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Strain Name:
C57BL/6J-MtgxR4843Btlr/Mmmh
Stock Number:
042456-MU
Citation ID:
RRID:MMRRC_042456-MU
Other Names:
R4843 (G1), C57BL/6J-MtgxR4843Btlr
Major Collection:

Strain Information

Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108912
Homologene: 18444
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: p100 co-activator, Tudor-SN
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56463
Homologene: 8665
Srfbp1
Name: serum response factor binding protein 1
Synonyms: 2810036K01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67222
VEGA: 18
Homologene: 12101
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Rtf1
Name: RTF1, Paf1/RNA polymerase II complex component
Synonyms: 6530416A09Rik, 2900005O08Rik, Gtl7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76246
Homologene: 133868
Unc13d
Name: unc-13 homolog D
Synonyms: Munc13-4, 2610108D09Rik, Jinx
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70450
Homologene: 26714
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Ten-m2, D3Bwg1534e, 9330187F13Rik, 2610040L17Rik, Odz2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237339
Homologene: 18226
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: Stank, 1110014O20Rik, B230339E18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15258
Homologene: 68766
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: 8430415E05Rik, 1700034M03Rik, Ccdc132
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73288
Homologene: 11498
Acp1
Name: acid phosphatase 1, soluble
Synonyms: LMW-PTP, Acp-1, 4632432E04Rik, Lmptp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11431
VEGA: 12
HGNC: HGNC:122
Homologene: 38274
Spag9
Name: sperm associated antigen 9
Synonyms: 4733401I23Rik, syd1, 4831406C20Rik, Mapk8ip4, JIP4, 3110018C07Rik, JLP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: D330024H06Rik, A930031B09Rik, Ankrd15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
Cdan1
Name: codanin 1
Synonyms: CDA-I, CDA1, 1500015A01Rik, codanin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Prmt5
Name: protein arginine N-methyltransferase 5
Synonyms: Jbp1, Jak-binding protein 1, Skb1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27374
Homologene: 4454
Pnisr
Name: PNN interacting serine/arginine-rich
Synonyms: 5730406M06Rik, Sfrs18
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66625
Homologene: 32802
Rpf2
Name: ribosome production factor 2 homolog
Synonyms: 2810470K21Rik, Bxdc1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67239
Homologene: 6404
AW554918
Name: expressed sequence AW554918
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225289
Homologene: 52652
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 1810037O03Rik, 9530009M10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Washc5
Name: WASH complex subunit 5
Synonyms: strumpellin, E430025E21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223593
VEGA: 15
Homologene: 8898
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1, G1-415-19, ferf1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Hmgcll1
Name: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208982
Homologene: 27863
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Mtrf1l
Name: mitochondrial translational release factor 1-like
Synonyms: 9130004K12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108853
Homologene: 5905
Ripk2
Name: receptor (TNFRSF)-interacting serine-threonine kinase 2
Synonyms: CCK, CARDIAK, RIP2, RICK, CARD3, D4Bwg0615e, 2210420D18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192656
Homologene: 37856
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Zxdc
Name: ZXD family zinc finger C
Synonyms: B930086F11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 80292
Homologene: 82340
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
Or6c1b
Name: olfactory receptor family 6 subfamily C member 1B
Synonyms: GA_x6K02T2PULF-11116958-11117896, MOR111-5, Olfr786
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258542
HGNC: HGNC:8355
Homologene: 133582
Adam5
Name: a disintegrin and metallopeptidase domain 5
Synonyms: tMDCII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11499
HGNC: HGNC:212
Homologene: 49138
Fbxw10
Name: F-box and WD-40 domain protein 10
Synonyms: SM2SH2, SM25H2, Fbw10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213980
Homologene: 32757
Tpsg1
Name: tryptase gamma 1
Synonyms: TMT, Prss31
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26945
Homologene: 74994
Tmem106a
Name: transmembrane protein 106A
Synonyms: 0610008L10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217203
Homologene: 16996
Or5p69
Name: olfactory receptor family 5 subfamily P member 69
Synonyms: GA_x6K02T2PBJ9-10697517-10698461, MOR204-10, Olfr494
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258732
Homologene: 133602
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: B430315C20Rik, Hisppd2a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 327655
Homologene: 49395
Vmn1r68
Name: vomeronasal 1 receptor 68
Synonyms: Gm6898
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628580
Homologene: 120153
Kcnip1
Name: Kv channel-interacting protein 1
Synonyms: 2900046L02Rik, KCHIP1, 3202002F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70357
