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Strain Name:
C57BL/6J-MtgxR4844Btlr/Mmmh
Stock Number:
042457-MU
Citation ID:
RRID:MMRRC_042457-MU
Other Names:
R4844 (G1), C57BL/6J-MtgxR4844Btlr
Major Collection:

Strain Information

St8sia1
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Synonyms: alpha-2,8-sialyltransferase, ST8Sia I, GD3S, GD3 synthase, Siat8, Siat8a, 9330109E03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20449
Homologene: 2282
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Jarid2
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Ndufv1
Name: NADH:ubiquinone oxidoreductase core subunit V1
Synonyms: 24 kDa (FP)
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17995
HGNC: HGNC:7716
Homologene: 5151
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
Atad5
Name: ATPase family, AAA domain containing 5
Synonyms: LOC237877, C130052G03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237877
Homologene: 32611
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Cobl
Name: cordon-bleu WH2 repeat
Synonyms: C530045F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12808
Homologene: 9058
Ccnf
Name: cyclin F
Synonyms: CycF, Fbxo1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12449
VEGA: 17
HGNC: HGNC:1591
Homologene: 1335
Vti1a
Name: vesicle transport through interaction with t-SNAREs 1A
Synonyms: Vti1-rp2, 1110018K19Rik, 1110014F16Rik, 4921537J05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 53611
VEGA: 19
Homologene: 39963
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Dennd10
Name: DENN domain containing 10
Synonyms: 1810055E12Rik, Fam45a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67894
Homologene: 10217
Cit
Name: citron
Synonyms: CRIK-SK, citron-N, citron kinase, Cit-k, C030025P15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Vars1
Name: valyl-tRNA synthetase 1
Synonyms: G7a, D17H6S56E, Bat-6, Bat6, Vars2, Vars
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22321
Homologene: 4587
Coch
Name: cochlin
Synonyms: Coch-5B2, D12H14S564E
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Kcnn2
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms: small conductance calcium-activated potassium channel 2, SK2, fri, bc
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 140492
HGNC: HGNC:6291
Homologene: 135651
Jak3
Name: Janus kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16453
HGNC: HGNC:6193
Homologene: 181
Sv2a
Name: synaptic vesicle glycoprotein 2a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64051
Homologene: 32237
Igsf9
Name: immunoglobulin superfamily, member 9
Synonyms: NRT1, Dasm1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 93842
Homologene: 10815
Mxra8
Name: matrix-remodelling associated 8
Synonyms: 1200013A08Rik, DICAM, Asp3, limitrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74761
HGNC: HGNC:7542
Homologene: 11500
Tars1
Name: threonyl-tRNA synthetase 1
Synonyms: ThrRS, D15Wsu59e, Tars
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110960
VEGA: 15
Homologene: 11852
Cfap97
Name: cilia and flagella associated protein 97
Synonyms: 1110068E21Rik, 4933411K20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66756
Homologene: 12026
Gpr107
Name: G protein-coupled receptor 107
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277463
Homologene: 81077
Rfx7
Name: regulatory factor X, 7
Synonyms: 2510005N23Rik, 9930116O05Rik, D130086K05Rik, Rfxdc2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319758
Homologene: 11275
1600029O15Rik
Name: RIKEN cDNA 1600029O15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 665268
Aldh1a1
Name: aldehyde dehydrogenase family 1, subfamily A1
Synonyms: ALDH1, E1, Ahd-2, Ahd2, Raldh1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11668
HGNC: HGNC:402
Homologene: 110441
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alpha myosin, Myhc-a, alpha cardiac MHC, cardiomyopathy, hypertrophic 1, Myhca, A830009F23Rik, alpha-MHC, alphaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Hormad1
Name: HORMA domain containing 1
Synonyms: 4921522K05Rik, Nohma
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67981
Homologene: 69415
Astn2
Name: astrotactin 2
Synonyms: 1d8, Astnl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56079
Homologene: 77850
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319555
Homologene: 72261
Tcp11l2
Name: t-complex 11 (mouse) like 2
Synonyms: E430026E19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216198
Homologene: 17129
Pwwp2b
Name: PWWP domain containing 2B
Synonyms: D930023J19Rik, D7Ertd517e, Pwwp2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101631
Homologene: 19056
Adamts3
Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
Synonyms: 6330442E02Rik, 1100001H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: SUR2B, SUR2A, Sur2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Vmn1r194
Name: vomeronasal 1 receptor 194
Synonyms: Gm11294
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 626299
Homologene: 110880
Gpaa1
Name: GPI anchor attachment protein 1
Synonyms: mGAA1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14731
HGNC: HGNC:4446
Homologene: 37852
Zfp518a
Name: zinc finger protein 518A
Synonyms: 6330417C12Rik, 2810401C22Rik, Zfp518
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72672
VEGA: 19
Homologene: 19378
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102747
Homologene: 9782
C9orf72
Name: C9orf72, member of C9orf72-SMCR8 complex
Synonyms: 3110043O21Rik, Dennd9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73205
Homologene: 10137
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327963
Homologene: 88945
Acvrl1
