Strain Name:
C57BL/6J-MtgxR4722Btlr/Mmmh
Stock Number:
041987-MU
Citation ID:
RRID:MMRRC_041987-MU
Other Names:
R4722 (G1), C57BL/6J-MtgxR4722Btlr
Major Collection:

Gene Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320790
Homologene: 19067
Zic4
Name: zinc finger protein of the cerebellum 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22774
Homologene: 32075
Oxr1
Name: oxidation resistance 1
Synonyms: C7B, C7, 2210416C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170719
VEGA: 15
Homologene: 24993
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: 5830453M24Rik, Pdzgef1, RA-GEF-1, CNRasGEF, nRapGEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76089
Homologene: 35477
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Autotaxin, Npps2, PD-Ialpha, Pdnp2, ATX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, 3110054G10Rik, D130023A07Rik, 2010321I05Rik, Tnrc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233833
Homologene: 41399
Rnmt
Name: RNA (guanine-7-) methyltransferase
Synonyms: 2610002P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67897
Homologene: 2816
Fam133b
Name: family with sequence similarity 133, member B
Synonyms: 2900022K02Rik, 5830415L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68152
Homologene: 85443
2700097O09Rik
Name: RIKEN cDNA 2700097O09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 72658
Homologene: 36458
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: MICAL-3, C130040D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194401
Homologene: 85288
Med27
Name: mediator complex subunit 27
Synonyms: 1500015J03Rik, 2310042P07Rik, D2Ertd434e, Crsp8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68975
HGNC: HGNC:2377
Homologene: 3152
Ttk
Name: Ttk protein kinase
Synonyms: Esk1, Mps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22137
Homologene: 2489
Gas8
Name: growth arrest specific 8
Synonyms: Gas11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104346
HGNC: HGNC:4166
Homologene: 1135
Epm2aip1
Name: EPM2A (laforin) interacting protein 1
Synonyms: A930003G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77781
Homologene: 8875
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, LOC381026, 9330188B09Rik, D630001M17Rik, 4921513O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
St6galnac3
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Synonyms: ST6GalNAc III, Siat7c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20447
Homologene: 7938
Abcf1
Name: ATP-binding cassette, sub-family F (GCN20), member 1
Synonyms: Abc50, D17Wsu166e, GCN20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224742
HGNC: HGNC:70
Homologene: 849
Tbc1d1
Name: TBC1 domain family, member 1
Synonyms: 1110062G02Rik, Nob1, Nobq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57915
Homologene: 56856
Dtl
Name: denticleless E3 ubiquitin protein ligase
Synonyms: 5730564G15Rik, 2810047L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76843
Homologene: 32313
Abca17
Name: ATP-binding cassette, sub-family A (ABC1), member 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381072
Homologene: 86807
Avpr1a
Name: arginine vasopressin receptor 1A
Synonyms: V1aR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54140
HGNC: HGNC:895
Homologene: 568
Oip5
Name: Opa interacting protein 5
Synonyms: 5730547N13Rik, Lint-25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70645
Homologene: 5268
AW554918
Name: expressed sequence AW554918
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225289
Homologene: 52652
Uxs1
Name: UDP-glucuronate decarboxylase 1
Synonyms: 1600025I13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67883
Homologene: 41609
Gipc3
Name: GIPC PDZ domain containing family, member 3
Synonyms: Gipc3, Rgs19ip3, Ahl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 209047
Homologene: 77068
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Rbm22
Name: RNA binding motif protein 22
Synonyms: 8430430L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66810
Homologene: 69245
