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Strain Name:
C57BL/6J-MtgxR4824Btlr/Mmmh
Stock Number:
042440-MU
Citation ID:
RRID:MMRRC_042440-MU
Other Names:
R4824 (G1), C57BL/6J-MtgxR4824Btlr
Major Collection:

Strain Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Rps8
Name: ribosomal protein S8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20116
Homologene: 133143
Zfp13
Name: zinc finger protein 13
Synonyms: Krox-8, Zfp-13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22654
VEGA: 17
Homologene: 2580
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 37,875,432 bp
  • A to G, chromosome 1 at 75,550,623 bp
  • G to A, chromosome 1 at 86,024,326 bp
  • A to G, chromosome 1 at 86,137,098 bp
  • C to T, chromosome 1 at 169,961,195 bp
  • G to A, chromosome 1 at 193,174,657 bp
  • A to G, chromosome 2 at 25,277,752 bp
  • T to A, chromosome 2 at 29,940,203 bp
  • A to G, chromosome 2 at 30,082,949 bp
  • G to A, chromosome 2 at 52,204,879 bp
  • A to G, chromosome 2 at 52,675,810 bp
  • T to A, chromosome 2 at 77,124,336 bp
  • T to C, chromosome 2 at 87,857,277 bp
  • A to C, chromosome 2 at 88,050,088 bp
  • T to A, chromosome 2 at 128,628,690 bp
  • C to T, chromosome 2 at 148,875,174 bp
  • T to A, chromosome 2 at 164,393,231 bp
  • A to T, chromosome 2 at 165,292,002 bp
  • A to G, chromosome 3 at 27,885,008 bp
  • C to T, chromosome 3 at 33,813,155 bp
  • A to G, chromosome 3 at 92,365,896 bp
  • A to G, chromosome 3 at 138,065,676 bp
  • G to A, chromosome 3 at 138,429,046 bp
  • C to T, chromosome 4 at 4,016,216 bp
  • G to A, chromosome 4 at 64,017,620 bp
  • A to G, chromosome 4 at 107,350,503 bp
  • G to C, chromosome 4 at 117,155,155 bp
  • C to A, chromosome 4 at 133,556,023 bp
  • A to G, chromosome 4 at 148,617,593 bp
  • C to A, chromosome 4 at 148,944,571 bp
  • A to T, chromosome 4 at 154,666,887 bp
  • T to C, chromosome 5 at 24,440,143 bp
  • T to C, chromosome 5 at 32,844,399 bp
  • A to G, chromosome 5 at 44,034,390 bp
  • T to A, chromosome 5 at 114,415,726 bp
  • T to G, chromosome 5 at 115,643,395 bp
  • T to G, chromosome 5 at 120,738,346 bp
  • T to A, chromosome 5 at 123,631,023 bp
  • T to A, chromosome 5 at 123,790,133 bp
  • C to A, chromosome 5 at 136,990,174 bp
  • T to A, chromosome 5 at 149,595,332 bp
  • C to T, chromosome 5 at 150,043,161 bp
  • T to C, chromosome 5 at 150,539,735 bp
  • A to T, chromosome 6 at 76,980,781 bp
  • C to G, chromosome 6 at 124,509,081 bp
  • C to T, chromosome 7 at 7,387,063 bp
  • T to C, chromosome 7 at 26,380,564 bp
  • A to T, chromosome 7 at 49,409,001 bp
  • T to A, chromosome 7 at 79,750,069 bp
  • G to T, chromosome 7 at 119,786,813 bp
  • C to A, chromosome 7 at 120,475,479 bp
  • T to C, chromosome 7 at 127,883,735 bp
  • C to A, chromosome 7 at 140,779,896 bp
  • T to A, chromosome 7 at 141,864,185 bp
  • T to A, chromosome 8 at 18,632,687 bp
  • A to G, chromosome 8 at 24,533,859 bp
  • A to G, chromosome 8 at 44,989,114 bp
  • T to C, chromosome 8 at 45,255,342 bp
  • G to A, chromosome 8 at 72,200,460 bp
  • T to C, chromosome 8 at 126,591,433 bp
  • T to A, chromosome 9 at 23,223,660 bp
  • A to G, chromosome 9 at 39,184,205 bp
  • A to G, chromosome 9 at 55,249,121 bp
  • T to G, chromosome 9 at 87,204,159 bp
  • T to A, chromosome 9 at 96,688,201 bp
  • T to C, chromosome 9 at 124,028,772 bp
  • A to G, chromosome 10 at 11,185,364 bp
  • T to A, chromosome 10 at 79,865,673 bp
  • T to C, chromosome 10 at 111,507,655 bp
  • A to G, chromosome 10 at 127,993,655 bp
  • A to G, chromosome 11 at 30,118,295 bp
  • T to A, chromosome 11 at 35,797,825 bp
  • A to G, chromosome 11 at 53,465,643 bp
  • T to C, chromosome 11 at 60,553,871 bp
  • G to A, chromosome 11 at 62,309,096 bp
  • T to C, chromosome 11 at 65,152,615 bp
  • A to G, chromosome 11 at 69,677,995 bp
  • A to T, chromosome 11 at 70,961,624 bp
  • C to T, chromosome 11 at 73,012,572 bp
  • A to G, chromosome 11 at 73,602,600 bp
  • C to A, chromosome 11 at 93,925,702 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • G to T, chromosome 11 at 108,414,261 bp
  • C to A, chromosome 11 at 117,722,905 bp
  • T to C, chromosome 11 at 120,099,166 bp
  • A to T, chromosome 11 at 120,375,586 bp
  • C to A, chromosome 12 at 29,849,400 bp
  • A to G, chromosome 12 at 79,054,803 bp
  • A to G, chromosome 13 at 49,379,012 bp
  • T to A, chromosome 13 at 53,110,683 bp
  • A to T, chromosome 13 at 55,604,349 bp
  • A to T, chromosome 13 at 59,729,241 bp
  • T to C, chromosome 13 at 93,093,574 bp
  • C to T, chromosome 13 at 96,616,487 bp
  • C to G, chromosome 13 at 109,116,866 bp
  • A to T, chromosome 13 at 112,723,298 bp
  • A to T, chromosome 14 at 8,665,997 bp
  • A to G, chromosome 14 at 14,175,885 bp
  • C to A, chromosome 14 at 40,840,344 bp
  • A to G, chromosome 15 at 10,485,742 bp
  • A to T, chromosome 15 at 59,333,636 bp
  • T to A, chromosome 15 at 75,271,720 bp
  • T to A, chromosome 15 at 102,981,793 bp
  • G to A, chromosome 16 at 15,888,114 bp
  • C to T, chromosome 16 at 19,957,028 bp
  • A to C, chromosome 16 at 96,162,029 bp
  • C to A, chromosome 17 at 15,733,124 bp
  • T to A, chromosome 17 at 18,151,921 bp
  • T to C, chromosome 17 at 23,576,823 bp
  • C to A, chromosome 17 at 24,501,129 bp
  • T to C, chromosome 17 at 28,806,486 bp
  • T to A, chromosome 17 at 34,050,963 bp
  • T to A, chromosome 18 at 23,960,192 bp
  • T to A, chromosome 18 at 37,690,449 bp
  • A to T, chromosome 19 at 4,200,537 bp
  • A to G, chromosome 19 at 4,362,787 bp
  • C to T, chromosome 19 at 6,472,321 bp
  • A to C, chromosome 19 at 13,828,354 bp
  • G to A, chromosome 19 at 29,585,842 bp
  • A to G, chromosome 19 at 36,981,048 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4824 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042440-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.