Strain Name:
C57BL/6J-MtgxR4712Btlr/Mmmh
Stock Number:
041981-MU
Citation ID:
RRID:MMRRC_041981-MU
Other Names:
R4712 (G1), C57BL/6J-MtgxR4712Btlr
Major Collection:

Gene Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: 5730405M06Rik, Rxrip13, N-CoR, A230020K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Pcdh9
Name: protocadherin 9
Synonyms: A730003J17Rik, C530050I23Rik, C630029H24Rik, 1500001L12Rik, LOC382930
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Lpp
Name: LIM domain containing preferred translocation partner in lipoma
Synonyms: B130055L10Rik, 9430020K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 210126
VEGA: 16
HGNC: HGNC:6679
Homologene: 4075
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: B930014J03Rik, Bmn, 2410030O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Rngtt
Name: RNA guanylyltransferase and 5'-phosphatase
Synonyms: mouse capping enzyme
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 24018
Homologene: 37851
Zfp101
Name: zinc finger protein 101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22643
Homologene: 137226
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm3, Shrm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Eprs
Name: glutamyl-prolyl-tRNA synthetase
Synonyms: 3010002K18Rik, 2410081F06Rik, Qprs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Prmt1
Name: protein arginine N-methyltransferase 1
Synonyms: Hrmt1l2, 6720434D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15469
HGNC: HGNC:5187
Homologene: 21477
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: Zfat1, LOC380993, Zfp406
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 380993
Homologene: 16829
Tpx2
Name: TPX2, microtubule-associated
Synonyms: p100, REPP86, 2610005B21Rik, DIL2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72119
HGNC: HGNC:1249
Homologene: 8107
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Hspe1
Name: heat shock protein 1 (chaperonin 10)
Synonyms: Hsp10, mitochondrial chaperonin 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15528
HGNC: HGNC:5269
Homologene: 20500
Gfral
Name: GDNF family receptor alpha like
Synonyms: GRAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404194
Homologene: 45748
Siva1
Name: SIVA1, apoptosis-inducing factor
Synonyms: CD27bp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 30954
VEGA: 12
Homologene: 4692
Ahcyl1
Name: S-adenosylhomocysteine hydrolase-like 1
Synonyms: Ahcy-rs3, DCAL, IRBIT, 1110034F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229709
HGNC: HGNC:344
Homologene: 77353
Skor1
Name: SKI family transcriptional corepressor 1
Synonyms: C230094B15Rik, Lbxcor1, Corl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 207667
Homologene: 18175
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Rbp-3, Irbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Gfra2
Name: glial cell line derived neurotrophic factor family receptor alpha 2
Synonyms: GFR alpha 2, GFR alpha-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14586
VEGA: 14
HGNC: HGNC:4244
Homologene: 1145
Chst10
Name: carbohydrate sulfotransferase 10
Synonyms: ST, Hnk-1st
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98388
Homologene: 21013
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Tmprss7
Name: transmembrane serine protease 7
Synonyms: matriptase-3, B230219I23Rik, LOC385645
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208171
Homologene: 18178
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, Dnahc2, Dnhd3, 2900022L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Olfr351
Name: olfactory receptor 351
Synonyms: GA_x6K02T2NLDC-33554926-33553994, MOR127-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258944
HGNC: HGNC:8221
Homologene: 10583
A4galt
Name: alpha 1,4-galactosyltransferase
Synonyms: Gb3 synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239559
VEGA: 15
Homologene: 9690
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17876
Homologene: 69079
Sh3rf1
Name: SH3 domain containing ring finger 1
Synonyms: Posh, Sh3md2, 2200003J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 59009
Homologene: 10988
Csf1
Name: colony stimulating factor 1 (macrophage)
Synonyms: CSF-1, M-CSF, colony-stimulating factor-1, Csfm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12977
HGNC: HGNC:2432
Homologene: 7282
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209012
Homologene: 41205
Rhobtb2
Name: Rho-related BTB domain containing 2
Synonyms: E130206H14Rik, Dbc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 246710
VEGA: 14
Homologene: 22873
Slc20a1
Name: solute carrier family 20, member 1
Synonyms: PiT-1, Glvr1, Glvr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20515
Homologene: 38049
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
2210016F16Rik
Name: RIKEN cDNA 2210016F16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 70153
Homologene: 13005
Olfr124
Name: olfactory receptor 124