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, NaG, Nav2, 1110034K09Rik, Scn6a, Nax
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20272
Homologene: 55706
Adtrp
Name: androgen dependent TFPI regulating protein
Synonyms: 9530008L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109254
Homologene: 13107
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Naip-rs4, Birc1f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Tdrd5
Name: tudor domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214575
Homologene: 18312
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: 2610014H22Rik, Mll2, Wbp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75410
Homologene: 22838
Or10ak12
Name: olfactory receptor family 10 subfamily AK member 12
Synonyms: GA_x6K02T2QD9B-18726774-18727577, GA_x6K02T2QD9B-18723799-18724749, MOR259-5, MOR259-12, Olfr1335, Olfr1334-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 435804
Homologene: 138635
Zfp712
Name: zinc finger protein 712
Synonyms: 4921504N20Rik, mszf31, mszf89
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78251
VEGA: 13
Homologene: 136296
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243961
Homologene: 22949
Krt84
Name: keratin 84
Synonyms: HRb-1, Krt2-3, Krt2-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16680
VEGA: 15
HGNC: HGNC:6461
Homologene: 22473
Bcl3
Name: B cell leukemia/lymphoma 3
Synonyms: Bcl-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12051
HGNC: HGNC:998
Homologene: 81738
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54380
Homologene: 8558
Mlxip
Name: MLX interacting protein
Synonyms: Mondoa, Mir, bHLHe36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208104
Homologene: 22851
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: Sglt1, sodium glucose cotransporter 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20537
Homologene: 55456
Or4c15
Name: olfactory receptor family 4 subfamily C member 15
Synonyms: GA_x6K02T2Q125-50409367-50408432, MOR233-21, MOR233-16P, Olfr1211
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258025
Homologene: 81548
Kctd8
Name: potassium channel tetramerisation domain containing 8
Synonyms: A730087N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243043
Homologene: 18464
Fut9
Name: fucosyltransferase 9
Synonyms: mFUT9, mFuc-TIX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14348
HGNC: HGNC:4020
Homologene: 4800
Or4c104
Name: olfactory receptor family 4 subfamily C member 104
Synonyms: GA_x6K02T2Q125-50231574-50230642, MOR230-8, Olfr1199
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258450
Homologene: 128092
Ccdc130
Name: coiled-coil domain containing 130
Synonyms: 4930527D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67736
Homologene: 12183
Tubal3
Name: tubulin, alpha-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238463
VEGA: 13
Homologene: 23488
Cdc25b
Name: cell division cycle 25B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12531
HGNC: HGNC:1726
Homologene: 41451
Toe1
Name: target of EGR1, member 1 (nuclear)
Synonyms: 4933424D16Rik, 4930584N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68276
Homologene: 11823
Or10a4
Name: olfactory receptor family 10 subfamily A member 4
Synonyms: P2, MOR263-5, GA_x6K02T2PBJ9-9470146-9471093, Olfr17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18314
Homologene: 23241
Amz2
Name: archaelysin family metallopeptidase 2
Synonyms: ESTM12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13929
Aldh1b1
Name: aldehyde dehydrogenase 1 family, member B1
Synonyms: 2700007F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72535
HGNC: HGNC:407
Homologene: 115470
Asic2
Name: acid-sensing (proton-gated) ion channel 2
Synonyms: Mdeg, BNaC1a, BNC1, Accn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11418
HGNC: HGNC:99
Homologene: 137202
Prl7a2
Name: prolactin family 7, subfamily a, member 2
Synonyms: PLP-F, Prlpf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19114
HGNC: HGNC:9445
Homologene: 49263
Vmn1r212
Name: vomeronasal 1 receptor 212
Synonyms: V1rh18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171275
