Strain Name:
C57BL/6J-MtgxR4805Btlr/Mmmh
Stock Number:
041999-MU
Citation ID:
RRID:MMRRC_041999-MU
Other Names:
R4805 (G1), C57BL/6J-MtgxR4805Btlr
Major Collection:

Strain Information

Arhgef7
Name: Rho guanine nucleotide exchange factor
Synonyms: Cool, PIX, Pak interacting exchange factor, p85SPR, betaPix-c, betaPix-b, cool-1, betaPix
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54126
Homologene: 2895
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, MYH-beta/slow, beta-MHC, B-MHC, MyHC-I, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Wsb1
Name: WD repeat and SOCS box-containing 1
Synonyms: 2700038M07Rik, 1110056B13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78889
Homologene: 9218
Dhx35
Name: DEAH-box helicase 35
Synonyms: Ddx35, 1200009D07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71715
Homologene: 6406
Mapkap1
Name: mitogen-activated protein kinase associated protein 1
Synonyms: D230039K05Rik, Sin1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227743
Homologene: 11473
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: D6Ertd380e, 9530019N15Rik, Mi-2beta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: E130014J05Rik, Ayu17-449
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214133
Homologene: 49498
Ccnt1
Name: cyclin T1
Synonyms: CycT1, 2810478G24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12455
HGNC: HGNC:1599
Homologene: 947
Ipo7
Name: importin 7
Synonyms: RanBP7, Imp7, A330055O14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233726
HGNC: HGNC:9852
Homologene: 4659
Zmat3
Name: zinc finger matrin type 3
Synonyms: Wig1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22401
Homologene: 32545
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: 5230400C17Rik, Pip5k3, PipkIII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18711
Homologene: 32115
Gm14403
Name: predicted gene 14403
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433520
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Shisal1
Name: shisa like 1
Synonyms: 1810041L15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72301
Homologene: 28255
Naxd
Name: NAD(P)HX dehydratase
Synonyms: 2810407E01Rik, 0710008K08Rik, Carkd
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69225
Homologene: 6333
Lmo2
Name: LIM domain only 2
Synonyms: Rbtn-2, Rbtn2, Rhom-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16909
HGNC: HGNC:6642
Homologene: 4072
Steap3
Name: STEAP family member 3
Synonyms: 1010001D01Rik, pHyde
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68428
Homologene: 10084
Nobox
Name: NOBOX oogenesis homeobox
Synonyms: Og2x
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18291
Homologene: 51066
Scnn1g
Name: sodium channel, nonvoltage-gated 1 gamma
Synonyms: ENaC gamma
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20278
Homologene: 20280
Flywch1
Name: FLYWCH-type zinc finger 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224613
VEGA: 17
Homologene: 72130
Ttn
Name: titin
Synonyms: connectin, L56, 1100001C23Rik, mdm, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: smMHC, SM2, SM1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320558
Homologene: 8604
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 1110004O12Rik, 9130019P20Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Ifi206
Name: interferon activated gene 206
Synonyms: Gm4955, Pyblhin-C
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102639543
HGNC: HGNC:5395
Homologene: 115929
Ttc41
Name: tetratricopeptide repeat domain 41
Synonyms: Gnn, BC030307
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103220
VEGA: 10
Homologene: 52968
Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: D030049F17Rik, Nedl2, A730039N16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329152
Homologene: 66192
Krt20
Name: keratin 20
Synonyms: 9030623C06Rik, CK20, cytokeratin 20
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66809
Homologene: 56837
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243961
Homologene: 22949
Or5b101
Name: olfactory receptor family 5 subfamily B member 101
Synonyms: GA_x6K02T2RE5P-3357666-3356743, MOR202-6, Olfr1453
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258695
HGNC: HGNC:8324
Homologene: 120159
Ighv2-7
Name: immunoglobulin heavy variable 2-7
Synonyms: Gm16597
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 780793
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231589
Homologene: 129606
Snap47
Name: synaptosomal-associated protein, 47
Synonyms: SNAP-47, 1110031B06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67826
Homologene: 14206
Ntn4
Name: netrin 4
Synonyms: beta-netrin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57764
Homologene: 10934
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: 1700074E13Rik, D130067I03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210417
Homologene: 18180
Serpina5
Name: serine (or cysteine) peptidase inhibitor, clade A, member 5
Synonyms: Pci, antitrypsin, alpha-1 antiproteinase, PAI-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268591
HGNC: HGNC:8723
Homologene: 20159
Pramel15
Name: PRAME like 15
Synonyms: EG627009, Gm13125, Pramef20
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 627009
Homologene: 133194
Rad21l
Name: RAD21-like (S. pombe)
Synonyms: Gm14160
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668929
Homologene: 82650
Itga2b
Name: integrin alpha 2b
Synonyms: platelet glycoprotein IIb, GpIIb, alphaIIb, CD41, GP IIb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16399
HGNC: HGNC:6138
Homologene: 37304
Lrrc31
Name: leucine rich repeat containing 31