Name: activin A receptor, type II-like 1
Synonyms: Alk1, activin receptor-like kinase-1, Acvrlk1, Alk-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11482
HGNC: HGNC:175
Homologene: 20058
Gnat2
Name: G protein subunit alpha transducin 2
Synonyms: Gnat-2, Tcalpha, Gt-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14686
HGNC: HGNC:4394
Homologene: 21092
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Cyp3a13
Name: cytochrome P450, family 3, subfamily a, polypeptide 13
Synonyms: IIIAm2, steroid inducible
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13113
Homologene: 133564
Smpdl3b
Name: sphingomyelin phosphodiesterase, acid-like 3B
Synonyms: 1110054A24Rik, Asml3b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100340
Homologene: 8708
Serpine2
Name: serine (or cysteine) peptidase inhibitor, clade E, member 2
Synonyms: nexin, PN-1, PI7, protease nexin 1, Spi4, B230326M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20720
HGNC: HGNC:8951
Homologene: 21247
Vash2
Name: vasohibin 2
Synonyms: B130052G07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226841
Homologene: 57005
Or2f1b
Name: olfactory receptor family 2 subfamily F member 1B
Synonyms: 18A, MOR257-2, GA_x6K02T2P3E9-4797841-4796888, Olfr38
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258988
HGNC: HGNC:8246
Homologene: 72050
Or1a1
Name: olfactory receptor family 1 subfamily A member 1
Synonyms: GA_x6K02T2P1NL-4348188-4349129, MOR125-5_p, IA7, Olfr403
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 404316
Homologene: 8219
Coq4
Name: coenzyme Q4
Synonyms: D2Ertd97e, EST-MNCb4625
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227683
Homologene: 68641
Adrm1b
Name: adhesion regulating molecule 1B
Synonyms: Gm9774
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100043022
Lpxn
Name: leupaxin
Synonyms: 4933402K05Rik, A530083L21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107321
VEGA: 19
Homologene: 3536
Pkig
Name: protein kinase inhibitor, gamma
Synonyms: PKIgamma
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18769
HGNC: HGNC:9019
Homologene: 5133
Chst11
Name: carbohydrate sulfotransferase 11
Synonyms: C4ST-1, C4ST1, C4ST, chondroitin 4, 1110020P09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 58250
Homologene: 56808
Gm17511
Name: predicted gene, 17511
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100502641
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Fam75d1b, Gm4934
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238662
VEGA: 13
Gm10576
Name: predicted gene 10576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
RP24-150D8.2
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Ighv14-1
Name: immunoglobulin heavy variable 14-1
Synonyms: Gm16996
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 780801
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 79,799,524 bp
  • T to C, chromosome 1 at 150,445,879 bp
  • A to G, chromosome 1 at 172,497,170 bp
  • C to T, chromosome 1 at 190,978,494 bp
  • G to A, chromosome 2 at 11,718,271 bp
  • T to C, chromosome 2 at 29,796,014 bp
  • T to A, chromosome 2 at 31,188,674 bp
  • C to T, chromosome 2 at 163,721,162 bp
  • T to G, chromosome 3 at 92,429,425 bp
  • T to C, chromosome 3 at 95,570,931 bp
  • T to A, chromosome 3 at 96,188,379 bp
  • T to C, chromosome 3 at 108,095,515 bp
  • A to G, chromosome 4 at 6,273,655 bp
  • A to G, chromosome 4 at 35,213,565 bp
  • A to G, chromosome 4 at 65,644,730 bp
  • T to C, chromosome 4 at 101,054,510 bp
  • T to C, chromosome 4 at 132,738,058 bp
  • A to G, chromosome 4 at 155,842,694 bp
  • T to C, chromosome 5 at 25,315,113 bp
  • T to A, chromosome 5 at 89,677,816 bp
  • T to C, chromosome 5 at 115,846,374 bp
  • T to C, chromosome 5 at 119,831,346 bp
  • A to T, chromosome 5 at 137,917,551 bp
  • T to A, chromosome 6 at 42,762,460 bp
  • T to C, chromosome 6 at 142,689,098 bp
  • T to A, chromosome 6 at 142,829,270 bp
  • C to T, chromosome 7 at 24,199,376 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • G to A, chromosome 7 at 127,286,282 bp
  • C to A, chromosome 7 at 139,255,586 bp
  • A to G, chromosome 8 at 46,169,675 bp
  • A to T, chromosome 8 at 71,681,655 bp
  • A to T, chromosome 8 at 72,667,114 bp
  • C to T, chromosome 9 at 58,208,234 bp
  • T to C, chromosome 9 at 60,677,283 bp
  • C to T, chromosome 9 at 72,593,242 bp
  • G to T, chromosome 10 at 83,191,089 bp
  • G to T, chromosome 10 at 84,613,691 bp
  • A to T, chromosome 11 at 12,254,740 bp
  • T to C, chromosome 11 at 20,708,667 bp
  • A to T, chromosome 11 at 74,084,399 bp
  • A to G, chromosome 11 at 74,196,076 bp
  • G to A, chromosome 11 at 80,114,311 bp
  • G to A, chromosome 11 at 102,193,231 bp
  • G to A, chromosome 11 at 115,323,375 bp
  • G to A, chromosome 12 at 51,602,694 bp
  • T to G, chromosome 12 at 113,932,002 bp
  • T to C, chromosome 13 at 22,245,053 bp
  • T to C, chromosome 13 at 44,913,772 bp
  • C to T, chromosome 13 at 59,718,355 bp
  • A to G, chromosome 14 at 54,947,194 bp
  • G to A, chromosome 15 at 11,385,195 bp
  • C to T, chromosome 15 at 76,332,308 bp
  • T to C, chromosome 15 at 101,135,528 bp
  • G to T, chromosome 17 at 24,230,357 bp
  • A to G, chromosome 17 at 35,011,612 bp
  • A to T, chromosome 18 at 45,683,120 bp
  • A to G, chromosome 19 at 4,012,574 bp
  • A to G, chromosome 19 at 12,833,172 bp
  • A to G, chromosome 19 at 20,634,400 bp
  • T to A, chromosome 19 at 40,914,896 bp
  • A to G, chromosome 19 at 55,391,865 bp
  • GTCT to GT, chromosome 19 at 60,834,997 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4844 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042457-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.