Strain Name:
C57BL/6J-MtgxR4768Btlr/Mmmh
Stock Number:
042409-MU
Citation ID:
RRID:MMRRC_042409-MU
Other Names:
R4768 (G1), C57BL/6J-MtgxR4768Btlr
Major Collection:

Strain Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268281
Homologene: 6489
Acadm
Name: acyl-Coenzyme A dehydrogenase, medium chain
Synonyms: MCAD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11364
HGNC: HGNC:89
Homologene: 3
Gabrg1
Name: gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Prrx1
Name: paired related homeobox 1
Synonyms: K-2, Prx1, mHox, Pmx1, mHox, A230024N07Rik, MHox1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18933
HGNC: HGNC:9142
Homologene: 7896
Etv1
Name: ets variant 1
Synonyms: ER81, Etsrp81
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Myo1e
Name: myosin IE
Synonyms: 2310020N23Rik, 9130023P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Suclg2
Name: succinate-Coenzyme A ligase, GDP-forming, beta subunit
Synonyms: D6Wsu120e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20917
Homologene: 2854
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Aimp1
Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Synonyms: Emap2, AIMP1/p43, 9830137A06Rik, Scye1, EMAPII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13722
Homologene: 31260
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Cmas
Name: cytidine monophospho-N-acetylneuraminic acid synthetase
Synonyms: CMP-Neu5Ac synthase, D6Bwg0250e, CMP-sialic acid synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12764
Homologene: 7670
Vars
Name: valyl-tRNA synthetase
Synonyms: G7a, D17H6S56E, Bat-6, Bat6, Vars2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22321
Homologene: 4587
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: NMHC II-C, 2400004E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71960
Homologene: 23480
Zzz3
Name: zinc finger, ZZ domain containing 3
Synonyms: 3110065C23Rik, 6430567E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108946
Homologene: 9182
Top3a
Name: topoisomerase (DNA) III alpha
Synonyms: Top IIIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21975
Homologene: 3394
Fut8
Name: fucosyltransferase 8
Synonyms: alpha (1,6) fucosyltransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 53618
VEGA: 12
HGNC: HGNC:4019
Homologene: 9650
Fam13c
Name: family with sequence similarity 13, member C
Synonyms: C030038O19Rik, 1200015N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71721
Homologene: 11490
Slc9a2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2
Synonyms: NHE2, 4932415O19Rik, 2210416H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226999
Homologene: 20661
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: STK, Fv-2, Ron, CDw136, friend virus susceptibility 2, PTK8, Fv2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: dunce, Dpde3, 9630011N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Amdhd1
Name: amidohydrolase domain containing 1
Synonyms: 1300019J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71761
Homologene: 14730
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233651
Homologene: 2771
Xylt2
Name: xylosyltransferase II
Synonyms: E030002B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217119
Homologene: 23349
Fcsk
Name: fucose kinase
Synonyms: L-fucose kinase, 1110046B12Rik, Fuk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234730
Homologene: 15452
Arhgap5
Name: Rho GTPase activating protein 5
Synonyms: p190-B, p190B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11855
VEGA: 12
HGNC: HGNC:675
Homologene: 907
Kansl1l
Name: KAT8 regulatory NSL complex subunit 1-like
Synonyms: C430010P07Rik, 1110028C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68691
Homologene: 27376
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268527
Homologene: 8780
Brd8dc
Name: BRD8 domain containing
Synonyms: 4933408B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 271508
Rxfp1
Name: relaxin/insulin-like family peptide receptor 1
Synonyms: LOC381489, Lgr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381489
Homologene: 11007
Atxn1
Name: ataxin 1
Synonyms: Atx1, Sca1, 2900016G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20238
VEGA: 13
Homologene: 281
Ugt1a6a
Name: UDP glucuronosyltransferase 1 family, polypeptide A6A
Synonyms: UGT1.6, Ugt1a6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94284
Homologene: 85959
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: Dtgn1, MDC-L, D430033C21Rik, C130072N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Pilrb1
Name: paired immunoglobin-like type 2 receptor beta 1
Synonyms: Fdact, Pilrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 170741
Homologene: 114502
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100009609
Or8k28
Name: olfactory receptor family 8 subfamily K member 28
Synonyms: GA_x6K02T2Q125-47925557-47924616, MOR188-8, MOR256-52P, Olfr1066
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257880