Synonyms: MOR256-3, A3, GA_x6K02T2PSCP-2264806-2265753
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 259064
Homologene: 74266
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: Pla2g1br, PLA2-I receptor, M-type receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Gsdmc
Name: gasdermin C
Synonyms: Gsdmc1, Mlze
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 83492
HGNC: HGNC:7151
Homologene: 69487
Slc2a7
Name: solute carrier family 2 (facilitated glucose transporter), member 7
Synonyms: OTTMUSG00000010396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 435818
Homologene: 72470
Obox3
Name: oocyte specific homeobox 3
Synonyms: Ohx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246791
Homologene: 44937
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Elp4
Name: elongator acetyltransferase complex subunit 4
Synonyms: A330107A17Rik, Paxneb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77766
HGNC: HGNC:1171
Homologene: 32433
Narf
Name: nuclear prelamin A recognition factor
Synonyms: 4430402O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67608
Homologene: 57048
Olfr827
Name: olfactory receptor 827
Synonyms: MOR210-5, GA_x6K02T2PULF-11878777-11877809
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258297
Homologene: 27117
Cfh
Name: complement component factor h
Synonyms: Sas-1, Sas1, Mud-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Gpr137b
Name: G protein-coupled receptor 137B
Synonyms: C80741, 2310041G17Rik, Tm7sf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 83924
VEGA: 13
Homologene: 2454
Kif4-ps
Name: kinesin family member 4, pseudogene
Synonyms: Kif4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74947
Efhb
Name: EF hand domain family, member B
Synonyms: 4921525D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 211482
VEGA: 17
Homologene: 16982
Paqr6
Name: progestin and adipoQ receptor family member VI
Synonyms: 1500001B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68957
Homologene: 19746
Pced1b
Name: PC-esterase domain containing 1B
Synonyms: Fam113b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239647
VEGA: 15
Homologene: 16301
Batf2
Name: basic leucine zipper transcription factor, ATF-like 2
Synonyms: 4933430F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74481
Homologene: 12569
Pcdha3
Name: protocadherin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 192163
HGNC: HGNC:8669
Homologene: 129613
2900055J20Rik
Name: RIKEN cDNA 2900055J20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 38,865,841 bp
  • T to A, chromosome 1 at 55,089,110 bp
  • A to T, chromosome 1 at 140,108,536 bp
  • T to A, chromosome 1 at 185,428,108 bp
  • A to T, chromosome 2 at 36,860,369 bp
  • A to T, chromosome 2 at 60,428,650 bp
  • A to C, chromosome 2 at 69,506,551 bp
  • A to G, chromosome 2 at 105,904,459 bp
  • A to T, chromosome 2 at 125,088,837 bp
  • T to C, chromosome 2 at 125,341,316 bp
  • A to G, chromosome 2 at 129,199,691 bp
  • T to A, chromosome 2 at 152,885,038 bp
  • T to A, chromosome 3 at 88,366,254 bp
  • A to G, chromosome 3 at 107,667,231 bp
  • T to A, chromosome 3 at 107,753,849 bp
  • T to C, chromosome 3 at 135,544,814 bp
  • A to G, chromosome 4 at 33,379,394 bp
  • A to G, chromosome 4 at 150,168,469 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • T to C, chromosome 6 at 73,025,012 bp
  • A to G, chromosome 7 at 15,626,839 bp
  • A to T, chromosome 7 at 44,981,636 bp
  • A to G, chromosome 8 at 61,361,759 bp
  • A to C, chromosome 9 at 63,139,573 bp
  • T to A, chromosome 9 at 76,193,445 bp
  • A to T, chromosome 9 at 121,244,370 bp
  • G to A, chromosome 10 at 130,210,422 bp
  • T to A, chromosome 11 at 62,344,834 bp
  • T to A, chromosome 11 at 69,516,590 bp
  • T to C, chromosome 11 at 121,245,339 bp
  • T to C, chromosome 12 at 101,146,275 bp
  • T to A, chromosome 12 at 112,646,902 bp
  • T to C, chromosome 13 at 13,359,389 bp
  • G to A, chromosome 13 at 58,381,803 bp
  • A to T, chromosome 14 at 24,177,983 bp
  • T to C, chromosome 14 at 33,960,658 bp
  • T to C, chromosome 14 at 69,799,711 bp
  • T to A, chromosome 14 at 70,925,937 bp
  • C to A, chromosome 14 at 93,888,631 bp
  • G to T, chromosome 15 at 63,779,537 bp
  • A to T, chromosome 15 at 68,110,475 bp
  • G to T, chromosome 15 at 83,227,609 bp
  • A to T, chromosome 15 at 90,984,755 bp
  • A to G, chromosome 15 at 97,384,794 bp
  • T to C, chromosome 16 at 24,761,657 bp
  • A to T, chromosome 16 at 45,690,760 bp
  • C to A, chromosome 17 at 33,394,483 bp
  • T to A, chromosome 17 at 37,805,700 bp
  • T to C, chromosome 17 at 53,451,669 bp
  • T to G, chromosome 17 at 87,678,385 bp
  • A to T, chromosome 18 at 36,946,507 bp
  • G to T, chromosome 18 at 40,257,180 bp
  • C to A, chromosome 19 at 6,171,327 bp
  • T to A, chromosome 19 at 57,652,950 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4712 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041981-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.