock Number:
041943-MU
Citation ID:
RRID:MMRRC_041943-MU
Other Names:
R4692 (G1), C57BL/6J-MtgxR4692Btlr
Major Collection:

Gene Information

Gsn
Name: gelsolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227753
HGNC: HGNC:4620
Homologene: 147
Sox9
Name: SRY (sex determining region Y)-box 9
Synonyms: 2010306G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20682
Homologene: 294
Cwf19l2
Name: CWF19-like 2, cell cycle control (S. pombe)
Synonyms: 3230401L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244672
Homologene: 12366
Kif13b
Name: kinesin family member 13B
Synonyms: GAKIN, N-3 kinesin, C130021D12Rik, 5330429L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16554
VEGA: 14
Homologene: 9073
Sbno2
Name: strawberry notch 2
Synonyms: Stno
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216161
VEGA: 10
Homologene: 8981
N6amt1
Name: N-6 adenine-specific DNA methyltransferase 1 (putative)
Synonyms: 5830445C04Rik, Pred28, Hemk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67768
Homologene: 5637
Mrgpra1
Name: MAS-related GPR, member A1
Synonyms: MrgA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233221
Homologene: 79615
Robo1
Name: roundabout guidance receptor 1
Synonyms: DUTT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19876
Homologene: 2206
Klhl12
Name: kelch-like 12
Synonyms: C3ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240756
Homologene: 23317
Crebbp
Name: CREB binding protein
Synonyms: CBP, KAT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Rbl2
Name: RB transcriptional corepressor like 2
Synonyms: Rb2, p130, retinoblastoma-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 19651
HGNC: HGNC:9894
Homologene: 4098
Cenpe
Name: centromere protein E
Synonyms: N-7 kinesin, CENP-E, 312kDa, Kif10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Paxip1
Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: PTIP, D5Ertd149e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 55982
HGNC: HGNC:8624
Katnip
Name: katanin interacting protein
Synonyms: D430042O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233865
Homologene: 45841
Fance
Name: Fanconi anemia, complementation group E
Synonyms: 2810451D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72775
HGNC: HGNC:3586
Homologene: 11066
Cyp7b1
Name: cytochrome P450, family 7, subfamily b, polypeptide 1
Synonyms: hct-1, D3Ertd552e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13123
HGNC: HGNC:2652
Homologene: 3544
Snx13
Name: sorting nexin 13
Synonyms: RGS-PX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217463
VEGA: 12
Homologene: 41011
Arhgap20
Name: Rho GTPase activating protein 20
Synonyms: 6530403F17Rik, A530023E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244867
Homologene: 18938
Sh3rf1
Name: SH3 domain containing ring finger 1
Synonyms: Posh, 2200003J05Rik, Sh3md2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 59009
Homologene: 10988
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Speer2
Name: spermatogenesis associated glutamate (E)-rich protein 2
Synonyms: SPEER-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224318
Homologene: 69402
Oas3
Name: 2'-5' oligoadenylate synthetase 3
Synonyms: 2'-5' oligoadenylate synthetase-like 10, Oasl10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 246727
HGNC: HGNC:8088
Homologene: 4510
Zfp329
Name: zinc finger protein 329
Synonyms: 2810439M05Rik, 4632409L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67230
Homologene: 23459
Cog2
Name: component of oligomeric golgi complex 2
Synonyms: 1190002B08Rik, 2700012E02Rik, Cog2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76332
HGNC: HGNC:6546
Homologene: 7206
Car10
Name: carbonic anhydrase 10
Synonyms: CA-RP X, 2700029L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72605
HGNC: HGNC:1369
Homologene: 23201
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Smgc
Name: submandibular gland protein C
Synonyms: Sfc21, 2310010P21Rik, DXImx49e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223809
2310057J18Rik
Name: RIKEN cDNA 2310057J18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67719
Homologene: 82613
Zfp932
Name: zinc finger protein 932
Synonyms: 2310001H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69504
Homologene: 137770
Coro1b
Name: coronin, actin binding protein 1B
Synonyms: coronin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 23789
HGNC: HGNC:2253
Homologene: 40790
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57435
Homologene: 69311
Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Synonyms: CAKbeta, Raftk, calcium-dependent tyrosine kinase, related adhesion focal tyrosine kinase, cellular adhesion kinase beta, proline-rich tyrosine kinase 2, PYK2, E430023O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19229
HGNC: HGNC:9612
Homologene: 23001
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319634