Homologene: 79468
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 80721
Homologene: 23530
Or8b12
Name: olfactory receptor family 8 subfamily B member 12
Synonyms: GA_x6K02T2PVTD-31428850-31429782, MOR161-2, Olfr874
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258882
Homologene: 17377
Clca4c-ps
Name: chloride channel accessory 4C, pseudogene
Synonyms: Gm6289, Clca4c, Gm18718
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 622139
Krt27
Name: keratin 27
Synonyms: Krt1-c29, mIRSa3.1, stpm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16675
Homologene: 7805
Or7d10
Name: olfactory receptor family 7 subfamily D member 10
Synonyms: 18A, MOR143-1, GA_x6K02T2PVTD-13660026-13660964, Olfr77
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258336
HGNC: HGNC:8380
Homologene: 133688
Mdfi
Name: MyoD family inhibitor
Synonyms: I-mf, I-mfa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17240
HGNC: HGNC:6967
Homologene: 21150
Bmp4
Name: bone morphogenetic protein 4
Synonyms: Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12159
HGNC: HGNC:1071
Homologene: 7247
Upp2
Name: uridine phosphorylase 2
Synonyms: UDRPASE2, UPASE2, UP2, 1700124F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76654
Homologene: 12654
Mrgpra3
Name: MAS-related GPR, member A3
Synonyms: G protein-coupled receptor, MrgA3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233222
Homologene: 131159
Zcchc24
Name: zinc finger, CCHC domain containing 24
Synonyms: 2310047A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71918
Homologene: 66746
Gm13938
Name: predicted gene 13938
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Or8b55
Name: olfactory receptor family 8 subfamily B member 55
Synonyms: GA_x6K02T2PVTD-32518237-32519172, MOR161-3, Olfr922
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258777
VEGA: 9
Homologene: 27262
Asb5
Name: ankyrin repeat and SOCs box-containing 5
Synonyms: 1110018D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76294
Homologene: 12637
Igkv9-120
Name: immunoglobulin kappa chain variable 9-120
Synonyms: Gm5571
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434025
Gm10862
Name: predicted gene 10862
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Gm15200
Name: predicted gene 15200
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Ighv1-5
Name: immunoglobulin heavy variable V1-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 668469
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 40,726,374 bp
  • A to G, chromosome 1 at 66,801,133 bp
  • G to A, chromosome 1 at 83,023,113 bp
  • TAAAAAAAAA to TAAAAAAA, chromosome 1 at 88,215,928 bp
  • A to G, chromosome 1 at 163,257,765 bp
  • A to C, chromosome 2 at 4,092,086 bp
  • T to C, chromosome 2 at 58,777,895 bp
  • C to T, chromosome 2 at 76,768,766 bp
  • A to T, chromosome 2 at 86,455,650 bp
  • T to C, chromosome 3 at 79,686,868 bp
  • A to G, chromosome 3 at 132,683,772 bp
  • A to T, chromosome 3 at 144,889,647 bp
  • A to G, chromosome 3 at 152,448,783 bp
  • A to G, chromosome 3 at 153,922,942 bp
  • A to G, chromosome 5 at 70,754,173 bp
  • G to A, chromosome 5 at 137,857,526 bp
  • G to T, chromosome 6 at 68,050,367 bp
  • T to G, chromosome 6 at 95,566,488 bp
  • T to C, chromosome 6 at 142,764,431 bp
  • G to T, chromosome 7 at 29,004,821 bp
  • A to T, chromosome 7 at 44,613,675 bp
  • C to A, chromosome 7 at 47,589,728 bp
  • A to G, chromosome 7 at 84,947,394 bp
  • T to C, chromosome 7 at 105,771,620 bp
  • G to A, chromosome 8 at 54,584,996 bp
  • T to C, chromosome 8 at 110,892,134 bp
  • A to C, chromosome 9 at 19,920,545 bp
  • T to C, chromosome 9 at 37,746,881 bp
  • T to A, chromosome 9 at 38,815,949 bp
  • T to C, chromosome 9 at 70,370,469 bp
  • C to A, chromosome 9 at 107,911,650 bp
  • A to G, chromosome 10 at 11,181,540 bp
  • C to A, chromosome 10 at 42,698,260 bp
  • T to C, chromosome 10 at 50,700,499 bp
  • T to A, chromosome 10 at 70,551,750 bp
  • T to A, chromosome 10 at 93,534,484 bp
  • A to G, chromosome 11 at 60,762,490 bp
  • T to C, chromosome 11 at 94,670,472 bp
  • T to A, chromosome 11 at 99,349,525 bp
  • T to C, chromosome 12 at 16,740,070 bp
  • T to C, chromosome 12 at 38,827,793 bp
  • T to C, chromosome 12 at 52,557,492 bp
  • A to G, chromosome 12 at 77,365,280 bp
  • A to T, chromosome 12 at 114,513,523 bp
  • A to G, chromosome 13 at 45,557,548 bp
  • A to G, chromosome 13 at 109,933,874 bp
  • C to A, chromosome 14 at 25,715,258 bp
  • C to T, chromosome 14 at 46,385,924 bp
  • A to G, chromosome 14 at 68,634,815 bp
  • A to T, chromosome 16 at 14,131,597 bp
  • T to C, chromosome 17 at 35,004,962 bp
  • G to A, chromosome 17 at 47,824,550 bp
  • T to C, chromosome 18 at 34,580,952 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4768 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042409-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.