Synonyms: E230002P03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320352
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, Vmn2r119, EG383258
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383258
Homologene: 129687
Vmn1r10
Name: vomeronasal 1 receptor 10
Synonyms: V1rc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113858
Homologene: 76459
Zswim3
Name: zinc finger SWIM-type containing 3
Synonyms: 4921517A06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67538
Homologene: 15436
Acaa1b
Name: acetyl-Coenzyme A acyltransferase 1B
Synonyms: thiolase B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235674
HGNC: HGNC:82
Homologene: 91131
Gpr161
Name: G protein-coupled receptor 161
Synonyms: LOC240888, vl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240888
Homologene: 17824
Gstm2
Name: glutathione S-transferase, mu 2
Synonyms: Gstb-2, Gstb2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14863
Homologene: 121492
Mrgprb3
Name: MAS-related GPR, member B3
Synonyms: MrgB3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404238
Homologene: 138632
Gal3st4
Name: galactose-3-O-sulfotransferase 4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330217
Homologene: 11633
Zfp764
Name: zinc finger protein 764
Synonyms: 8030466O12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233893
Homologene: 62158
Mgat4d
Name: MGAT4 family, member C
Synonyms: 4933434I20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67555
Homologene: 128538
Aebp1
Name: AE binding protein 1
Synonyms: ACLP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11568
HGNC: HGNC:303
Homologene: 878
Tspo2
Name: translocator protein 2
Synonyms: 2510027D20Rik, Bzrpl1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70026
Homologene: 12344
4931414P19Rik
Name: RIKEN cDNA 4931414P19 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74359
VEGA: 14
Homologene: 11078
Med24
Name: mediator complex subunit 24
Synonyms: Trap100, D11Ertd307e, R75526, 100kDa, DRIP100, Gse2, Pparb2, Thrap4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23989
Homologene: 40795
Thumpd2
Name: THUMP domain containing 2
Synonyms: 2810025A12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72167
VEGA: 17
Homologene: 11898
RP24-150H14.4
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Gm5283
Name: predicted gene 5283
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 383936
Or2t29
Name: olfactory receptor family 2 subfamily T member 29
Synonyms: GA_x6K02T2NKPP-882068-883006, MOR275-6P, Olfr329-ps, Olfr329
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259148
Homologene: 133015
Ighv1-83
Name: immunoglobulin heavy variable 1-83
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 620140
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,840,859 bp
  • T to A, chromosome 1 at 65,268,800 bp
  • T to A, chromosome 1 at 120,243,886 bp
  • T to C, chromosome 1 at 130,188,539 bp
  • A to T, chromosome 1 at 139,053,384 bp
  • T to A, chromosome 1 at 165,306,460 bp
  • T to A, chromosome 1 at 173,481,386 bp
  • T to A, chromosome 1 at 185,345,307 bp
  • G to A, chromosome 2 at 34,597,422 bp
  • T to C, chromosome 2 at 76,747,529 bp
  • T to C, chromosome 2 at 103,981,062 bp
  • T to G, chromosome 2 at 151,668,007 bp
  • T to C, chromosome 2 at 158,815,474 bp
  • C to T, chromosome 2 at 164,820,179 bp
  • T to C, chromosome 2 at 177,508,699 bp
  • T to C, chromosome 2 at 178,393,961 bp
  • G to T, chromosome 3 at 17,230,959 bp
  • A to T, chromosome 3 at 30,691,297 bp
  • A to G, chromosome 3 at 32,343,355 bp
  • A to T, chromosome 3 at 107,985,095 bp
  • A to G, chromosome 3 at 133,467,315 bp
  • A to G, chromosome 4 at 144,377,020 bp
  • C to T, chromosome 5 at 109,156,465 bp
  • T to A, chromosome 5 at 138,265,471 bp
  • T to C, chromosome 6 at 43,305,119 bp
  • T to G, chromosome 6 at 57,113,617 bp
  • T to C, chromosome 6 at 125,128,945 bp
  • T to C, chromosome 7 at 44,343,711 bp
  • C to T, chromosome 7 at 48,643,306 bp
  • T to A, chromosome 7 at 110,051,484 bp
  • T to C, chromosome 7 at 121,746,602 bp
  • T to A, chromosome 7 at 127,406,257 bp
  • C to T, chromosome 8 at 11,510,250 bp
  • G to A, chromosome 8 at 11,831,552 bp
  • T to G, chromosome 8 at 83,358,158 bp
  • A to G, chromosome 9 at 119,156,946 bp
  • G to T, chromosome 10 at 86,729,798 bp
  • C to T, chromosome 10 at 93,644,500 bp
  • AGAGGAGGAGGAGGAGGAGGAGGAGGA to AGAGGAGGAGGAGGAGGAGGAGGA, chromosome 11 at 5,871,750 bp
  • A to T, chromosome 11 at 55,283,979 bp
  • G to A, chromosome 11 at 58,542,570 bp
  • A to G, chromosome 11 at 59,428,517 bp
  • A to C, chromosome 11 at 79,240,391 bp
  • C to T, chromosome 11 at 98,710,442 bp
  • A to G, chromosome 11 at 99,428,985 bp
  • T to C, chromosome 11 at 102,467,866 bp
  • A to G, chromosome 11 at 103,504,309 bp
  • G to A, chromosome 12 at 104,102,201 bp
  • A to T, chromosome 12 at 113,807,534 bp
  • A to T, chromosome 12 at 115,963,869 bp
  • T to C, chromosome 14 at 54,595,454 bp
  • T to C, chromosome 14 at 54,985,133 bp
  • T to A, chromosome 15 at 82,066,427 bp
  • T to A, chromosome 15 at 84,417,196 bp
  • C to T, chromosome 15 at 98,544,308 bp
  • T to A, chromosome 16 at 14,234,465 bp
  • A to C, chromosome 17 at 23,760,617 bp
  • A to G, chromosome 17 at 48,449,993 bp
  • G to T, chromosome 17 at 55,592,581 bp
  • G to A, chromosome 17 at 81,026,701 bp
  • C to A, chromosome 18 at 36,632,803 bp
  • T to A, chromosome 19 at 13,028,297 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4805 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041999-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.