Homologene: 63366
Spag6l
Name: sperm associated antigen 6-like
Synonyms: PF16, Spag6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 50525
Homologene: 8252
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: 9430057O19Rik, Ccp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231093
Homologene: 11053
Olfr1314
Name: olfactory receptor 1314
Synonyms: GA_x6K02T2Q125-73139026-73138088, MOR245-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258442
Homologene: 121538
Zscan26
Name: zinc finger and SCAN domain containing 26
Synonyms: Zfp187
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 432731
Homologene: 43739
Olfr895
Name: olfactory receptor 895
Synonyms: GA_x6K02T2PVTD-31962461-31963411, MOR170-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258875
Homologene: 74253
Arl2
Name: ADP-ribosylation factor-like 2
Synonyms: arf-like protein 2, 2610009M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56327
HGNC: HGNC:693
Homologene: 1260
Platr26
Name: pluripotency associated transcript 26
Synonyms: LOC381371, Gm1631
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381371
Vstm5
Name: V-set and transmembrane domain containing 5
Synonyms: 2200002K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69137
VEGA: 9
Homologene: 45982
Fam53c
Name: family with sequence similarity 53, member C
Synonyms: 2810012G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66306
VEGA: 18
HGNC: HGNC:1336
Homologene: 9586
C2cd6
Name: C2 calcium dependent domain containing 6
Synonyms: 1700052H20Rik, 4930408G06Rik, Als2cr11, Als2cr11b, Gm33589, C2cd6b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102636554
Homologene: 134310
Mapk7
Name: mitogen-activated protein kinase 7
Synonyms: ERK5, BMK1, big MAP kinase 1, Erk5-T, b2b2346Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23939
HGNC: HGNC:6880
Homologene: 2060
Pfn4
Name: profilin family, member 4
Synonyms: 2900024P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 382562
VEGA: 12
Homologene: 20046
1700034P13Rik
Name: RIKEN cDNA 1700034P13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73331
Igkv2-137
Name: immunoglobulin kappa chain variable 2-137
Synonyms: Gm16955
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 692187
BEGAIN_
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
9230104M06Rik
Name: RIKEN cDNA 9230104M06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 108168035
VEGA: 12
Spag6
Name: sperm associated antigen 6
Synonyms: BC061194, Spag6l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381350
Homologene: 133723
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 9,748,074 bp
  • T to C, chromosome 1 at 59,003,350 bp
  • C to T, chromosome 1 at 134,475,883 bp
  • T to C, chromosome 2 at 18,699,243 bp
  • A to G, chromosome 2 at 35,298,871 bp
  • A to G, chromosome 2 at 71,730,921 bp
  • A to G, chromosome 2 at 112,092,681 bp
  • T to A, chromosome 3 at 18,072,564 bp
  • A to G, chromosome 3 at 135,216,379 bp
  • T to C, chromosome 5 at 27,772,097 bp
  • T to C, chromosome 5 at 30,890,151 bp
  • G to A, chromosome 5 at 110,009,186 bp
  • T to C, chromosome 5 at 120,769,355 bp
  • T to A, chromosome 6 at 48,482,687 bp
  • T to C, chromosome 6 at 67,555,987 bp
  • T to C, chromosome 7 at 12,810,632 bp
  • T to A, chromosome 7 at 47,335,698 bp
  • T to C, chromosome 7 at 125,867,669 bp
  • T to C, chromosome 8 at 61,353,854 bp
  • T to A, chromosome 8 at 91,122,419 bp
  • T to C, chromosome 8 at 124,545,406 bp
  • T to C, chromosome 9 at 3,428,709 bp
  • A to T, chromosome 9 at 15,257,422 bp
  • C to T, chromosome 9 at 38,268,530 bp
  • A to G, chromosome 9 at 51,785,788 bp
  • A to T, chromosome 10 at 28,973,886 bp
  • A to G, chromosome 10 at 80,086,327 bp
  • A to G, chromosome 11 at 61,489,242 bp
  • A to T, chromosome 11 at 77,113,681 bp
  • T to C, chromosome 11 at 93,185,158 bp
  • C to A, chromosome 11 at 112,782,977 bp
  • A to T, chromosome 12 at 4,774,486 bp
  • A to G, chromosome 12 at 35,086,918 bp
  • A to G, chromosome 12 at 109,033,892 bp
  • A to T, chromosome 12 at 113,000,072 bp
  • A to G, chromosome 13 at 21,445,257 bp
  • C to A, chromosome 14 at 64,803,575 bp
  • C to T, chromosome 14 at 66,157,069 bp
  • T to A, chromosome 15 at 55,423,468 bp
  • T to C, chromosome 15 at 91,854,561 bp
  • T to C, chromosome 16 at 4,114,863 bp
  • T to A, chromosome 16 at 69,857,972 bp
  • T to G, chromosome 16 at 72,960,202 bp
  • T to C, chromosome 16 at 87,356,966 bp
  • C to T, chromosome 17 at 28,317,110 bp
  • C to A, chromosome 17 at 56,103,762 bp
  • A to C, chromosome 18 at 34,768,690 bp
  • T to C, chromosome 19 at 4,149,419 bp
  • T to C, chromosome 19 at 6,137,746 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4692 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041943-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.