Homologene: 22824
Actl11
Name: actin-like 11
Synonyms: 4921517D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67722
Homologene: 69412
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041449
Homologene: 135775
Fap
Name: fibroblast activation protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14089
HGNC: HGNC:3590
Homologene: 48282
Ap2s1
Name: adaptor-related protein complex 2, sigma 1 subunit
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232910
HGNC: HGNC:565
Homologene: 3001
Cnppd1
Name: cyclin Pas1/PHO80 domain containing 1
Synonyms: 1810031K17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69171
Homologene: 9238
Ces1g
Name: carboxylesterase 1G
Synonyms: Ces-1, Ses-1, Ces1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12623
HGNC: HGNC:1863
Homologene: 137354
Car15
Name: carbonic anhydrase 15
Synonyms: Cals2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 80733
Homologene: 113791
Mir99ahg
Name: Mir99a and Mirlet7c-1 host gene (non-protein coding)
Synonyms: 2810055G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77994
Cers6
Name: ceramide synthase 6
Synonyms: T1L, similar to TRH1, 4732462C07Rik, CerS6, Lass6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241447
Homologene: 72228
Plod3
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Synonyms: lysyl hydroxylase 3, LH3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26433
HGNC: HGNC:9083
Homologene: 843
Zfp677
Name: zinc finger protein 677
Synonyms: A830058L05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210503
Homologene: 138402
Npdc1
Name: neural proliferation, differentiation and control 1
Synonyms: NPDC-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18146
HGNC: HGNC:7899
Homologene: 32050
Rrp8
Name: ribosomal RNA processing 8
Synonyms: 2900001K19Rik, 1500003O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101867
Homologene: 5621
Marveld3
Name: MARVEL (membrane-associating) domain containing 3
Synonyms: MARVD3, 1810006A16Rik, Mrvldc3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73608
Homologene: 12504
Stoml3
Name: stomatin (Epb7.2)-like 3
Synonyms: SRO, SLP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229277
Homologene: 16628
Paqr7
Name: progestin and adipoQ receptor family member VII
Synonyms: PGLP, 2310021M12Rik, mPR, Mpra
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71904
Homologene: 12420
Gm11011
Name: predicted gene 11011
Type: Gene
Species: Mouse
Chromosome: 2
Ighv16-1
Name: immunoglobulin heavy variable 16-1
Synonyms: Gm7005
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629812
Gm10425
Name: predicted gene 10425
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 75,136,442 bp
  • G to T, chromosome 1 at 134,955,733 bp
  • G to A, chromosome 2 at 25,408,945 bp
  • G to T, chromosome 2 at 62,544,374 bp
  • G to A, chromosome 2 at 69,068,659 bp
  • T to A, chromosome 2 at 119,705,536 bp
  • T to C, chromosome 2 at 120,729,976 bp
  • C to A, chromosome 2 at 121,326,887 bp
  • T to C, chromosome 2 at 169,587,320 bp
  • T to A, chromosome 3 at 53,498,210 bp
  • T to C, chromosome 4 at 16,155,073 bp
  • T to A, chromosome 4 at 21,857,400 bp
  • A to G, chromosome 4 at 134,506,967 bp
  • T to C, chromosome 5 at 31,059,031 bp
  • G to A, chromosome 5 at 136,991,000 bp
  • A to T, chromosome 5 at 146,096,261 bp
  • T to C, chromosome 6 at 3,536,974 bp
  • T to G, chromosome 6 at 28,668,643 bp
  • A to G, chromosome 6 at 38,819,257 bp
  • A to G, chromosome 6 at 90,382,272 bp
  • T to C, chromosome 7 at 10,527,977 bp
  • C to A, chromosome 7 at 16,743,346 bp
  • A to G, chromosome 7 at 105,734,796 bp
  • G to A, chromosome 7 at 108,368,143 bp
  • T to A, chromosome 7 at 144,031,409 bp
  • G to A, chromosome 8 at 24,813,536 bp
  • A to T, chromosome 8 at 93,331,265 bp
  • A to G, chromosome 8 at 104,621,540 bp
  • C to A, chromosome 8 at 109,962,070 bp
  • A to G, chromosome 9 at 76,072,634 bp
  • G to T, chromosome 9 at 107,929,492 bp
  • G to A, chromosome 9 at 108,107,189 bp
  • A to G, chromosome 9 at 111,366,078 bp
  • G to T, chromosome 10 at 5,823,696 bp
  • A to T, chromosome 10 at 26,331,879 bp
  • C to A, chromosome 10 at 40,247,002 bp
  • G to A, chromosome 10 at 119,930,015 bp
  • G to T, chromosome 10 at 129,437,447 bp
  • T to A, chromosome 11 at 33,644,504 bp
  • T to A, chromosome 11 at 36,024,020 bp
  • G to A, chromosome 11 at 62,847,325 bp
  • T to C, chromosome 11 at 94,097,818 bp
  • T to C, chromosome 11 at 101,586,195 bp
  • G to A, chromosome 11 at 116,074,259 bp
  • T to A, chromosome 12 at 30,896,145 bp
  • T to C, chromosome 12 at 111,428,053 bp
  • A to T, chromosome 12 at 114,068,884 bp
  • G to A, chromosome 14 at 31,264,963 bp
  • A to T, chromosome 14 at 54,516,125 bp
  • G to T, chromosome 14 at 67,676,976 bp
  • A to G, chromosome 15 at 59,350,371 bp
  • A to T, chromosome 15 at 74,572,841 bp
  • A to G, chromosome 16 at 17,836,608 bp
  • A to C, chromosome 16 at 77,595,256 bp
  • C to T, chromosome 17 at 21,392,526 bp
  • A to T, chromosome 17 at 25,370,617 bp
  • T to C, chromosome 18 at 25,340,000 bp
  • A to G, chromosome 18 at 52,488,677 bp
  • T to G, chromosome 19 at 25,431,007 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4843 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042456-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.