Homologene: 110880
Fuom
Name: fucose mutarotase
Synonyms: 1810014F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69064
Homologene: 19598
Mutyh
Name: mutY DNA glycosylase
Synonyms: 5730495A01Rik, Myh, Mutyhbeta, Mutyhalpha, Mutyhc, Mutyhb, Mutyha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70603
HGNC: HGNC:7527
Homologene: 8156
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 192161
Homologene: 130700
Gkn3
Name: gastrokine 3
Synonyms: 1190003M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68888
Homologene: 87422
Zdhhc4
Name: zinc finger, DHHC domain containing 4
Synonyms: 2900029I10Rik, 1810021D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72881
Homologene: 10006
Slfn14
Name: schlafen 14
Synonyms: LOC237890, Slfn14-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237890
Homologene: 19082
Gm14415
Name: predicted gene 14415
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Or5p61
Name: olfactory receptor family 5 subfamily P member 61
Synonyms: GA_x6K02T2PBJ9-10489044-10488091, MOR204-30P, MOR204-40_p, Olfr485
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258041
Homologene: 110483
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 43,774,846 bp
  • T to C, chromosome 1 at 72,611,337 bp
  • A to T, chromosome 1 at 156,302,375 bp
  • G to T, chromosome 1 at 191,556,841 bp
  • T to A, chromosome 2 at 29,524,435 bp
  • T to A, chromosome 2 at 66,700,884 bp
  • T to G, chromosome 2 at 88,756,012 bp
  • T to C, chromosome 2 at 88,929,980 bp
  • C to T, chromosome 2 at 119,613,011 bp
  • C to T, chromosome 2 at 131,193,351 bp
  • T to G, chromosome 2 at 177,104,746 bp
  • A to G, chromosome 3 at 79,069,173 bp
  • A to T, chromosome 3 at 153,411,529 bp
  • T to A, chromosome 4 at 8,822,445 bp
  • T to C, chromosome 4 at 25,799,734 bp
  • T to G, chromosome 4 at 45,803,472 bp
  • T to A, chromosome 4 at 113,893,855 bp
  • A to T, chromosome 4 at 116,805,200 bp
  • T to A, chromosome 4 at 116,816,872 bp
  • T to C, chromosome 4 at 118,808,949 bp
  • T to A, chromosome 5 at 3,543,949 bp
  • A to G, chromosome 5 at 33,146,711 bp
  • T to C, chromosome 5 at 64,263,557 bp
  • G to A, chromosome 5 at 69,341,201 bp
  • A to T, chromosome 5 at 123,447,202 bp
  • A to G, chromosome 5 at 143,321,781 bp
  • C to T, chromosome 6 at 87,383,525 bp
  • T to C, chromosome 6 at 121,038,525 bp
  • C to T, chromosome 7 at 19,812,523 bp
  • G to A, chromosome 7 at 30,583,202 bp
  • T to A, chromosome 7 at 44,313,214 bp
  • T to A, chromosome 7 at 107,097,570 bp
  • T to A, chromosome 7 at 108,159,238 bp
  • T to C, chromosome 7 at 123,192,090 bp
  • A to G, chromosome 7 at 140,099,567 bp
  • A to T, chromosome 8 at 84,258,810 bp
  • T to A, chromosome 8 at 123,525,635 bp
  • C to T, chromosome 9 at 83,868,593 bp
  • G to T, chromosome 9 at 91,379,204 bp
  • TGTCGCCG to TG, chromosome 9 at 111,272,084 bp
  • T to G, chromosome 10 at 81,341,295 bp
  • T to A, chromosome 10 at 122,449,001 bp
  • T to A, chromosome 11 at 34,695,471 bp
  • A to T, chromosome 11 at 81,968,183 bp
  • T to C, chromosome 11 at 83,283,418 bp
  • C to T, chromosome 11 at 109,434,631 bp
  • G to T, chromosome 12 at 55,061,137 bp
  • G to T, chromosome 13 at 3,928,185 bp
  • T to C, chromosome 13 at 22,883,908 bp
  • A to G, chromosome 13 at 27,660,875 bp
  • T to C, chromosome 13 at 41,767,347 bp
  • A to G, chromosome 13 at 67,042,113 bp
  • G to T, chromosome 13 at 100,307,072 bp
  • A to G, chromosome 14 at 55,854,395 bp
  • T to C, chromosome 15 at 41,813,649 bp
  • T to G, chromosome 15 at 54,887,589 bp
  • C to A, chromosome 15 at 91,688,901 bp
  • A to T, chromosome 15 at 101,528,411 bp
  • A to G, chromosome 17 at 24,265,429 bp
  • T to C, chromosome 17 at 35,958,041 bp
  • C to A, chromosome 18 at 25,174,715 bp
  • C to T, chromosome 18 at 37,091,880 bp
  • G to A, chromosome 18 at 60,564,391 bp
  • T to A, chromosome 18 at 68,305,881 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4722 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041987-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.